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Adaptive Algorithms of Nonlinear Approximation with Finite Terms

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1663-1672页

作者： wen bin wei Yue Sheng XU Pei Xin YE Department 4 Air Force Radar Academy Wuhan 430019 P. R. China Institute of Mathematics Chinese Academy of Sciences Beijing 100080 P. R. China Department of Mathematics Nankai University Tianjin 300000 P. R. China

This paper deals with realizable adaptive algorithms of the nonlinear approximation with finite terms based on wavelets. We present a concrete algorithm by which we may find the required index set Am for the greedy algorithm Gm^P（., Ψ）. This makes the greedy algorithm realize the near best approximation in practice. Moreover, we study the efficiency of the finite-term approximation of another Mgorithm introduced by Birge and Massart.

关键词： nonlinear approximation dictionary Haar system adaptive algorithm near best approximation

Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 822-830页

作者： Fang Ruan wen-Jun Kong Qian Fan Hong-wei Dong wei Zhang wen-bin wei Ying Jie Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing Infectious Eye Disease Diagnosis and Treatment CenterBeijing 100069China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300020China

AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 ***:A cross-sectional observational design was *** 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,*** Surface Disease Index(OSDI),Five-item Dry Eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this ***:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression.

关键词： COVID-19 dry eye disease recurrent infection mental health

Long-term outcome of pathologic myopic foveoschisis treated with posterior scleral reinforcement followed by vitrectomy

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 975-982页

作者： Yao Huang Yue Qi wen-bin wei An-Li Duan Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM: To report the long-term outcome of posterior scleral reinforcement(PSR) followed by vitrectomy for pathologic myopic foveoschisis(MF).METHODS: The records of 27 patients(44 eyes) treated with posterior scleral reinforcement(PSR) followed by vitrectomy for pathologic MF were retrospectively *** best-corrected visual acuity(BCVA), refractive error, axial length, and spectral-domain optical coherence tomography findings and complications were ***: Forty-four eyes of 27 patients were included in this study. The follow-up period was 47.98±18.23mo(24-83mo). The mean preoperative BCVA(logMAR) was 1.13±0.63, and the mean postoperative BCVA was 0.30±0.33at the last visit. There showed a significant improvement in BCVA postoperatively(P<0.001). Postoperative BCVA in 41eyes(93%) was improved compared with the preoperative one. Forty-two eyes(95.45%) got total resolution of the MF after surgery. The remaining two eyes(4.55%) got partial resolution of foveoschisis. The preoperative foveal thickness was 610.45±217.11 μm and the postoperative foveal thickness at the last visit was significantly reduced to 177.64±55.40 μm(P<0.001). The preoperative axial length was 29.60±1.71 mm, and the postoperative axial length was 29.74±1.81 mm at the last visit. There was no significant increase in axial length within 47.98±18.23mo of follow-up(P=0.562). There was no recurrence of foveoschisis or occurrence of full-thickness macular hole during the whole follow-up ***: For pathologic MF, PSR followed by vitrectomy is an effective procedure to improve the visual acuity and the anatomical structure of macula. It can also stabilize the axial length for a long time.

关键词： myopic foveoschisis posterior scleral reinforcement vitrectomy

Rock engineering property of the high-steep open-pit slope and its stability

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Journal of Coal Science & Engineering(China) 2010年第1期16卷 35-40页

作者： PENG wen-bin YU wei-jian School of Energy and Safety Engineering Hunan University of Science and Technology Xiangtan 411201 China

According to the rock engineering property and stability of high-steep open-pitslopes, various factors were collected on the basis of rock engineering system (RSE) theory,and the interaction matrix of stability evaluation was ***, the stabilityevaluation index (S_p) of the slope was put *** of the S_p value and the correspondingstable state were given on the basis of thirty-six *** is found that the followingrelationships exist: unstable (easy landslide): S_p***, the stability evaluation indexwas applied on the high-steep open-pit slope of one *** results and monitoringdata indicate that the index meets the necessity of the property of slope engineering, and ithas an important engineering purpose for landslide forecasting of high-steep slopes.

