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血液净化对重度中暑小型猪肠道组织闭锁小带蛋白-1和闭合蛋白表达的影响和意义

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中国血液净化 2025年第1期24卷 40-43页

作者：常林遇范文文张静倪军新乡医学院研究生学院新乡453000 中国人民解放军陆军第八十三集团军医院血液内分泌科新乡453000

目的观察血液净化对重度中暑小型猪肠道组织闭锁小带蛋白-1(zonula occludens-1,ZO-1)和闭合蛋白(Occludin)表达的影响。方法构建小型猪重度中暑(heatstroke,HS)模型,血液净化干预治疗前后进行肠道组织功能评价。按照随机数字表法分3组... 详细信息

目的观察血液净化对重度中暑小型猪肠道组织闭锁小带蛋白-1(zonula occludens-1,ZO-1)和闭合蛋白(Occludin)表达的影响。方法构建小型猪重度中暑(heatstroke,HS)模型,血液净化干预治疗前后进行肠道组织功能评价。按照随机数字表法分3组:对照组(空白对照)、模型组(重度中暑模型)、干预组(血液净化治疗),每组各6只。HE染色观察肠道组织的病理形态变化;chiu’s评分法评估肠道组织的损伤程度;免疫组织化学法(immunohistochemistry,IHC)观察肠道组织ZO-1和Occludin的表达。结果相对于模型组,干预组小型猪肠道组织细胞充血、水肿程度减轻,肠道黏膜结构较为完整。对照组、模型组和干预组的肠道chiu’s评分比较差异有统计学意义(F=44.245,P<0.001);对照组、模型组和干预组的肠道组织ZO-1(F=152.477,P<0.001)和Occludin(F=40.360,P<0.001)比较差异有统计学意义。结论血液净化对重度中暑小型猪肠道损伤具有保护作用,可能与上调ZO-1和Occludin的表达有关。

关键词：重度中暑肠道组织紧密连接蛋白血液净化

Fabrication of Chemically-Modified Electrode Containing 1:12 Phosphomolybdic Anions by Sol-Gel Technique and Its Electrocatalytic Reduction of BrO₃^-Anions

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chinese Chemical Letters 1998年第12期9卷 0-0,0-0页

作者： Song, wen Bo Sun, chang Qing Department of Chemistry Jilin University Changchun 130023 China

A novel chemically-modified electrode containing 1:12 phosphomolybdic anions was achieved on the surface of platinum electrode by the sol-gel technique. The electrode exhibits a high catalytic activity towards the ele... 详细信息

关键词： Chemically-modified electrode Electrocatalysis Polyoxometallates Sol-gel technique

The global integrative network:integration of signaling and metabolic pathways

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aBIOTECH 2022年第4期3卷 281-291页

作者： Yuying Lin Shen Yan Xiao chang Xiaoquan Qi Xu chi Department of Dermatology Xuan Wu HospitalBeijing100053China Agricultural Information Institute Chinese Academy of Agricultural ScienceBeijing100081China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing100093China The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing100101China

The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological *** integration of signaling and metabolic pathways can provide an essential reference framework for crosstalk ***,current databases use distinct structures to present signaling and metabolic pathways,which leads to the chaos in the integrated ***,for the metabolic pathways,the metabolic enzymes and the reactions are disconnected by the current widely accepted layout of edges and nodes,which hinders the topological analysis of the integrated ***,we propose a novel“meta-pathway”structure,which uses the uniformed structure to display the signaling and metabolic pathways,and resolves the difficulty in linking the metabolic enzymes to the reactions *** compiled a comprehensive collection of global integrative networks(GINs)by merging the meta-pathways of 7077 *** demonstrated the assembly of the signaling and metabolic pathways using the GINs of four species—human,mouse,Arabidopsis,and *** all of the nodes were assembled into one major network for each of the four species,which provided opportunities for robust crosstalk and topological analysis,and knowledge graph construction.

关键词： Signaling pathways Metabolic pathways Integration Crosstalk of pathways

Construction of Polymeric DNA Network and Application for Cell Manipulation

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chinese Journal of Chemistry 2023年第15期41卷 1875-1887页

作者： Lele chang Rui Zhang Jing Wang chi Yao Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin300350China

Comprehensive Summary Deoxyribonucleic acid(DNA)is a biomacromolecule,as well as a polymeric material,whose sequences with different manipulative structures enable them to implement a series of functions,such as reorganization,target,and *** to existing traditional materials incapable of multifunctional integration,the polymeric DNA network is a form of material that can achieve functional integration while maintaining specific DNA ***,precise target enabled by DNA network is one of the most essential components of cellular ***,the DNA network is indispensable and irreplaceable to cell manipulation that it is a versatile tool for the understanding of basic laws of living life and treatments of diseases,such as cell isolation,cell delivery,and cell ***,the construction of polymeric DNA network is briefly introduced from the aspects of assembly modules,construction methods,and properties.

