检索结果-南通市图书馆

ZIF-8 coated gold nanospheres: A multi-responsive drug delivery system promoting the killing effect of photothermal therapy against osteosarcoma cells

引用

Nano Research 2024年第3期17卷 1772-1784页

作者： Miao Lei Weiye Cai Luetao Zou Bin Yu Lin Chen Yang cao Shanlin Xiang chao Song Jiandu Lei Wei Jiang Zhenming Hu Department of Orthopedics Orthopedic Laboratory of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou 646699China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing 400010China Department of Orthopedics Chongqing University Three Gorges HospitalChongqing 404000China Department of Geriatrics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025China Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing 100083China

Photothermal therapy(PTT)has been widely used in the treatment of tumors,but its efficacy is greatly limited by the inability of precise drug delivery and the increase of heat shock proteins(HSPs)caused by high *** article describes a therapeutic strategy to enhance PTT with starvation therapy in conjunction with ferroptosis mechanism.A nanoparticle platform ZIF-8@GA was constructed by wrapping together glucose oxidase(GOX)and gold nanospheres(AuNPs)loaded with dihydroartemisinin(DHA)with zeolitic imidazolate framework-8(ZIF-8).This platform can take advantage of the micro-environment of osteosarcoma(OS)cells,featuring low pH and high reactive oxygen species(ROS),for precision drug *** can effectively catalyze glucose to produce gluconic acid and H_(2)O_(2),and DHA can also induce ROS production in OS *** produced by GOX and DHA can further generate lipid peroxidation(LPO)and lead to ferroptosis of OS *** the same time,ROS and LPO produced can inhibit the expression of HSPs,thereby increasing the therapeutic effect of *** vitro experiments show that the nanoparticles are pH and ROS responsive.1μg/mL GOX combined with 0.2μg/mL DHA promotes ferroptosis of OS cells,and increases the killing effect of near-infrared(NIR)on OS *** in vivo experiments showed that the nano drug-delivery platform combined with PTT can effectively inhibit the growth of OS ***,this study provides a new idea for the treatment of OS with biomaterials combined with various treatment methods.

关键词： zeolitic imidazolate framework-8(ZIF-8) gold nanospheres(AuNPs) photothermal therapy(PTT) starvation therapy ferroptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

引用

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi Zhang Qian Chen Pan cao Chun-Xia Shi Lu-Yi Zhang Lu-wen Wang Zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP homologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： SIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary supplementation with succinic acid improves growth performance and flesh quality of adult Nile tilapia (Oreochromis niloticus) fed a high-carbohydrate diet

引用

ANIMAL NUTRITION 2024年第3期18卷 390-407页

作者： cao, Manxia Xie, Ningning Zhang, Jianmin Jiang, Ming Huang, Feng Dong, Lixue Lu, Xing wen, Hua Tian, Juan Chinese Acad Fishery Sci Key Lab Freshwater Biodivers Conservat Minist Agr Yangtze River Fisheries Res Inst Wuhan 430223 Peoples R China Wuhan Polytech Univ Key Lab Anim Nutr & Feed Sci Hubei Prov Wuhan 430023 Peoples R China

To evaluate the effects of dietary supplementation with succinic acid on growth performance, flesh quality, glucose, and lipid metabolism of Nile tilapia (Oreochromis niloticus) fed a high-carbohydrate diet (HCD), five iso-nitrogenous and iso-lipidic diets were prepared as follows: HCD (control group) consisting of 55% corn starch and HCD supplemented with 0.5%, 1.0%, 2.0%, and 4.0% succinic acid, respectively. Tilapia with an initial body weight of 204.90 +/- 1.23 g randomly assigned to 15 tanks with 3 replicates per group and 10 fish per tank fed for 8 weeks. Increasing dietary succinic acid supplementation resulted in significant second-order polynomial relationship in the weight gain rate (WGR), specific growth rate (SGR), feed conversion ratio (FCR), protein efficiency rate (PER), viscerosomatic index, condition factor, and contents of muscular crude lipid and glycogen (P < 0.05). The hepatosomatic index, mesenteric fat index, liver glycogen content and crude lipid contents of the whole-body and liver demonstrated significantly linear and second-order polynomial relationship (P < 0.05). Quadratic curve model analysis based on WGR, SGR, PER, and FCR demonstrated that optimal supplementation with succinic acid in the HCD of Nile tilapia ranged from 1.83% to 2.43%. Fish fed with 1.0% succinic acid had higher muscular hardness, increased the contents of alkali-soluble hydroxyproline in collagen, docosahexaenoic acid (DHA) and n-3 polyunsaturated fatty acid (n-3PUFA) in muscle, and lower total fatty acid content in muscle (P < 0.05) compared with the control group. Compared to the control group, dietary supplementation with 1.0% succinic acid significantly increased the contents of total bounding amino acid (arginine, histidine, isoleucine, lysine, methionine, alanine, proline), total flavor amino acid (free aspartic acid), the catalase (CAT) activity and total antioxidant capacity, and the mRNA relative expression levels of CAT, superoxide dismutase (SOD), and nucl

