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Journal of Environmental Sciences 2016年第8期28卷 83-91页

作者： Xia hu Jiti Zhou Guangfei Liu bing Gui Key Laboratory of Industrial Ecology and Environmental Engineering Ministry of Education School of Environmental Science and TechnologyDalian University of Technology

As significant differences in cellular physiology, metabolic potential and genetics occur among strains with morphological similarity, the screening of appropriate microalgae species for effective CO2 fixation and biodiesel production is extremely critical. In this study, ten strains of Chlorella were cultivated in municipal wastewater influent（MWI） and their tolerance for MWI, CO2 fixation efficiency and lipid productivity were assessed. The results showed that the biomass concentrations of four strains（Chlorella vulgaris, Chlorella64.01, Chlorella regularis var. minima and Chlorella sp.） were significantly higher than other strains. When the cultivation systems were aerated with 10% CO2, Chlorella sp. showed the highest CO2 fixation efficiency（35.51%）, while the highest lipid accumulation（58.48%） was observed with C. vulgaris. Scanning electron microscopy images revealed that the cells of both Chlorella sp. and C. vulgaris kept their normal morphologies after 15 day batch *** findings indicated that Chlorella sp. and C. vulgaris have fairly good tolerance for MWI,and moreover, Chlorella sp. was appropriate for CO2 fixation while C. vulgaris represented the highest potential for producing biodiesel.

关键词： Chlorella strains CO2fixation Lipid accumulation Municipal wastewater influent

Enhanced control of DFIG-used back-to-back PWM VSC under unbalanced grid voltage conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1330-1339页

作者： hu Jia-bing HE Yi-kang NIAN Heng School of Electrical Engineering Zhejiang University Hangzhou 310027 China

This paper presents a unified positive-and negative-sequence dual-dq dynamic model of wind-turbine driven doubly-fed induction generator(DFIG) under unbalanced grid voltage conditions. Strategies for enhanced control and operation of a DFIG-used back-to-back(BTB) PWM voltage source converter(VSC) are proposed. The modified control design for the grid-side converter in the stationary αβ frames diminishes the amplitude of DC-link voltage ripples of twice the grid frequency,and the two proposed control targets for the rotor-side converter are alternatively achieved,which,as a result,improve the fault-ride through(FRT) capability of the DFIG based wind power generation systems during unbalanced network supply. A complete unbalanced control scheme with both grid-and rotor-side converters included is designed. Finally,simulation was carried out on a 1.5 MW wind-turbine driven DFIG system and the validity of the developed unified model and the feasibility of the proposed control strategies are all confirmed by the simulated results.

关键词： Unbalanced grid voltage Doubly-fed induction generator (DFIG) Back-to-back (BTB) Fault-ride through (FRT) Voltage source converter (VSC)

VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release

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Cellular & Molecular Immunology 2021年第5期18卷 1186-1196页

作者： wen-Rui He Li-Bo Cao Yu-Lin Yang Duo hua Ming-Ming hu Hong-bing Shu Department of Infectious Diseases Frontier Science Center for Immunology and MetabolismMedical Research InstituteZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanChina Research Unit of Innate Immune and Inflammatory Diseases Chinese Academy of Medical SciencesWuhanChina

Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated vaccinia virus-related kinase 2 (VRK2) as a key regulator of this process. VRK2 deficiency inhibited the induction of antiviral genes and caused earlier and higher mortality in mice after viral infection. Upon viral infection, VRK2 associated with voltage-dependent anion channel 1 (VDAC1) and promoted VDAC1 oligomerization and mtDNA release, leading to the cGAS-mediated innate immune response. VRK2 was also required for mtDNA release and cGAS-mediated innate immunity triggered by nonviral factors that cause Ca^(2+) overload but was not required for the cytosolic nucleic acid-triggered innate immune response. Thus, VRK2 plays a crucial role in the mtDNA-triggered innate immune response and may be a potential therapeutic target for infectious and autoimmune diseases associated with mtDNA release.

