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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： wen-Qian Ma Ming-Chang Miao Ping-An Ding bi-bo Tan wen-bo Liu Shuo Guo Li-Mian Er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration bioinformatics

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Black hole evaporation and its remnants with the generalized uncertainty principle including a linear term

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Communications in Theoretical Physics 2024年第2期76卷 125-136页

作者： bo Yu Zheng-wen Long College of Physics Guizhou UniversityGuiyang550025China

In recent years,researchers have investigated the evaporation of Schwarzschild black holes using various forms of the generalized uncertainty principle(GUP),metric quantum correction,and noncommutative geometry,***,there are differences between the GUP correction and the other two methods in terms of describing the later stages of black hole ***,some studies argue that the GUP with a negative parameter cannot effectively correct black hole evaporation,while others contend that the positivity or negativity of the GUP parameters should not affect the correction *** the above into consideration,we reconsider black hole evaporation with the generalized uncertainty principle including a linear term(LGUP),and examine the case of negative *** results indicate that the evaporation behavior of both Schwarzschild black holes and Reissner–Nordstr?m black holes,under LGUP correction,is consistent with the results of metric quantum correction and non-commutative ***,the negative parameter LGUP can also effectively correct for black hole evaporation.

关键词： black hole evaporation generalized uncertainty principle negative parameter

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Vibration Response and Stress Analysis of Planar Elastic Tube Bundle Induced by Fluid Flow

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Chinese Journal of Mechanical Engineering 2018年第2期31卷 89-96页

作者： De-Rong Duan Pei-Qi Ge wen-bo bi Yan-Ying Dong School of Mechanical Engineering Shandong University Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education Shandong University

Flow?induced vibration plays a positive role on heat transfer enhancement. Meanwhile, it is also a negative factor for fatigue strength. Satisfying the fatigue strength is the primary prerequisite for heat transfer enhancement. This paper numerically studied the flow?induced vibration of planar elastic tube bundle based on a two?way fluid–structure interaction(FSI) calculation. The numerical calculation involved the unsteady, three?dimensional incompressible governing equations solved with finite volume approach and the dynamic balance equation of planar elastic tube bundle solved with finite element method combined with dynamic mesh scheme. The numerical approach was verified by comparing with the published experimental results. Then the vibration trajectory, deformation and stress contour of planar elastic tube bundle were all studied. Results show that the combined movement of planar elastic tube bundle represents the agitation from inside to outside. The vibration of out?of?plane is the main vibration form with the typically sinusoidal behavior because the magnitude of displacement along the out?of?plane direction is the 100 times than the value of in?plane direction. The dangerous point locates in the innermost tube where the equivalent stress can be utilized to study the multiaxial fatigue of planar elastic tube bundle due to the alternating stress concentration. In the velocity range of 0.2-3 m/s, it is inferred that the vibration amplitude plays a role on the stress response and the stress amplitude is susceptible to the fluid velocity. This research paves a way for studying the fatigue strength of planar elastic tube bundle by flow?induced vibration.

关键词： Flow?induced vibration Planar elastic tube bundle Vibration response Stress analysis

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Feedback of Efficient Shock Acceleration on Magnetic-field Structure Inside Young Type Ia Supernova Remnants

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Research in Astronomy and Astrophysics 2024年第6期24卷 234-244页

作者： Jun-Yu Shen bi-wen Bao Li Zhang Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China Key Laboratory of Statistical Modeling and Data Analysis of Yunnan Province Yunnan UniversityKunming 650091China

Using an effective adiabatic index γ_(eff) to mimic the feedback of efficient shock acceleration,we simulate the temporal evolution of a young type Ia supernova remnant (SNR) with two different background magnetic field(BMF) topologies:a uniform and a turbulent *** density distribution and magnetic-field characteristics of our benchmark SNR are studied with two-dimensional cylindrical magnetohydrodynamic *** γ_(eff)is considered,we find that:(1) the two-shock structure shrinks and the downstream magnetic-field orientation is dominated by the Rayleigh–Taylor instability structures;(2) there exists more quasi-radial magnetic fields inside the shocked region;and (3) inside the intershock region,both the quasi-radial magnetic energy density and the total magnetic energy density are enhanced:in the radial direction,with γ_(eff)=1.1,they are amplified about 10–26 times more than those with γ_(eff)=5/*** in the angular direction,the total magnetic energy densities could be amplified about 350 times more than those with γ_(eff)=5/3,and there are more grid cells within the intershock region where the magnetic energy density is amplified by a factor greater than 100.

