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Elemene-containing hyperthermic intraperitoneal chemotherapy combined with chemotherapy for elderly patients with peritoneal metastatic advanced gastric cancer

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World Journal of Clinical Cases 2022年第5期10卷 1498-1507页

作者： Zhi-Xiong Chen Jin Li wen-bin liu Shou-Ru Zhang Hao Sun Department of Gastrointestinal Cancer Center Chongqing University Cancer HospitalChongqing 400030China Department of Ultrasound The Fifth People's Hospital of ChongqingChongqing 400062China Department of Hepatobiliary and Pancreatic Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Teaching and Research Section Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Almost all elderly patients with peritoneal metastatic gastric cancer(PGC)are unlikely to tolerate cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy(HIPEC)and adjuvant ***,determining how to optimize the treatment strategy for such patients has always been a clinical *** HIPEC and palliative adjuvant chemotherapy can benefit patients with ***,optimizing HIPEC and chemotherapy regimens has potential clinical value in reducing side effects,and improving treatment tolerance and clinical *** To explore the effect of HIPEC containing elemene,which is an anti-cancer component extracted in traditional Chinese herbal medicine,combined with reduced capecitabine and oxaliplatin(CapeOx)chemotherapy regimens,in elderly patients with *** In the present study,39 of 52 elderly PGC patients were included and assigned to different HIPEC treatment groups[lobaplatin group(group L)and mixed group(group M)]for *** was used for all three HIPECs in group *** group M,lobaplatin was used in the middle of the three HIPECs,and elemene was used for the first and third *** HIPEC,patients received CapeOx *** incidence of complications(abdominal infection,lung infection,and urinary tract infection),myelosuppression,immune function(CD4/CD8 ratio),average length of hospital stay,and prognosis were compared between these two *** There was no significant difference in the incidence of complications between the two groups during hospitalization(P>0.05).Compared to patients in group M,patients in group L exhibited severe myelosuppression(P=0.027)and increased length of hospital stay(P=0.045).However,no overall survival benefit was observed in group ***,the immune function of patients in group M was less affected(P<0.001),when compared to that of patients in group *** multivariate analysis suggested that the cycles of chemotherapy after perfusion s

关键词： Gastric cancer Hyperthermic intraperitoneal chemotherapy Peritoneal metastasis Oxaliplatin Capecitabine

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Experiments on acoustic measurement of fractured rocks and application of acoustic logging data to evaluation of fractures

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Petroleum Science 2017年第3期14卷 520-528页

作者： Bao-Zhi Pan Ming-Xin Yuan Chun-Hui Fang wen-bin liu Yu-Hang Guo Li-Hua Zhang Faculty of Geo-exploration Science and Technology Jilin University Changchun 130012 Jilin China

Fractures in oil and gas reservoirs have been the topic of many studies and have attracted reservoir research all over the world. Because of the complexities of the fractures, it is difficult to use fractured reservoir core samples to investigate true underground conditions. Due to the diversity of the fracture parameters, the simulation and evaluation of fractured rock in the laboratory setting is also difficult. Previous researchers have typically used a single material, such as resin, to simulate fractures. There has been a great deal of simplifying of the materials and conditions, which has led to disappointing results in application. In the present study, sandstone core samples were selected and sectioned to simulate fractures, and the changes of the compressional and shear waves were measured with the gradual increasing of the fracture width. The effects of the simulated fracture width on the acoustic wave velocity and amplitude were analyzed. Two variables were defined： H represents the amplitude attenuation ratio of the compressional and shear wave, and x represents the transit time difference value of the shear wave and compressional wave divided by the transit time of the compressional wave. The effect of fracture width on these two physical quantities was then analyzed. Finally, the methods of quantitative evaluation for fracture width with H and x were obtained. The experimental results showed that the rock fractures linearly reduced the velocity of the shear and compressional waves. The effect of twin fractures on thecompressional velocity was almost equal to that of a single fracture which had the same fracture width as the sum of the twin fractures. At the same time, the existence of fractures led to acoustic wave amplitude attenuations, and the compressional wave attenuation was two times greater than that of the shear wave. In this paper, a method was proposed to calculate the fracture width with x and H, then this was applied to the array acoustic

关键词： Fractured rockAcoustic wave amplitude Fracture width Acoustic wave velocity Experimental measurement

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Screening and identifkation of proteins interacting with nudeostemin