关键词： cGAS Mita/Sting mitostress innate immune response mitochondrial DNA

基于CNN和Transformer交叉教学的半监督医学图像分割

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陕西科技大学学报 2025年第1期43卷 185-192页

作者：杨云胡雯青杨虹吴亚男陕西科技大学电子信息与人工智能学院陕西西安710021 西安富德医疗电子有限公司陕西西安710075 西安计量技术研究院陕西西安710199

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer... 详细信息

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer交叉教学的半监督医学图像分割方法.该方法将经典的深度协同训练从一致性正则化简化为交叉教学,利用循环伪标签方案使两个网络的预测差异转换为无监督损失,以鼓励两个网络具有一致的低熵预测.所提方法在ISIC 2018数据集上进行实验,在采用20%的标注比例时,Dice系数和Jaccard系数分别达到87.25%和79.17%,相比于监督U-Net++的训练结果分别提升了2.89%和3.53%,并且优于目前主流的半监督学习方法,验证了所提方法在半监督医学图像分割上的有效性和泛化性.

关键词：半监督学习图像语义分割交叉教学循环伪标签

Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan Meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang Ma Lina hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

A Confocal Technique Applicable to Studies of Cellular pH-related Signaling in Plants

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Journal of Integrative Plant Biology 2008年第6期50卷 682-690页

作者： bing-bing Lit Zhi-hui Gao Xiao-Yan Zhou hui-Bo Ren Min Xie Yi-Juan Fan Jian-Fang hu wen-Suo Jia College of Agronomy and Biotechnology China Agricultural University Beijing 100094 China

pH may act as a crucial signal in both animal and plant cells. It is very difficult to monitor pH signals and this has largely hindered progress in the investigation of pH signaling, particulady systematic pH signaling. Here, we report the development of a confocal technique to monitor leaf apoplastic pH in intact plants, which is particularly suitable for the studies on root to shoot signaling. A variety of different pH indicators and plant species were tested. It was found that different pH indicators, for example, 2＇,7＇-Bis-（2-carboxyethyl）-5-（and-6）-carboxyfluoresce （BCECF）, SNARF-4F 5-（and-6）- carboxylic acid （SNARF） and DM-NERF （NERF）, were of different properties, and to successfully monitor pH at a sub-cellular level, the comparability between the pH indicator and plant species must be involved according to their suitable pH range and loading characteristics. The loading characteristics of different pH indicators differ with different plant species, cell types and their developing stages. No matter what methods were adopted, BCECF and SNARF could not be loaded specifically in the leaf apoplast in sunflower, tomato, and Comelina communis L. In contrast, regardless of the methods adopted, NERF could be loaded efficiently and specifically in the leaf apoplast in C. communis, but not in other plants. In C. communis, the determination coefficient for in vitro and in situ calibration of NERF was very high, which was respectively 0.9951 and 0.991 6, and therefore, the adoption of NERF together with C. communis could construct an ideal experimental system that is suitable for the investigation of pH systematic signaling. Ratio image analysis demonstrated that the leaf apoplastic pH was about 5.5 in non-stressed conditions, and water deficit could trigger an increase in pH by about half a pH unit, which is the first evidence to directly indicate that pH is able to act as a systematic signal under water deficit conditions.

关键词： confocal microscope pH signaling water deficit.

HYDRODYNAMIC STUDY ON A PECTORAL FIN ROWING MODEL OF A FISH

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Journal of Hydrodynamics 2009年第4期21卷 463-472页

作者： hu wen-tong Department of Engineering Mechanics Shanghai Jiao Tong University Shanghai 200240 China

Fish pectoral fin movement involves primarily a drag-based and a lift-based mechanisms to produce thrust. A numerical study on a pectoral fin rowing propulsion model based on the drag-based mechanism is presented in this article. The propulsive mechanism of the pectoral fin rowing model is related with the voriticity and pressure in the flow field. The relationship between the thrust and kinematic parameters and the wake-captured problem are analyzed. It is shown that a high thrust is produced in the power stroke, mainly due to the backward translation acceleration, the anticlockwise angular acceleration and the absence of stall in the uniform translation. Moreover, the flow control mechanism and the effect of dynamic flexible deformation are further analyzed. To properly choose controllable factors and adopt an appropriate dynamic deformation can improve the propulsive performance.

