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Cost-effectiveness analysis of early veno-venous hemofiltration for severe acute pancreatitis in China

World Journal of Gastroenterology 2008年第12期14卷 1872-1877页

作者： Kun Jiang Xin-Zu Chen Qing Xia wen-fu tang Lei Wang Department ofIntegrated Traditional Chinese and Western Medicine West ChinaHospital Sichuan University Chcngdu 610041 Sichuan ProvinceChina Department of General Surgery West ChinaHospital Sichuan University Chengdu 610041 Sichuan ProvinceChina

AIM： To determine the most cost-effective hemofiltration modality for early management of severe acute pancreatitis （SAP） in China. METHODS： We carried out a search of Pub-Medline and Chinese Biomedical Disk database. Controlled clinical trials on Chinese population were included in the analysis. The four decision branches that were analyzed were： continuous or long-term veno-venous hemofiltration （CVVH/LVVH）, short-term veno-venous hemofiltration （SVVH）, SVVH plus peritoneal dialysis （PD）, and non-hemofiltration control group. The effectiveness of the technique was determined by survival rate, complications prevention and surgery preservation. The total cost of hospitalization was also assessed. RESULTS： The SVVH only technique was the least costly modality, $5809 （44449 RMB）, and was selected as the baseline treatment modality. SVVH only arm achieved the lowest C/E ratio in terms of overall survival, complications prevention and surgery preservation. In incremental cost-effectiveness analysis, the CWH/ LVVH only and the control arms were inferior to other techniques. Sensitivity analysis showed SVVH only and SVVH plus PD arms overlapped in C/survival ratio. CONCLUSION： The role of early veno-venous hemofiltration as an alternative therapy for SAP remains controversial. However, we propose that early use of short-term high-volume veno-venous hemofiltration would have a beneficial impact on the management of SAP.

关键词： Veno-venous hemofiltration Severe acutepancreatitis Early management Cost-effectiveness Health economics

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Early nasogastric enteral nutrition for severe acute pancreatitis: A systematic review

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World Journal of Gastroenterology 2007年第39期13卷 5253-5260页

作者： Kun Jiang Xin-Zu Chen Qing Xia wen-fu tang Lei Wang Department of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of General Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM: To evaluate the effectiveness and safety of early nasogastric enteral nutrition (NGEN) for patients with severe acute pancreatitis (SAP). METHODS: We searched Cochrane Central Register of Controlled Trials (Issue 2, 2006), Pub-Medline (1966-2006), and references from relevant articles. We included randomized controlled trials (RCTs) only, which reported the mortality of SAP patients at least. Two reviewers assessed the quality of each trial and collected data independently. The Cochrane Collaboration’s RevMan 4.2.9 software was used for statistical analysis. RESULTS: Three RCTs were included, involving 131 patients. The baselines of each trial were comparable. Meta-analysis showed no significant differences in mortality rate of SAP patients between nasogastric and conventional routes (RR = 0.76, 95% CI = 0.37 and 1.55, P = 0.45), and in other outcomes, including time of hospital stay (weighted mean difference = -5.87, 95% CI = -20.58 and 8.84, P = 0.43), complication rate of infection (RR = 1.41, 95% CI = 0.62 and 3.23, P = 0.41) or multiple organ defi ciency syndrome (RR = 0.97, 95% CI = 0.27 and 3.47, P = 0.97), rate of admission to ICU (RR = 1.00, 95% CI = 0.48 and 2.09, P = 0.99) or conversion to surgery (RR = 0.66, 95% CI = 0.12 and 3.69, P = 0.64), as well as recurrence of re-feeding pain and adverse events associated with nutrition. CONCLUSION: Early NGEN is a breakthrough in the management of SAP. Based on current studies, early NGEN appears effective and safe. Since the available evidence is poor in quantity, it is hard to make an accurate evaluation of the role of early NGEN in *** recommendation to clinical practice, further high qualified, large scale, randomized controlled trials are needed.