关键词： Oreochromis niloticus High-carbohydrate diet Succinic acid Antioxidant capacity Muscular nutritional value Muscle growth SHRIMP LITOPENAEUS-VANNAMEI ANTIOXIDANT CAPACITY BODY-COMPOSITION GENE-EXPRESSION FATTY-ACIDS GLUCOSE-HOMEOSTASIS STARCH LEVELS SEA-BASS METABOLISM MUSCLE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zonal activation of molecular carbon dioxide and hydrogen over dual sites Ni-Co-MgO catalyst for CO_(2) methanation:Synergistic catalysis of Ni and Co species

引用

Journal of Energy Chemistry 2024年第4期91卷 213-225页

作者： Zonglin Li Jianjun Chen Yu Xie Junjie wen Huiling weng Mingxue Wang Jingyi Zhang Jinyan cao Guocai Tian Qiulin Zhang Ping Ning Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500YunnanChina National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500YunnanChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina

An in-depth mechanism in zonal activation of CO_(2)and H2molecular over dual-active sites has not been revealed ***,Ni-Co-MgO was rationally constructed to elucidate the CO_(2)methanation *** abundant surface nickel and cobalt components as active sites led to strong Ni-Co interaction with charge transfer from nickel to ***,electron-enriched Coδ-species participated in efficient chemisorption and activation of CO_(2)to generate monodentate ***,plentiful available Ni0sites facilitated H2dissociation,thus CO_(2)and H2were smoothly activated at zones of Coδ-species and Ni0,*** in situ DRIFTS,quasi situ XPS,TPSR,and DFT calculations substantiated a new formate evolution mechanism via monodentate carbonate instead of traditional bidentate carbonate based on synergistic catalysis of Coδ-species and *** zonal activation of CO_(2)and H2by tuning electron behaviors of double-center catalysts can boost heterogeneous catalytic hydrogenation performance.

关键词： Zonal activation CO_(2) methanation Dual active sites Synergistic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Z-scheme Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)heterojunctions enable exceptional visible photocatalytic degradation of organic pollutant

引用

Rare Metals 2024年第7期43卷 3161-3172页

作者： Feng Huang Muhammad Humayun Gang Li Ting-Ting Fan wen-Lin Wang Yu-Lin cao Anton Nikiforov Chun-Dong Wang Jing Wang Key Laboratory of Analytical Science and Technology of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei UniversityBaoding071002China Energy Water and Environment LabCollege of Humanities and SciencesPrince Sultan University11586 RiyadhSaudi Arabia Baoding Green Yijia Environmental Protection Technology Ltd Baoding 071051China Physics Laboratory Industrial Training CenterShenzhen Polytechnic UniversityShenzhen 518055China Department of Applied Physics Ghent University9000 GhentBelgium School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

One key strategy to enhance photocatalytic performance is to improve the transfer and separation efficiency of photogenerated carriers by building optimized ***,novel Bi_(4)O_5Br_(2)/NH_(2)-MIL-125(Ti)Z-scheme heterojunctions are fabricated and used as photocatalysts for organic pollutant *** NH_(2)-MIL-125(Ti)nanosheets are exfoliated via a self-developed alkali solution stripping approach and then uniformly decorated on Bi_(4)O_(5)Br_(2).The as-prepared Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)presents more than 90%degradation of various pollutants,outperforming the counterpart individual *** various characterization results suggest that the enhanced degradation rate is due to the more intimate face-to-face interfacial contact of the lamellar Z-scheme heterojunction materials,in which the migration path of carriers from the material's interior to the surface can be reduced,in turn enhancing migration efficiency and separation capability significantly.A possible photocatalytic reaction mechanism is proposed based on the photoelectric behaviors,radical trapping experiments and liquid chromatography mass spectrometry *** work promotes the development of new photocatalytic materials for heterojunctions with face-to-face interfacial contacts,as well as the effective purification of wastewater in environmental remediation.

关键词： Z-scheme heterojunctions Photocatalysis Alkaline solution stripping Bi_(4)O_(5)Br_(2) NH_(2)-MIL-125(Ti)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial distribution characteristics and influence factor analysis of landslides——case study of the Hanwang area in Qinba Mountains

引用

Earthquake Research Advances 2024年第3期4卷 55-65页

作者： Jikai Zhang Yanbo cao wen Fan wenbo Zheng Zequan Wang Chengcheng He Hongquan Teng School of Geological Engineering and Geomatics Chang’an UniversityXi'an710054China Mine Geological Disasters Mechanism and Prevention Key Laboratory Xi'an710054China China DK Comprehensive Investigate and Design Research Institute Co. Ltd.Xi'an710054China Shaanxi Engineering Technology Research Center for Urban Geology and Underground Space Xi'an710068China Shaanxi Hydrogeology Engineering Geology and Environment Geology Survey CenterXi'an710068China Chang'an University Xi'anShaanxiChina

The geological hazards of landslides in Hanwang Town, Ziyang County, Ankang City, Shaanxi Province, have emerged. Yet, the current understanding of the spatial distribution characteristics and influencing factors of landslides in this area remains unclear. Combining the results of remote sensing interpretation and field investigation, seven influencing factors, namely, elevation, slope direction, slope gradient, distance from rivers, distance from faults, engineering geologic lithology, and distance from roads, are selected for the study. The distribution characteristics of landslides in each influencing factor and the influence of the resolution of the Digital Elevation Model(DEM) on the results are statistically and analytically analyzed. Furthermore, two highrisk landslides within the study area were subjected to comprehensive analysis, integrating the findings from drilling and other field investigations in order to examine their deformation mechanisms. Based on this analysis,the following conclusions were derived:(1) 34 landslides in the study area, mainly small earth landslides, with a distribution density of 0.42/km~2, threatening 414 people and property of about 55.87 million Yuan.(2)The landslides in the study area easily occur in the <400 m elevation range;the landslides are developed in all slope directions, the gradient is mainly concentrated in the range of 10°–40°, the distribution density of the landslides is higher in the closer distance from the river and the faults(0–200 m), the landslide-prone strata are mainly the softer and weaker metamorphic rocks, and the landslides are mainly around roads.(3) The resolution of the DEM should be selected based on the specific conditions of the study area, the requirements of the investigation, and the scale of the landslide. Opting for an appropriate DEM resolution is advantageous for understanding the patterns of landslides and conducting risk assessments in the region.(4) The Zhengjiabian landslide is a trac

关键词： Landslide Spatial distribution Influence factor Landslide density Deformation mechanism DEM

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zeros of Complete Symmetric Polynomials over Finite Fields

引用

Journal of Systems Science & Complexity 2024年第4期37卷 1772-1788页

作者： cao Wei School of Mathematics and Statistics Minnan Normal UniversityZhangzhou 363000China

Wan and Zhang(2021) obtained a nontrivial lower bound for the number of zeros of complete symmetric polynomials over finite fields,and proposed a problem whether their bound can be *** this paper,the author improves Wan-Zhang's bound from three *** proposed results are based on the estimates related to the number of certain permutations and the value sets of non-permutation polynomials associated to the complete symmetric *** the author believes that there are still possibilities to improve the bounds and hence Wan-Zhang's bound.

关键词： Complete symmetric polynomial finite field permutation polynomial value set

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fe-Ni-F electrocatalyst for enhancing reaction kinetics of water oxidation

引用

Chinese Journal of Structural Chemistry 2024年第2期43卷 60-65页

作者： Yi Zhang Biao Wang chao Hu Muhammad Humayun Yaping Huang Yulin cao Mosaad Negem Yigang Ding Chundong Wang School of Chemical Engineering and Pharmacy Key Laboratory of Green Chemical Process of Ministry of EducationKey Laboratory of Novel Reactor and Green Chemical Technology of Hubei ProvinceWuhan Institute of TechnologyWuhan430073PR China Energy Waterand Environment LabCollege of Humanities and SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia School of Integrated Circuits Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan430074PR China Physics Laboratory Industrial Training CenterShenzhen Polytechnic UniversityShenzhen518055PR China Chemistry Department Faculty of ScienceFayoum UniversityFayoum63514Egypt

Highly active and low-cost oxygen evolution reaction(OER)catalytic electrodes are extremely essential for exploration of green hydrogen via water ***,an advanced Fe-Ni-F electrocatalyst is fabricated by a facile annealing strategy using ammonium fluoride,of which the structure feature is unveiled by XRD,FESEM,TEM,EDS,BET,and XPS *** as-prepared Fe-Ni-F addresses a low overpotential of 277 mV and a small Tafel slope of 49 mV dec^(-1)at a current density of 10 mA cm^(-2),significantly outperforming other control samples as well as the state-of-the-art RuO_(2).The advanced nature of our Fe-Ni-F catalyst could also be further evidenced from the robust stability in KOH alkaline solution,showing as 5.41%degradation after 24 h continuous *** analysis,it suggests that the decent catalytic activity should be attributed to the formed bimetallic(oxy)hydroxides because of the introduction of fluoride and the synergistic effect of iron and nickel towards oxygen *** work represents the potential of Fe-and/or Ni-based fluoride as efficient catalyst for low-energy consumption oxygen generation.

关键词： Fluoride Oxygen evolution reaction Fe-Ni-F Reaction kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pt nanodendrites with a PtIr alloy surface structure exhibit excellent stability toward acidic hydrogen evolution reaction

引用

Nano Research 2024年第6期17卷 4844-4849页

作者： Chang Liu Zongnan Wei Minna cao Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

The development of effective and stable electrocatalysts for the hydrogen evolution reaction(HER)in acidic electrolytes is a significant *** this work,homogeneous Pt nanodendrites(Pt NDs)with a PtIr shell were successfully synthesized by a two-step wet chemical *** open three-dimensional(3D)dendritic structure exhibited exceptional electrocatalytic characteristics,exposing as many active sites as ***,by alloying Ir with Pt on the surface,catalytic activity was greatly enhanced while ensuring extremely high *** surface-enriched platinum nanodendritic catalysts(Pt@PtIr NDs)outperformed the control samples and the commercial *** acidic HER test,Pt@PtIr NDs had a lower overpotential(22 mV)than Pt NDs(26 mV)and commercial Pt/C(31 mV)at 10 mA/cm^(2),and the activity of Pt@PtIr NDs remained consistent even after undergoing a continuous durability test for at least 168 h,which was much superior to the performance of commercial Pt/C(10 h)under identical test *** study revealed that the application of 3D Pt dendritic metal alloys may offer a chance for the development of enhanced electrocatalysts in acidic HER.

关键词： Pt nanodendrites iridium high stability hydrogen evolution reaction alloy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-Resource Collaborative Service Restoration of a Distribution Network with Decentralized Hierarchical Droop Control

引用

Protection and Control of Modern Power Systems 2024年第1期9卷 19-37页

作者： Wei Zhang Cong Zhang Jiayong Li Lipeng Zhu Shiran cao wen Huang Zhikang Shuai College of Electrical and Information Engineering Hunan UniversityChangshaChina Hunan University ChangshaChina CSEE Journal of Power and Energy Systems Chinese Journal of Electrical Engineerin

To improve the resilience of distribution networks(DNs)in the event of extreme natural disasters such as typhoons and rainstorms,it is imperative to efficiently implement distribution service restoration(DSR)to restore loads as soon as *** previous studies,DSR has mainly adopted the distributed resource model with droop or PQ *** inhibits the exploitation of the potential of distributed generators(DGs)in load restoration when the DN loses support from the upstream transmission ***,this paper proposes a multi-resource collaborative service restoration(MRCSR)approach for DNs incorporating local soft open points,DGs,and tie *** MRCSR model is developed by integrating a decentralized hierarchical droop control(DHDC)strategy and incorporating the frequency and voltage features of the load demand.A two-stage iterative feedback optimization(TSIFO)algorithm is then developed to analyze the MRCSR model in an accurate and efficient ***,the proposed model and algo-rithm are tested on the modified IEEE 33-bus system and a practical distribution system of the Taiwan Power Company to verify their effectiveness and advantages over existing approaches.

关键词： service Service integrating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：