检索结果-南通市图书馆

Comparison of clinical features and outcomes of proliferative,fibrotic,and mixed subtypes of IgG4-related disease:A retrospective cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第3期137卷 303-311页

作者： Linyi Peng Xinlu Zhang Jiaxin Zhou Jieqiong Li Zheng Liu hui Lu Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng wen Zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalNational Clinical Research Center for Dermatologic and Immunologic DiseasesState Key Laboratory of Complex Severe and Rare DiseasesThe Ministry of Education Key LaboratoryBeijing 100730China Institute of Clinical Medicine Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Immunoglobulin G4-related disease(IgG4-RD)is a recently recognized immune-mediated disorder that can affect almost any organ in the human ***4-RD can be categorized into proliferative and fibrotic subtypes based on patients’clinicopathological *** study aimed to compare the clinical manifestations,laboratory findings,and treatment outcomes of IgG4-RD among different ***:We prospectively enrolled 622 patients with newly diagnosed IgG4-RD at Peking Union Medical College Hospital from March 2011 to August *** patients were divided into three groups according to their clinicopathological characteristics:proliferative,fibrotic,and mixed *** compared demographic features,clinical manifestations,organ involvement,laboratory tests,and treatment agents across three *** then assessed the differences in treatment outcomes among 448 patients receiving glucocorticoids alone or in combination with ***,risk factors of relapse were revealed by applying the univariate and multivariate Cox regression ***:We classified the 622 patients into three groups consisting of 470 proliferative patients,55 fibrotic patients,and 97 mixed patients,*** found that gender distribution,age,disease duration,and frequency of allergy history were significantly different among *** terms of organ involvement,submandibular and lacrimal glands were frequently involved in the proliferative subtype,while retroperitoneum was the most commonly involved site in both fibrotic subtype and mixed *** comparison of laboratory tests revealed that eosinophils(P=0.010),total IgE(P=0.006),high-sensitivity C-reactive protein(P<0.001),erythrocyte sedimentation rate(P<0.001),complement C4(P<0.001),IgG(P=0.001),IgG1(P<0.001),IgG4(P<0.001),and IgA(P<0.001),at baseline were significantly different among three *** with proliferative and mixed subtypes,the fibrotic subtype showed the

关键词： IgG4-related disease Proliferative subtype Fibrotic subtype Clinical features Treatment outcome

Computed tomography-based radiomic model for the prediction of neoadjuvant immunochemotherapy response in patients with advanced gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4115-4128页

作者： Jun Zhang Qi Wang Tian-hui Guo wen Gao Yi-Miao Yu Rui-Feng Wang Hua-Long Yu Jing-Jing Chen Ling-Ling Sun Bi-Yuan Zhang Hai-Ji Wang Department of Radiation Oncology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Radiology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Neoadjuvant immunochemotherapy(nICT)has emerged as a popular treatment approach for advanced gastric cancer(AGC)in clinical practice ***,the response of AGC patients to nICT displays significant heterogeneity,and no existing radiomic model utilizes baseline computed tomography to predict treatment *** To establish a radiomic model to predict the response of AGC patients to *** Patients with AGC who received nICT(n=60)were randomly assigned to a training cohort(n=42)or a test cohort(n=18).Various machine learning models were developed using selected radiomic features and clinical risk factors to predict the response of AGC patients to *** individual radiomic nomogram was established based on the chosen radiomic signature and clinical *** performance of all the models was assessed through receiver operating characteristic curve analysis,decision curve analysis(DCA)and the Hosmer Lemeshow goodness-of-fit *** The radiomic nomogram could accurately predict the response of AGC patients to *** the test cohort,the area under curve was 0.893,with a 95%confidence interval of *** indicated that the clinical application of the radiomic nomogram yielded greater net benefit than alternative *** A nomogram combining a radiomic signature and a clinical signature was designed to predict the efficacy of nICT in patients with *** tool can assist clinicians in treatment-related decision-making.

