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Avoidance of Linkage Drag Between Blast Resistance Gene and the QTL Conditioning Spikelet Fertility Based on Genotype Selection Against Heading Date in Rice

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Rice science 2009年第1期16卷 21-26页

作者： LIU wen-qiang fan Ye-yang CHEN Jie SHI Yong-feng Wu Jian-li Chinese National Center for Rice Improvement/State Key Laboratory for Rice Biology China National Rice Research Institute Hangzhou 310006 China

Previous study showed that a linkage drag between a blast resistance gene Pi25（t） and QTLs conditioning spikelet fertility （qSF-6） and number of filled grains per panicle （qNFGP-6） was detected on the short arm of chromosome 6. A larger population was used for further verification, and the results confirmed the linkage drag between the blast resistance gene and QTL conditioning spikelet fertility, other than QTL conditioning number of filled grains per panicle. Breakdown or avoidance of the linkage drag could be achieved by selection against the genotype background of a heading-date gene （qHD-7） that resided in the region between RM2 and RM214 on chromosome 7. For further validation, two lines with almost identical genotypes on all chromosomal regions except the Pi25（t） region on chromosome 6 were chosen to develop a new population The results showed that qSF-6 could be further subdivided into qSF-6-1 and qSF-6-2. When the genotype of the region between RM2 and RM214 was from rice variety Zhong 156, the linkage drag between Pi25（t） and qSF-6-2 was detected and the allele of qSF-6-2 from rice variety Gumei 2 reduced the spikelet fertility. When the genotype of the region between RM2 and RM214 was from Gumei 2, no linkage drag was detected. This indicates that the linkage drag between the blast resistance gene and the QTL conditioning spikelet fertility could be broken down or avoided under a certain background genotype selection against heading-date and provides a marker aided solution for high level of blast resistance and yield breeding in rice and other crops as well.

关键词： rice (Oryza sativa) linkage drag blast resistance quantitative trait locus spikelet fertility heading date

Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG Weilin WANG Qijiao XIAO Huahua CHEN Xiaoxiao XIE fan ZENG wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

Retrospective Analysis of Thrombolysis Therapy for 64 Cases of Acute Myocardial Infarction with Elevated ST Segment

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Chinese Journal of Integrative Medicine 2009年第6期15卷 462-465页

作者：傅晓霞肖文剑吕健吴乐文杨帆 The First Traditional Chinese Medicine Hospital of Zhanjiang City Guangdong Medical College

Objective:To explore the cardiac protective effect of integrative therapy in acute myocardial infarction(AMI) with elevated ST segment after ***:Sixty-four AMI patients who having received decimalization by thrombolysis were assigned to two groups by retrospective analysis,36 patients in the treated group and 28 in the control *** were treated by intravenous administering of urokinase for thrombolysis,and to the treated group,intravenous dripping of Xueshuantong Injection(血栓通注射液,XST) ...

关键词： acute myocardial infarction with elevated ST-segment integrative medical therapy Xueshuantong Injection

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui Wei Shu-Hui fan Li Chen Jie Wang Xiao-Qian yang Chun-Hao yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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“保险消费者”概念辨析

现代法学 2017年第2期39卷 79-93页

作者：温世扬范庆荣中南财经政法大学法学院武汉430072 武汉大学法学院武汉430072

保险消费者"概念问题的实质,即将《消保法》作为保险相对人保护自身权益的法律依据之一。其理论基础为,外部性、自然垄断、信息不对称等《消保法》的立法缘由在保险领域中同样存在。法人和其他组织不宜纳入保险消费者的范畴。主要目的... 详细信息

保险消费者"概念问题的实质,即将《消保法》作为保险相对人保护自身权益的法律依据之一。其理论基础为,外部性、自然垄断、信息不对称等《消保法》的立法缘由在保险领域中同样存在。法人和其他组织不宜纳入保险消费者的范畴。主要目的可以作为区分保险消费者与投资者的标准。保险消费者包括投保人、被保险人、受益人。

关键词：保险消费者保险法消费者保护法投资者保险相对人

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

果品产量统计数据空间离散化研究——以北京平谷区为例

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浙江农业学报 2016年第12期28卷 2116-2122页

作者：刘玉范文洋郜允兵唐林楠国家农业信息化工程技术研究中心北京100097 北京舜土规划顾问有限公司北京100070

果品产量是衡量区域农产品生产功能的重要指标。果品产量的空间离散化,有助于揭示区域内部要素的空间差异性和获取微观尺度的果品产量数据。该研究依据地形起伏度和土地利用分区将平谷区划分为平原区、浅山区和深山区,并分别建立离散化... 详细信息

果品产量是衡量区域农产品生产功能的重要指标。果品产量的空间离散化,有助于揭示区域内部要素的空间差异性和获取微观尺度的果品产量数据。该研究依据地形起伏度和土地利用分区将平谷区划分为平原区、浅山区和深山区,并分别建立离散化模型进行修正,将村果品产量离散到500 m×500 m格网下的果园图斑上。结果表明:(1)村果品模拟产量与果品实际产量的相关性系数由总体样本建模的0.585提高到分区建模的0.690,表明分区建模是一种有效的方法。(2)各区影响因素与产量的关系存在差异。平原区果园面积对果品产量呈现线性影响;浅山区和深山区果园面积对果品产量的影响较为剧烈,呈幂指数关系,并且增加海拔高度和坡度2个变量后模型的拟合效果均有改善。(3)在自然环境、社会经济等综合影响下,平谷区果品产量呈现地带性分布。其中,产量较高的区域集中分布于地形相对平缓、自然本底较好、农民劳作便利的浅山带;而平原区和深山区分别受政策限制和地形限制,果品产量相对较低。

关键词：果品产量土地利用空间离散化平谷区

基于污染密集指数甄别污染密集型行业及其聚类法验证

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科技和产业 2017年第4期17卷 5-10页

作者：范文虎杨昆山西省科学技术情报研究所太原030001

随着节能减排工作在我国如火如荼地兴起,需要重点节能减排的污染密集型产业需要通过技术创新、产业转型、新能源开发等手段,尽可能地减少能源消耗、减少温室气体排放。首先,计算污染密集指数以进行2014年我国污染密集行业的甄别,通过聚... 详细信息

随着节能减排工作在我国如火如荼地兴起,需要重点节能减排的污染密集型产业需要通过技术创新、产业转型、新能源开发等手段,尽可能地减少能源消耗、减少温室气体排放。首先,计算污染密集指数以进行2014年我国污染密集行业的甄别,通过聚类分析法验证甄别出污染密集型行业;其次,概述污染密集型产业的污染状况;最后,探讨污染密集型产业的节能减排路径。

关键词：节能减排污染密集指数聚类分析能源