关键词： Enteral nutrition Nasogastric tube Severe acute pancreatitis Systematic review Meta-analysis

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Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis

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World Journal of Gastroenterology 2017年第8期23卷 1367-1374页

作者： Yu-Mei Zhang Hong-Yu Ren Xian-Lin Zhao Juan Li Jun-Yi Li fu-Sheng Wu Hang Su wen-fu tang Sichuan Provincial Pancreatitis Center Department of Integrative Medicine West China Hospital Sichuan University Department of Integrative Medicine Chengdu Integrated TCM and Western Medicine Hospital School of Acupuncture Chengdu University of Traditional Chinese Medicine

AIM To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. METHODS Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP. The tissue concentrations of aloeemodin, rhein, emodin, chrysophanol, honokiol, rheo chrysophanol, magnolol, hesperidin, naringenin and naringin in the liver of the treated rats were detected by high-performance liquid chromatography tandem mass spectrometry. Alanine transaminase (ALT) and aspartate transaminase (AST) in serum, inflammatory mediators in the liver and pathological scores were evaluated. RESULTS The major components of DCQD were detected in the liver, and their concentrations increased dose-dependently. The high dose of DCQD showed a maximal effect in ameliorating the pathological damages, decreasing the pro-inflammatory mediators tumor necrosis factor-a and interleukin (IL)-6 and increasing anti-inflammatory mediators IL-4 and IL-10 in the liver. The pathological scores in the pancreas for the MG were significantly higher than those for the SOG (P < 0.05). DCQD could reduce the pathological scores in the pancreas and liver of the rats with SAP, especially in the HDG. Compared to the SOG, the ALT and AST levels in serum were higher in the MG (P < 0.05), while there was no statistical difference in the MG and HDG. CONCLUSION DCQD could alleviate liver damage by altering the inflammatory response in rats with SAP based on the liver distribution of its components.

关键词： Pharmacokinetics Pharmacodynamics Da-Cheng-Qi decoction Acute pancreatitis Acute liver injury

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Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components

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World Journal of Gastroenterology 2009年第47期15卷 5992-5999页

作者： Han-Lin Gong wen-fu tang Qin Yu Jin Xiang Qing xia Guang-Yuan Chen Xi Huang Mao-Zhi Liang Department of Integrated Traditional Chinese and Western Medicine West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Clinical Pharmacology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group(n=6). Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by *** Cmax(chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023) and AUC(rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272)of DCQD component were obviously lower in SAP group than in control *** T1/2α of chrysophanol and rheochrysidin(P=0.0467 and 0.0005,respectively)and Tmax of chrysophanol and rheochrysidin(P=0.0101 and 0.0037,respectively) lasted longer in SAP group than in control group. CONCLUSION:SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters.

关键词： Severe acute pancreatitis Da-Cheng-Qi Decoction, Pharmacokinetics Components

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Extracellular vesicles in the pathogenesis and treatment of acute lung injury

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军事医学研究:英文版 2023年第4期10卷 478-498页

作者： Qian Hu Shu Zhang Yue Yang Jia‑Qi Yao wen‑fu tang Christopher J.Lyon Tony Ye Hu Mei‑Hua Wan Department of Integrated Traditional Chinese and Western Medicine West China Hospital of Sichuan UniversityChengdu 610041China Department of Emergency Medicine Emergency Medical LaboratoryWest China Hospital of Sichuan UniversityChengdu 610041China Center of Cellular and Molecular Diagnosis Tulane University School of Medicine1430 Tulane Ave.New OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane Ave.New OrleansLA 70112USA West China Hospital(Airport)of Sichuan University Chengdu 610299China

Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are common life-threatening lung diseases associated with acute and severe *** have high mortality rates,and despite decades of research on clinical ALI/ARDS,there are no effective therapeutic *** of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and ***,studies on the role of extracellular vesicles(EVs)in regulating normal and pathophysiologic cell activities,including inflammation and injury responses,have attracted *** and dysfunctional cells often secrete EVs into serum or bronchoalveolar lavage fluid with altered cargoes,which can be used to diagnose and predict the development of ALI/*** secreted by mesenchymal stem cells can also attenuate inflammatory reactions associated with cell dysfunction and injury to preserve or restore cell function,and thereby promote cell proliferation and tissue *** review focuses on the roles of EVs in the pathogenesis of pulmonary inflammation,particularly ALI/ARDS.

