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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng wang Hao Nian Yan-Fang wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Chung-type Law of the Iterated Logarithm for Continuous Time Random Walk

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Acta Mathematicae Applicatae Sinica 2017年第4期33卷 959-966页

作者： wen-sherlg wang School of Economics Hangzhou Dianzi University Hangzhou 310018 China College of Science Hangzhou Normal University Hangzhou 310036 China

A continuous time random walk is a random walk subordinated to a renewal process used in physics to model anomalous diffusion. In this paper, we establish a Chung-type law of the iterated logarithm for continuous time... 详细信息

关键词： continuous time random walk law of the iterated logarithm stable law anomalous diffusion

On p-variation of bifractional Brownian motion

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Applied Mathematics(A Journal of Chinese Universities) 2011年第2期26卷 127-141页

作者： wang wen-sheng Department of Mathematics Hangzhou Normal University Hangzhou 310036 China

In this paper we study p-variation of bifractional Brownian motion. As an applica-tion, we introduce a class of estimators of the parameters of a bifractional Brownian motion andprove that both of them are strongly consistent; as another application, we investigate fractalnature related to the box dimension of the graph of bifractional Brownian motion.

关键词： Bifractional Brownian motion variation strongly consistent fractal nature.

Strong Laws of Large Numbers for Random Walks in Random Sceneries

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Acta Mathematicae Applicatae Sinica 2007年第3期23卷 495-500页

作者： wen-sheng wang Department of Statistics East China Normal University Shanghai 200062 China

In this paper, we study strong laws of large numbers for random walks in random sceneries. Some mild sufficient conditions for the validity of strong laws of large numbers are obtained.

关键词： Random walk in random scenery law of large numbers

Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du wang Rongjie Lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

A Strong Approximation Theorem for Quasi-associated Sequences

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Acta Mathematica Sinica,English Series 2005年第6期21卷 1269-1276页

作者： wen Sheng wang Department of Statistics East China Normal University Shanghai 200062 P. R. China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China

By combining the Csorgo-Révész quantile transform methods and the Skorohod-Strassen martingale embedding theorem, we prove a strong approximation theorem for quasi-associated random variables with mean zero and finite （2 ＋ δ）th moment under polynomial decay rate. As a consequence, the decay rate for a strong approximation theorem of associated sequences of Yu （1996） is weakened.

关键词： Quasi-association Partial sum Strong approximation Quantile transform

A LIL and Limit Distributions for Trimmed Sums of Random Vectors Attracted to Operator Semi-stable Laws

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1555-1565页

作者： wen Sheng wang Department of Mathematics Hangzhou Normal University

Let θ∈^d be a unit vector and let X, X1, X2,…… be a sequence of i.i.d. Xd-valued random vectors attracted to operator semi-stable laws. For each integer n ≥1, let X1,≤……≤ Xn,n denote the order statistics of X1, X2,..., Xn according to priority of index, namely ｜（X1,nθ）｜≥…≥ [（Xn,n,θ）1, where （., .） is an inner product on Rd. For all integers r ≥ 0, define by （r）Sn =∑n-r i=1Xi,n the trimmed sum. In this paper we investigate a law of the iterated logarithm and limit distributions for trimmed sums （r）Sn. Our results give information about the maximal growth rate of sample paths for partial sums of X when r extreme terms are excluded. A stochastically compactness of （r）Sn is obtained.

关键词： Operator semi-stable law domain of attraction law of the iterated logarithm stochastically compactness affine normalized partial sum trimmed sum

Non Blow-up Criterion for the 3-D Magneto-hydrodynamics Equations in the Limiting Case

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Acta Mathematica Sinica,English Series 2017年第7期33卷 969-980页

作者： wen Dong wang School of Mathematical Sciences Dalian University of TechnologyDalian 116024P.R.China

In this paper, we prove that suitable weak solution （u,b） of tne 3-D MHD equations can be extended beyond T if u E L∞（0,T; La（R3）） and the horizontal components bh of the magnetic field satisfies the well-known Ladyzhenskaya-Prodi-Serrin condition, which improves the corresponding regularity criterion by Mahalov-Nicolaenko-Shilkin.

关键词： Suitable weak solution MHD equations regularity criterion