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Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma:A comprehensive review

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World Journal of Hepatology 2024年第4期16卷 537-549页

作者： Jing-Jing Li Jia-Xi Mao Han-Xiang Zhong Yuan-Yu Zhao Fei Teng Xin-Yi Lu Li-Ye Zhu Yang Gao Hong fu wen-Yuan Guo Department of Liver Surgery and Organ Transplantation Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China

The tumor microenvironment is a complex network of cells,extracellular matrix,and signaling molecules that plays a critical role in tumor progression and *** and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage ***,recent studies have shown that lymphatic endothelial cells(LECs)and blood endothelial cells(BECs)also play multifaceted roles in the tumor microenvironment beyond their structural functions,particularly in hepatocellular carcinoma(HCC).This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC,including their involvement in angiogenesis,immune modulation,lymphangiogenesis,and *** providing a detailed account of the complex interplay between LECs,BECs,and tumor cells,this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.

关键词： Lymphatic endothelial cells Blood endothelial cells Hepatocellular carcinoma Tumor microenvironment

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua fu Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling wen Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan wen Ze-huai LI Chun-ji OUYANG wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2.16 and May 30,2.18 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2.weeks and followed by a 2.week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12.weeks)and were followed up for 12.*** primary outcome was change in TCSS-TS score at 12.and 2. *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632.patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12.week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P2.weeks and the increase of SNCV of median nerve at 2. weeks in the control group were greater than those in the intervention group(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

Experimental study on the effect of wind on pointing accuracy of antenna structures

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Astronomical Techniques and Instruments 2024年第5期1卷 284-294页

作者： Li fu Wang Li Lingling Wang wen Guo Qinghui Liu Zhiqiang Shen Xu Wang Haiming Liu Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Sichuan Institute of Building Research Chengdu 400074China University of Chinese Academy of Sciences Beijing 101408China School of Civil Engineering Chongqing Jiaotong UniversityChongqing 610000China Merchants Chongqing Communications Technology Research&Design Institute Co.Ltd. Chongqing 400067China

Wind loads have instantaneity and turbulence characteristics that will lead to pointing errors in antenna structures,and these errors cannot be ignored in high-frequency *** the Tianma 65 m radio telescope(TMRT)as an example object,the pointing errors caused by wind loads are investigated using an accelerometer ***,the resonant frequency range of the antenna structure is used for reference to acquire useful signals through the bandpass filtering ***,the direct current(DC)component of these signals is filtered out using the fast discrete Fourier transform method,and the baseline of the acceleration is corrected using the least-squares ***,the acceleration integral is solved approximately using the discrete trapezoidal area method,and the structural vibration displacement of the antenna is determined using a double integral of *** pointing errors are then obtained based on the displacement relationship between the primary and subreflector *** the wind speed is 3.2.m/s,the antenna pitch angle is 61.7°and the wind direction angle is 80°,the generated pitch pointing error is 3.05'',and the azimuth pointing error is 1.14''.These results are consistent with those obtained via inclinometer measurements,thus validating the signal processing method and the pointing error calculation method proposed in this *** research methods and data analysis results reported here provide a basis for further wind-induced pointing error correction studies.

关键词： Accelerometer Double integral Pointing error Bandpass filtering

Analysis and Assessment on the Heavy Metals in a Severely Degraded Subtropical Red Soil Region

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American Journal of Plant Sciences 2024年第2期15卷 110-121页

作者： Fang Wang Yun Zhou Xiangping fu Yuxiao Zhao Yiyao wen Xintao Cui Shunbao Lu Yanjie Zhang College of Life Sciences Jiangxi Normal University Nanchang China Fengxi Street Office Guangfeng China College of Foreign Languages Jiangxi Agricultural University Nanchang China

5 different forests of Pinus massoniana, Schima superba, Liquidambar formosana, P. massoniana × S. superba, P. massoniana × L. formosana as the research object were set up to study the Cr, Cu and Zn content of degraded red soil region in subtropics. The soil heavy metal pollution degree was evaluated by national environmental quality standard (II class). The results showed that three soil metals of P. massoniana × S. superba were the highest, and the soil metals enrichment ability was strong. The order of single factor pollution index of metal elements was Cu (1.38) > Cr (0.81) > Zn (0.42., and moderately pollution, pollution warning and no pollution, respectively. There was no significant correlation between three soil heavy metals and soil total carbon (TC), total nitrogen (TN) and total phosphorus (TP). These results suggested that the accumulation of heavy metal elements was not derived from the parent material of soil. There was a significant positive correlation between the three metal elements which indicated that the sources of the three elements were similar. The structural equation model showed that the direct and indirect effects among the influencing factors ultimately affected the activity of heavy metals by cascade effects.