关键词： Acute lung injury(ALI) Acute respiratory distress syndrome(ARDS) Extracellular vesicles(EVs) Pulmonary inflammation Mesenchymal stem cells(MSCs)

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Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury

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World Journal of Gastroenterology 2017年第46期23卷 8169-8181页

作者： Lv Zhu Jun-Yi Li Yu-Mei Zhang Hong-Xin Kang Huan Chen Hang Su Juan Li wen-fu tang Sichuan Provincial Pancreatitis Center Department of Integrative MedicineWest China HospitalSichuan University Department of Traditional Chinese Medicine Wuhan Union Hospital

AIM To explore the pharmacokinetics and pharmacodynamics of Shengjiang decoction(SJD) in rats with acute pancreatitis(AP) for protecting against multiple organ *** An AP model was established by retrograde perfusion of 3.5% sodium taurocholate into the biliopancreatic duct, and a control group(CG) received 0.9% sodium chloride instead. Twelve male Sprague-Dawley rats were randomly divided into a CG treated with SJD(CG + SJD) and a model group treated with SJD(MG + SJD), both of which were orally administered with SJD(5 g/kg) 2 h after surgery. Blood samples were collected via the tail vein at 10, 20, and 40 min and 1, 2, 3, 4, 6, 8, and 12 h after a single dose of SJD to detect its main components using high-performance liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameters were compared. In the pharmacodynamic experiment, 18 male SpragueDawley rats were randomly divided into a CG, an AP model group(MG), and an SJD treated AP group(SJDG). Serum amylase, lipase, and inflammatory cytokines were measured, and heart, lung, liver, spleen, pancreas, kidney, and intestine tissues were collected for pathological *** The MG + SJD displayed significantly shorter mean residence time(MRT) and higher clearance(CL) for emodin and aloe-emodin; significantly shorter time of maximum concentration and T1/2 and a lower area under curve(AUC) for aloe-emodin; a significantly higher AUC and lower CL for rhein; and longer MRT and lower CL for chrysophanol than the CG + SJD. In the pharmacodynamic experiment, the amylase, interleukin(IL)-6, IL-10, and tumor necrosis factor(TNF)-α levels in the MG were higher than those in the CG(P < 0.05). After the herbal decoction treatment, the SJDG had higher IL-10 and lower TNF-α levels than the MG(P < 0.05). The MG had the highest pathological scores, and the pathological scores of the lung, pancreas, kidney, and intestine in the SJDG were significantly lower than those in the MG(P < 0.05).CONCLUSION

关键词： Pancreatic distribution Pharmacodynamics Shengjiang decoction Pharmacokinetics Acute pancreatitis

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Effects of Yue-Bi-tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury

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World Journal of Gastroenterology 2020年第43期26卷 6810-6821页

作者： Jing Hu Yu-Mei Zhang Yi-Fan Miao Lv Zhu Xiao-Lin Yi Huan Chen Xi-Jing Yang Mei-Hua Wan wen-fu tang Department of Integrative Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Traditional Chinese Medicine Xiang’an Hospital of Xiamen UniversityXiamen 361101Fujian ProvinceChina Animal Experiment Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The complications acute lung injury and acute kidney injury caused by severe inflammation are the main reasons of high mortality of severe acute pancreatitis(SAP).These two complications can both lead to water metabolism and acid-base balance disorders,which could act as additional critical factors affecting the disease ***(AQPs),which can regulate the transmembrane water transport,have been proved to participate in the pathophysiological process of SAP and the associated complications,such as acute lung injury and acute kidney ***,exploring herbs that can effectively regulate the expression of AQP in SAP could benefit the prognosis of this *** To determine whether Yue-Bi-tang(YBT)can regulate the water metabolism in rats with severe acute pancreatitis via regulating the expression of *** Sprague-Dawley rats were randomly divided into three groups,sham operation group(SOG),model group(MG),and treatment group(TG).SAP was induced with 3.5%sodium taurocholate in the MG and *** in the TG were administered with YBT while SOG and MG rats were given the same volume of *** and tissue samples were harvested to detect serum inflammatory cytokines,histopathological changes,malondialdehyde and superoxide dismutase in the lung,and protein and mRNA expression of kidney injury molecule-1,α-smooth muscle actin,and vimentin in the kidney,and AQP1 and 4 in the lung,pancreas,and *** The serum interleukin-10,tumor necrosis factorα,and creatinine levels were higher in the MG than in the *** necrosis factorαlevel in the TG was lower than that in the *** level in lung tissues was higher than in the *** pathological scores and edema scores of the pancreas,lung,and kidney tissues in the MG were all higher than those in the SOG and *** protein expression of AQP4 in lung tissues and AQP1 in kidney tissues in the MG were higher than those in the SOG and *** expression of vimentin was s