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World Journal of Gastroenterology 2005年第31期11卷 4812-4814页

作者： Hai-Xia Yang Geng-Lin Jin Ling Meng Jian-Zhi Zhang wen-bin liu Cheng-Chao Shou Department of Biochemistry and Molecular Biology Peking University School of Oncology and Beijing Institute for Cancer Research Beijing 100034 China

AIM： To identify the proteins interacting with nucleostemin （NS）, thereby gaining an insight into the function of NS. METHODS： Yeast two-hybrid assay was performed to screen a human placenta cDNA library with the full length of NS as a bait. X-Gal assay and β-galactosidase filter assay were subsequently conducted to check the positive clones and the gene was identified by DNA sequencing. To further confirm the interaction of two proteins, the DNA fragment coding NS and the DNA fragment isolated from the positive clone were inserted into the mammalian expression vector pcDNA3 and pcDNA3-myc, respectively. Then, two plasmids were cotransfected into the COS-7 cells by DEAE-dextron. The total protein from the cotransfected cells was extracted and coimmunoprecipitation and Western blot were performed with suitable antibodies sequentially. RESULTS： Two positive clones that interacted with NS were obtained from human placenta cDNA library. One was an alpha isoform of human protein phosphatase 2 regulatory subunit B （B56）（PPP2RSA） and the other was a novel gene being highly homologous to the gene associated with spondylo paralysis. The co-immunoprecipitation also showed that NS specifically interacted with PPP2R5A. CONCLUSION： NS and PPP2R5A interact in yeast and mammalian cells, respectively, which is helpful for addressing the function of NS in cancer development and progression.

关键词： Nucleostemin Yeast two-hybrid Co-IP

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Phase Matching Achieved by Bandgap Widening in Infrared Nonlinear Optical Materials[ABa_(3)Cl_(2)][Ga_(5)S_(10)](A=K,Rb,and Cs)

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CCS Chemistry 2021年第3期3卷 964-973页

作者： bin-wen liu Hui-Yi Zeng Xiao-Ming Jiang Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002

Large nonlinear optical(NLO)coefficient(d_(ij)),high laser damage threshold(LDT),and phase matching(PM)are crucial for the practical applications of IR NLO crystals.A great number of IR NLO materials with high dij have been explored,but many of them suffer from non-PM,which dramatically decreases their ultimate NLO output *** settle this problem,we have developed a new strategy involving modulating normal dispersion via bandgap(E_(g))widening to achieve PM in this *** synthesized successfully three new wide E_(g)(∼4.0 eV)IR NLO salt-inclusion sulfides[ABa_(3)Cl_(2)][Ga_(5)S_(10)](A=K,1;Rb,2;and Cs,3)with PM behaviors,mainly ascribed to the PM cut-off wavelength blue shift that originated from the wide Eg values,with less contribution from birefringence *** the compounds possessed large second-harmonic-generation(SHG)efficiency(∼1×AgGaS_(2))and hitherto the highest LDTs(188–200 MW/cm^(2),at 1.06μm,10 ns pulse width)for known chalcogenides with SHG efficiencies comparable to that of commercial silver gallium sulfide(AgGaS_(2))crystal.

关键词： chalcogenide infrared nonlinear optic phase matching second-harmonic generation laser damage threshold

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Novel modified min-sum decoding algorithm for low-density parity-check codes

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The Journal of China Universities of Posts and Telecommunications 2010年第4期17卷 1-5,46页

作者： liu Hai-yang , QU wen-ze, liu bin, LI Jiang-peng, LUO Shi-dong, CHEN Jie Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, China Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China

The problem of improving the performance of min-sum decoding of low-density parity-check （LDPC） codes is considered in this paper. Based on min-sum algorithm, a novel modified min-sum decoding algorithm for LDPC codes is proposed. The proposed algorithm modifies the variable node message in the iteration process by averaging the new message and previous message if their signs are different. Compared with the standard min-sum algorithm, the modification is achieved with only a small increase in complexity, but significantly improves decoding performance for both regular and irregular LDPC codes. Simulation results show that the performance of our modified decoding algorithm is very close to that of the standard sum-product algorithm for moderate length LDPC codes.