关键词： Gastric cancer Radiomics Computed tomography Neoadjuvant immunochemotherapy Machine learning Immunology

开放世界物体识别与检测系统:现状、挑战与展望

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算机研究与发展 2024年第9期61卷 2128-2141页

作者：聂晖王瑞平陈熙霖中国科学院计算技术研究所北京100190 中国科学院大学北京100049

探究了从封闭环境到开放世界环境的转变及其对视觉感知(集中于物体识别和检测)与深度学习领域的影响.在开放世界环境中,系统软件需适应不断变化的环境和需求,这为深度学习方法带来新挑战.特别是,开放世界视觉感知要求系统理解和处理训... 详细信息

探究了从封闭环境到开放世界环境的转变及其对视觉感知(集中于物体识别和检测)与深度学习领域的影响.在开放世界环境中,系统软件需适应不断变化的环境和需求,这为深度学习方法带来新挑战.特别是,开放世界视觉感知要求系统理解和处理训练阶段未见的环境和物体,这超出了传统封闭系统的能力.首先讨论了技术进步带来的动态、自适应系统需求,突出了开放系统相较封闭系统的优势.接着,深入探讨了开放世界的定义和现有工作,涵盖开集学习、零样本学习、小样本学习、长尾学习、增量学习等5个开放维度.在开放世界物体识别方面,分析了每个维度的核心挑战,并为每个任务数据集提供了量化的评价指标.对于开放世界物体检测,讨论了检测相比识别的新增挑战,如遮挡、尺度、姿态、共生关系、背景干扰等,并强调了仿真环境在构建开放世界物体检测数据集中的重要性.最后,强调开放世界概念为深度学习带来的新视角和机遇,是推动技术进步和深入理解世界的机会,为未来研究提供参考.

关键词：开放世界视觉感知物体检测物体识别评价指标仿真环境

Magnetic resonance imaging of extraocular rectus muscles abnormalities in acute acquired concomitant esotropia

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第1期17卷 119-125页

作者： Jia-Yu Chen Li-Rong Zhang Jia-wen Liu Jie Hao hui-Xin Li Qiong-Yue Zhang Zhao-hui Liu Jing Fu Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Key Laboratory of Ophthalmology&Visual SciencesCapital Medical UniversityBeijing 100176China Department of Radiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of Industrial Engineering and Operation Research University of CaliforniaBerkeley 94720USA

AIM:To investigate the difference of medial rectus(MR)and lateral rectus(LR)between acute acquired concomitant esotropia(AACE)and the healthy controls(HCs)detected by magnetic resonance imaging(MRI).METHODS:A case-control *** subjects with AACE and eighteen HCs were *** scanning data were conducted in target-controlled central gaze with a 3-Tesla magnetic resonance *** muscles(EOMs)were scanned in contiguous image planes 2-mm thick spanning the EOM origins to the globe *** form posterior partial volumes(PPVs),the LR and MR cross-sections in the image planes 8,10,12,and 14 mm posterior to the globe were summed and multiplied by the 2-mm slice *** data were classified according to the right eye,left eye,dominant eye,and non-dominant eye,and the differences in mean cross-sectional area,maximum cross-sectional area,and PPVs of the MR and LR muscle in the AACE group and HCs group were compared under the above classifications ***:There were no significant differences between the two groups of demographic *** mean cross-sectional area of the LR muscle was significantly greater in the AACE group than that in the HCs group in the non-dominant eyes(P=0.028).The maximum cross-sectional area of the LR muscle both in the dominant and non-dominant eye of the AACE group was significantly greater than the HCs group(P=0.009,P=0.016).For the dominant eye,the PPVs of the LR muscle were significantly greater in the AACE than that in the HCs group(P=0.013),but not in the MR muscle(P=0.698).CONCLUSION:The size and volume of muscles dominant eyes of AACE subjects change significantly to overcome binocular *** LR muscle become larger to compensate for the enhanced convergence in the AACE.

关键词： acute acquired concomitant esotropia magnetic resonance imaging extraocular muscles

Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE Jun-yu SONG Jin-bin LI Long HE Zhen-fan HUANG Zhuo-jian LIU Zheng-lin CHEN Gui-rong WANG Hai-yan wen Su-ru ZHOU Heng-li MA hui-lin DU Qun WU Yong-qiang LI Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： Xuan Zhang Zhe Wang Gui-Ling Lin Fang-Zhi Wei Yan-Ping Zhuang wen-Lu Xu Qi Zhang hui-Tao Wu Zi-Man He Xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(P<0.05).A correlation was identified between total social support and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海洋平台主机舱振动建模仿真分析及试验研究

