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生物安全防护水平三级实验室新风口设计的考虑

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中国医药生物技术 2010年第3期5卷 226-228页

作者：韩文东孙志平丁悦娜瞿涤复旦大学上海医学院三级生物安全防护实验室/医学分子病毒学教育部卫生部重点实验室上海200032

目前,随着SARS病毒、禽流感病毒、耐药结核菌等高致病性病原微生物的不断涌现,生物安全成为世界各国普遍关注的研究焦点,同时生物安全实验室的建设也进入一个快速发展的时期。为加强对病原微生物感染的控制、提高生物安全防护能力,我国... 详细信息

目前,随着SARS病毒、禽流感病毒、耐药结核菌等高致病性病原微生物的不断涌现,生物安全成为世界各国普遍关注的研究焦点,同时生物安全实验室的建设也进入一个快速发展的时期。为加强对病原微生物感染的控制、提高生物安全防护能力,我国各省市疾病预防控制中心、高校或科研院所建造了生物安全防护水平为三级的实验室（biosafety level 3 laboratory，简称BSL-3实验室）。

关键词：生物安全实验室三级实验室防护水平 laboratory 病原微生物感染疾病预防控制中心 BSL-3实验室设计

Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

1470nm半导体激光局部切除治疗老年高危膀胱癌的临床价值探讨

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现代泌尿生殖肿瘤杂志 2018年第1期10卷 13-15页

作者：文瀚东王涛潘铁军徐耀鹏谢汉平李晓山广州军区武汉总医院泌尿外科 430070

目的探讨1 470nm半导体激光局部切除在治疗老年高危膀胱癌中的临床价值。方法回顾性分析2014年3月至2016年3月在我院行1 470nm半导体激光膀胱癌膀胱局部彻底切除的48例老年高危膀胱癌患者的临床资料,患者年龄75.3~92.6岁,平均82.5岁;术... 详细信息

目的探讨1 470nm半导体激光局部切除在治疗老年高危膀胱癌中的临床价值。方法回顾性分析2014年3月至2016年3月在我院行1 470nm半导体激光膀胱癌膀胱局部彻底切除的48例老年高危膀胱癌患者的临床资料,患者年龄75.3~92.6岁,平均82.5岁;术后病理证实18例为肌层浸润性膀胱癌,30例为非肌层浸润性高级别尿路上皮膀胱癌。结果 48例患者均顺利完成手术,平均手术时间(46.3±9.6)min,术中出血(13.6±2.8)ml,术后膀胱冲洗(2.6±0.5)d,留置尿管(7.2±1.5)d,1例发生灌注液外渗,经穿刺引流治愈。随访12~36个月,8例影像学检查复发,2例出现明显肉眼血尿行介入止血治疗。结论采用1 470nm半导体激光局部彻底切除治疗老年高危膀胱癌安全,能有效控瘤、延缓疾病进展、降低肿瘤出血及相关并发症,改善老年患者生活质量。

关键词：高危膀胱癌老年 1 470 nm激光

Effect of Precipitation on Hot Deformation Behavior and Processing Maps of Nickel-Base UNS N10276 Alloy

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Acta Metallurgica Sinica(English Letters) 2017年第11期30卷 1119-1134页

作者： En-Xiang Pu wen-Jie Zheng Zhi-Gang Song han Feng han dong School of Materials Science and Engineering Tsinghua University Beijing 100084 China Central Iron and Steel Research Institute Beijing 100081China

The hot deformation characteristics and processing maps of aged nickel-base UNS N10276 alloy were inves- tigated and compared with those of solution-treated UNS N10276 alloy at temperatures of 950-1250 ℃ and strain rates between 0.01 and 10 s-1. The dominant precipitated phase in the aged alloy was identified as topologically close-packed （TCP） # phase enriched in Mo and Ni. The precipitates present in the UNS N10276 alloy could significantly facilitate flow softening after peak stress at temperatures lower than 1150 ℃ and strain rates higher than 0.01 s-1. Processing maps at true strains of 0.1-0.9 were developed using the dynamic materials model and experimental flow stress data. Although aging treatment slightly shrank the suitable hot working window of this alloy, the aged alloy showed higher peak efficiencies of power dissipation and smaller unstable regions in comparison with solution-treated alloy. Furthermore, aging treatment eliminated the instability region of processing maps at true strains of 0.2-0.5. The precipitated phase promoted dynamic recrystallization （DRX） by the particle-stimulated nucleation （PSN） mechanism, which resulted in the larger fraction of DRX as well as finer and more uniform grain structure in the aged alloy specimens compared to the solution-treated alloy.

