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Clinical outcomes in patients with ICU-related pancreatitis

World Journal of Gastroenterology 2009年第39期15卷 4938-4944页

作者： Chia-Cheng Tseng wen-feng fang Yu-Hsiu Chung Yi-Hsi Wang Ivor S Douglas Meng-Chih Lin Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Chang Gung University College of Medicine Kaohsiung Hsien 83301 Taiwan. China Department of Respiratory Care Chang Gung Institute of Technology Chiayi Hsien 61363 Taiwan China Division of Pulmonary Sciences and Critical Care Medicine University of Colorado at Denver and Health Sciences Center Denver Colorado Denver Health Medical Center Denver 80204 Colorado

AIM:To identify risk factors predictive of intensive care unit(ICU) mortality in patients with ventilator-related *** clinical outcomes of patients with ventilator-related pancreatitis were compared with those of patients with pancreatitis-related respiratory failure as well as ***:One hundred and forty-eight patients with respiratory failure requiring mechanical ventilation and concomitant acute pancreatitis were identified from a prospectively collected dataset of 9108 consecutive patients admitted with respiratory failure over a period of five *** patients met the criteria for ventilator-related pancreatitis,and 88(control patients),for pancreatitis-related respiratory ***:Mortality rate in ventilator-related pancreatitis was comparable to that in ICU patients without pancreatitis by case-control methodology(P=0.544).Multivariate logistic regression analysis identified low PaO2/FiO2(OR:1.032,95% CI:1.006-1.059,P=0.016) as an independent risk factor for mortality in patients with ventilator-related *** mortality rate in patients with ventilator-related pancreatitis was lower than that in patients with acute pancreatitis-related respiratory failure(P<0.001).CONCLUSION:We found that low PaO2/FiO2 was an independent clinical parameter predictive of ICU mortality in patients with ventilator-related pancreatitis.

关键词： Acute pancreatitis Hyperamylasemia Hyperlipasemia Mechanical ventilation Respiratory failure

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The impact of both platinum-based chemotherapy and EGFR-TKIs on overall survival of patients with advanced non-small cell lung cancer

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Chinese Journal of Cancer 2014年第2期33卷 105-114页

作者： Jian-Wei Zhang Yuan-Yuan Zhao Ying Guo Cong Xue Zhi-Huang Hu Yan Huang Hong-Yun Zhao Jing Zhang Xuan Wu wen-feng fang Yu-Xiang Ma Li Zhang State Key Laboratory of Oncology in South China Department of Medical Oncology Sun Yat-sen University Cancer Center Clinical Trials Center Sun Yat-sen University Cancer Center

Both platinum-based doublet chemotherapy(PBC) and epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs) prolong the survival of patients with advanced non-small cell lung cancer(NSCLC). In early studies, most patients underwent PBC as first-line treatment, but not all patients could afford EGFR-TKIs as second-line treatment. To understand the impact of PBC and EGFR-TKIs on NSCLC prognosis, we evaluated the association between the receipt of both regimens and overall survival(OS). Using MEDLINE and EMBASE, we identified prospective, randomized, controlled phase III clinical trials in advanced NSCLC that met the inclusion criteria: in general population with advanced NSCLC, the percentage of patients treated with both PBC and EGFR-TKIs was available in the trial and OS was reported. After collecting data from the selected trials, we correlated the percentage of patients treated with both PBC and EGFR-TKIs with the reported OS, using a weighted analysis. Fifteen phase III clinical trials—involving 11,456 adult patients in 32 arms—were included in the analysis, including 6 trials in Asian populations and 9 in non-Asian(predominantly Caucasian) populations. The OS was positively correlated with the percentage of patients treated with both PBC and EGFR-TKIs(r = 0.797, P < 0.001). The correlation was obvious in the trials in Asian populations(r = 0.936, P < 0.001) but was not statistically significant in the trials in predominantly Caucasian populations(r = 0.116, P = 0.588). These results suggest that treatment with PBC and EGFR-TKIs may provide a survival benefit to patients with advanced NSCLC, highlighting the importance of having both modalities available for therapy.

