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Chinese Chemical Letters 2015年第6期26卷 790-792页

作者： De-Long Kong Ye huang Lai-Yang Ren wen-Hua feng Department of New Drug Research and Development Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical College

Bedaquiline is a new medicine for pulmonary multi-drug resistant tuberculosis （MDR-TB）, which is a pure enantiomer with two chiral centers. The current industrial preparation process requires the separation of active Bedaquiline from a mixture of four isomers. Obviously, direct dispose of the other three undesired stereoisomers will cause significant waste and increase the unnecessary cost of production. Here, we developed an efficient, facile and scalable process for recycling the inactive stereoisomers of Bedaquiline. All these inactive stereoisomers could be recycled by their conversion to two important intermediates in the Bedaquiline synthesis via a base-catalyzed Csp3-Csp3 bond cleavage of a benzyl alcohol intermediate. And the precise conditions and mechanism of the base-catalyzed cleavage reaction were discussed.

关键词： Bedaquiline Inactive stereoisomers RecycleCsp3-Csp3 cleavage

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Aggregated impact of allowance allocation and power dispatching on emission reduction

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Journal of Modern Power Systems and Clean Energy 2017年第6期5卷 936-946页

作者： Chao JIANG Yusheng XUE Jie huang feng XUE Fushuan wen Kang LI Nanjing University of Science and Technology(NJUST) Nanjing 210094China State Grid Electric Power Research Institute(SGEPRI) Nanjing 211000China Universiti Teknologi Brunei(UTB) Brunei MuaraBrunei Queen’s University BelfastUK

Climate change has become one of the most important issues for the sustainable development of social *** has made great efforts in reducing CO2 emissions and promoting clean *** Emission Trading Systems(ETSs)have been launched in two provinces and five cities in China,and a national level ETS will be implemented in the third quarter of 2017,with preparations for China’s national ETS now well under *** the meantime,a new round of China’s electric power system reform has entered the implementation *** variables from both electricity and emission markets willimpose potential risks on the operation of generation companies(Gen Cos).Under this situation,by selecting key variables in each domain,this paper analyzes the combined effects of different allowance allocation methods and power dispatching models on power system *** parameters are set based on a provincial power system in China,and the case studies are conducted based on dynamic simulation platform for macro-energy systems(DSMES)software developed by the *** selected power dispatching models include planned dispatch,energy saving power generation dispatch and economic *** selected initial allowance allocation methods in the emission market include the grandfathering method based on historical emissions and the benchmarking method based on actual *** on the simulation results and discussions,several policy implications are highlighted to help to design an effective emission market in China.

关键词： Emission trading system(ETS) Allowance allocation Power dispatching Generation company Emission reduction

Pricing permanent convertible bonds in EVG model

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Applied Mathematics(A Journal of Chinese Universities) 2012年第3期27卷 268-280页

作者： YANG Xiao-feng YU Jin-ping huang wen-li LI Sheng-hong Department of Mathematics Zhejiang UniversityHangzhou 310027China Department of Mathematics Zhejiang University of Science and TechnologyHangzhou 310023 China

By considering the failure of normal distribution and continuous assumption in financial modeling, this paper attempts to apply the Exponential Variance Gamma （EVG） model into the pricing framework of permanent convertible bonds with call clause. Following framework of Gapeev ＆ Kiihn（2005）, we obtain an explicit solution to the bond price and optimal stopping strategies, which shows that the new pricing framework is quite different from the continuous model and even the Jump Diffusion model. Compared with the numerical calculation, the closed form results price convertible bonds quickly and accurately.

关键词： convertible bond call clause variance gamma process.

End-to-End Self-Driving Using Deep Neural Networks with Multi-auxiliary Tasks

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Automotive Innovation 2019年第2期2卷 127-136页

作者： Dan Wang Junjie wen Yuyong Wang Xiangdong huang feng Pei GAC R&D Center 381 Wushan RoadTianheGuangzhouChina

End-to-end self-driving is a method that directly maps raw visual images to vehicle control signals using deep convolutional neural network(CNN).Although prediction of steering angle has achieved good result in single task,the current approach does not effectively simultaneously predict the steering angle and the *** this paper,various end-to-end multi-task deep learning networks using deep convolutional neural network combined with long short-term memory recurrent neural network(CNN-LSTM)are designed and compared,which could obtain not only the visual spatial information but also the dynamic temporal information in the driving scenarios,and improve steering angle and speed ***,two auxiliary tasks based on semantic segmentation and object detection are proposed to improve the understanding of driving *** are conducted on the public Udacity dataset and a newly collected Guangzhou Automotive Cooperate *** results show that the proposed network architecture could predict steering angles and vehicle speed *** addi-tion,the impact of multi-auxiliary tasks on the network performance is analyzed by visualization method,which shows the salient map of ***,the proposed network architecture has been well verified on the autonomous driving simu-lation platform Grand Theft Auto V(GTAV)and experimental road with an average takeover rate of two times per 10 km.