关键词： UNS N10276 alloy Precipitation Hot deformation Processing map

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全腹腔镜肾输尿管切除在肾盂癌中的应用研究

现代泌尿生殖肿瘤杂志 2015年第3期7卷 145-148页

作者：李功成潘铁军文瀚东沈国球广州军区武汉总医院泌尿外科 430070

目的探讨腹腔镜辅助下肾输尿管全长切除术治疗肾盂癌的安全性及有效性。方法收集2009年1月至2014年8月间在我院采用两种不同术式行腹腔镜辅助下肾输尿管全长切除术的68例肾盂癌患者的临床资料,全腹腔镜下为A术式,即经后腹腔肾输尿管全... 详细信息

目的探讨腹腔镜辅助下肾输尿管全长切除术治疗肾盂癌的安全性及有效性。方法收集2009年1月至2014年8月间在我院采用两种不同术式行腹腔镜辅助下肾输尿管全长切除术的68例肾盂癌患者的临床资料,全腹腔镜下为A术式,即经后腹腔肾输尿管全长切除＋经腹腹腔镜膀胱壁内段袖状切除＋延长下腹部穿刺点切口取肾术,共行20例;对照研究组为B术式,即后腹腔镜肾输尿管全长切除＋经尿道电切膀胱袖状切除＋经下腹部切口取肾术,共行48例。比较两组手术时间、术中出血量、耻骨后留置引流管时间、导尿管留置时间、术后住院时间、术后早期并发症、局部复发、远处转移等指标。结果 68例均顺利完成手术。A术式和B术式的手术时间分别为（220.19±37.21）和（210.31±42.21）min,术中出血量分别为（104.35±24.36）和（134.02±53.50）ml,耻骨后引流管留置时间分别为（3.1±0.8）和（5.1±2.3）d,留置导尿管时间分别为（6.3±1.2）和（7.1±1.3）d,术后住院时间分别为（6.4±1.6）和（7.2±1.2）d。A术式出现发热1例;B术式出现发热8例,漏尿2例,严重肉眼血尿6例,经对症处理痊愈。术后随访6-72个月,A术式复发及转移各1例,B术式分别为4和3例。A术式的术中出血量、耻骨后引流管留置时间、留置导尿管时间、术后住院时间、术后早期并发症均较B术式少,两者比较差异有统计学意义（P〈0.05）。结论经后腹腔肾输尿管全长切除＋经腹腹腔镜膀胱壁内段袖状切除＋延长下腹部穿刺点切口取肾术治疗肾盂癌具有损伤小、术后恢复快、住院时间短的优点,并不增加肿瘤复发转移率,是一种安全、有效的微创治疗方法。

关键词：腹腔镜肾盂癌肾输尿管切除术

基于地理分区的陕北黄土高原生态系统服务权衡/协同的尺度效应研究

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水土保持研究 2025年第1期32卷 305-315页

作者：温昕王继军韩晓佳中国科学院水土保持与生态环境研究中心中国科学院水利部水土保持研究所中国科学院大学西北农林科技大学水土保持研究所中国科学院生态环境研究中心

[目的]明晰生态系统服务的权衡/协同关系，保证生态系统服务长期有效供应，实现流域生态保护与高质量发展。[方法]以典型退耕区陕北黄土高原为例，利用1990—2020年土地利用变化数据，基于InVEST模型量化4种关键生态系统服务即碳储量、... 详细信息

[目的]明晰生态系统服务的权衡/协同关系，保证生态系统服务长期有效供应，实现流域生态保护与高质量发展。[方法]以典型退耕区陕北黄土高原为例，利用1990—2020年土地利用变化数据，基于InVEST模型量化4种关键生态系统服务即碳储量、产水量、土壤保持量和生境质量的时空分布特征，通过相关性分析探讨了各类生态系统服务间的权衡/协同关系和呈现的尺度特征。[结果](1) 1990—2020年碳储量和生境质量处于不断增加的趋势，产水量和土壤保持量呈现先降低后增加总体增加的趋势，空间上呈东南略低西北略高的分布。(2)陕北黄土高原生态系统服务以协同作用为主，且在1990—2020年协同效应不断增强，权衡作用主要发生在产水量与其他生态系统服务之间，权衡作用的区域主要分布在研究区西部和东北部地区。(3)生态系统服务间的权衡/协同作用存在着空间尺度效应，随着空间尺度的增加，相关性逐渐增强而显著性有所下降，且作用关系的方向性会发生改变。[结论]陕北黄土高原生态系统服务以协同为主，生态系统服务间的权衡/协同作用存在着空间尺度效应。