关键词： LDPC codes sum-product algorithm min-sum algorithm modified min-sum algorithm

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Effects of angiotensin Ⅱ receptor antagonist, Losartan on the apoptosis, proliferation and migration of the human pancreatic stellate cells

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World Journal of Gastroenterology 2005年第41期11卷 6489-6494页

作者： wen-bin liu Xing-Peng Wang Kai Wu Ru-Ling Zhang Shanghai No. 1 People's Hospital Shanghai Jiaotong UniversityShanghai 200080 China

AIM： To investigate the effects of AT, （Type 1 angiotensin Ⅱ receptor） antagonist （Losartan） on the apoptosis, proliferation and migration of the human pancreatic stellate cells （hPSCs）. METHODS： hPSCs were isolated from pancreatic sample of patients with pancreatic carcinoma using radioimmunoassay （RIA） technique to detect the concentration of AngⅡ in culture media and cell homogenate. Immunocytochemistry （ICC） and in situ hybridization （ISH） methods were utilized to test AT1 expression in hPSCs. Effects of Losartan on hPSCs proliferation, apoptosis and migration were investigated using BrdU incorporation, TUNEL, flow cytometry （FCM）, and phase-contrast microscope separately when cells treated with Losartan. Immunofluorescence and Western blot were applied to quantify the expression of type Ⅰ collagen in hPSCs. RESULTS： There exists AT1 expression in hPSCs, while no AngⅡ was detected in culture media and cell homogenate. Losartan induces cell apoptosis in a doseand time-dependent manner （apparently at 10^-5 mol/L）, no pro-proliferative effect was observed in the same condition. Corresponding dosage of Losartan can also alleviate the motion capability and type Ⅰ collagen content of hPSCs compared with AngⅡ treatment and non-treatment control groups. CONCLUSION： These findings suggest that paracrine not autocrine functions of AngⅡ may have effects on hPSCs, which was mediated by AT1 expressed on cells, while Losartan may exert anti-fibrotic effects by inhibiting hPSCs motion and partly by inducing apoptosis.

关键词： Pancreatic stellate cell Angiotensin Ⅱ receptor Antagonist Losarta n

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An improved model of damage depth of shock-melted metal in microspall under triangular wave loading

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Chinese Physics B 2021年第9期30卷 412-418页

作者： wen-bin liu An-Min He Kun Wang Jian-Ting Xin Jian-Li Shao Nan-Sheng liu Pei Wang Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Institute of Applied Physics and Computational Mathematics Beijing 100094China Graduate School of China Academy of Engineering Physics Beijing 100088China College of Materials Science and Engineering Hunan UniversityChangsha 410082China Science and Technology on Plasma Physics Laboratory Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Center for Applied Physics and Technology Peking UniversityBeijing 100871China

Damage depth is an important dynamic parameter for describing the degree of material damage and is also a key fundamental issue in the field of impact compression *** present work is dedicated to the damage depth of shock-melted metal in microspall under triangular wave loading,and an improved model of damage depth considering the material's compressibility and relative movement is *** damage depth obtained from the proposed model is in good agreement with the laser-driven shock loading *** with the previous model,the proposed model can predict the damage depth of shock-melted metal in microspall more ***,two-groups of the smoothed particle hydrodynamics(SPH)simulations are carried out to investigate the effects of peak stress and decay length of the incident triangular wave on the damage depth,*** the decay length increases,the damage depth increases *** the peak stress increases,the damage depth increases nonlinearly,and the increase in damage depth gradually slows *** results of the SPH simulations adequately reproduce the results of the proposed model in terms of the damage ***,it is found that the threshold stress criterion can reflect the macroscopic characteristics of microspall of melted metal.

关键词： damage depth theoretical modeling microspall triangular wave

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Novel predictive and prognostic strategies of hepatitis B virus related hepatocellular carcinoma

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Hepatoma Research 2016年第1期2卷 331-340页

作者： wen-bin liu Fan Yang Ding-Yi Shao Guang-wen Cao Department of Epidemiology Second Military Medical UniversityShanghai 200433China

Hepatocellular carcinoma(HCC)is a common malignancy and an important cause of cancer death *** hepatitis B virus(HBV)infection is the major cause of *** studies of HBV-induced carcinogenesis not only discovered many new biomarkers but also developed a novel theory:Cancer Evolution-Development(Cancer Evo-Dev).Cancer Evo-Dev provides an evolutionary insight of developing more reasonable predictive and prognostic *** chronic inflammatory microenvironment of cancer evolution,genetic polymorphisms of inflammatory factors,and HCC-related HBV mutations that negatively selected by host immunity may help greatly in identifying HBV-infected individuals who are more likely to develop HCC or benefit from HCC prophylactic *** expression signatures and somatic mutation profiles reflect the different patterns of signaling pathway networks underlying tumor heterogeneity and can be applied to improve the molecular classification and prognostic stratification of HCC *** cells that survive the selection can retro-differentiate into tumor initial cells and aggressive *** of mutants or their hallmarks in cell-free DNA in peripheral blood potentially improve the early diagnosis,prognosis prediction,and personalized treatment of HBV-caused HCC.