关键词： Subtropical Forest Type Degraded Red Soil Heavy Metals Pollution Evaluation

AI for organic and polymer synthesis

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Science China Chemistry 2024年第8期67卷 2461-2496页

作者： Xin Hong Qi Yang Kuangbiao Liao Jianfeng Pei Mao Chen Fanyang Mo Hua Lu wen-Bin Zhang Haisen Zhou Jiaxiao Chen Lebin Su Shuo-Qing Zhang Siyuan Liu Xu Huang Yi-Zhou Sun Yuxiang Wang Zexi Zhang Zhunzhun Yu Sanzhong Luo Xue-Feng fu Shu-Li You Center of Chemistry for Frontier Technologies Department of ChemistryZhejiang UniversityHangzhou 310027China Center of Basic Molecular Science Department of ChemistryTsinghua UniversityBeijing 100084China Guangzhou National Laboratory Guangzhou 510005China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China School of Materials Science and Engineering Peking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China AI for Science(AI4S)-Preferred Program Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China Department of Chemical Sciences National Natural Science Foundation of ChinaBeijing 100085China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Recent years have witnessed the transformative impact from the integration of artificial intelligence with organic and polymer synthesis. This synergy offers innovative and intelligent solutions to a range of classic problems in synthetic chemistry. These exciting advancements include the prediction of molecular property, multi-step retrosynthetic pathway planning, elucidation of the structure-performance relationship of single-step transformation, establishment of the quantitative linkage between polymer structures and their functions, design and optimization of polymerization process, prediction of the structure and sequence of biological macromolecules, as well as automated and intelligent synthesis platforms. Chemists can now explore synthetic chemistry with unprecedented precision and efficiency, creating novel reactions, catalysts, and polymer materials under the datadriven paradigm. Despite these thrilling developments, the field of artificial intelligence(AI) synthetic chemistry is still in its infancy, facing challenges and limitations in terms of data openness, model interpretability, as well as software and hardware support. This review aims to provide an overview of the current progress, key challenges, and future development suggestions in the interdisciplinary field between AI and synthetic chemistry. It is hoped that this overview will offer readers a comprehensive understanding of this emerging field, inspiring and promoting further scientific research and development.

关键词： organic synthesis polymer synthesis machine learning prediction chemical database automated synthesis

菜豆EST-SSR分子标记开发及部分种质分子身份证构建

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西南大学学报（自然科学版） 2024年第6期46卷 63-73页

作者：付阳云文晓鹏贵州大学农业生物工程研究院/山地植物资源保护与种质创新教育部重点实验室贵阳550025

为开发菜豆高效新型分子标记,从分子水平解析菜豆重要种质的遗传多样性及亲缘关系,基于菜豆转录组数据,设计EST-SSR引物,建立EST-SSR标记系统.利用PCR筛选出多态性引物,结合毛细管电泳,分析81份菜豆种质的亲缘关系,并构建分子身份证.通... 详细信息

为开发菜豆高效新型分子标记,从分子水平解析菜豆重要种质的遗传多样性及亲缘关系,基于菜豆转录组数据,设计EST-SSR引物,建立EST-SSR标记系统.利用PCR筛选出多态性引物,结合毛细管电泳,分析81份菜豆种质的亲缘关系,并构建分子身份证.通过MISA软件,在菜豆转录组数据852.6条非冗余序列中,共挖掘出11649个EST-SSR位点.菜豆转录组SSR标记主要重复单元为1~3个碱基,其中单碱基为主要类型,占总量的56.7%;其次是三碱基重复,占总量的2..1%.从12.对EST-SSR引物中筛选出18对多态性高、重复性好的引物进行PCR扩增.供试种质的多态性信息量(PIC)为0.50~0.95,平均为0.88;遗传相似性系数为0.15~0.65,以0.35为阈值可将81份种质分为3大类,其中贵州种质主要分布于第Ⅰ,Ⅲ类,而省外品种仅分布在第Ⅱ类.利用核心引物TDc9和TDc66可以有效区分81份菜豆种质,并构建其分子身份证.研究开发的EST-SSR标记系统,可用于菜豆种质的鉴定及亲缘关系分析.

