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Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 1-13页

作者： Li Xu wen-Jun Chen Cai-Jun Tian Yan zhang Yan Ma Tian-Hao Li Hong-Jie Liu zhe zhang Department of the First College English College of Foreign LanguageShandong University of Traditional Chinese MedicineJinanChina Department of Oncology Linyi People's HospitalLinyiChina Department of Internal Medicine of Traditional Chinese Medicine The First Clinical CollegeShandong University of Traditional Chinese MedicineJinanChina Department of Chinese Materia Medica College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Department of Medicinal Chemistry College of PharmacyShandong University of Traditional Chinese MedicineJinanChina Community Healthcare Center Shenzhen Traditional Chinese Medicine HospitalShenzhenChina Department of Fundamentals of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Shandong Co-Innovation Center of Classic TCM Formula College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina

Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve randomized controlled trials(RCTs)of CHMs combined with tacrine,galantamine,rivastigmine,donepezil,or memantine,following strict inclusion and exclusion *** research papers published in English,Chinese,and Japanese were *** primary outcome was the mini-mental state examination(MMSE)score and the secondary outcomes were AD assessment scale cognitive subscale(ADAS-Cog)score and safety ***-analysis was carried out using Rev Man 5.3 and subgroup analysis was conducted to identify the sources of ***:A total of 15 RCTs with 1386 participants were included in this *** donepezil was used in the retrieved ***-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score(z=9.45;Pz=5.53;Pzil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.

关键词： Alzheimer's disease Chinese herbal medicine donepezil memantine meta-analysis randomized controlled trials rivastigmine

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Insight into structural degradation of NCMs under extreme fast charging process

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Rare Metals 2024年第1期43卷 41-50页

作者： Yu Tang Xing-Yu Wang Jin-Can Ren Bo-wen Chen zhi-Yong Huang Wei Wang Ya-Lan Huang Bing-Hao zhang Si Lan zhang-Long He Qi Liu Hao He Department of Physics City University of Hong KongHong Kong 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China College of Materials Science and Engineering Changsha University of Science&TechnologyChangsha 410114China

Lithium-ion batteries(LIBs)with extreme fast charging(XFC)capability are considered an effective way to alleviate range anxiety for electric vehicle(EV)*** to the high ionic and electronic conductivity of LiNi_(x)Co_(y)Mn_zO_(2)(x+y+z=1,NCM)cathodes,the inevitable Li plating of graphite in NCM|graphite cell is usually identified as a key bottleneck for XFC ***,the capacity decay mechanism of cathode materials under XFC has not been fully *** this work,three typical NCM cathode materials with different Ni fractions were chosen and their electrochemical performances under XFC associated with structural evolution were investigated.A faster capacity decay of NCMs under XFC conditions is observed,especially for Ni-rich ***-situ X-ray diffraction(XRD)reveals that the multiple caxis parameters appear at the high-voltage regions in Nirich NCMs,which is probably triggered by the larger obstruction of Li(de)***,NCMs with moderate Ni fraction also present a similar trend under XFC *** phenomenon is more detrimental to the structural and morphological stability,resulting in a faster capacity decay than that under low current *** work provides new insight into the degradation mechanism of NCMs under XFC conditions,which can promote the development of NCM cathode materials with XFC capability.

关键词： Lithium-ion batteries Ni fraction Extreme fast charging Structural evolution

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脐血IL-25、IL-33水平与早期婴儿湿疹的相关性研究

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中国儿童保健杂志 2024年第2期32卷 196-201页

作者：杨云月王文革谭汉旭杨云彦卢旭俊北京中医药大学东直门医院儿科北京100700 空军军医大学空军特色医学中心儿科北京100142

目的探索新生儿脐血白细胞介素25(IL-25)、白细胞介素33(IL-33)水平与42d内婴儿湿疹发病的相关性,以期为早期婴儿湿疹的预防提供理论支持。方法选取2020年10月-2021年10月在空军特色医学中心妇产科出生的符合纳入标准的145例新生儿为... 详细信息

目的探索新生儿脐血白细胞介素25(IL-25)、白细胞介素33(IL-33)水平与42d内婴儿湿疹发病的相关性,以期为早期婴儿湿疹的预防提供理论支持。方法选取2020年10月-2021年10月在空军特色医学中心妇产科出生的符合纳入标准的145例新生儿为研究对象,出生时收集脐带静脉血并测定脐血中IL-25及IL-33水平;42d后随访记录婴儿湿疹的发病情况和严重程度。结果在145例婴儿中,有79例患湿疹,患病率为54.5%。湿疹组脐血IL-25水平明显低于无湿疹组(z=4.957,Pz=4.594,P21.1pg/mL)是影响42d婴儿湿疹发生的危险因素(OR值分别为4.296、4.034、2.759,P0.05)。其中,脐血IL-33水平与分娩方式有关(P22.1pg/mL(敏感度为64.6%,特异度为69.7%)。Spearman相关性检验发现脐血IL-33水平与湿疹面积和严重程度指数(EASI评分)具有线性相关性(r=0.398,P<0.001)。结论家族过敏史、较低水平的脐血IL-25及较高水平的脐血IL-33是42d婴儿湿疹的重要影响因素,且较高水平的脐血IL-33会加重42d婴儿湿疹的严重程度。

