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Effect of herbicide acetochlor on cytochrome P450 monooxygenases and GST of earthworms Eisenia fetida

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Journal of Environmental Sciences 2006年第1期18卷 135-140页

作者： XIAO Neng-wen liU Xiang-hui li Wei GE Feng State Key Lab of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing 100080 China

To assess the sublethal toxicity of the herbicide acetochlor to earthworms and to find out biomarkers possible inducted under acetochlor exposure, Eiseniafetida was exposed to artificial soils supplemented with different concentrations of acetochlor（5, 10, 20, 40 and 80 mg/kg soil）. Effects of the acetochlor on cytochrome P450 monooxygenases p-nitroanisole O-demethylase（ODM）, aldrin epoxidase（AE） and glutathione-S-transferases （GSTs） activities were determined. The results revealed cytochrome P450 monooxygenases were elevated with increasing concentrations of acetochlor, and the AE activity increased significantly compared with control at the concentration of 80 mg/kg （P〈0.05）. However, ODM activity from E. fetida was not induced significantly by acetochlor at all treatments（P〉0.05）. Sodium dodecyl sulfate-polyacryamide gel electrophoresis（SDS-PAGE） showed that one protein band was visualized and no evident differences were found in protein profiles between treatments and control. The GST activity increased significantly with longer duration（P〈0.05） and increasing concentrations of acetochlor exposure（P〈0.05）. This study showed that the monooxygenases and GSTs activities in E. fetida could be induced by acetochlor, and thus, the AE and GST could be used in sublethal assays for soil contamination surveys and GST could be used as biomarkers of acetochlor exposure in E. fetida.

关键词： acetochlor Eiseniafetida p-nitroanisole O-demethylase aldrin epoxidase GST

Multifunctional carbon materials from rugose rose for energy storage and water purification

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 1-13页

作者： Peng-hui li hui Zhou wen-Juan Wu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai 200237China

With the advancement of social process,the resource problem is becoming more prominent,biomass materials come into being,and it is becoming more and more important to explore and prepare efficient and multifunctional biomass materials to alleviate the problems of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon materials(NRRC)were produced by one-step carbonization of withered rose as raw material and melamine as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon material had the most abundant pores and the best microspherical graded pore structure,with a specific surface area of up to 1393 m2·g^(-1),a pore volume of 0.68 cm3·g^(-1),and a nitrogen-doped content of 5.52%.Electrochemical tests showed that the maximum specific capacitance of NRRC in the three-electrode system was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was combined with favorable capacitance retention performance and cycling *** NRRC//NRRC symmetric supercapacitors were further assembled,and the maximum energy density of a single device was 23.88 Wh·kg^(-1),which still maintains excellent capacitance retention and cyclic charging/discharging *** example,the capacitance retention rate was always close to 96.27%with almost negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system,the super capacitive performance of NRRC porous carbon materials was comparable to the electrochemical performance of many reported biomass porous carbon materials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon materials had excellent water purification *** dye adsorption test confirmed that NRRC had a high adsorption capacity(491.47 mg·g^(-1))for methylene *** undoubtedly also showed a potential and promising avenue for high value-added utilization

关键词： rose carbon adsorption electrode material electrochemical performance

Orbital Stability of Solitary Waves of Compound KdV-type Equation

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Acta Mathematicae Applicatae Sinica 2015年第4期31卷 1033-1042页

作者： Wei-guo ZHANG hui-wen li Xiao-shuang BU Lan-yun BIAN School of Science University of Shanghai for Science and Technology

In this paper, we study the orbital stability of solitary waves of compound KdV-type equation in the form of ut ＋ auPux ＋ bu2pux ＋ Uzzz = 0 （b 〉 0, p 〉 0）. Our results imply that orbital stability of solitary waves is affected not only by the highest-order nonlinear term bu2pux, but also the nonlinear term auPux. For the case of b 〉 0 and 0 〈 p ≤ 2, we obtain that the positive solitary wave Ul（X - ct） is stable when a 〉 0, while that unstable when a 〈 0. The stability for negative solitary wave u2（x - ct） is on the contrary. In particular, we point that the nonlinear term with coefficient a makes contributes to the stability of the solitary waves when p= 2 and a〉0.

关键词： orbital stability compound KdV-type equation solitary waves spectral analysis

Hypercalcemia Appeared in a Patient with Glucagonoma Treated with Octreotide Acetate Long-acting Release

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Chinese Medical Sciences Journal 2012年第3期27卷 182-184页

作者： Rui Min Mei li Jiang-feng Mao Feng Gu hui-juan Zhu wen-hui li Yu-xiu li Department of Endocrinology Key Laboratory of Endocrinology of the Ministry of HealthPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

PABCREATIC neuroendocrine tumours are uncommon neoplasms of the *** may cause a clinical syndrome due to hormone *** is a rare kind of pancreatic tumors. Here we report a case of glucagonoma. Hypercalcemia occurred wh... 详细信息

关键词： octreotide acetate long-acting release glucagonoma hypercalcemia

Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

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Genes & Diseases 2020年第3期7卷 351-358页

作者： Wei Xiong Yong liao Ji-Yong Qin wen-hui li Zhao-You Tang The Department of Radiation Oncology Yunnan Cancer HospitalThe Third Affiliated Hospital of Kunming Medical UniversityKunmingChina Institute for Viral Hepatitis The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina liver Cancer Institute and Zhongshan Hospital Fudan UniversityShanghaiChina

The phenomenon of enhanced invasion and metastasis of residual tumor cells has been observed in an increasing number of patients receiving chemoradiotherapy recently,and tumor metastasis will undoubtedly limit patient ***,the key mechanism by which chemoradiotherapy affects the invasion and metastasis of tumor cells remains *** have shown that chemoradiotherapy may directly act on tumor cells and alter the tumor microenvironment,or induce cell apoptosis and autophagy to promote tumor cell survival and *** this review,we summarize the potential mechanisms by which chemoradiotherapy may affect the biological behavior of tumor cells and open up new avenues for reducing tumor recurrence and metastasis after *** insights will improve the efficacy of chemoradiotherapy.

