检索结果-南通市图书馆

Intelligent risk identification of gas drilling based on nonlinear classification network

Petroleum Science 2023年第5期20卷 3074-3084页

作者： wen-he xia Zong-Xu Zhao Cheng-xiao Li Gao Li Yong-Jie Li Xing Ding xiang-Dong Chen School of Electrical Engineering and Information Southwest Petroleum UniversityChengdu 610500SichuanChina CCDC Drilling&Production Engineering Technology Research Institute Deyang 618500SichuanChina School of Oil&Natural Gas Engineering Southwest Petroleum UniversityChengdu 610500SichuanChina School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina

During the transient process of gas drilling conditions,the monitoring data often has obvious nonlinear fluctuation features,which leads to large classification errors and time delays in the commonly used intelligent classification *** with the structural features of data samples obtained from monitoring while drilling,this paper uses convolution algorithm to extract the correlation features of multiple monitoring while drilling parameters changing with time,and applies RBF network with nonlinear classification ability to classify the *** the training process,the loss function component based on distance mean square error is used to effectively adjust the best clustering center in *** field applications show that,the recognition accuracy of the above nonlinear classification network model for gas production,water production and drill sticking is 97.32%,95.25%and 93.78%.Compared with the traditional convolutional neural network(CNN)model,the network structure not only improves the classification accuracy of conditions in the transition stage of conditions,but also greatly advances the time points of risk identification,especially for the three common risk identification points of gas production,water production and drill sticking,which are advanced by 56,16 and 8 *** has won valuable time for the site to take correct risk disposal measures in time,and fully demonstrated the applicability of nonlinear classification neural network in oil and gas field exploration and development.

关键词： Gas drilling Intelligent identification of drilling risk Nonlinear classification RBF Neural Network K-means algorithm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Induction of APOBEC3G in human hepatoma cells by interferon-α stimulation

引用

Journal of Microbiology and Immunology 2006年第3期4卷 222-230页

作者： YAN CHANG LEI YONG wen he CHUN xia GUO Department of Infectious Disease Union Hospital Ton~i Medical College Huazhong University of Scienceand Technology Wuhan P. R. China.

To clarify the role of APOBEC3G （A3G） in cellular defense against hepatitis B virus （HBV）, the expression of A3G in normal human liver and the regulation of the A3G expression in hepatoma cell line （HuH-7） were investigated. Expression level of APOBEC3s mRNA in human liver was determined by RT-PCR. HuH-7 and hepG2 cells were treated with various concentrations of IFN-α（0 U/ml, 100 U/ml, 500 U/ml, 1000 U/ml）for 12 h. The mRNA levels were measured by a quantitative RT-PCR, the results were normalized relative to the specimens without IFN-α stimulation. Total protein of HuH-7 cells treated with various concentrations of IFN-α for 48 h was subjected to Western blot analysis. For reporter gene assay, HuH-7 cells were transfected with the reporter plasmids containing IRF- E sites and its mutants with different lengths. Then the cells were treated with or without 1200 U/ml IFN-α for additional 12 h （ 1000 U/ml） after 24 h of transfection, and the cell lysate was prepared and assayed for lueiferase activity. It was found that normal human liver expressed the rnR_NA of A3G. A3G mRNA expression in HuH-7 and hepG2 cells were up-regulated by IFN-α stimulation in a dose-depen- dent manner. Western blot analysis indicated that A3G protein expression was also enhanced by IFN-α stimulation. Sequence analysis showed the existence of putative sites of IFN regulatory factor element （IRF-E） in 5＇ region of A3G gene upstream the initiation eodon. IFN-α stimulation results in 6- to 8- fold increase in lueiferase activity in cells transfeeted with the plasmid containing IRF-E sites of the 5＇ upstream sequences, whereas luciferase activity did not change in cells transfected with the plasmid containing mutant IRF-E sites or without IRF-E sites. As a conclusion, A3G are expressed in normal human liver. A3G expression was up-regulated by IFN-α stimulation in hepatoma cells and could be involved in host defense mechanisms against HBV. IRF-E site in 5＇ region of APOBEC3G gene upstream the init

关键词： APOBEC3G IFN-α hepatoma cell IRF-E

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

重大突发疫病对我国肉禽产业链市场价格的影响研究--以非洲猪瘟为例

引用

农业现代化研究 2022年第2期43卷 318-327页

作者：何雯霞熊涛尚燕华中农业大学经济管理学院湖北武汉430070

非洲猪瘟造成我国生猪存栏量急剧下滑,生猪价格快速上涨。由于产品替代,鸡肉和牛肉产业也遭受冲击,价格持续上涨。但是,肉禽市场价格上涨在多大程度上是由非洲猪瘟导致的,非洲猪瘟对肉禽产业链横向与纵向市场价格的影响是否有异,目前还... 详细信息

非洲猪瘟造成我国生猪存栏量急剧下滑,生猪价格快速上涨。由于产品替代,鸡肉和牛肉产业也遭受冲击,价格持续上涨。但是,肉禽市场价格上涨在多大程度上是由非洲猪瘟导致的,非洲猪瘟对肉禽产业链横向与纵向市场价格的影响是否有异,目前还未被充分讨论。为此,本文运用样本外预测法开展反事实推断,探究非洲猪瘟对猪肉、鸡肉和牛肉市场的上、中、下游价格的净影响,进而基于有向无环图和历史分解法分析非洲猪瘟下肉禽产业链价格间的变动关系。研究表明:非洲猪瘟爆发15个月后,生猪价格和猪肉零售价净增长率分别达到266%和184%。随后两个月内,猪肉批发价、鸡肉批发和零售价、牛肉批发和零售价的净增长率也相继达到最高值。非洲猪瘟爆发期间,生猪价格、猪肉批发和零售价是导致鸡肉和牛肉零售价格上涨的主要原因。在此基础上提出应完善动物疫病长效防控机制和信息监测体系,加强肉禽产业链建设,优化畜禽产业结构以有效降低重大突发疫病对肉禽市场价格的冲击力度。