关键词：生态系统服务权衡/协同作用尺度效应地理分区陕北黄土高原

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碎冰连续碰撞下船舶损伤模式研究

南通航运职业技术学院学报 2021年第1期20卷 46-48页

作者：韩文栋白帅王金锋赵晓东鲁明骅崔健山东省青岛船舶技术服务中心日照分中心山东日照276800

针对航行于碎冰水域的船舶航行速度、碎冰尺寸对船舶结构进行小能量多次碰撞的影响机理研究,并通过数值仿真模拟航行在碎冰水域环境中发生的船-冰碰撞情况。利用控制变量法,定量研究船舶在航速、碰撞次数、碎冰尺寸等参数下的船舶动态... 详细信息

针对航行于碎冰水域的船舶航行速度、碎冰尺寸对船舶结构进行小能量多次碰撞的影响机理研究,并通过数值仿真模拟航行在碎冰水域环境中发生的船-冰碰撞情况。利用控制变量法,定量研究船舶在航速、碰撞次数、碎冰尺寸等参数下的船舶动态结构响应特性,进一步揭示船舶在不同碰撞工况下其自身损伤变形的规律特性,得到船舶在不同航速、碎冰尺寸等情况下碎冰与船舶多次碰撞下的损伤模式。

关键词：碎冰小能量多次碰撞累积损伤

Multipoint Heave Motion Prediction Method for Ships Based on the PSO-TGCN Model

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China Ocean Engineering 2023年第6期37卷 1022-1031页

作者： DING Shi-feng MA Qun ZHOU Li han Sen dong wen-bo School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

During ship operations,frequent heave movements can pose significant challenges to the overall safety of the ship and completion of cargo *** existing heave compensation systems suffer from issues such as dead zones and control system time lags,which necessitate the development of reasonable prediction models for ship heave *** this paper,a novel model based on a time graph convolutional neural network algorithm and particle swarm optimization algorithm(PSO-TGCN)is proposed for the first time to predict the multipoint heave movements of ships under different sea *** enhance the dataset's suitability for training and reduce interference,various filter algorithms are employed to optimize the *** training process utilizes simulated heave data under different sea conditions and measured heave data from multiple *** results show that the PSO-TGCN model predicts the ship swaying motion in different sea states after 2 s with 84.7%accuracy,while predicting the swaying motion in three different *** performing a comparative study,it was also found that the present method achieves better performance that other popular *** model can provide technical support for intelligent ship control,improve the control accuracy of intelligent ships,and promote the development of intelligent ships.

关键词： ship motion prediction time delay multipoint forecast time-graph convolutional neural network particle swarm optimization

Prediction of blast furnace gas generation based on data quality improvement strategy

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Journal of Iron and Steel Research International 2023年第5期30卷 864-874页

作者： Shu-han Liu wen-qiang Sun Wei-dong Li Bing-zhen Jin Department of Energy Engineering School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina State Environmental Protection Key Laboratory of Eco-Industry(Northeastern University) Ministry of Ecology and EnvironmentShenyang 110819LiaoningChina State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114009LiaoningChina Ansteel Iron and Steel Research Institute Ansteel Group Corporation LimitedAnshan 114009LiaoningChina General Heavy Section Mill Angang Steel Company LimitedAnshan 114021LiaoningChina

The real-time energy flow data obtained in industrial production processes are usually of low *** is difficult to accurately predict the short-term energy flow profile by using these field data,which diminishes the effect of industrial big data and artificial intelligence in industrial energy *** real-time data of blast furnace gas(BFG)generation collected in iron and steel sites are also of low *** order to tackle this problem,a three-stage data quality improvement strategy was proposed to predict the BFG *** the first stage,correlation principle was used to test the sample *** the second stage,the original sample set was rectified and *** the third stage,Kalman filter was employed to eliminate the noise of the updated sample *** method was verified by autoregressive integrated moving average model,back propagation neural network model and long short-term memory *** results show that the prediction model based on the proposed three-stage data quality improvement method performs *** short-term memory model has the best prediction performance,with a mean absolute error of 17.85 m3/min,a mean absolute percentage error of 0.21%,and an R squared of 95.17%.

关键词： Blast furnace gas Iron and steel industry Data quality improvement Artificial intelligence Gas generation prediction