关键词：非小细胞肺癌生存期患者晚期化疗中国人民银行酪氨酸激酶抑制剂表皮生长因子受体

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Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2485-2488页

作者： Si-Chong Han Gui-Zhen Wang Ya-Ning Yang wen-feng fang Bei-Bei Sun Jian-Dong Zhang Hua-Qiang Zhou Li Zhang Yan Wang Guang-Biao Zhou State Key Laboratory of Molecular Oncology and Department of Internal Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Lung Cancer Research Centre and State Key Laboratory of Oncology in South China Sun Yat-Sen University Cancer CenterGuangzhouChina Shanxi Bethune Hospital Affiliated with Shanxi Academy of Medical Sciences TaiyuanChina

Dear Editor,Programmed cell death 1 ligand 1(PD-L1)has been used as a biomarker for immune checkpoint inhibitors(ICIs)which exert durable efficacy in non-small cell lung cancer(NSCLC).^(1,2)However,many PD-L1-high pat... 详细信息

关键词： lung cancer death

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Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin wen-feng fang Jui-Ning Yeh John Y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(P<0.001).The protein levels of inflammation[interleukin(IL)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all P<0.001).Animals were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all P<0.0001),whereas arterial oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

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Multiple oncogenic mutations related to targeted therapy in nasopharyngeal carcinoma

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Chinese Journal of Cancer 2015年第4期34卷 177-183页

作者： Jian-Wei Zhang Tao Qin Shao-Dong Hong Jing Zhang wen-feng fang Yuan-Yuan Zhao Yun-Peng Yang Cong Xue Yan Huang Hong-Yuan Zhao Yu-Xiang Ma Zhi-Huang Hu Pei-Yu Huang Li Zhang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Medical Oncology Sun Yat-sen University Cancer Center Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center

Introduction:An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma(NPC).However,targeted therapy-related oncogenic mutations have not been fully *** study aimed to detect targeted therapy-related oncogenic mutations in NPC and to determine which targeted therapy might be potentially effective in treating ***:By using the SNaPshot assay,a rapid detection method,19 mutation hotspots in 6 targeted therapy-related oncogenes were examined in 70 NPC *** associations between oncogenic mutations and clinicopathologic factors were ***:Among 70 patients,12(17.1%) had mutations in 5 oncogenes:7(10.0%) had v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog(KIT) mutation,2(2.8%) had epidermal growth factor receptor(EGFR) mutation,1(1.4%) had phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha(PIK3CA) mutation,1(1.4%) had Kirsten rat sarcoma viral oncogene homolog(KRAS) mutation,and 1(1.4%) had simultaneous EGFR and v-Raf murine sarcoma viral oncogene homolog B1(BRAF) *** significant differences were observed between oncogenic mutations and clinicopathologic ***,these oncogenic mutations were not associated with tumor recurrence or ***:Oncogenic mutations are present in NPC *** efficacy of targeted drugs on patients with the related oncogenic mutations requires further validation.

关键词：基因突变靶向治疗鼻咽癌致癌表皮生长因子受体快速检测方法原癌基因同源基因

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Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3911-3924页

作者： Fan Liang Gui-Zhen Wang Yan Wang Ya-Ning Yang Zhe-Sheng wen Dong-Ni Chen wen-feng fang Bin Zhang Lu Yang Chen Zhang Si-Chong Han Fu-Ying Yang Di Wang Li-Jun Liang Zheng Wang Yong Zhao Chang-Li Wang Li Zhang Guang-Biao Zhou State Key Laboratory of Molecular Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesBeijingChina Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouChina Department of Lung Cancer Tianjin Lung Cancer CenterNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjinChina Department of Medical Oncology and Radiation Sickness Peking University Third HospitalBeijingChina