关键词： high-steep slope rock engineering system property stability evaluation open-pit mine

Peptidome profiling of human serum of uveal melanoma patients based on magnetic bead fractionation and mass spectrometry

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 939-947页

作者： Xiang-Yu Shi Qing Li wen-bin wei Li-Ming Tao Department of Ophthalmology the Second Hospital Affiliated to Anhui Medical University Hefei 230601 Anhui Province China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology ＆ Visual Science Key Laboratory Beijing 100730 China

AIM： To find new biomarkers for uveal melanoma （UM） by analyzing the serum peptidome profile. METHODS： Proteomic spectra in patients with UM before and after operation were analyzed and compared with those of healthy controls. Magnetic affinity beads were used to capture serum peptides and matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometer were used to compile serum peptide profiles. RESULTS： A panel of 49 peptides were differentially expressed between UM patients and controls, of which 33 peptides were of higher intensities in patient group and 16 peptides were of higher intensities in control group. Based on combined use of these potential markers, peptides with mean molecular masses of 1467 and 9289.0 Da provide high sensitivity （83.3%）, specificity （100%） and accuracy rate （93.0%） together to differentiate melanoma patients from healthy controls. At the time point of 6mo postoperatively, the levels of many peptides differentially expressed before surgery showed no more statistical difference between the patients and the control group. Fibrinogen o-chain precursors were identified as potential UM markers. CONCLUSION： We have shown that a convenient and fast proteomic technique, affinity bead separation and MALDI- TOF analysis combined with bioinformatic software, facilitates the identification of novel biomarkers for UM.

关键词： uveal melanoma protein biomarker peptidomeprofile magnetic bead fractionation mass spectrometry

Regional chemotherapy for uveal melanoma liver metastases

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 293-300页

作者： Yang-Xu Tao Hao-wen Li Jing-Ting Luo Yang Li wen-bin wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artiﬁcial Intelligence Research and Veriﬁcation Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Chemotherapy remains an important approach for the treatment of liver metastases from uveal melanoma(UM).Compared with systemic chemotherapy,regional chemotherapy has similar efficacy and fewer systemic adverse *** chemotherapy for UM liver metastases includes hepatic ar ter y infusion(HAI),transarterial chemoembolization(TACE),and isolated hepatic perfusion(IHP).In this review,we aim to examine the efficacy of regional chemotherapy and compare HAI,TACE,and IHP in terms of overall survival(OS).The three approaches showed no obvious difference in OS results.

关键词： uveal melanoma liver metastasis regional chemotherapy

Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1258-1268页

作者： Ying-Chih Wang Xuan Yang wen-bin wei Xiao-Lin Xu Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren HospitalCapital Medical University

AIM： To reveal the insight mechanism of liver metastasis in uveal melanoma, we investigated cell functions of microRNA-21 in three different uveal melanoma cell lines and analyze the relationship of target gene p53 and its downstream targets which been found significant expression in our previous ***： Quantitative real-time polymerase chain reaction （qRT-PCR） was used to detect microRNA-21 expression in normal uveal tissue and uveal melanoma cell lines. Lenti-virus expression system was used to construct OCM-1, MuM-2B and M619 cell line with stable overexpression and inhibition of microRNA-21. In vitro cell function tests such as cell proliferation, cell apoptosis, cell circle and abilities of migration and invasion were examined by MTT, BrdU assay, flow cytometry, transwell assay and Matrigel invasion assay respectively. The target gene was predicted by bioinformatics and confirmed by using a dual luciferase reporter assay. The expression of p53 and its suspected downstream targets LIM and SH3 protein 1 （LASP1） and Glutathione S Transferase pi （GST-Pi） were determined by qRT-PCR in mRNA level and western blotting analysis in protein level. Finally, the effect of microRNA-21 in a xenograft tumor model was assessed in four-week-old BALB/c nude mice. RESULTS： Compared to normal uveal melanoma, expressions of microRNA-21 were significantly higher in uveal melanoma cell lines. Overexpression of microRNA-21 promoted proliferation, migration, and invasion of OCM-1, M619 and MuM-2B cells, while inhibition of microRNA-21 reveal opposite effects. Wild type p53 was identified as a target gene of microRNA-21-3p, and proved by dual luciferase reporter assay. Up-regulated microRNA-21 inhibited the expression of wild type p53 gene, and the increased expression of LASP1 in mRNA level and protein level, while down-regulated microRNA-21 presented opposite way. However, GST-pi showed the potential pattern as expected, but relative mRNA level showed no statistically signific