关键词：非洲猪瘟肉类产业链价格有向无环图历史分解价格动态关系

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中西医结合治疗复发性口腔溃疡

引用

中国实验方剂学杂志 2010年第8期16卷 212-214页

作者：汪文银何文霞方俊王芳宜昌市第一人民医院湖北宜昌443000

目的:观察中西医结合治疗复发性口腔溃疡疗效。方法:观察180例门诊病人,随机分为治疗组和对照组。治疗组90例,对照组90例。治疗组采用西医局部用药加口服中药。对照组采用西医局部用药。结果:近期疗效总有效率治疗组为97.78%,对照组为87... 详细信息

目的:观察中西医结合治疗复发性口腔溃疡疗效。方法:观察180例门诊病人,随机分为治疗组和对照组。治疗组90例,对照组90例。治疗组采用西医局部用药加口服中药。对照组采用西医局部用药。结果:近期疗效总有效率治疗组为97.78%,对照组为87.78%。两组比较,差异有显著性(P<0.05)。远期疗效总有效率治疗组为82.22%,对照组为61.11%。两组比较,差异有显著性(P<0.05)。结论:中西医结合治疗复发性口腔溃疡有较好疗效。

关键词：中西医结合复发性口腔溃疡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高职计算机网络技术专业课程体系改革探析

引用

电脑知识与技术 2009年第4期5卷 2678-2679页

作者：何文霞湖北工业大学湖北武汉430068

通过分析鄂东职业技术学院计算机网络技术专业课程体系，提出了基于工作过程课程体系的构建方法，指出了未来专业课程体系改革的一个方向。

关键词：高职教育计算机网络技术工作过程构建方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抑郁障碍患者疗效的影响因素分析与护理对策

引用

齐齐哈尔医学院学报 2013年第19期34卷 2943-2944页

作者：何文霞江苏省南通市第四人民医院 226005

目的分析影响抑郁障碍患者疗效的相关因素,提供针对性的护理措施。方法对2009年1月至2011年12月收治的375例抑郁障碍患者,整理符合抑郁障碍诊断的病例资料,进行回顾性统计分析,找出显著影响疗效的因素。结果有明显心理应激因素的患者治... 详细信息

目的分析影响抑郁障碍患者疗效的相关因素,提供针对性的护理措施。方法对2009年1月至2011年12月收治的375例抑郁障碍患者,整理符合抑郁障碍诊断的病例资料,进行回顾性统计分析,找出显著影响疗效的因素。结果有明显心理应激因素的患者治愈率高于无明显心理应激因素的患者(χ2=8.524,P<0.01);初中及以下学历人群治愈率高于高中及以上学历人(χ2=13.988,P<0.01)。结论提示抑郁障碍患者的疗效与有无明显心理应激因素以及学历层次有一定的相关性,虽然这些不能视为决定性因素,但在临床治疗与护理中可以作为参考因素予以重视。

关键词：抑郁障碍影响因素分析与护理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of CYP2D6*10 alleles on risperidone pharmacokinetics in Chinese healthy volunteers

Impact of CYP2D6*10 alleles on risperidone pharmacokinetics ...

引用

第十三次全国临床药理学学术大会

作者： wen-Juan he,Xin-xia Liu,Yin-Song Zhu,Min-Jun Cao,Hui Chen Institute of Clinical Pharmacology,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030

Objective To evaluate the impact of the CYP2D6 genotype on the pharmacokinetics of risperidone in Chinese healthy subjects. Methods A single oral dose of 2 mg risperidone pharmacokinetic study was performed in 30 healthy Chinese *** concentrations of risperidone were measured by high-performance liquid chromatography with tandem mass spectroscopy detection(LC-MS/MS) *** pharmacokinetic parameters were analyzed by a noncompartmental linear PK *** CYP2D6 genotypes were identified by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) *** Subjects were grouped as CYP2D6*1/*1(n=6),CYP2D6*1/*10(n=8) and CYP2D6*10/*10(n=16) according to their *** differences were observed in the C,t,AUC and CL/F of risperidone between CYP2D6*1/*1 and CYP2D6*10/*10(P0.05).The T values of CYP2D6* 1 /* 1,CYP2D6* 1 /* 10 and CYP2D6* 10/* 10 were 1.13±0.28,0.78±0.15 and 1.13±0.63 h,respectively. Conclusion Compared with the CYP2D6*1/*1 allele,the CYP2D6*10/*10 allele had apparent influence on the pharmacokinetics of risperidone with a decreased enzyme activity of CYP2D6;while the CYP2D6*1/*10 allele didn’t exhibit significantly influence on the pharmacokinetics of *** results suggest that genotyping of CYP2D6 might be helpful in predicting the pharmacokinetics of risperidone and guide clinical reasonable administration.

关键词： CYP2D6 genotype risperidone pharmacokinetics

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

辅助教学平台的设计与开发

引用

常州信息职业技术学院学报 2015年第1期14卷 26-30页

作者：胡慧何文霞苏州工业职业技术学院江苏苏州215104

辅助教学平台适应当前教学模式改革,利用***、Java Script程序设计语言和Visual Studio、SQL Server等开发工具,实现学生登录系统后可以在线学习、练习与测试,教师登录后实现师生信息管理、试题管理,根据难易程度自动组卷,阅卷与查看成绩。

关键词：辅助教学平台 *** JavaScript

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

引用

Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

引用

Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang xia Ning Xu wen Sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：