舰船科学技术 2024年第5期46卷 74-79页

作者：李慧殷学文吴文伟刘媛慧中国船舶科学研究中心、船舶振动噪声重点实验室、深海技术科学太湖实验室江苏无锡214082

为了优化结构整体减振性能,以某海洋平台主机舱为研究对象,利用典型运行工况下平台的振动试验实测数据对主机舱柴发机组引起的结构振动传递进行仿真分析,建立不同的主机舱振动计算模型,比较不同边界条件、不同隔振器刚度对计算结果的影... 详细信息

为了优化结构整体减振性能,以某海洋平台主机舱为研究对象,利用典型运行工况下平台的振动试验实测数据对主机舱柴发机组引起的结构振动传递进行仿真分析,建立不同的主机舱振动计算模型,比较不同边界条件、不同隔振器刚度对计算结果的影响,提出适用于工程实用的较为精确的主机舱整体有限元仿真模型。通过计算推进器40%功率状态和航行状态2种典型运行工况下主机激励经由机脚、隔振器传递到平台基座的振动传递,并与实船测试结果进行比较,验证了有限元分析模型的合理性和精确性,计算结果可靠,具有较高的工程价值,为后续海洋平台主机舱隔振优化设计提供参考。

关键词：主机舱振动仿真建模振动传递试验对比

在线全文

学校读者我要写书评

暂无评论

鸡卵泡选择和闭锁调控机制研究进展

农业生物技术学报 2024年第1期32卷 200-208页

作者：张文慧聂瑞雪凌遥李俊英张博张浩中国农业大学动物科学技术学院

鸡(Gallus gallus)卵巢中的各阶段发育卵泡和闭锁卵泡数量及其比例与产蛋性能相关，组织良好的卵泡发育次序对于提高产蛋数和维持产蛋持续性非常重要。本文综合分析卵泡选择和闭锁过程中的生理表型变化，总结了影响鸡卵泡选择和闭锁的... 详细信息

鸡(Gallus gallus)卵巢中的各阶段发育卵泡和闭锁卵泡数量及其比例与产蛋性能相关，组织良好的卵泡发育次序对于提高产蛋数和维持产蛋持续性非常重要。本文综合分析卵泡选择和闭锁过程中的生理表型变化，总结了影响鸡卵泡选择和闭锁的主要调控机制，重点讨论了颗粒细胞自噬、凋亡及炎症反应在卵泡闭锁中的作用，提出了今后的研究方向和建议，对解析鸡产蛋性状遗传机制具有重要的参考价值。

关键词：鸡卵泡选择卵泡闭锁颗粒细胞

Association between tobacco exposure and bladder cancer recurrence:A systematic review and meta-analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2024年第2期14卷 145-157页

作者： Lei Xiang Qi-Qi Xie Si-Si Xu wen-Jie Ruan Dong-hui Xu Yao-Yao Gan Jia Zuo wen-Jun Xu Zhi-Peng Li Department of Rehabilitation Medicine First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

BACKGROUND However,the connection between smoking and the prognosis of patients with bladder cancer remains *** To determine whether smoking is linked to the recurrence and progression of bladder *** As of July 20,2022,relevant English-language research was identified by searching PubMed,the Web of Science,and the Cochrane *** pooled the available data from the included studies using a random effects *** analysis and sensitivity analysis were also *** A total of 12 studies were included in this *** combined analysis revealed that tobacco exposure was associated with a significantly greater recurrence rate than nonsmoking status[odd ratios(OR)=1.76,95%CI:1.84-2.93],and the progression of bladder cancer was significantly greater in smokers than in nonsmokers(OR=1.21,95%CI:1.02-1.44).Stratified analysis further revealed that current smokers were more likely to experience relapse than never-smokers were(OR=1.85,95%CI:1.11-3.07).Former smokers also had a greater risk of relapse than did never-smokers(OR=1.73,95%CI:1.09-2.73).Subgroup analysis indicated that non-Caucasians may be more susceptible to bladder cancer recurrence than Caucasians are(OR=2.13,95%CI:1.74-2.61).CONCLUSION This meta-analysis revealed that tobacco exposure may be a significant risk factor for both the recurrence and progression of bladder cancer.

关键词： Smoking Bladder Cancer Recurrence Progress