关键词：脐血婴儿湿疹白细胞介素25 白细胞介素33

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Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 242-253页

作者： zHU Qian Rang KOK E Dieuwertje BEKELE Hailu Tesfaye MANUSAMA Koen zHANG Jing Xian XIE Wei zONG wen Qi zUO Hui zHANG Jian KAMPMAN Ellen DAI Yue Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient

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Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 343-353页

作者： Li-Xiang Liu Hao Wang Bo Gao Ting-Ting Xu Qing-Gang Yuan Shi-zhen zhou Chao Ding Ji Miao wen-Xian Guan Department of General Surgery Nanjing Drum Tower HospitalNanjing Drum Tower Hospital Clinical CollegeNanjing Medical UniversityNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Clinical Nutrition Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina Department of General Surgery Nanjing Drum Tower Clinical College of Xuzhou Medical UniversityNanjing 210008Jiangsu ProvinceChina

BACKGROUND The controlling nutritional status(CONUT)score effectively reflects a patient’s nutritional status,which is closely related to cancer *** study invest-igated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer,and compared the predictive ability of the CONUT score with other *** To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative *** This retrospective analysis included 217 patients with newly diagnosed *** CONUT score was calculated based on the serum albumin level,total lymphocyte count,and total cholesterol *** cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by the receiver operating characteristic *** associations between the CONUT score and the prognosis were performed using Kaplan-Meier curves and Cox regression *** Using the cutoff value of the CONUT score,patients were stratified into CONUT low(n=189)and CONUT high groups(n=28).The CONUT high group had worse overall survival(OS)(P=0.013)and relapse-free survival(RFS)(P=0.015).The predictive performance of CONUT was superior to the modified Glasgow prognostic score,the prognostic nutritional index,and the neutrophil-to-lymphocyte ***,the predictive performances of CONUT+tumor node metastasis(TNM)stage for 3-year OS[area under the receiver operating characteristics curve(AUC)=0.803]and 3-year RFS(AUC=0.752)were no less than skeletal muscle mass index(SMI)+TNM *** CONUT score was negatively correlated with SMI(P<0.01).CONCLUSION As a nutritional indicator,the CONUT score could predict long-term outcomes after radical surgery for colorectal cancer,and its predictive ability was superior to other *** correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.

关键词： Controlling nutritional status Colorectal cancer Prognostic marker Sarcopenia Skeletal muscle

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Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

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zoological Research 2024年第2期45卷 233-241页

作者： Peng Li Ting zhang Ruo Wu Jun-Yu zhang Yan zhuo Shan-Gang Li Jiao-Jian Wang wen-Ting Guo zheng-Bo Wang Yong-Chang Chen State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Neural tube defects(NTDs)are severe congenital neurodevelopmental disorders arising from incomplete neural tube *** folate supplementation has been shown to mitigate the incidence of NTDs,some cases,often attributable to genetic factors,remain *** SHROOM3 gene has been implicated in NTD cases that are unresponsive to folate supplementation;at present,however,the underlying mechanism remains *** tube morphogenesis is a complex process involving the folding of the planar epithelium of the neural *** determine the role of SHROOM3 in early developmental morphogenesis,we established a neuroepithelial organoid culture system derived from cynomolgus monkeys to closely mimic the in vivo neural plate *** of SHROOM3 resulted in shorter neuroepithelial cells and smaller *** morphological changes were attributed to the insufficient recruitment of cytoskeletal proteins,namely fibrous actin(F-actin),myosin II,and phospho-myosin light chain(PMLC),to the apical side of the neuroepithelial ***,these defects were not rescued by folate *** sequencing revealed that differentially expressed genes were enriched in biological processes associated with cellular and organ *** summary,we established an authentic in vitro system to study NTDs and identified a novel mechanism for NTDs that are unresponsive to folate supplementation.

