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Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

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Journal of Traditional Chinese Medicine 2025年

作者： MIN Yu ZHENG Meifeng SUN Ju PENG Zetong CAO Zhixian huang Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine Department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and fengchi (GB20).Conclusion: Baihui (GV20) and fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

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Construction and optimization of a base editor based on the MS2 system

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Animal Models and Experimental Medicine 2019年第3期2卷 185-190页

作者： Shuzhen Zhang Songjie feng wen Jiang Xingxu huang Jieping Chen Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina School of Life Science and Technology ShanghaiTech UniversityShanghaiChina

Background:Catalytic defect Cas9‐cytosine deaminase fusion is widely used in base *** Multiple copy numbers of the MS2 binding site(MBS)can recruit multiple MS2 coat proteins(MCPs),which are usually applied to amplify *** study aimed to apply the MS2 signal amplification system to the base editing system in order to achieve simultaneous mutations of multiple bases at the target genome ***:Multiple copy numbers of the MS2 were ligated to the 3′‐end of sgRNA,and MCP was fused to the 5′‐end of cytosine *** MS2 was recognized by MCP to recruit cytosine deaminase for base substitutions(C‐T)at the target *** Cas9 variants,different cytosine deaminases and different copy numbers of MS2 were tested in this system,and the different versions of base editors were compared by editing efficiency and ***:In this study,dCas9,nCas9(D10A)and nCas9(H840A)were *** these 3 Cas9 variants,dCas9 exhibited higher base mutation *** cytosine deaminases were then applied and the efficiency of rAPOBEC1 deaminase was found to be higher than *** also increased the copy numbers of MS2 linked to sgRNA from 2 to ***,the sgRNA‐12x MS2 did not improve the editing efficiency or increase the editing ***:An optimal version of base editor based on the MS2 system,MS2‐BErAPOBEC1(sgRNA‐2x MS2,MCP‐rAPOBEC1 and dCas9),was *** tool can simultaneously mutate multiple bases at the target site,providing a new approach for the study of genome functions.

关键词： base editing functional screening MS2‐MCP simultaneously multiple mutagenesis

Periodic Folded Wave Patterns for(2+1)-Dimensional Higher-Order Broer-Kaup Equation

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Communications in Theoretical Physics 2008年第10期50卷 827-831页

作者： huang wen-Hua College of Science Huzhou University Huzhou 313000 China Shanghai Institute of Mathematics and Mechanics Shanghai University Shanghai 200072 China

A general solution including three arbitrary functions is obtained for the (2+1)-dimensional higher-orderBroer-Kaup equation by means of WTC truncation *** proper multiple valued functions and Jacobielliptic functions in the seed solution,special types of periodic folded waves are *** long wave limit theseperiodic folded wave patterns may degenerate into single localized folded solitary wave *** interactions ofthe periodic folded waves and their degenerated single folded solitary waves are investigated graphically and are foundto be completely elastic.

关键词： higher-order Broer Kaup equation WTC truncation method periodic folded wave

Comparison of Different Excitation Schemes in Bimodal Atomic Force Microscopy in Air and Liquid Environments

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Acta Mechanica Solida Sinica 2021年第2期34卷 163-173页

作者： Zhenyang huang Pengfei wen Xilong Zhou Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics School of ScienceWuhan University of TechnologyWuhan 430070China

Bimodal amplitude modulation atomic force microscopy(AM-AFM)is widely used in nanoscale topography and compositional contrast imaging for various *** this work,we use computational simulation to compare the dynamic behaviors of AFM cantilevers in three commonly used excitation schemes in bimodal AM-AFM,i.e.,the cantilever base excitation,the cantilever end excitation,and the uniform excitation along the length of the cantilever,in both air and liquid *** amplitude and phase spectroscopy curves and the frequency responses acquired from the three excitation schemes are compared and *** results would be useful in guiding the selection of excitation methods and the optimization of imaging conditions.

关键词： Atomic force microscopy Amplitude modulation Bimodal Excitation schemes

Noninvasive beam diagnosis based on the TM_(010)mode

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Nuclear Science and Techniques 2024年第7期35卷 115-125页

作者： Chuang-Ye Song wen-Hui huang Department of Engineering Physics Tsinghua University BeijingBeijing100084China of Education Beijing100084China

A resonant cavity based on the TM_(010)mode is an effective tool for noninvasive beam characterization. This technique has the advantages of a high signal-to-noise ratio, compact structure, and is related to multiple parameters compared with other beam monitors. In this study, high-precision measurements of the bunch charge, arrival time, bunch length, and energy parameters based on the TM_(010)mode are discussed. A cavity beam arrival time monitor(BAM) utilizing a phase cavity has been widely used in many facilities. Regarding bunch-length measurements, the influence of the beam energy, beam offset,and longitudinal spectrum on the TM_(010)mode are carefully considered to reduce errors, and the theoretical resolution of two cavities with different frequencies is analyzed. Owing to the dependence of the beam velocity of the beam loss factor, this method can also be used for the detection low beam energy using two cavities with the same frequency but different cavity lengths. A set of three cavities with different lengths and frequencies of 1.902 and 11.424 GHz is presented for measuring the four aforementioned parameters.