关键词： pectoral fin drag-based propulsion propulsion mechanism computational fluid dynamics

Update on techniques for cryopreservation of human spermatozoa

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Asian Journal of Andrology 2022年第6期24卷 563-569页

作者： Chuan huang Yu-Lin Tang Jian-Ling hu wen-Jun Zhou Zeng-hui huang Xue-Feng Luo Zheng Li wen-bing Zhu Institute of Reproductive and Stem Cell Engineering Basic Medicine CollegeCentral South UniversityChangsha 410000China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410000China Department of Andrology Center for Men's HealthShanghai General HospitalShanghai Key Lab of Reproductive MedicineShanghai 200025China

In the 1960s,sperm cryopreservation was developed as a method to preserve ***,techniques for the cryopreservation of human spermatozoa have been widely used in assisted ***,although sperm cryobiology has made notable achievements,the optimal method for the recovery of viable spermatozoa after cryopreservation remains *** sperm quality can be affected by cryoprotectants,ice formation,storage conditions,and osmotic stress during the freezing *** review discusses recent advances in different cryopreservation techniques,cryoprotectants,and freezing and thawing methods during cryopreservation and new indications for the use of cryopreserved spermatozoa.

关键词： cryodamage cryoprotectant dry preservation freezing and thawing sperm cryopreservation

Endoscopic sphincterotomy plus large-balloon dilation vs endoscopic sphincterotomy for choledocholithiasis:A meta-analysis

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World Journal of Gastroenterology 2013年第48期19卷 9453-9460页

作者： Xiao-Ming Yang bing hu Department of Endoscopy Eastern Hepatobiliary Surgery Hospital Second Military Medical University

AIM:To perform a meta-analysis of large-balloon dilation(LBD)plus endoscopic sphincterotomy(EST)vs EST alone for removal of bile duct ***:Databases including PubMed,EMBASE,the Cochrane Library,the Science Citation Index,and important meeting abstracts were searched and evaluated by two reviewers *** main outcome measures included:complete stone removal,stone removal in the first session,use of mechanical lithotripsy,procedure time,and procedure-related complications.A fixed-effects model weighted by the Mantel-Haenszel method was used for pooling the odds ratio(OR)when heterogeneity was not significant among the *** a Q test or I2statistic indicated substantial heterogeneity,a random-effects model weighted by the DerSimonian-Laird method was ***:Six randomized controlled trials involving835 patients were *** was no significant heterogeneity for most results;we analyzed these using a fixed-effects ***-analysis showed EST plus LBD caused fewer overall complications than EST alone(OR=0.53,95%CI:0.33-0.85,P=0.008);sub-category analysis indicated a significantly lower risk of perforation in the EST plus LBD group(Peto OR=0.14,95%CI:0.20-0.98,P=0.05).Use of mechanical lithotripsy in the EST plus LBD group decreased significantly(OR=0.26,95%CI:0.08-0.82,P=0.02),especially in patients with a stone size larger than 15 mm(OR=0.15,95%CI:0.03-0.68,P=0.01).There were no significant differences between the two groups regarding complete stone removal,stone removal in the first session,post-endoscopic retrograde cholangiopancreatography pancreatitis,bleeding,infection of biliary tract,and procedure ***:EST plus LBD is an effective approach for the removal of large bile duct stones,causing fewer complications than EST alone.

关键词： Balloon dilation Cholangiopancreatography Endoscopic retrograde Choledocholithiasis Endoscopic sphincterotomy Meta-analysis

Multidisciplinary approaches in the management of advanced hepatocellular carcinoma:Exploring future directions

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4052-4054页

作者： Xin-Jin Liu Yi-Xiu Lin Liu-Xiang Chen wen-Juan Yang bing hu Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Recently,we read the article“Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of the literature”published in the World Journal of Gastrointestinal *** prognosis of advanced hepatocellular carcinoma(HCC)is poor,and multidisciplinary comprehensive treatment is currently the main research *** case report demonstrated the efficacy of the combination therapy of transcatheter arterial chemoembolization,hepatic arterial infusion chemotherapy,epclusa,lenvatinib and sintilimab for a patient with advanced HCC,and the report can serve as a reference for clinical *** would also like to share some of our views.

关键词： Hepatocellular carcinoma Multidisciplinary conversion therapy Pathological complete response Comment