关键词： Neural tube defects SHROOM3 Neuroepithelial Organoids Cynomolgus monkey

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电磁式线-角振动激振器气隙磁场特性分析

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计量学报 2024年第6期45卷 857-863页

作者：俞金辉唐波陈伟杨建根何闻中国计量大学计量测试工程学院浙江杭州310018 宁波水表(集团)股份有限公司浙江宁波315033 浙江大学浙江省先进制造技术重点实验室浙江杭州310027

针对传统单轴激振器无法复现线-角空间耦合运动的问题,提出了一种可实现复合振动的电磁式线-角振动激振器磁路结构,并对其气隙磁场特性进行分析。首先构建了激振器的磁路和线圈结构,基于等效电流法,建立了气隙磁场的解析模型,与有限元... 详细信息

针对传统单轴激振器无法复现线-角空间耦合运动的问题,提出了一种可实现复合振动的电磁式线-角振动激振器磁路结构,并对其气隙磁场特性进行分析。首先构建了激振器的磁路和线圈结构,基于等效电流法,建立了气隙磁场的解析模型,与有限元分析结果的最大相对误差为1.25%,验证了解析模型的正确性;接着研究了各磁路参数对气隙磁场分布特性的影响规律,以及线圈电流产生的磁场与原磁场的耦合效应,并分析了线圈在运动过程中的受力情况;最后研制了激振器磁路拓扑结构样机,分别对线、角振动气隙磁场进行了实验测量,测得结果与有限元计算结果的最大相对误差小于5%,进一步验证了所提出磁路结构的有效性。

关键词：振动计量激振器等效电流法线-角振动气隙磁场电磁耦合

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基于BOPPPS教学模式的软件应用课程教学探讨——以“地下结构分析及软件应用”课程为例

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教育教学论坛 2024年第32期 132-135页

作者：杨文波西南交通大学土木工程学院四川成都610031

随着我国经济的飞速发展,软件应用也在不断进步。针对软件应用课程教学中存在的一些问题,包括轻实践、重理论,学生积极性不高,教学目标不明确,等等。通过引入BOPPPS教学模式,同时结合“地下结构分析及软件应用”课程的特色,从教学导入... 详细信息

随着我国经济的飞速发展,软件应用也在不断进步。针对软件应用课程教学中存在的一些问题,包括轻实践、重理论,学生积极性不高,教学目标不明确,等等。通过引入BOPPPS教学模式,同时结合“地下结构分析及软件应用”课程的特色,从教学导入、学习目标、教学前测、参与式学习、教学后测及课后总结等六大模块探讨了该课程的具体教授过程,以期更好地组织教学内容和过程,提高学生的学习效果和参与度,也为软件应用类课程提供一种教学改革思路和方向。

关键词： BOPPPS 教学模式数值模拟地下结构软件应用

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基于低频外差干涉的光纤环形器重合度检测

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物理学报 2024年第8期73卷 138-147页

作者：戴玉张文喜孔新新沈杨翊徐豪张晓强中国科学院空天信息创新研究院北京100094 中国科学院大学光电学院北京101400

光纤点衍射环形器是激光相干多普勒测振系统中光纤光路和空间光光路耦合的关键器件,其耦合效率等性能参数对测振系统测量准确度和测量距离的提升具有重要意义.常规环形器重合度检测采用能量监测法和远场重合度监测法,不能对光纤失配因... 详细信息

光纤点衍射环形器是激光相干多普勒测振系统中光纤光路和空间光光路耦合的关键器件,其耦合效率等性能参数对测振系统测量准确度和测量距离的提升具有重要意义.常规环形器重合度检测采用能量监测法和远场重合度监测法,不能对光纤失配因素进行定量分析,环形器耦合效率的一致性无法保障.针对上述问题,提出了一种基于低频外差干涉的相位检测技术,利用干涉相位信息进行光纤相对姿态解算,可有效解决光纤环形器重合度定量检测的问题.对不同光纤相对姿态形成的干涉波前进行了仿真分析和实验验证,给出了光纤相对横向位移、纵向位移和光轴偏离角度与干涉相位PV(peak-to-valley)值、zernike系数和环形器耦合效率间的规律,实现了干涉相位到光纤失配因素的分离解算,解算结果可指导光纤相对姿态的调整.最后通过实验验证了该技术的可行性,结果表明该技术对于光纤横向位移的检测精度优于1μm,为提升光纤环形器重合度提供了新的检测途径.

关键词：光纤失配对准误差外差干涉测量耦合效率

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TCP-1,a novel peptide to diagnose early colon cancer

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Chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu Baoying wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen zhang Yan Li Chi-Hin Cho Chongjing zhang Xiaoguang Chen Yan Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1)showed excellent specificity for colon ***-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1 to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1,keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1 in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1 was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1 to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1(reduced by almost 35%)and 2-fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1 in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

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