关键词： methods:numerical ISM:magnetic fields ISM:supernova remnants magnetohydrodynamics(MHD)

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Numerical analysis of shell-side flow-induced vibration of elastic tube bundle in heat exchanger

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Journal of Hydrodynamics 2018年第2期30卷 249-257页

作者： Jia-dong Ji Pei-qi Ge wen-bo bi School of Mechanical Engineering Anhui University of Science and Technology Huainan 232001 China School of Mechanical Engineering Shandong University Jinan 250061 China

The responses of the flow-induced vibration of an elastic tube bundle subjected to the shell-side cross flow are investigated in this paper. The weak coupling method and the fluid solid interface are used to solve the fluid-structure interaction problem with consideration of the geometry and physical natures. The effects of the shell-side fluid flow velocity and the structural parameters on the flow-induced vibration are discussed. Numerical results demonstrate that the vibration frequency and amplitude at the monitor points increase with the increase of the shell-side water inlet velocity in all directions. The wall thickness and the external diameter of the elastic tube bundle have significant effects on the responses of the flow-induced vibration. The structural parameters affect the vibration frequency and amplitude, and the vibration equilibrium position in the water flow direction. The vibration frequency decreases with the increase of the tube external diameter. In addition, the vibration in the water flow direction has a lower equilibrium position when the elastic tube bundle has a larger wall thickness or smaller external diameter.

关键词： Flow-induced vibration heat exchanger elastic tube bundle fluid-structure interaction shell-side fluid weak coupling method

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Nomogram model including LATS2 expression was constructed to predict the prognosis of advanced gastric cancer after surgery

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 518-528页

作者： Nan Sun bi-bo Tan Yong Li Department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hubei ProvinceChina Third Department of General Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Gastric cancer is a leading cause of cancer-related deaths *** assessments are typically based on the tumor-node-metastasis(TNM)staging system,which does not account for the molecular heterogeneity of this ***2,a tumor suppressor gene involved in the Hippo signaling pathway,has been identified as a potential prognostic biomarker in gastric *** To construct and validate a nomogram model that includes LATS2 expression to predict the survival prognosis of advanced gastric cancer patients following ra-dical surgery,and compare its predictive performance with traditional TNM *** A retrospective analysis of 245 advanced gastric cancer patients from the Fourth Hospital of Hebei Medical University was *** patients were divided into a training group(171 patients)and a validation group(74 patients)to deve-lop and test our prognostic *** performance of the model was determined using C-indices,receiver operating characteristic curves,calibration plots,and decision *** The model demonstrated a high predictive accuracy with C-indices of 0.829 in the training set and 0.862 in the validation *** under the curve values for three-year and five-year survival prediction were significantly robust,suggesting an excellent discrimination *** plots confirmed the high concordance between the predictions and actual survival *** We developed a nomogram model incorporating LATS2 expression,which significantly outperformed conven-tional TNM staging in predicting the prognosis of advanced gastric cancer patients *** model may serve as a valuable tool for individualized patient management,allowing for more accurate stratification and im-proved clinical *** validation in larger patient cohorts will be necessary to establish its generaliza-bility and clinical utility.

关键词： Gastric cancer LATS2 Column line graph Prognosis Advanced gastric cancer survival Molecular biomarkers Predictive analytics in oncology Survival analysis

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Structure engineering of cathode host materials for Li-S batteries

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Rare Metals 2024年第4期43卷 1370-1389页

作者： Jia-Jun Long Hua Yu wen-bo Liu School of New Energy and Materials Southwest Petroleum UniversityChengdu610500China School of Mechanical Engineering Sichuan UniversityChengdu610065China

Although lithium-sulfur batteries are one of the favorable candidates for next-generation energy storage devices,a few key challenges that have not been addressed have limited its *** challenges include lithium dendrite growth in the anode side,volume change of the active material,poor electrical conductivity,dissolution and migration of poly sulfides,and slow rate of solid-state reactions in the cathode *** the electrochemical performance of lithium-sulfur batteries is greatly affected by the design of the cathode host material,it has also been widely discussed in addressing the abovementioned *** this paper,three design ideas of cathode host materials in terms of microstructure,crystal structure and electronic structure are introduced and ***,the current progress of these three structural design strategies and their effects on the electrochemical performance of lithium-sulfur batteries are discussed in ***,future directions in the structural design of cathode materials for lithium-sulfur batteries are discussed and further perspectives are provided.

