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Ganoderma lucidum spore oil enhances the effect of paclitaxel,improves the tolerance to paclitaxel and prolongs the survival in Lewis tumor-bearing mice

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Cancer Advances 2024年第12期7卷 1-6页

作者： Hong-Fei Cai Zhao-Jian Jiang Cheng Yuan Lin Cao Qin Wang Ya-Ming Han Qin Zhang Jing Li wen-dong xu Ju-Yan Liu Guangzhou HanFang Pharmaceutical Company Limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Nanchang Research Institute Sun Yat-Sen UniversityNanchang 330096China Guangzhou Pharmaceutical Holdings Limited Guangzhou 510130China

Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported ***:The tumor,spleen,and thymus were weighed at the end of the *** blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of NK cells was detected by LDH assay,and the proliferation index of lymphocytes was determined by CCK-8 *** overall and mean survival time and life extension rate were calculated using SPSS ***:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of *** underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and ***,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of NK cells in mice treated with ***:GLSO may enhance the efficacy of PTX by boosting the activity of immune NK cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving *** findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.

关键词： Ganoderma lucidum spore oil Traditional Chinese Medicine lung cancer paclitaxel tolerance survival

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Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons

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Neuroscience Bulletin 2021年第9期37卷 1289-1302页

作者： Wei Lin wen-wen Zhang Ning Lyu Hong Cao wen-dong xu Yu-Qiu Zhang Department of Translational Neuroscience Jing’an District Centre Hospital of ShanghaiState Key Laboratory of Medical Neurobiology and Institutes of Brain ScienceFudan UniversityShanghai 200032China Department of Hand Surgery Huashan HospitalFudan UniversityShanghai 200040China Department of Neurobiology School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China

Growth differentiation factor 15(GDF-15)is a member of the transforming growth factor-β*** is widely distributed in the central and peripheral nervous *** and how GDF-15 modulates nociceptive signaling remains ***,we found that peripheral GDF-15 significantly elevated nociceptive response thresholds to mechanical and thermal stimuli in naïve and arthritic ***,we demonstrated that GDF-15 decreased the excitability of small-diameter dorsal root ganglia(DRG)***,GDF-15 concentration-dependently suppressed tetrodotoxin-resistant sodium channel Nav1.8 currents,and shifted the steady-state inactivation curves of Nav1.8 in a hyperpolarizing ***-15 also reduced window currents and slowed down the recovery rate of Nav1.8 channels,suggesting that GDF-15 accelerated inactivation and slowed recovery of the *** results showed that activin receptor-like kinase-2(ALK2)was widely expressed in DRG medium-and small-diameter neurons,and some of them were *** of ALK2 prevented the GDF-15-induced inhibition of Nav1.8 currents and nociceptive *** of PKA and ERK,but not PKC,blocked the inhibitory effect of GDF-15 on Nav1.8 *** results suggest a functional link between GDF-15 and Nav1.8 in DRG neurons via ALK2 receptors and PKA associated with MEK/ERK,which mediate the peripheral analgesia of GDF-15.

关键词： Growth differentiation factor-15 Tetrodotoxin-resistant sodium channel Nav1.8 Dorsal root ganglion Whole-cell recording Activin receptor-like kinase-2 Pain

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Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury

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Neural Regeneration Research 2016年第4期11卷 670-675页

作者： Ye-chen Lu Han-qiu Liu xu-yun Hua Yun-dong Shen wen-dong xu Jian-guang xu Yu-dong Gu Department of Hand Surgery Huashan HospitalFudan University Department of Radiology Huashan HospitalFudan University State Key Laboratory of Medical Neuroscience Fudan University

Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve *** is believed that the capability of brain plasticity is crucial for the recovery of hand *** supplementary motor area may play a key role in brain remodeling after peripheral nerve *** this study,we explored the activation mode of the supplementary motor area during a motor imagery *** investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery *** from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor *** result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain *** of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function.

关键词： nerve regeneration peripheral nerve injury brachial plexus injury neuronal plasticity supplementary motor area premotor area magnetic resonance imaging motor preparation motor imagery clinical restoration of hand function cortical remodeling block design neural regeneration

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Low-power laser therapy for carpal tunnel syndrome:effective optical power

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Neural Regeneration Research 2016年第7期11卷 1180-1184页

作者： Yan Chen Cheng-qiang Zhao Gang Ye Can-dong Liu wen-dong xu Department of Neurology Tongji HospitalTongji University School of Medicine Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Department of Rehabilitation Medicine Tongji HospitalTongji University School of Medicine

Low-power laser therapy has been used for the non-surgical treatment of mild to moderate carpal tunnel syndrome,although its efficacy has been a long-standing *** laser parameters in low-power laser therapy are closely related to the laser effect on human *** evaluate the efficacy of low-power laser therapy,laser parameters should be accurately measured and controlled,which has been ignored in previous clinical ***,we report the measurement of the effective optical power of low-power laser therapy for carpal tunnel *** monitoring the backside reflection and scattering laser power from human skin at the wrist,the effective laser power can be *** clinical measurements from 30 cases,we found that the effective laser power differed significantly among cases,with the measured laser reflection coefficient ranging from 1.8% to 54%.The reflection coefficient for 36.7% of these 30 cases was in the range of 10–20%,but for 16.7% of cases,it was higher than 40%.Consequently,monitoring the effective optical power during laser irradiation is necessary for the laser therapy of carpal tunnel syndrome.

