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Total ionizing dose effect modeling method for CMOS digital-integrated circuit

Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-Hui Liu Xiao-Peng Zhang Gang Liu wen-dan tan Xin-dan Zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

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Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG BIN tanG dan XU wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

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Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

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Tungsten 2025年第1期7卷 100-111页

作者： Zhi-Qi Zhang Liu Yang wen Luo Vladimir An Jing Li Bao-dan Liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

关键词： Low temperature activity Monolithic mesh catalysts NH3-SCR SO2 tolerance V2O5-WO3/TiO2

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Active control of friction realized by vibrational excitation:Numerical simulation based on the Prandtl-Tomlinson model and molecular dynamics

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Friction 2023年第7期11卷 1225-1238页

作者： Xiao MA Xinfeng tan dan GUO Shizhu wen State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

Superlubricity and active friction control have been extensively researched in order to reduce the consumption of fossil energy,the failure of moving parts,and the waste of *** vibration-induced superlubricity(VIS)presents a promising solution for friction reduction since it does not require high-standard ***,the mechanism underlying the VIS remains unclear since the atomic-scale information in a buried interface is unavailable to experimental *** this paper,the mechanism of VIS was examined via numerical calculation based on the Prandtl-Tomlinson(PT)model and molecular dynamics(MD)*** results revealed that the pushing effect of stick-slip is one of the direct sources of friction reduction ability under vibrational excitation,which was affected by the response amplitude,frequency,and the trace of the ***,the proportion of this pushing effect could be modulated by changing the phase difference when applying coupled vibrational excitation in x-and *** results in a significant change in friction reduction ability with *** this way,active friction control from the stick-slip to superlubricity can be achieved conveniently.

关键词： superlubricity vibration friction control molecular dynamics(MD)

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Experimental investigation of propagation mechanisms and fracture morphology for coalbed methane reservoirs

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Petroleum Science 2018年第4期15卷 815-829页

作者： Chi Ai Xiao-Xuan Li Jun Zhang dan Jia wen-Jing tan College of Petroleum Engineering Northeast Petroleum University College of Geoscience and Technology China University of Petroleum (East China)

Fracture propagation mechanisms in coalbed methane(CBM) reservoirs are very complex due to the development of the internal cleat system. In this paper, the characteristics of initiation and propagation of hydraulic fractures in coal specimens at different angles between the face cleat and the maximum horizontal principal stress were investigated with hydraulic fracturing tests. The results indicate that the interactions between the hydraulic fractures and the cleat system have a major effect on fracture networks. "Step-like’’ fractures were formed in most experiments due to the existence of discontinuous butt cleats. The hydraulic fractures were more likely to divert or propagate along the butt cleat with an increase in the angles and a decrease in the horizontal principal stress difference. An increase in the injection rate and a decrease in the fracturing fluid viscosity were more conducive to fracture networks. In addition, the influence on fracture propagation of the residual coal fines in the wellbore was also studied. The existence of coal fines was an obstacle in fracturing, and no effective connection can be formed between fractures. The experimental investigation revealed the fracture propagation mechanisms and can provide guidance for hydraulic fracturing design of CBM reservoirs.

关键词： Coalbed methane reservoir Butt cleat Propagation mechanisms Fracture morphology Step-like fractures

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Sensing nanomaterials of wearable glucose sensors

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Chinese Chemical Letters 2021年第1期32卷 221-228页

作者： Guanglei Li dan wen State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University(NPU)and Shaanxi Joint Laboratory of GrapheneXi'an 710072China

The metabolic disorder of glucose in human body will cause diseases such as diabetes and *** the determination of glucose content is very important in clinic *** recent years,researchers have proposed various non-invasive wearable sensors for rapid and real-time glucose monitoring from human body *** those reviews which discussed performances,detection environments or substrates of the wearable glucose sensor,this review focuses on the sensing nanomaterials since they are the key elements of most wearable glucose *** sensing nanomaterials such as carbon,metals,and conductive polymers are summarized in *** also the structural characteristics of different sensing nanomaterials and the corresponding wearable glucose sensors are ***,we prospect the future development requirements of sensing nanomaterials for wearable glucose *** review would give some insights to the further development of wearable glucose sensors and the modern medical treatment.

关键词： Wearable sensors Glucose detection Sensing nanomaterials Noninvasive detection Flexibility

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Hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients

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World Journal of Gastroenterology 2015年第28期21卷 8653-8659页

作者： Guo-Hong Ge Yun Ye Xin-Bei Zhou Li Chen Cong He dan-Feng wen You-wen tan Department of Hepatosis The Third Hospital of Zhenjiang Affiliated Jiangsu University

AIM:To investigate the virological relapse rate in hepatitis B e antigen(HBeAg)-negative patients after antiviral therapy discontinuation and analyze the factors associated with virological ***:Among patients diagnosed with chronic hepatitis B infection between May 2005 and July2010,204 were eligible for *** Kaplan-Meier method and log-rank test were used to calculate the cumulative rate of relapse and compare cumulative relapse rates between *** Cox proportional hazards regression model was used to evaluate the predictive factor of virological ***:The 2 and 1 year cumulative risks of virological relapse after antiviral therapy discontinuation were 79.41%(162/204) and 43.82%(71/162),*** analysis revealed that only post treatment hepatitis B surface antigen(HBsAg)level was associated with virological relapse {P= 0.011).The cumulative risk of virological relapse was higher in the patients with HBsAg levels ≥1500 IU/L than in those with HBsAg levels < 1500 IU/L(P= 0.0013).The area under the curve was 0.603(P= 0.033).The cutoff HBsAg value for predicting virological relapse was 1443IU/L CONCLUSION:We found that the virological relapse rate remained high after antiviral therapy discontinuation in the HBeAg-negative patients and that the post treatment HBsAg levels predicted virological relapse.