关键词： Self-driving Multi-auxiliary tasks CNN-LSTM Deep learning

Thermophysical properties of solution precursor plasma-sprayed La2Ce2O7 thermal barrier coatings

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Rare Metals 2019年第7期38卷 689-694页

作者： Bei-Bei feng Yi Wang Qiang Jia Wei huang Hong-Li Suo wen Ma School of Materials Science and Engineering Beijing University of Technology Beijing 100022 China The Key Laboratory of Advanced Functional Materials Ministry of Education of China Beijing University of Technology Beijing 100022 China School of Materials Science and Engineering Inner Mongolia University of Technology Huhhot 010051. China

La2Ce2O7 (LCO) is a promising candidate for thermal barrier coatings (TBCs) due to that it provides better thermal insulation than yttria-stabilized zirconia (YSZ) does. In this work, a TBC LCO was produced by solution precursor plasma spraying (SPPS). After the solution precursors were prepared and the spraying parameters were optimized, the thermophysical properties and thermal shock performance of the coatings were tested. It was found that the SPPS coating with segmentation crack density of 6 mm^-1 had the porosities of about 33.5% at spray distances of 35 mm. The thermal conductivity of the SPPS coatings is 0.50-0.75 W·m^-1·K^-1, much lower than that of the atmospheric plasma spraying (APS) coatings (0.85-1.25 W·m^-1·K^-1). The thermal shock performance of the SPPS coatings reached 60 cycles, much better than the APS coatings. This improvement is due to the segmentation cracks in the coatings, which can improve strain tolerance and effectively relieve internal stress. This study provides reference significance for further research on thermal barrier coatings.

关键词： La2Ce2O7 Solution precursor plasma spraying Thermal conductivity Segmentation cracks

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Characterization and mapping of a novel light-dependent lesion mimic mutant lmm6 in rice(Oryza sativa L.)

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Journal of Integrative Agriculture 2015年第9期14卷 1687-1696页

作者： XIAO Gui-qing ZHANG Hai-wen LU Xiang-yang huang Rong-feng College of Bioscience and Biotechnology Hunan Agricultural University Hunan Agricultural Bioengineering Research Institute Biotechnology Research Institute Chinese Academy of Agricultural Sciences

A novel rice lesion mimic mutant (LMM) was isolated from an ethane methyl sulfonate (EMS)-induced 02428 mutant bank. The mutant, tentatively designated as lmm6, develops necrotic lesions in the whole growth period along with changes in several important agronomic traits. We found that the initiation of the lesions was induced by light and cel death occurred in lmm6 accompanied with accumulation of reactive oxygen species (ROS). The lower chlorophyl content, soluble protein content and superoxide dismutase (SOD) activity, the higher malondialdehyde (MDA) content were detected in lmm6 than in the wild type (WT). Moreover, the observation by transmission electronic microscope (TEM) demonstrated that some organel es were damaged and the stroma lamel a of chloroplast was irregular and loose in mesophyl cel of lmm6. In addition, lmm6 was more resistant than WT to rice blast fungus Magnaporthe grisea infection, which was consistent with increased expression of four genes involved in the defense-related reaction. Genetic analysis showed that mutant trait of lmm6 is inherited as a monogenic recessive nuclear gene located on the long arm of chromosome 6. Using simple sequence repeat (SSR) markers, the target gene was ifnal y delimited to an interval of 80.8 kb between markers MM2359 and MM2370, containing 7 annotated genes. Taken together, our results provide the information to identify a new gene involved in rice lesion mimic, which wil be helpful in clarifying the mechanism of cel death and disease resistance in rice.

关键词： rice lesion mimic mutant gene mapping ROS blast resistance

A distributed location management strategy for next- generation IP-based wireless networks

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The Journal of China Universities of Posts and Telecommunications 2006年第3期13卷 38-42页

作者： SONG Mei feng Rui-jun huang Jian-wen SONG Jun-de PCN and CAD Center School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Location management is the most important function in mobility management technology. The hierarchical structure of the proposed hierarchical network-layer mobility management （HNMM） can reduce the signaling cost. The selforganizing topology scheme can enhance the robustness and quality of the mobility management. The information of location of the mobile node is stored in the distributed database, which makes the storage of the location information more reliable and robust, and more flexible strategies can be used. The numeric results show that HNMM can provide better performance than the general structure of mobile IPv6, when the mobile nodes move frequently and when there is high traffic throughput.

关键词： location management mobile IPv6 mobility management IP-based wireless networks

Higher-order topology induced by structural buckling

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National Science Review 2022年第8期9卷 55-61页

作者： Huaqing huang feng Liu School of Physics Peking University Collaborative Innovation Center of Quantum Matter Center for High Energy Physics Peking University Department of Materials Science and Engineering University of Utah

Higher-order topological insulator(HOTI) states, such as two-dimension(2D) HOTI featured with topologically protected corner modes at the intersection of two gapped crystalline boundaries, have attracted much recent interest. However, the physical mechanism underlying the formation of HOTI states is not fully understood, which has hindered our fundamental understanding and discovery of HOTI materials. Here we propose a mechanistic approach to induce higher-order topological phases via structural buckling of 2D topological crystalline insulators(TCIs). While in-plane mirror symmetry is broken by structural buckling, which destroys the TCI state, the combination of mirror and rotation symmetry is preserved in the buckled system, which gives rise to the HOTI state. We demonstrate that this approach is generally applicable to various 2D lattices with different symmetries and buckling patterns, opening a horizon of possible materials to realize 2D HOTIs. The HOTIs so generated are also shown to be robust against buckling height fluctuation and in-plane displacement. A concrete example is given for the buckledβ-Sb monolayer from first-principles calculations. Our finding not only enriches our fundamental understanding of higher-order topology, but also opens a new route to discovering HOTI materials.

关键词： higher-order topological insulators structural buckling rotation-reflection symmetry buckled honeycomb antimony monolayer