Indoleamine 2,3-dioxygenase 1(IDO1),the enzyme that catabolizes tryptophan(Trp)metabolism to promote regulatory T cells(Tregs)and suppress CD8+T cells,is regulated by several intrinsic signaling ***,we found that tobacco smoke,a major public health concern that kills 8 million people each year worldwide,induced IDO1 in normal and malignant lung epithelial cells in vitro and in *** carcinogen nicotine-derived nitrosaminoketone(NNK)was the tobacco compound that upregulated IDO1 via activation of the transcription factor c-Jun,which has a binding site for the IDO1 *** NNK receptorα7 nicotinic acetylcholine receptor(α7nAChR)was required for NNK-induced c-Jun activation and IDO1 *** A/J mice,NNK reduced CD8+T cells and increased ***,smoker patients with non-small-cell lung cancer(NSCLC)exhibited high IDO1 levels and low Trp/kynurenine(Kyn)*** NSCLC patients,smokers with lower IDO1 responded better to anti-PD1 antibody treatment than those with higher *** data indicate that tobacco smoke induces IDO1 to catabolize Trp metabolism and immune suppression to promote carcinogenesis,and lower IDO1 might be a potential biomarker for anti-PD1 antibodies in smoker patients,whereas IDO1-high smoker patients might benefit from IDO1 inhibitors in combination with anti-PD1 antibodies.

关键词： PD1 metabolism lung

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Radical microsurgical treatment of intramedullary spinal cord tumors

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Chinese Medical Journal 2006年第16期119卷 1343-1347页

作者： PENG Lin QI Song-tao CHEN Zhuang FEN wen-feng fang Lu-xiong HUANG Li-jing CHENG Jiang-peng Department of Neurosurgery Nanfang Hospital Southern Medical University Guangzhou 510515 China

Background The surgical treatment of intramedullary spinal cord tumor aims at complete removal and minimal postoperative deficit. This study was undertaken to evaluate the microsurgical features of intramedullary spinal cord tumors and the time for surgery and prognosis. Methods Twenty-one patients with intramedullary spinal cord tumor who had been treated at Nanfang Hospital, Guangzhou, China since 2000 were studied retrospectively. Fifteen patients were men and 6 women, aged 2-60 years （mean 29.28 years）. Thirteen patients had the tumor in the cervical segments, 4 in medulla-cervical segments, 1 in cervicothoracic segment, and 3 in thoracic spine. All the patients underwent microsurgery for the tumor through posterior approaches by laminectomy. The tumor was exposed through dorsal myelotomy, then tumor plane was removed carefully from the entire rostrocaudal area. The dura was sutured routinely. In case of tumors occupying too many spinal segments, titanium strip was applied to reconstruct the vertebral plate and keep the spinal column stable. All the patients were subjected to MR imaging early after operation. Results Complete removal of the tumor was made in 15 patients, subtotal removal in 5, and partial resection in 1. Neurological recovery was related primarily to preoperative neurological conditions of the patients. Patients with minor neurological deficit showed stable sensory and motor function or minor loss in the early postoperative period, and neurological function tended to improve with time. But those with significant or long-standing deficit could hardly demonstrate any recovery. The dissection interface between the tumor and normal cord tissue was the most important factor influencing the extent of surgical removal. Conclusions Intramedullary spinal cord tumor mostly take place in cervical segments, with glioma as the commonest type. Microsurgery is the major treatment of choice, by which tumor plane could be totally resected. Excellent micros

关键词： spinal cord neoplasms microsurgery radiotherapy chemotherapy

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Gefitinib(an EGFR tyrosine kinase inhibitor)plus anlotinib(an multikinase inhibitor)for untreated,EGFR-mutated,advanced non-small cell lung cancer(FL-ALTER):a multicenter phase III trial

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Signal Transduction and Targeted Therapy 2024年第9期9卷 4091-4102页