关键词： Lithium-sulfur batteries Structure engineering Cathode Host materials

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Reversibly sensitizing-storing-releasing ^(1)O_(2) within a single platinum(Ⅱ)-acetylide-based metallacycle molecule via laser power modulation

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Science China Chemistry 2024年第2期67卷 604-611页

作者： Ruyi Zhou wen Lv bo Li bo Yu Sudi Zhang Yucheng Zhou Shujuan Liu Qiang Zhao State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts and Telecommunications(NUPT)Nanjing210023China College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and Telecommunications(NUPT)Nanjing210023China

Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy(PDT) for solid tumors,which is highly dependent on tissue oxygen *** this study,we developed a platinum(Ⅱ)-acetylide-based metallacycle compound bearing six 1,4-dimethylnaphthalenes(DMN) groups,and controlled the photodynamic and photothermal effects of the compound by adjusting the power of 730 nm laser to achieve reversible sensitization,storage and release of 1~O_(2) within a single *** compound formed nanoparticles by self-assembly and exhibited good water solubility and *** laser irradiation,the strong spin-orbit coupling of platinum atoms in the metallacycle facilitated 1~O_(2) *** produced 1~O_(2) was captured by the DMN carriers and transported into the hypoxic tumor,where 1~O_(2) release was triggered owing to the good photothermal effect of the extended conjugation of the *** therapy,the metallacycle serving as a photosensitizer,1~O_(2) carrier,and photothermal reagent,achieved the synergistic therapy of PDT/PTT,demonstrating the versatility of the *** study proposes a new strategy to develop phototherapy agents that are suitable for hypoxic tumors.

关键词： metallacycles singlet oxygen endoperoxides near-infrared absorption synergistic treatment

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UAV-assisted cooperative offloading energy efficiency system for mobile edge computing

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Digital Communications and Networks 2024年第1期10卷 16-24页

作者： Xue-Yong Yu wen-Jin Niu Ye Zhu Hong-bo Zhu Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Nanjing210003China Engineering Research Centerof Health Service System Based on Ubiquitous Wireless Networks Ministry of EducationNanjng Universityof Posts and Telecommunications Nanjing210003China

Reliable communication and intensive computing power cannot be provided effectively by temporary hot spots in disaster areas and complex terrain ground *** this has greatly developed the application and integration of UAV and Mobile Edge Computing(MEC)to the Internet of Things(loT).However,problems such as multi-user and huge data flow in large areas,which contradict the reality that a single UAV is constrained by limited computing power,still *** to allowing UAV collaboration to accomplish complex tasks,cooperative task offloading between multiple UAVs must meet the interdependence of tasks and realize parallel processing,which reduces the computing power consumption and endurance pressure of *** the computing requirements of the user terminal,delay constraint of a computing task,energy constraint,and safe distance of UAV,we constructed a UAV-Assisted cooperative offloading energy efficiency system for mobile edge computing to minimize user terminal energy ***,the resulting optimization problem is originally nonconvex and thus,difficult to solve *** tackle this problem,we developed an energy efficiency optimization algorithm using Block Coordinate Descent(BCD)that decomposes the problem into three convex ***,we jointly optimized the number of local computing tasks,number of computing offloaded tasks,trajectories of UAV,and offloading matching relationship between multi-UAVs and multiuser *** results show that the proposed approach is suitable for different channel conditions and significantly saves the user terminal energy consumption compared with other benchmark schemes.

关键词： Computation offloading Internet of things(IoT) Mobile edge computing(MEC) Block coordinate descent(BCD)

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Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing Ma bo Wang Xiaodi Li Shuo Wang wen Wang Yongzhen Peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen ***,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater *** this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of *** using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 *** long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,*** eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase *** in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and ***,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial ***,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass bio-carriers Partial denitrification Mainstream wastewater

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