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科尔沁草地植物种质资源的数量特征

生态学杂志 2017年第10期36卷 2699-2706页

作者：孙睿徐文铎陈玮张粤中国科学院森林生态与管理重点实验室中国科学院沈阳应用生态研究所沈阳110016 中国科学院大学北京100049

以通辽地区科尔沁草地为研究对象,采用样地调查探析该地区草地植物种质资源数量特征。结果表明:通辽地区科尔沁草地的植物种类组成十分丰富和复杂,共有42科,163属,276种,其中优良牧草种类占35.15%;可将草地类型划分为5大类、7个亚类、1... 详细信息

以通辽地区科尔沁草地为研究对象,采用样地调查探析该地区草地植物种质资源数量特征。结果表明:通辽地区科尔沁草地的植物种类组成十分丰富和复杂,共有42科,163属,276种,其中优良牧草种类占35.15%;可将草地类型划分为5大类、7个亚类、17个草地组,其中以羊草(Leymus chinensis)为建群种的群落占主要优势,分布最为广泛;因此,本文深入研究了羊草群落的生物量与物种多样性、地理分布的关系,即羊草群落随着物种多样性的增加,群落地上生物量明显增加,呈正相关关系;同时,羊草群落的地上生物量也受到地理因子变化的影响,地上生物量随着经度升高而增加,随着纬度升高而降低。本研究对增加该地区优质牧草产量、改良退化草地、发展草原畜牧业提供了重要的科学数据,对于更好恢复和管理该地区重要的草地资源以及地区经济发展具有重要意义。

关键词：生物多样性植物种重要值草地地上生物量地理分布格局科尔沁草地

Rationale and study design for one-stop assessment of renal artery stenosis and renal microvascular perfusion with contrast-enhanced ultrasound for patients with suspected renovascular hypertension

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Chinese Medical Journal 2019年第1期132卷 63-68页

作者： Jun-Hong Ren Na Ma Si-Yu Wang You-Jing Sun Yue-Wei zhang Fa-Jin Guo Yong-Jun Li Tian-Hui Li Hu Ai wen-duo zhang Peng Li Wei-Hua Ma Department of Sonography Beijing HospitalNational Center of GerontologyBeijing 100730China Vascular Department Beijing HospitalNational Center of GerontologyBeijing 100730China Nephrology Department Beijing HospitalNational Center of GerontologyBeijing 100730China Department of Cardiology Beijing HospitalNational Center of GerontologyBeijing 100730China Beijing Hospital National Center of GerontologyBeijing 100730China

Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and ***,this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. Methods:This will be a single-center diagnostic study with a sample size of *** with chronic kidney disease (CKD) and suspected of having resistant hypertension will be *** with Stages 1–3 CKD will undergo CEUS and computed tomography (CT) angiography (CTA).Values obtained by CEUS and CTA for diagnosing low-grade (lumen reduced by <60%) and high-grade (lumen reduced by ≥60%) RAS will be ***,all patients will also undergo radionuclide *** diagnostic value for RAS will be assessed by the receiver operating characteristic curve,including the accuracy,sensitivity,specificity,positive predictive values,negative predictive values,and area under the *** correlation analysis will be performed to assess the association between CEUS findings for RMP and glomerular filtration rate measured by a radionuclide imaging method. Conclusion:The data gathered from this study will be used to evaluate the feasibility of expanding clinical applications of CEUS for evaluation of patients with suspected renovascular hypertension.

关键词： Renovascular hypertension contrast-enhanced ultrasound renal artery stenosis renal microvascular perfusion

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Effect of norepinephrine or phentolamine microinjected into caudate nucleus on the pain threshold of rat tail-flick

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Effect of norepinephrine or phentolamine microinjected into ...

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Guang-wen zhang~1,duo zhang~2,He-Ren GAO~2,Yu LIANG~3,Ying HANG~2,Run-Sheng JIAO~2,Hui zhang~2,Man-Ying XU~(2,*) 1 Third Affiliated Hospital 2 Laboratory of Neural Electrophysiology,Department of Physiology,Harbin Medical University,Harbin 150081, China 3 Mudanjiang Medical College,Mudanjiang 157000,China

＜正＞Objective To investigate the influences of caudate nucleus injection of different doses alpha-adrenoceptor agonist norepinephrine（NE） or antagonist phentolamine on the pain threshold of rat *** The tail-flick latency（TFL） of rat was recorded using the thermal pain *** measure the effects of the caudate nucleus injection of NE（2μg/2μl or 8μg/2μl）,phentolamine（1μg/2μl or 4μg/2μl） or normal saline（2μl） on *** The caudate nucleus injection of the higher dose of 8μg NE shortened the TFL,the higher dose of 4μg phentolamine lengthened the TFL（P＜0.01）.However,injection of the lower dose of 2μg NE into the caudate nucleus lengthened the TFL,the lower dose of 1μg phentolamine shortened the TFL（P＜0.01）.Conclusion Injection of alpha-adrenoceptors agonist 2μg NE into the caudate nucleus produced the antinociceptive effects on the responses to noxious thermal stimulation in tail-flick tests. However,injection of 8μg NE into the caudate nucleus caused hyperalgesic *** contrast,injection of alpha-adrenoceptors antagonist phentolamine 1μg into the caudate nucleus produced hyperalgesic actions on the responses to noxious thermal stimulation in tail-flick tests,4μg caused analgesic *** results indicate that the caudate nucleus of rat injection of different doses of NE or phentolamine have opposing effects,i.e.,exhibiting the analgesic effect or the hyperalgesic *** is revealed that the effects of different doses NE in the caudate nucleus of the rat on the pain threshold of tail-flick are involved in the different subtypes of alpha-adrenoceptors.

关键词： Caudate nucleus norepinephrine phentolamine tail-flick latency

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： wen Jin LIU Zhanzhi WU Zhengwei PAN Yu zhang Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen Bo Zeng Xiaofeng zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao wen Ming Zhou Minjie Luo Wangming zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-Fang Feng wen-Ting He Tong zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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