关键词： Hepatocellular carcinoma hepatitis B virus evolution prediction prognosis

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Ebola virus disease: From epidemiology to prophylaxis

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Journal of Medical Colleges of PLA(China) 2014年第4期29卷 208-216页

作者： wen-bin liu Zi-Xiong Li Yan Du Guang-wen Cao Department of Epidemiology Second Military Medical University

The outbreak of Ebola virus disease(EVD) continues to spread through West Africa. Since the first reported EVD in March 2014, the number of cases has increased rapidly, with the fatality rate of >50%. The most prevalent Ebola virus belongs to the species of Zaire ebolavirus, with a mortality rate as high as 90%. Although there were introduced cases in other continents, Africa is the endemic area where fruit bats and apes are suspected to be Ebola virus carriers. The virus might be transmitted from the host animals to humans if humans consume relative raw and contaminated meats; however, human-to-human transmission via close contact is the major route of current outbreaks. EVD happens at any seasons and affected people of any race in any age groups. Direct contact with body fluids of EVD patients and living in the contaminated environment greatly increase the risk of being infected. Transmission viaaerosol is less possible but the transmission via droplet is possible in humans. Thus, health care providers are facing danger of getting Ebola virus infection. So far, there are limited vaccines, drugs and/or therapies to prevent Ebola virus infection or treat EVD. Medical workers should follow the current standard prophylactic procedures. Military forces can orchestrate efficient care to mass EVD casualties. Although it is necessary to speed up the pace of developing effective vaccine and therapeutics for the prevention and treatment of EVD, public health prophylaxis is the most important issue at present to control the spread of this disease cost-effectively.

关键词： Ebola virus disease Epidemiology Outbreak Virology Prophylaxis

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Using the spike protein feature to predict infection risk and monitor the evolutionary dynamic of coronavirus

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Infectious Diseases of Poverty 2020年第2期9卷 30-37页

作者： Xiao-Li Qiang Peng Xu Gang Fang wen-bin liu Zheng Kou Institute of Computing Science and Technology Guangzhou UniversityGuangzhou 510006China

Background:Coronavirus can cross the species barrier and infect humans with a severe respiratory ***-CoV-2 with potential origin of bat is still circulating in *** this study,a prediction model is proposed to evaluate the infection risk of non-human-origin coronavirus for early ***:The spike protein sequences of 2666 coronaviruses were collected from 2019 Novel Coronavirus Resource(2019nCoVR)Database of China National Genomics Data Center on Jan 29,2020.A total of 507 human-origin viruses were regarded as positive samples,whereas 2159 non-human-origin viruses were regarded as *** capture the key information of the spike protein,three feature encoding algorithms(amino acid composition,AAC;parallel correlation-based pseudo-amino-acid composition,PC-PseAAC and G-gap dipeptide composition,GGAP)were used to train 41 random forest *** optimal feature with the best performance was identified by the multidimensional scaling method,which was used to explore the pattern of human ***:The 10-fold cross-validation results showed that well performance was achieved with the use of the GGAP(g=3)*** predictive model achieved the maximum ACC of 98.18%coupled with the Matthews correlation coefficient(MCC)of *** clusters for human coronaviruses(229E,NL63,OC43,HKU1,MERS-CoV,SARS-CoV,and SARS-CoV-2)were *** cluster for SARS-CoV-2 was very close to that for SARS-CoV,which suggests that both of viruses have the same human receptor(angiotensin converting enzyme II).The big gap in the distance curve suggests that the origin of SARS-CoV-2 is not clear and further surveillance in the field should be made *** smooth distance curve for SARS-CoV suggests that its close relatives still exist in nature and public health is challenged as ***:The optimal feature(GGAP,g=3)performed well in terms of predicting infection risk and could be used to explore the evolutionary dynamic in a simple,fast a

关键词： Coronavirus Cross-species infection Spike protein Machine learning

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