关键词： DNA network DNA nanotechnology Cell manipulation Cell isolation and interference

Recent progress on photoactive nonprecious transition-metal complexes

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Science china Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

Clustering feature decision trees for semi-supervised classification from high-speed data streams

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第8期12卷 615-628页

作者： wen-hua XU Zheng QIN Yang chang Department of Computer Science and Technology Tsinghua University Beijing 100084 China School of Software Tsinghua University Beijing 100084 China

Most stream data classification algorithms apply the supervised learning strategy which requires massive labeled *** approaches are impractical since labeled data are usually hard to obtain in *** this paper,we build a clustering feature decision tree model,CFDT,from data streams having both unlabeled and a small number of labeled *** applies a micro-clustering algorithm that scans the data only once to provide the statistical summaries of the data for incremental decision tree ***-clusters also serve as classifiers in tree leaves to improve classification accuracy and reinforce the any-time *** experiments on synthetic and real-world datasets show that CFDT is highly scalable for data streams while gener-ating high classification accuracy with high speed.

关键词： Clustering feature vector Decision tree Semi-supervised learning Stream data classification Very fast decision tree

The dynamic response of a high-density polyethylene slow-release structure under launching overload

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Defence Technology（防务技术） 2023年第8期26卷 143-156页

作者： Ke-Bin Zhang wen-Bin Li Yu Zheng wen-Jin Yao chang-Fang Zhao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

Based on the 60 mm artillery grenade,a slow-release structure was designed to reduce the severity of ammunitions response to accidental thermal stimulation and improve the thermal stability of *** slow-release structure was made of high-density polyethylene(HDPE) and connected the fuse and the projectile body through internal and external *** study the safety of the slowrelease structure under artillery launching overload,mechanical analysis of the slow-release structure was simulated via finite element analysis(FEA).The impacts of various factors(e.g.,fuse mass,number of threads,and nominal diameter of internal threads of the slow-release structure) on the connection strength of the slow-release structure were studied.A strength-prediction model based on the fuse mass and internal thread parameters was established by fitting the maximum effective stress of the slowrelease *** led to good prediction *** conclusion,this study provides references and theoretical support for the design of thermal protection structures insensitive to ammunition.

关键词： Artillery ammunition HDPE Finite element analysis Slow-release structure Threaded connection

Broadband absorption performance of 3D-printed polyetheretherketone-based electromagnetic wave-absorbing composites

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chinese Journal of Aeronautics 2024年第8期37卷 547-558页

作者： Lin BAI Nan chang Meiying ZHAO chi HOU Yi CAO Dichen LI School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Chengdu Aircraft Design and Research Institute Chengdu 610091China Xi’an Key Laboratory of Advanced Structure Design and Application of Aircraft Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710054China

The rapid development of additive manufacturing technology has offered a new avenue for designing and fabricating high wave-absorbing meta *** this study,the mechanical properties and broadband absorption performance of Poly-Ether-Ether-Ketone(PEEK)–based electromagnetic wave–absorbing composite materials was *** high-performance polymer PEEK was used as the matrix,and the materials with electromagnetic wave loss,such as reduced graphene oxide,Carbonyl Iron(CI),and Flake CI(FCI),were used as *** on the theory of impedance matching,a wave-absorbing structure with a gradual impedance gradient was designed and *** test results showed that at the 2.0–18.0 GHz frequency band,the coverage rate of the effective absorption bandwidth was up to 72.0%,the average optimal reflectivity was–18.09 dB,and the wide-angle absorption range was 0°–30°.The advantages of additive manufacturing technology in designing and fabricating wave-absorbing structures are presented,demonstrating that the technology is an effective method for creating broadband absorbing structures.

关键词： Absorption performance Additive manufacturing Electromagnetic absorption PEEK composite materials Gradual structure Broadband absorption

Dynamic compression characteristics of layered rock mass of significant strength changes in adjacent layers

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第2期12卷 353-365页

作者： Sen wen Chunshun Zhang Yulin chang Ping Hu Institute of Geotechnical and Rail Transport Engineering Henan UniversityKaifeng475004China Department of Civil Engineering Monash UniversityClaytonVIC3800Australia School of Civil Engineering University of South ChinaHengyang421001China

Layered rock mass of significant strength changes for adjacent layers is frequently observed in underground excavation,and dynamic loading is a prevalent scenario generated during *** order to improve the driving efficiency and reduce engineering accidents,dynamic compression characteristics of this kind of rock mass should be *** dynamic properties of a layered composite rock mass are investigated through a series of rock tests and numerical *** rock mass is artificially made of various proportions of sand,cement and water to control the distinct strength variations at various composite layers separated by parallel bedding *** rock specimens are prefabricated in a specially designed mould and then cut into 50 mm in diameter and 50 mm in height for split Hopkinson pressure bar(SHPB)dynamic compression *** test results reveal that increasing strain rate causes the increases of peak strength,σ_p,and the corresponding failure strain,ε_p,while the dynamic elastic modulus,E_d,remains almost ***,under the same strain rates,Ed of the composite rock specimen is found to decline first and then increase as the dip angle of bedding plane *** obtained rock failure patterns due to various dip angles lead to failure modes that could be classified into four categories from our dynamic ***,a series of counterpart numerical simulations has been undertaken,showing that dynamic responses are in good agreement with those obtained from the SHPB *** numerical analysis enables us to Iook into the dynamic characteristics of the composite rock mass subjected to a broader range of strain rates and dip angles than these being tested.

关键词： Rock dynamics Split hopkinson pressure bar(SHPB) Layered composite rock specimen Dip angle of bedding plane Strain rate Numerical simulation