关键词： tunnel moderate irradiation inferred hemisphere reflecting absolute calibration Probability consent

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Decision and Coordination in a Closed-Loop Supply Chain with Product Recycling Under Different Low-Carbon Regulations

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Journal of the Operations Research Society of China 2024年第3期12卷 695-728页

作者： Qian-dong dong Hai-wen xu School of Management and Engineering Nanjing UniversityNanjing210093JiangsuChina School of Science Civil Aviation Flight University of ChinaGuanghan618307SichuanChina

The implementation of recycling activity is of great significance to closed-loop supply chain ***’environmental awareness and governmental subsidy are considered in the two-echelon closed-loop supply *** types of decision-making structures are proposed under different carbon emission *** subsidy sharing mechanism is designed to resolve the channel members’conflict caused by double *** paper provides insight into the effect of environmental awareness and government subsidy under different low-carbon regulations on the supply chain benefit and social welfare via the game *** analysis results display that the government subsidy and subsidy sharing mechanism are profitably beneficial to the whole supply chain and social ***,a noteworthy result reveals that social welfare is not always directly proportional to consumers’environmental *** welfare decreases slightly with the increase in consumers’environmental awareness when consumers’environmental awareness is ***,social welfare will be significantly improved when consumers’environmental awareness increases beyond a certain threshold.

关键词： Closed-loop supply chain Recycling Coordination Social welfare Game theory Carbon emissions

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Topological Vortices in a Spin-Triplet Superconductor

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Communications in Theoretical Physics 2008年第8期50卷 525-528页

作者： REN Ji-Rong WEI Shao-wen xu dong-Hui DUAN Yi-Shi Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

Based on the complex three-component order parameter model of a spin-triplet superconductor, by using the C-mapping theory, we derive a new equation describing the distribution of the magnetic field for vortices, which can be reduced to the modified London equation in the case of ｜ψ^2｜^2 ^- ｜ψ^3｜^2 = 0 and Wl^1= 1. A magnetic flux quantization condition for vortices in a spin-triplet superconductor is also derived, which is topological-invariant. Fhrthermore, the branch processes during the evolution of the vortices in a spin-triplet superconductor are discussed. We also point out that the sum of the magnetic flux quantization that those vortices carried is 2nФo （Фo is the unit magnetic flux）, that is to say, the sum of winding number is even, which needs to be proved by experiment.

关键词： spin-triplet superconductor topological defects bifurcation point

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Lightweight innovation ADIs help development of renewable energy and new technology industries in China

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China Foundry 2024年第5期21卷 507-515页

作者： Qi-dong Yan xu-dong Gong wen-bang Gong Jin-cheng Liu ADI Committee of China Foundry Association Beijing 100000China Yuzhou Henglilai New Materials Co. Ltd.Xuchang 452570HenanChina Kunshan Changjian Foundry Industry Co.Ltd. Kunshan 215311JiangsuChina School of Mechanical Engineering and Automation Wuhan Textile UniversityWuhan 430200China WFO Ferrous Metals Commission Shenyang 110022China

The world is undergoing profound changes in energy and *** are vigorously developing new sustainable energy sources and *** energy sources encompass various technologies such as wind turbines,solar energy,nuclear energy,and ***,emerging technology fields include new energy vehicles,robots,and artificial intelligence devices,among *** renewable energy industries and implementation of new technologies necessitate the development and adoption of new equipment and *** ductile iron(ADI)is renowned for its unique microstructure and superior *** utilizing ADI,lightweight and innovative castings can be designed to not only reduce weight but also save energy and decrease *** importantly,these castings enhance the efficiency and reliability of new energy equipment and emerging technology *** paper describes the development,applications,and future prospects of lightweight and innovative ADI castings within sectors such as solar photovoltaic(PV),wind power generation,industry robots,and trucks in China.

关键词： lightweight ADI renewable energy emission reduction

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Divergent defluorocarboxylation of α-CF_(3) alkenes with formate via photocatalyzed selective mono-or triple C-F bond cleavage

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Science China Chemistry 2024年第1期67卷 368-373页

作者： Xing-Yu Wang Pei xu wen-wen Liu Hao-Qiang Jiang Song-Lei Zhu dong Guo xu Zhu Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 22100China

Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives fromα-CF_(3)alkenes with formate as the carbonyl source was *** reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT)catalyst under visible-light-induced conditions at room *** acts as both the C1 source and the reductant through the generation of CO_(2)^(·-)species,which underwent Giese radical addition to electron-deficient alkenes to trigger the consecutive C-F bond cleavage and carboxylation process.