关键词： Chronic hepatitis B Virological relapse Hepatitis B surface antigen

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Global interpolating meshless shape function based on generalized moving least-square for structural dynamic analysis

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Applied Mathematics and Mechanics(English Edition) 2016年第9期37卷 1153-1176页

作者： dan XIE Kailin JIAN Weibin wen College of Aerospace Engineering Chongqing University State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing University College of Engineering Peking University

A global interpolating meshless shape function based on the generalized moving least-square （GMLS） is formulated by the transformation technique. Both the shape function and its derivatives meet the Kronecker delta function property. With the interpolating GMLS （IGMLS） shape function, an improved element-free Galerkin （EFG） method is proposed for the structural dynamic analysis. Compared with the conven- tional EFG method, the obvious advantage of the proposed method is that the essential boundary conditions including both displacements and derivatives can be imposed by the straightforward way. Meanwhile, it can greatly improve the ill-condition feature of the standard GMLS approximation, and provide good accuracy at low cost. The dynamic analyses of the Euler beam and Kirchhoff plate are performed to demonstrate the feasi- bility and effectiveness of the improved method. The comparison between the numerical results of the conventional method and the improved method shows that the proposed method has better stability, higher accuracy, and less time consumption.

关键词： structural dynamics meshless method element-free Galerkin (EFG)method generalized moving least-square (GMLS)

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L(1, 2)-edge-labelings for lattices

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Applied Mathematics(A Journal of Chinese Universities) 2014年第2期29卷 230-240页

作者： HE dan LIN wen-song Department of Mathematics Southeast University

For a graph G and two positive integers j and k, an m-L（j, k）-edge-labeling of G is an assignment on the edges to the set {0, 1, 2,..., m}, such that adjacent edges which receive labels differ at least by j, and edges which are distance two apart receive labels differ at least by k. The λj,k-number of G is the minimum m such that an m-L（j, k）-edge-labeling is admitted by G. In this article, the L（1, 2）-edge-labeling for the hexagonal lattice, the square lattice and the triangular lattice are studied, and the bounds for λj,k-numbers of these graphs are obtained.

关键词： L(j k)-edge-labeling line graph triangular lattice square lattice hexagonal lattice.

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Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1001-1006页

作者： HE dan tan Xiao-ning LI Lin-pei GAO wen-hui TIAN Xue-fei ZENG Pu-hua Hunan Academy of Chinese Medicine Changsha 410006China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208China Scientific Research Department The Affiliated Hospital of Hunan Academy of Traditional Chinese MedicineChangsha 410006China Oncology Department The Affiliated Hospital of Hunan Academy of Traditional Chinese MedicineChangsha 410006China School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China

Objective:To investigate the mechanism of induction of ferroptosis by brazilin in breast cancer ***:Breast cancer 4T1 cells were divided into 6 groups:control,brazilin 1/2 half maximal inhibitory concentration(IC_(50)),IC_(50),2×IC_(50),erastin(10μg/mL)and capecitabine(10μg/mL)*** effect of brazilin on the proliferation of 4T1 cells was detected by cell counting kit-8 assay,and the treatment dose of brazilin was *** effect of brazilin on the mitochondrial morphology of 4T1 cells,and the mitochondrial damage was evaluated under electron *** levels of Fe+,reactive oxygen species(ROS),malondialdehyde(MDA),glutathione(GSH)and glutathione peroxidase 4(GPX4)were estimated using various detection *** invasion and migration abilities of 4T1 cells were detected by scratch assay and transwell *** expressions levels of tumor protein p53,solute carrier family 7 member 11(SLC7A11),GPX4 and acyl-CoA synthetase long-chain family member 4(ACSL4)proteins were quantified by Western blot ***:Compared to the control group,the 10(1/2 IC_(50)),20(IC_(50))and 40(2×IC_(50))μg/mL brazilin,erastin,and capecitabine groups showed a significant decrease in the cell survival rate,invasion and migration abilities,GSH,SLC7A11 and GPX4 protein expression levels,and mitochondrial volume and ridge(P<0.05),and a significant increase in the mitochondria membrane density,Fe2+,ROS and MDA levels,and p53 and ACSL4 protein expression levels(P<0.05).Conclusions:Brazilin actuated ferroptosis in breast cancer cells,and the underlying mechanism is mainly associated with the p53/SLC7A11/GPX4 signaling pathway.

关键词： breast cancer brazilin ferroptosis p53/SLC7A11/GPX4 axis Chinese medicine

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