作者： Hua-Qiang Zhou Ya-Xiong Zhang Gang Chen Qi-Tao Yu Hua Zhang Guo-Wu Wu Di Wu Ying-Cheng Lin Jun-Fei Zhu Jian-Hua Chen Xiao-Hua Hu Bin Lan Ze-Qiang Zhou Hai-feng Lin Zi-Bing Wang Xiao-Lin Lei Suo-Ming Pan Li-Ming Chen Jian Zhang Tian-Dong Kong Ji-Cheng Yao Xin Zheng feng Li Li Zhang wen-feng fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Medical Oncology of Respirotary Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Department of Urogenital Oncology the First People’s Hospital of FoshanFoshan 52800China Department of Medical Oncology Meizhou People’s Hospital(Huangtang Hospital)Meizhou 514031China Department of Respiratory and Critical Care Medicine Shenzhen people’s HospitalShenzhen 518020China Department of Medical Oncology of Respirotary Cancer Hospital of Shantou University Medical CollegeShantou 515031China Department of Respiratory and Critical Care Medicine Taizhou Central HospitalTaizhou 318000China Department of Medical Oncology Hunan Provincial Cancer HospitalChangsha 410031China Department of Medical Oncology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Cardiothoracic Surgery Shantou Central HospitalShantou 515031China Department of Oncology the 2nd People’s Hospital of ShenzhenShenzhen 518025China Department of Medical Oncology the Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450003China Department of Oncology Affiliated Hospital of Panzhihua UniversityPanzhihua 617099China Department of Radiotherapy Yuebei People’s HospitalShaoguan 512099China Department of Oncology the First Affiliated Hospital of Shantou University Medicine CollegeShantou 515041China Department of Oncology ZhuJiang Hospital of Southern Medical University(The Second Clinical Medical College)Guangzhou 510280China Department of Respiratory Oncology the Third People’s Hospital of ZhengzhouZhengzhou 450001China Shanghai OrigiMed Co. LtdShanghaiChina

Dual inhibition of vascular endothelial growth factor and epidermal growth factor receptor(EGFR)signaling pathways offers the prospect of improving the effectiveness of EFGR-targeted *** this phase 3 study(***:NCT04028778),315 patients with treatment-naïve,EGFR-mutated,advanced non-small cell lung cancer(NSCLC)were randomized(1:1)to receive anlotinib or placebo plus gefitinib once daily on days 1–14 per a 3-week *** the prespecified final analysis of progression-free survival(PFS),a significant improvement in PFS was observed for the anlotinib arm over the placebo arm(hazards ratio[HR]=0.64,95%CI,0.48–0.80,P=0.003).Particularly,patients with brain metastasis and those harboring EGFR amplification or high tumor mutation load gained significant more benefits in PFS from gefitinib plus *** incidence of grade 3 or higher treatment-emergent adverse events was 49.7%of the patients receiving gefitinib plus anlotinib versus 31.0%of the patients receiving gefitinib plus *** plus gefitinib significantly improves PFS in patients with treatment-naïve,EGFR-mutated,advanced NSCLC,with a manageable safety profile.

关键词： cancer lung treatment

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-fang feng wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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基于R语言的网络舆情对股市影响研究

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兰州理工大学学报 2018年第4期44卷 103-108页

作者：朱昶胜孙欣冯文芳兰州理工大学计算机与通信学院甘肃兰州730050 兰州理工大学经济管理学院甘肃兰州730050

以开源R语言为平台,东方财富网的股评为研究对象,结合中文文本挖掘技术和SVR支持向量回归模型.利用中文挖掘技术,对股评进行去噪声、分词、同义词合并、去停用词、TFIDF、文本向量化将非结构化文本数据转化为结构化的特征向量矩阵,与股... 详细信息

以开源R语言为平台,东方财富网的股评为研究对象,结合中文文本挖掘技术和SVR支持向量回归模型.利用中文挖掘技术,对股评进行去噪声、分词、同义词合并、去停用词、TFIDF、文本向量化将非结构化文本数据转化为结构化的特征向量矩阵,与股票的收益率建立SVR回归模型,通过预测未来的股票收益率来预测股价的涨跌趋势.研究结果表明,预测股价涨跌趋势与实际趋势基本吻合,可以通过分析网络舆情来对股市未来发展趋势进行预测.

关键词：网络舆情 R语言中文文本挖掘 SVR模型

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