关键词：菜豆转录组分子标记开发 EST-SSR标记分子身份证

公平与效率能否兼得?——中国城镇化模式与城乡发展差距

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湘潭大学学报（哲学社会科学版） 2024年第5期48卷 59-64页

作者：文艺付经杨湘潭大学商学院湖南湘潭411105 上海交通大学安泰经济与管理学院上海200030

城镇化不仅有利于缩小城乡收入差距,促进公平,也有利于提升经济发展水平,提高效率。中国的城镇化模式大体可分为两类:以人口集聚在大城市及其周边地区的“城化”为主,以及以人口分散于小城镇的“镇化”为主。实证结果表明,在全国范围内... 详细信息

城镇化不仅有利于缩小城乡收入差距,促进公平,也有利于提升经济发展水平,提高效率。中国的城镇化模式大体可分为两类:以人口集聚在大城市及其周边地区的“城化”为主,以及以人口分散于小城镇的“镇化”为主。实证结果表明,在全国范围内,“城化”和“镇化”均有助于缩小城乡收入差距。但是,分区域来看,沿长江或沿海地区的“城化”不仅能显著缩小城乡收入差距,而且更为高效;而在内陆地区,“镇化”虽也能缩小城乡收入差距,但效率较低。

关键词：公平效率城镇化模式城乡收入差距

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数字金融、抵押品渠道与资产泡沫

中央财经大学学报 2024年第10期 50-62页

作者：王苗王文甫西南财经大学中国金融研究院四川大学经济学院

本文将数字金融对抵押品的影响引入包含理性泡沫和企业投资效率异质性的DSGE模型中,以探究资产泡沫在经济周期时的作用机制以及数字金融如何通过抵押品渠道对上述作用机制产生影响。结果表明:(1)在经济周期中,资产泡沫通过正反馈循环机... 详细信息

本文将数字金融对抵押品的影响引入包含理性泡沫和企业投资效率异质性的DSGE模型中,以探究资产泡沫在经济周期时的作用机制以及数字金融如何通过抵押品渠道对上述作用机制产生影响。结果表明:(1)在经济周期中,资产泡沫通过正反馈循环机制和再分配机制发挥作用。正反馈循环机制是资产泡沫增加引发的投资和企业价值波动性增强,形成自我强化的资产泡沫膨胀循环。再分配机制则是资产泡沫通过影响信贷资源分配提高了投资门槛。(2.在经济周期中,数字金融利用抵押品渠道对内生信贷约束进行调节,不仅能削弱资产泡沫的正反馈循环机制,还通过降低投资门槛改变其再分配机制,最终有效应对经济周期的波动。进一步看,数字金融借助抵押品渠道还能缓冲市场负面情绪冲击,并削弱金融加速器的放大作用。本文的研究结论可为优化数字金融的发展以及防范金融体系风险提供新的理论视角。

关键词：数字金融资产泡沫抵押品

Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 794-803页

作者： Peng Chen Hai-Dong Yang Jun-Jie Wang Zhen-Hua Zhu Hui-Min Zhao Xu-Yuan Yin Yuan Cai Hong-LiangZhu Jia-Lin fu Xin-Zhu Zhang wen-Xi Sun Li Hui Xiao-Bin Zhang Suzhou Medical College of Soochow University Suzhou 215123Jiangsu ProvinceChina Department of Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Psychiatry The Fourth People’s Hospital of LianyungangThe Affiliated Kangda College of Nanjing Medical UniversityLianyungang 222003Jiangsu ProvinceChina Research Center of Biological Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Neurology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina

BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6(IL-6)contributes to the pathophysiology of psychiatric ***,there was no study concerning the relationship between IL-6 concentrations and clinical features in the chronic phase of early-onset schizophrenia(EOS).AIM To investigate the relationship between serum IL-6 concentration and the clinical features of *** We measured serum IL-6 Levels from 74 patients with chronic schizophrenia,including 33 with age at onset2. years(EOS group)and 41 with onset≥2. years in[adult-onset schizophrenia(AOS)group],and from 41 healthy *** severities were evaluated using the Positive and Negative Syndrome Scale(PANSS).RESULTS Serum IL-6 concentrations were higher in both EOS and AOS groups than healthy controls(F=2..32.P0.05)after controlling for age,body mass index,and other *** symptom scores were higher in the EOS group than the AOS group(F=6.199,P=0.015).Serum IL-6 concentrations in the EOS group were negatively correlated with both total PANSS-negative symptom score(r=-0.389,P=0.032.and avolition/asociality subscore(r=-0.387,P=0.02.).CONCLUSION Patients with EOS may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the ***-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients.

关键词： Early-onset schizophrenia Interleukin 6 Negative symptoms Avolition Asociality