关键词： uveal melanoma microRNA-21 p53 LIMand SH3 protein 1 Glutathione S Transferase pi

miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 718-724页

作者： Yang Li Jing-Ting Luo Yue-Ming Liu wen-bin wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To investigate the role of microRNA-145(miRNA-145)and microRNA-205(miRNA-205)in proliferation and invasion of uveal melanoma(UM)***:The expression level of miRNA-145 and miR NA-205 from samples of UM patients were determined by real-time polymerase chain reaction(RT-PCR).The growth and invasion inhibitory effects were observed by the transfection of UM cells with miRNA-145 and *** epithelial-to-mesenchymal transition(EMT)-related proteins were screened by Western *** clinical samples from The Cancer Genome Atlas(TCGA)were applied to search for potential protein ***’s correlation analysis was applied to estimate co-expression between ***-luciferase reporter assay was used to verify the binding sites on target protein for miRNA-145 and ***:The expression levels of miRNA-145 and miRNA-205 in the samples from patients with UM were significantly lower than those in the normal tissue *** growth and invasion inhibitory effects were observed in human UM cells with miRNA-145 and miR NA-205 *** miRNA-145 and miRNA-205 could decrease the expression level of cell division control protein 42(CDC42).After database searching and sequence alignment,we identified that Neuropilin 1(NRP1)had binding sites for both miRNA-145 and ***:The miRNA-145 and miRNA-205 can reduce the proliferation,migration and invasion of UM cells by targeting the mRNA of its upstream protein NRP1 to down-regulate the expression level of CDC42.

关键词： uveal melanoma microRNA-145 microRNA-205 CDC42 NRP1

Elevated VEGF-A & PLGF concentration in aqueous humor of patients with uveal melanoma following Iodine-125 plaque radiotherapy

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 599-605页

作者： Meng-Xi Chen Yue-Ming Liu Yang Li Xuan Yang wen-bin wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Key Laboratory of Intraocular tumor Diagnosis and TreatmentBeijing 100730China

AIM: To measure the concentration of vascular endothelial growth factor-A(VEGF-A), and placental growth factor(PLGF) in aqueous humor of uveal melanoma patients before and after Iodine-125 plaque therapy(IPT), determine the postoperative fluctuation and evaluate associated factors in ***: Participants were 18 Chinese patients with uveal melanoma who were elected to IPT. Undiluted aqueous humor samples were collected at Iodine plaque implant and removal time, then stored immediately at-80℃ until assayed. The concentration of VEGF-A, PLGF and other 7 cytokines comprising interleukin-2(IL-2), IL-8, IL-10, interferon(IFN)-γ, programmed death(PD)-1, transforming growth factor(TGF)-β1 and insulin-like growth factor(IGF)-1 in aqueous humor was measured using Raybiotech immunoassay kit, a high throughput strategy. The VEGF-A and PLGF levels were compared across preoperation and postoperation subgroups, as well as those of other 7 interleukins. Correlation and grouped analyses were conducted to determine the independent effects of clinical parameters and other cytokines on VEGF-A and PLGF concentration or fluctuation. This study set a self-control ***: VEGF-A(P=0.038) and PLGF(P=0.026) were the only two increased cytokines after IPT. Preoperative and postoperative level of VEGF-A and PLGF(r=0.575, P=0.013;r=0.987, P<0.001) correlated with each other significantly. Level of VEGF-A(r=0.626, P=0.005;r=0.588, P=0.01) and PLGF(r=0.616, P=0.007;r=0.588, P=0.01) had positive correlation with tumor thickness consistently. Elevated VEGF-A or PLGF level were strong predictive factors of each other(P=0.007, OR=60.0). The elevated VEGF-A group showed a higher postoperative level of IFN-γ(P=0.005), IL-2(P<0.001) and IL-10(P=0.004) in aqueous humor. When the elevated PLGF group got similar results that a higher postoperative level of IFN-γ(P=0.007), IL-2(P<0.001) and IL-10(P=0.013) in aqueous humor. CONCLUSION: This study reveals that VEGF-A and PLGF in aqueous humor s

关键词： uveal melanoma vascular endothelial growth factor-A radioplaque therapy placental growth factor