关键词： C-F bond activation defluorocarboxylation carbon dioxide radical anion visible light

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柴芩承气汤辅助治疗对急性胰腺炎患者Th17/Treg免疫失衡和外周血TLR4/NF-κB通路mRNA表达的影响

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现代生物医学进展 2024年第4期24卷 739-742,763页

作者：王晓翔黄蕾温旭东付国川潘涛成都市第一人民医院(成都中医药大学附属中西医结合医院)消化内科四川成都610041

目的:观察柴芩承气汤辅助治疗对急性胰腺炎(AP)患者辅助性T细胞17(Th17)/调节性T细胞(Treg)免疫失衡和外周血Toll样受体4(TLR4)/核因子κB(NF-κB)通路m RNA表达的影响。方法:纳入2021年3月到2022年12月期间成都市第一人民医院收治的90... 详细信息

目的:观察柴芩承气汤辅助治疗对急性胰腺炎(AP)患者辅助性T细胞17(Th17)/调节性T细胞(Treg)免疫失衡和外周血Toll样受体4(TLR4)/核因子κB(NF-κB)通路m RNA表达的影响。方法:纳入2021年3月到2022年12月期间成都市第一人民医院收治的90例AP患者,按照随机数字表法分为对照组和实验组,各为45例。对照组患者接受常规西医治疗,实验组患者在对照组的基础上接受柴芩承气汤辅助治疗。对比两组疗效、中医证候评分、Th17/Treg免疫失衡相关指标、外周血TLR4/NF-κB通路m RNA表达。结果:实验组的临床总有效率高于对照组(P<0.05)。治疗1周后,两组腹痛剧烈、有痞满燥实坚征象、日晡潮热、恶心呕吐、小便短赤中医证候评分均下降,且实验组低于对照组(P<0.05)。治疗1周后,两组Th17细胞比例、Th17/Treg均下降,且实验组低于对照组(P<0.05),治疗1周后,两组Treg细胞比例升高,且实验组高于对照组(P<0.05)。治疗1周后,两组TLR4 m RNA、NF-κB m RNA均下降,且实验组低于对照组(P<0.05)。结论:柴芩承气汤辅助治疗AP患者,可提升治疗效果,降低中医证候积分,调节Th17/Treg免疫失衡和外周血TLR4/NF-κB通路m RNA表达。

关键词：柴芩承气汤急性胰腺炎 Th17/Treg免疫失衡 TLR4/NF-κB通路

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Experimental Study on Mixed-Mode(Ⅰ–Ⅱ)Fracture Toughness of Freshwater Ice

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Acta Mechanica Solida Sinica 2024年第2期37卷 252-264页

作者： Yaozhong xu Mao Zhou Xian Yi wen Hua Jiuzhou Huang wenyu Zhang Shiming dong Key Laboratory of Deep Underground Science and Engineering Ministry of EducationCollege of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province Sichuan UniversityChengdu610065China China Aerodynamics Research and Development Center/Low Speed Aerodynamics Research Institute Mianyang621000China College of Mechanical and Electrical Engineering Xichang UniversityXichang615000China

In recent years,the issue of aircraft icing has gained widespread *** breaking and detachment of dynamic ice can pose a threat to flight ***,the shedding and fracture mechanisms of dynamic ice are unclear and cannot meet the engineering needs of ice-shedding hazard ***,studying the fracture toughness of ice bodies has extremely important practical *** address this issue,this article uses a centrally cracked Brazilian disk(CCBD)specimen to measure the pure modeⅠtoughness and pure modeⅡfracture toughness of freshwater ice at different loading *** mixed-mode(Ⅰ–Ⅱ)fracture characteristics of ice are discussed,and the experimental results are compared and analyzed with the theoretical values of the generalized maximum tangential stress(GMTS)criterion considering the influence of *** results indicated that as the loading rate increases,the pure modeⅠtoughness and pure modeⅡfracture toughness of freshwater ice decrease,and the fracture toughness of freshwater ice is more sensitive to the loading rate.Ⅰn terms of fracture criteria,the theoretical value of the ratio of pure modeⅡfracture toughness to pure modeⅠfracture toughness based on the GMTS criterion is in good agreement with the experimental value,while the theoretical value based on the maximum tangential stress(MTS)criterion deviates significantly from the experimental value,indicating that the GMTS criterion considering the influence of T-stress can better predict the experimental results.

关键词： Freshwater ice Fracture criteria Centrally cracked Brazilian disk(CCBD) Mixed-mode(Ⅰ-Ⅱ) Loading rate

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