关键词： Yue-Bi-tang Aquaporins Sever acute pancreatitis Acute lung injury Acute kidney injury Water metabolism

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A Numerical Calculation Algorithm of the Inclination function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao Wei wen-lin tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

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Availability analysis of private cloud safety computer platform based on the Markov process

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Transportation Safety and Environment 2024年第1期6卷 103-108页

作者： Limin fu Jiakun wen Southwest Jiaotong University The School of Information Science&TechnologyChengduSichuan 610097China CRSC Research&Design Institute Group Co. LtdBeijing 100070China

To ensure the correctness of train control system design and development,the ways of simulation,test and formalization were *** to the safe critical attribute of train control system,the characters related to system safety were propounded such as real time,hybrid,distribution(concurrence)and reactivity,and the specific formal methods associated with every character were introduced in *** analysis and classification of the methods were done based on their mathematical basis and applications,and their advantages and disadvantages were *** result indicates that every method has determinate limitations,which is determined by the essences of model checking and theory *** is pointed out that the presentation of new method,the expansion of existing methods and the integration of many methods will be the development trend of formalization in train control system.

关键词： safety computer Markov process cloud computing availability analysis

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Optimal timing for the oral administration of DaCheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis

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World Journal of Gastroenterology 2017年第39期23卷 7098-7109页

作者： Yu-Mei Zhang Lin Zhu Xian-Lin Zhao Huan Chen Hong-Xin Kang Jian-Lei Zhao Mei-Hua Wan Juan Li Lv Zhu wen-fu tang Department of Integrative Medicine West China Hospital Sichuan University Digestive System Department Sichuan Integrative Medicine Hospital Department of Integrative Medicine Chengdu Integrated TCM and Western Medicine Hospital Department of Pharmacology School of Preclinical and Forensic Medicine West China Medical Center Sichuan University

AIM To identify the optimal oral dosing time of Da-Cheng-Qi decoction(DCQD) in rats with acute pancreatitis(AP) based on the pharmacokinetic and pharmacodynamic *** First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4 h G(a), 12 h G(a) and 24 h G(a)]. The NG(a) and model groups were administered DCQD(10 g/***) intragastrically at 4 h, 4 h, 12 h and 24 h, respectively, after AP models induced by 3% sodium taurocholate. Plasma samples were collected from the tails at 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after a single dosing with DCQD. Plasma and pancreatic tissue concentrations of the major components of DCQD were determined by high-performance liquid chromatography tandem mass spectroscopy. The pharmacokinetic parameters and serum amylase were detected and compared. Second, rats were divided into a sham-operated group [NG(b)] and three treatment groups [4 h G(b), 12 h G(b) and 24 h G(b)] with three corresponding control groups [MG(b)s]. Blood and pancreatic tissues were collected 24 h after a single dosing with DCQD. Serum amylase, inflammatory cytokines and pathological scores of pancreatic tissues were detected and *** The concentrations of emodin, naringin, honokiol, naringenin, aloe-emodin, chrysophanol and rheochrysidin in the 12 h G(a) group were higher than those in the 4 h G(a) group in the pancreatic tissues(P < 0.05). The area under the plasma concentration-time curve from time 0 to the time of the last measurable concentration values(AUC0→t) for rhein, chrysophanol, magnolol and naringin in the 12 h G(a) group were larger than those in the 4 h G(a) or 24 h G(a) groups. The 12 h G(a) group had a higher Cmax than the other two model groups. The IL-10 levels in the 12 h G(b) and 24 h G(b) groups were higher than in the MG(b)s(96.55 ± 7.84 vs 77.46 ± 7.42, 251.22 ± 16.15 vs 99.72 ± 4.7 respectively, P < 0.05), while in the 24 h G(b) group, the IL-10 leve

关键词： Da-Cheng-Qi decoction Acute pancreatitis Pharmacokinetics Oral dosing time Pharmacodynamics

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