关键词： Biological behavior Cancer Chemoradiotherapy Mechanism Invasion and metastasis

Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

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Journal of Iron and Steel Research International 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He Xin-hui Chen hui li Kai-hua Shi hui-wen Xiong Xin Xiang li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

The Perturbation Bound of the Extended Vertical linear Complementarity Problem

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Journal of the Operations Research Society of China 2024年第3期12卷 601-625页

作者： Shi-liang Wu wen li He-hui Wang School of Mathematics Yunnan Normal UniversityKunming650500YunnanChina School of Mathematical Sciences South China Normal UniversityGuangzhou510631GuangdongChina School of Mathematics and Statistics Yunnan UniversityKunming650091YunnanChina

In this paper,we discuss the perturbation analysis of the extended vertical linear complementarity problem(EVLCP).Under the assumption of the row W-property,we derive several absolute and relative perturbation bounds ... 详细信息

关键词： The extended vertical linear complementarity problem The row W-property The perturbation bound

Tuning heterogeneous microstructures to enhance mechanical properties of nano-TiN particle reinforced Haynes 230 composites by laser powder bed fusion

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Rare Metals 2024年第9期43卷 4548-4565页

作者： wen-Jie liu hui li Qian-Xing Yin He-Jun Du School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

Laser powder bed fusion(LPBF)is considered to be one of the most promising additive manufacturing technologies for producing components with geometries and high geometrical precision that are unattainable by traditional *** superalloy exhibits exceptional mechanical and high-temperature performances,rendering it a prime candidate for advanced aero-engine *** the high demand for LPBF-manufactured superalloys,the superalloy is one of the materials manufactured difficultly by LPBF due to their large laser absorptivity fluctuation,poor molten pool stability and sharp temperature ***,superalloys are characterized by severe pores,undesirable coarse columnar grains and poor mechanical *** this work,the effect of nano-TiN particles on defects,molten pool characteristics and microstructure and performance of the composites were *** 4.5 wt%TiN/Haynes230 samples exhibited exceptional nanohardness and elastic modulus with maximum values reaching 5.53 GPa and 240.03 GPa,*** superior mechanical properties were attributed to the combined effects of spatter and gas pore inhibition,grain refinement and duplex nanophases ***,the stability of molten pool was enhanced,and spatter was effectively suppressed by adding nano-TiN particles,while grain refinement and columnar to equiaxed transitions were ***,the matrix exhibited a high dislocation density due to a significant hindrance of dislocation movement caused by massive nano-phases(e.g.,TiN and M_(23)C_(6)),resulting in the formation of extensive dislocation tangles and *** work offers novel insights into the role of nanoparticles reinforced superalloy composites by LPBF.

关键词： Composites Laser powder bed fusion Molten pool characteristics Microstructure Mechanical properties

Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 35-42页

作者： li-li Miao Jing-wen Wang hui-hui liu Shuai Gao Yu-Chen Fan Kai Wang Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Hepatology Shandong UniversityJinan 250012China

Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnostic value for hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC). Methods: We enrolled 197 patients, 111 with HBV-HCC, 51 with chronic hepatitis B(CHB), and 35 healthy controls(HCs). The methylation status of GLDC promoter in peripheral mononuclear cells(PBMCs) was identified by methylation specific polymerase chain reaction(MSP). The mRNA expression was examined using real-time quantitative polymerase chain reaction(q PCR). Results: The methylation frequency of the GLDC promoter was significantly lower in HBV-HCC patients(27.0%) compared to that in CHB patients(68.6%) and HCs(74.3%)( P < 0.001). The methylated group had lower alanine aminotransferase level( P = 0.035) and lower rates of tumor node metastasis(TNM) Ⅲ/Ⅳ( P = 0.043) and T3/T4( P = 0.026). TNM stage was identified to be an independent factor for GLDC promoter methylation. GLDC mRNA levels in CHB patients and HCs were significantly lower than those in HBV-HCC patients( P = 0.022 and P < 0.001, respectively). GLDC mRNA levels were significantly higher in HBV-HCC patients with unmethylated GLDC promoters than those with methylated GLDC promoters( P = 0.003). The diagnostic accuracy of alpha-fetoprotein(AFP) combined with GLDC promoter methylation for HBV-HCC was improved compared with that of AFP alone(AUC: 0.782 vs. 0.630, P < 0.001). In addition, GLDC promoter methylation was an independent predictor for overall survival of HBV-HCC patients( P = 0.038). Conclusions: The methylation frequency of GLDC promoter was lower in PBMCs from HBV-HCC patients than that from patients with CHB and HCs. The combination of AFP and GLDC promoter hypomethylation significantly improved the diagnostic accuracy of HBV-HCC.

关键词： Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells