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Chinese Chemical Letters 1991年第10期2卷 817-820页

作者： Guo wen LI, Xue wen HU, hong ding and Ying Qiu LIANG Institute of Theoretical Chemistry, Jilin University, Changchun 130023

A novel amphiphile of 4-[4-(4-decyloxyphenylazo) naphthyloxy] butyl trimethylammonium bromide has been synthesized. It can form the stable bilayer in dilute aqueous solution.

关键词： AND ITS SELF-ASSEMBLING BEHAVIOR IN DILUTE AQUEOUS SOLUTION BUTYL TRIMETHYLAMMONIUM BROMIDE DECYLOXYPHENYLAZO NAPHTHYLOXY SYNTHESIS OF A NOVEL AMPHIPHILE ITS

Role of Whole-exome Sequencing in Phenotype Classification and Clinical Treatment of Pediatric Restrictive Cardiomyopathy

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Chinese Medical Journal 2017年第23期130卷 2823-2828页

作者： wen-hong ding Ling Han Yah-Yah Xiao Ying Mo Jing Yang Xiao-Fang Wang Mei Jin Department of Pediatric Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background： Restrictive cardiomyopathy （RCM） is the least common cardiomyopathy in which the walls are rigid and the heart is restricted from stretching and filling properly. Cardiac troponin I （cTnI） mutation-caused myofibril Ca2＋ hypersensitivity has been shown to be associated with impaired diastolic function. This study aimed to investigate the linkage between the genotype and clinical therapy of RCM. Methods： Five sporadic pediatric RCM patients confirmed by echocardiography were enrolled in this ***-exome sequencing （WES） was performed for the cohort to find out candidate causative gene variants. Sanger sequencing confirmed the WES-identified variants. Results： TNNI3 variants were found in all of the five patients. R192H mutation was shared in four patients while R204H mutation was found only in one patient. Structure investigation showed that the C terminus of TNNI3 was flexible and mutation on the C terminus was possible to cause the RCM. Catechins were prescribed for the five patients once genotype was confirmed. Ventricular diastolic function was improved in three patients during the follow-up. Conclusions： Our data demonstrated that TNNI3 mutation-induced RCM1 is the most common type of pediatric RCM in this study. In addition, WES is a reliable approach to identify likely pathogenic genes of RCM and might be useful for the guidance of clinical treatment scheme.

关键词： Pediatric Restrictive Cardiomyopathy Phenotype Classification TNNI3 Whole-exome Sequcncing

Balloon Angioplasty as a Modality to Treat Children with Pulmonary Stenosis Secondary to Complex Congenital Heart Diseases

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Chinese Medical Journal 2017年第23期130卷 2793-2801页

作者： Yan Gu Mei Jin Xiao-Fang Wang Bao-Jing Guo wen-hong ding Zhi-Yuan Wang Ya-Hui Zhang Department of Pediatric Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China

Background： Pulmonary stenosis is common in children with complex congenital heart diseases. Proper management of this problem, especially postoperatively, is still controversial. This study was designed to assess the rate and determinants of success or failure of balloon angioplasty for such lesions. Methods： Clinical and hemodynamic data from 40 pediatric patients （24 boys and 16 girls） with complex congenital heart diseases who underwent balloon angioplasty were reviewed retrospectively from January 2012 to December 2016. Patients were divided into four groups according to the site of stenosis, which included pulmonary valve stenosis （PVS）, valved conduit stenosis, pulmonary artery stenosis （PAS）, and supravalvular pulmonary stenosis （SVPS）. Success rates were calculated according to defined criteria for initial success and favorable clinical impacts, and comparison between the successful subgroup and the unsuccessful subgroups was analyzed. Results： Grouped by the site of stenosis, initial success rates varied from 40.0% to 52.4% with the greatest success being seen in the PVS group, followed by the PAS group and SVPS group. In the PVS group and the PAS group, there was no statistical difference among age at dilation, postoperative interval, balloon/stenosis ratio, or pressure gradient predilation between the successful and the unsuccessful subgroups. Favorable clinical impacts included success rates of balloon angioplasty in the SVPS group, which was best （100%）, followed by the PVS group （90.9%） and the PAS group （85.7%）. There were a total of two transient complications （5.0%）. Conclusions： Balloon angioplasty was proven to be a safe and useful modality in children with complex congenital heart diseases and postoperative pulmonary stenosis, which should be the initial therapeutic modality in selected patients.

关键词： Balloon Angioplasty Complex Congenital Heart Disease Pulmonary Stenosis

A case of primary malignant fibrous histiocytoma of the pancreas: CT and MRI findings

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World Journal of Gastroenterology 2008年第18期14卷 2942-2945页

作者： Ri-Sheng Yu Jia-Wei Wang Ying Chen wen-hong ding Xiu-Fang Xu Li-Rong Chen Department of Radiology Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China Department of Pathology Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

Primary malignant fibrous histiocytoma (MFH) of the pancreas is rare and a distinct clinical entity. We report a case of recurrence of pancreatic MFH with computed tomography (CT) and magnetic resonance imaging (MRI) findings. A 67-year-old man presented with a history of decreased body weight over the past 6 mo. Abdominal CT revealed a large, multilocular cystic mass in the head of the pancreas with obvious atrophy in the body and tail of the pancreas. After 6 mo postoperatively, MRI demonstrated a recurrent large mass in the primary area of the head of the pancreas. The lesion was heterogeneous, hypointense to the liver on T1-weighted imaging, and heterogeneously hyperintense to the liver with a hypointense area in the central part of the tumor on fat-saturated T2-weighted imaging. Contrast- enhanced T1-weighted imaging demonstrated a large multilocular cystic mass with a cystic wall, fibrous septa and enhancement of solid components. To the best of our knowledge, this is the first report on recurrence of primary MFH of the pancreas, and the first with MRI findings.