关键词： TM_(010)mode Noninvasive diagnosis Beam length Low energy

Analysis of drilling difficulty of extended-reach wells based on drilling limit theory

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Petroleum Science 2022年第3期19卷 1099-1109页

作者： wen-Jun huang De-Li Gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

With the continuous increase in vertical depths and horizontal displacements of directional wells,the difficulties of drilling operations continue to increase,and more accurate methods of drilling difficulty evaluation are *** this paper,a drilling difficulty evaluation method is built by combining drilling limit model and expert ***,the concept of drilling difficulty index is introduced,and the method to calculate drilling difficulty index is ***,the meanings of five drilling difficulty levels are explained and the optimization design method with drilling difficulty as the target is *** last,the theoretical model is applied to the extended-reach drilling of the Liuhua oilfield in the South China Sea,in which drilling difficulties are evaluated and the relationship between drilling difficulty and development control radius is *** results indicate that extended-reach drilling in the Liuhua oilfield is on the“normal”difficulty level on average,rotary drilling in 8_(1/2)-*** is the most difficult,and the main constraint conditions are excessive torque and high *** technology upgradation,the drilling difficulties are decreased,the development control radius increases from 6.6 to 11.4 km,and the maximum horizontalto-vertical ratio increases from 5.3 to ***,the development wells in marginal oilfields and adjustment wells in old oilfields can be drilled on“normal”difficulty ***,technology upgradation,especially drilling rig upgradation,is the most important development direction for extended-reach drilling in the South China Sea.

关键词： Extended-reach drilling South China Sea Drilling limit Drilling difficulty evaluation Drilling optimization design

Sesquiterpenoids from Curcuma wenyujin dreg and their biological activities

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Chinese Chemical Letters 2016年第10期27卷 1612-1616页

作者： Hui-feng huang Cai-Juan Zheng Guang-Ying Chen wen-Qing Yin Xian huang Zheng-Rong Mo Key Laboratory of Tropical Medicinal Plant Chemistry the Ministry of Education of China College of Chemistry and Chemical Engineering Hainan Normal University Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources the Ministry of Education of China School of Chemistry and PharmacyGuangxi Normal University Hainan Bikai Pharmaceutical Co. Ltd.

Four new sesquiterpenoids, 4,8-dioxo-6βhydroxyl-7β,l 1-epoxycarabrane （1）, 4,8-dioxo-6βhydroxyl- 7β,11-epoxycarabrane （2）, wenyujinins Q and R （3-4）, and nine known sesquiterpenoids （5-13） were isolated from the Curcuma wenyujin （C wenyujin） dreg. Their structures and relative configurations wereelucidated using 1D, 2D NMR, and HR-ESI-MS data. All the compounds were isolated for the first time from the C wenyujin dreg and evaluated for their antibacterial and antifungal activities. Compounds 3, 5- 8 exhibited strong broad-spectrum antifungal activities against tested nine pathogenic fungi.

关键词： Curcuma wenyujin dregSesquiterpenoidsAntibacterial activityAntifungal activity

Interaction of Mixed Porphyrin-polypyridyl Ru(II) Complex with Bovine Serum Albumin

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Chemical Research in Chinese Universities 2010年第5期26卷 693-698页

作者： XU Lei LIU Ya-nan MEI wen-jie huang Xiao-mei CHEN Tian-feng LIU Jie ZHENG wen-jie Department of Chemistry Jinan University Guangzhou 510632 P. R. China School of Pharmacy Guangdong Pharmaceutical University Guangzhou 510006 P. R. China

The interactions of mixed porphyrin-polypyridyl Ru（Ⅱ） complexes [m（Py-3＇）TPP-Ru（phen）2Cl]^＋（1） and its derivatives [Nim（Py-3＇）TPP-Ru（phen）2Cl]＋（2） and [Cum（Py-3＇）TPP-Ru（phen）2Cl]^＋（3）（phen=1,10-phenanthroline; m（Py-3＇）TPP=5-（3＇-pyridyl）-10,15,20-triphenylporphyrin） with bovine serum albumin（BSA） were investigated by fluorescence, UV-Vis and circular dichroism（CD） spectroscopies. The UV-Vis and CD spectral experiments indicated that the secondary structures of the protein were perturbed in the presence of the porphyrin Ru（Ⅱ） complex and the perturbation was enhanced under the irradiation with ultra-violet light. The fluorescence quenching mechanism of BSA by the three complexes was determined to be a static process, and the apparent binding constant K values for complexes 1, 2 and 3 measured by fluorescence quenching method were （3.86±0.03）×10^3 L/mol（n=0.94±0.04）, （5.69±0.04）× 103 L/mol（n=1.03±0.06）, and （6.54±0.02）× 10^3 L/mol（n=1.03±0.05）, respectively.

关键词： Porphyrin Bovine serum albumin(BSA) Ru(Ⅱ) complex Binding

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu huang Jinli huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume