检索结果-南通市图书馆

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

Neural Regeneration Research 2019年第4期14卷 613-620页

作者： wen-bo zhou Zong-Ning Miao Bin Zhang Wei Long Fang-Xiu Zheng Jing Kong Bin Yu Changzhou Women and Children Health Hospital Affiliated to Nanjing Medical University The Stem Cell Research Laboratory Wuxi Third People's Hospital

Studies have shown that the natural flavonoid luteolin has neurotrophic activity. In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. Ts65 Dn mice, which are frequently used as a model of Down syndrome, were intraperitoneally injected with 10 mg/kg luteolin for 4 consecutive weeks starting at 12 weeks of age. The Morris water maze test was used to evaluate learning and memory abilities, and the novel object recognition test was used to assess recognition memory. Immunohistochemistry was performed for the neural stem cell marker nestin, the astrocyte marker glial fibrillary acidic protein, the immature neuron marker DCX, the mature neuron marker NeuN, and the cell proliferation marker Ki67 in the hippocampal dentate gyrus. Nissl staining was used to observe changes in morphology and to quantify cells in the dentate gyrus. Western blot assay was used to analyze the protein levels of brain-derived neurotrophic factor(BDNF) and phospho-extracellular signal-regulated kinase 1/2(p-ERK1/2) in the hippocampus. Luteolin improved learning and memory abilities as well as novel object recognition ability, and enhanced the proliferation of neurons in the hippocampal dentate gyrus. Furthermore, luteolin increased expression of nestin and glial fibrillary acidic protein, increased the number of DCX^+ neurons in the granular layer and NeuN^+ neurons in the subgranular region of the dentate gyrus, and increased the protein levels of BDNF and p-ERK1/2 in the hippocampus. Our findings show that luteolin improves behavioral performance and promotes hippocampal neurogenesis in Ts65 Dn mice. Moreover, these effects might be associated with the activation of the BDNF/ERK1/2 pathway.

关键词： nerve regeneration luteolin hippocampus Ts65Dn mice neurogenesis ERK BDNF nestin GFAP NeuN Down syndrome neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spin glassy behavior and large exchange bias effect in cubic perovskite Ba0.8Sr0.2FeO3-δ

引用

Chinese Physics B 2019年第6期28卷 433-437页

作者： Yu-Xuan Liu Zhe-Hong Liu Xu-Bin Ye Xu-Dong Shen Xiao Wang bo-wen zhou Guang-Hui zhou You-wen Long Department of Physics and Synergetic Innovation Center for Quantum Effects and Applications of Hunan Province Hunan Normal UniversityChangsha 410081China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physics University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

A single-phase iron oxideBa0.8Sr0.2FeO3-δwith a simple cubic perovskite structure in Pm-3 m symmetry is successfully synthesized by a solid-state reaction method in O2 flow. The oxygen content is determined to be about 2.81, indicating the formation of mixed Fe3+and Fe4+charge states with a disorder fashion. As a result, the compound shows small-polaron conductivity behavior, as well as spin glassy features arising from the competition between the ferromagnetic interaction and the antiferromagnetic interaction. Moreover, the competing interactions also give rise to a remarkable exchange bias effect in Ba0.8 Sr0.2 FeO2.81, providing an opportunity to use it in spin devices.

关键词： high-pressure synthesis exchange bias effect spin glass

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Congruent melting of tungsten phosphide at 5 GPa and 3200℃ for growing its large single crystals

引用

Chinese Physics B 2020年第8期29卷 501-506页

作者： Xiao-Jun Xiang Guo-Zhu Song Xue-Feng zhou Hao Liang Yue Xu Shi-Jun Qin Jun-Pu Wang Fang Hong Jian-Hong Dai bo-wen zhou wen-Jia Liang Yun-Yu Yin Yu-Sheng Zhao Fang Peng Xiao-Hui Yu Shan-Min Wang Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics Southern University of Science and Technology(SUST)Shenzhen 518055China School of Physics University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As one of important members of refractory materials,tungsten phosphide(WP)holds great potential for fundamental study and industrial applications in many fields of science and technology,due to its excellent properties such as superconductivity and as-predicted topological band ***,synthesis of high-quality WP crystals is still a challenge by using tradition synthetic methods,because the synthesis temperature for growing its large crystals is very stringently required to be as high as 3000℃,which is far beyond the temperature capability of most laboratory-based devices for crystal *** addition,high temperature often induces the decomposition of metal phosphides,leading to off-stoichiometric samples based on which the materials'intrinsic properties cannot be *** this work,we report a high-pressure synthesis of single-crystal WP through a direct crystallization from cooling the congruent W-P melts at 5 GPa and^3200℃.In combination of x-ray diffraction,electron microscope,and thermal analysis,the crystal structure,morphology,and stability of recovered sample are well *** final product is phase-pure and nearly stoichiometric WP in a single-crystal form with a large grain size,in excess of one millimeter,thus making it feasible to implement most experimental measurements,especially,for the case where a large crystal is *** in synthesis of high-quality WP crystals at high pressure can offer great opportunities for determining their intrinsic properties and also making more efforts to study the family of transition-metal phosphides.

关键词： congruent melting tungsten phosphide single crystals high pressure and high temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei wen-bo Cao Sai-Jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroprotective effects of ligustrazine on hippocampus neurons in PTSD

Neuroprotective effects of ligustrazine on hippocampus neuro...

引用

中国解剖学会2011年年会

作者： wen Min,zhou bo,He Yu-hong, Zang Gui-yong.Department of Anatomy,Guiyang Medical University,Guiyang 550004

＜正＞Post-traumatic stress disorder（PTSD） is a stress-related mental disorder caused by experience of a traumatic *** is often accompanied by morphological and functional changes in the *** aim of this study was to reveal the neuroprotective effects of Ligustrazine on hippocampus neurons in PTSD *** Sprague Dawley rats（8-9 weeks old and 200-220 g）were exposed to SPS（single prolongd stress）.The SPS rats were randomly divided into two groups:SPS group and Ligustrazine treated *** Ligustrazine treated group were intraperitoneal（i.p.） injection of Ligustrazine（50 mg/kg） once daily for 10 *** SPS group were intraperitoneal（i.p.） injection with saline of the same dose at the same time Open field test,Morris water maze and brdu Immunohistochemical staining were used to detect the changes of behaver and Hippocampus *** results showed that Ligustrazine can significantly improve the behavioral performance and increase Hippocampus *** present findings suggest that Ligustrazine has a beneficial influence on PTSD.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

引用

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原发性甲状旁腺功能亢进症定位诊断

引用

中华骨质疏松和骨矿盐疾病杂志 2018年第2期11卷 215-219页

作者：樊海悦田文青周波重庆医科大学附属第一医院内分泌科重庆400016

原发性甲状旁腺功能亢进症系一种以甲状旁腺素不适当分泌过多为特征的内分泌病症。一经诊断明确,外科手术切除是最有效的治疗手段,而精确的术前定位对提高微创手术成功率等有重要意义。目前临床上除传统的超声、甲氧异晴闪烁成像外,一... 详细信息

原发性甲状旁腺功能亢进症系一种以甲状旁腺素不适当分泌过多为特征的内分泌病症。一经诊断明确,外科手术切除是最有效的治疗手段,而精确的术前定位对提高微创手术成功率等有重要意义。目前临床上除传统的超声、甲氧异晴闪烁成像外,一些新型CT和核素标记成像不断涌现,本文就其术前定位价值进行综述。

关键词：原发性甲状旁腺功能亢进症定位诊断核素显像

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

结合问题特征利用SE-Tree反向深度求解冲突集的方法

引用

电子学报 2017年第5期45卷 1175-1181页

作者：欧阳丹彤刘伯文周建华张立明吉林大学计算机科学与技术学院吉林长春130012 符号计算与知识工程教育部重点实验室(吉林大学) 吉林长春130012 吉林大学软件学院吉林长春130012

基于模型诊断是人工智能领域内的一个重要研究方向,求解极小冲突集在基于模型诊断中有着重要应用.在对结合CSISE-Tree求解冲突集方法深入研究的基础上,根据冲突集求解特征重构了结合枚举树的计算冲突集的过程,提出基于深度优先反向搜索... 详细信息

基于模型诊断是人工智能领域内的一个重要研究方向,求解极小冲突集在基于模型诊断中有着重要应用.在对结合CSISE-Tree求解冲突集方法深入研究的基础上,根据冲突集求解特征重构了结合枚举树的计算冲突集的过程,提出基于深度优先反向搜索求解冲突集的方法.针对CSISE-Tree方法求解时占用内存空间与元件总数指数级相关的缺点,构建反向深度搜索方法减小求解时所占用内存空间;针对CSISE-Tree方法不能对部分非极小的冲突集进行剪枝的问题,给出对非冲突集和更多非极小的冲突集进行剪枝的方法,有效减少了求解时调用SAT(boolean SATisfiability problem)求解器的次数;实验结果表明,与CSISE-Tree方法相比,本文提出的方法求解效率有明显的提升,并避免了求解时的内存爆炸问题.

关键词：基于模型诊断冲突集布尔约束可满足集合枚举树

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

引用

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei zhou Wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

引用

Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：