关键词： Pancreatic neoplasms Malignant fibrous histiocytoma Computed tomography Magnetic resonance imaging Tumor recurrence

Biochemical metabolic changes assessed by ^(31)P magnetic resonance spectroscopy after radiation-induced hepatic injury in rabbits

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World Journal of Gastroenterology 2009年第22期15卷 2723-2730页

作者： Ri-Sheng Yu Liang Hao Fei Dong Jian-Shan Mao Jian-Zhong Sun Ying Chen Min Lin Zhi-Kang Wang wen-hong ding Department of Radiology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China Department of Internal Medicine Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China Department of Pathology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China

AIM： To compare the features of biochemical metabolic changes detected by hepatic phosphorus-31 magnetic resonance spectroscopy （^31p MRS） with the liver damage score （LDS） and pathologic changes in rabbits and to investigate the diagnostic value of ^31p MRS in acute hepatic radiation injury. METHODS： A total of 30 rabbits received different radiation doses （ranging 5-20 Gy） to establish acute hepatic injury models. Blood biochemical tests, ^31p MRS and pathological examinations were carried out 24 h after irradiation. The degree of injury was evaluated according to LD5 and pathology. Ten healthy rabbits served as controls. The MR examination was performed on a 1.5 T imager using a 1H/^31P surface coil by the 2D chemical shift imaging technique. The relative quantities of phosphomonoesters （PME）, phosphodiesters （PDE）, inorganic phosphate （Pi） and adenosine triphosphate （ATP） were measured. The data were statistically analyzed. RESULTS：（1） Relative quantification of phosphorus metabolites：（a） ATP： there were significant differences （P 〈 0.05）（LDS-groups：control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.55±0.24 vs 1.27±0.09 vs 0.98±0.18; pathological groups： control group vs mild group vs moderate group vs severe group, 1.83±0.33 vs 1.58±0.25 vs 1.32±0.07 vs 1.02±0.18） of ATP relative quantification among control group, mild injured group, moderate injured group, and severe injured group according to both LDS grading and pathological grading, respectively, and it decreased progressively with the increased degree of injury （r = -0.723, P = 0.000）. （b） PME and Pi; the relative quantification of PME and Pi decreased significantly in the severe injured group, and the difference between the control group and severe injured group was significant （P 〈 0.05）（PME： 1DS- control group vs LDS-severe group, 0.86±0.23 vs 0.58±0.22, P = 0.031; pathological control group vs pathological severe group, 0.86±0.23 vs 0.60±0.21, P = 0.037; Pi： LDS-control

关键词： Liver Magnetic resonance spectroscopy Animal models Pathology Adenosine triphosphate

Feasibility of virtual touch tissues quantification technique in the assessment of liver fibrosis

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Feasibility of virtual touch tissues quantification techniqu...

第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会

作者： Department of Ultrasound,Zhongshan Hospital of Fudan University,Shanghai 200032,China wen SHEN hong ding wen-ping WANG Cong LI Chen XU Zhi-zhang XU

Objective To evaluate the feasibility of Virtual Touch Tissues Quantification(VTQ) technique in the assessment of liver fibrosis and to find the suitable measuring position of VTQ. Methods Liver stiffness was measured with SIEMENS ACUSON S2000 ultrasound system in totally 533 subjects including control group subjects(n=302),patients with hepatitis B virus(HBV)(n=191)

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Feasibility of Virtual Touch Tissues Quantification technique in the assessment of liver fibrosis

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中华医学会第十次全国超声医学学术会议

作者： SHEN wen,ding hong,WANG wen-ping,LI Cong,XU Chen,XU Zhi-zhang Department of Ultrasound,Zhongshan Hospital of Fudan University,Shanghai 200032,China

Objective:To evaluate the feasibility of Virtual Touch Tissues Quantification(VTQ) technique in the assessment of liver fibrosis and to find the suitable measuring position of ***:Liver stiffness was meas-

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna Liu Yi ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

Preliminary experience of contrast-enhanced real-time harmonic gray scale sonography in the diagnosis of renal artery stenosis

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中华医学会第十次全国超声医学学术会议

作者： Chao Lun Li,wen Ping Wang,hong ding,Bei Jian Huang,Nian An He Department of Ultrasound,Zhongshan Hospital of Fudan University,Shanghai 200032,China

Objective:To evaluate the diagnosis value of contrast-enhanced real-time harmonic gray scale sonography (CEUS) in the diagnosis of renal artery stenosis(RAS).Methods:Thirty patients with RAS including 7 patients after stent placement and 3 patients after renal transplantation were enrolled in this *** mean age was 57.6 years *** ultrasound examinations were performed with ESAOTE Technos DU8,Medison Accu-

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Comparative study of contrast-enhanced sonography and contrastenhanced CT in diagnosing focal splenic lesions

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第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会

作者： Department of Ultrasound,Zhongshan Hospital,Fudan University,Shanghai 200032,China Jia-ying CAO Hui ZHANG wen-ping WANG hong ding Bei-jian HUANG

Objective The purpose of this study was to compare the features of focal splenic lesions on contrast-enhanced ultrasonography with contrast CT and to evaluate the value of contrast-enhanced ultrasonography in the diagnosis of focal splenic lesions. Method Twenty patients were studied,including 6 cases of metastases,5 cases of hemangioma,4 cases

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