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China stroke surveillance report 2021

Military Medical Research 2024年第3期11卷 374-399页

作者： wen-Jun Tu Long-De Wang 无 Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China School of Public Health Peking UniversityBeijing 100191China Special Writing Group of China Stroke Surveillance Report

Since 2015,stroke has become the leading cause of death and disability in China,posing a significant threat to the health of its citizens as a major chronic non-communicable *** to the China Stroke High-risk Population Screening and Intervention Program,an estimated 17.8 million[95%confidence interval(CI)17.6–18.0million]adults in China had experienced a stroke in 2020,with 3.4 million(95%CI 3.3–3.5 million)experiencing their first-ever stroke and another 2.3 million(95%CI 2.2–2.4 million)dying as a ***,approximately 12.5%(95%CI 12.4%–12.5%)of stroke survivors were left disabled,as defined by a modified Rankin Scale score greater than 1,equating to 2.2 million(95%CI 2.1–2.2 million)stroke-related disabilities in *** the population ages and the prevalence of risk factors like diabetes,hypertension,and hyperlipidemia continues to rise and remains poorly controlled,the burden of stroke in China is also increasing.A large national epidemiological survey initiated by the China Hypertension League in 2017 showed that the prevalence of hypertension was 24.7%;the awareness,treatment,and control rates in hypertensive patients were:60.1%,42.5%,and 25.4%,respectively.A nationally representative sample of the Chinese mainland population showed that the weighted prevalence of total diabetes diagnosed by the American Diabetes Association criteria was 12.8%,suggesting there are 120 million adults with diabetes in China,and the awareness,treatment,and control rates in diabetic patients were:43.3%,49.0%,and 49.4%,***“Sixth National Health Service Statistical Survey Report in 2018”showed that the proportion of the obese population in China was 37.4%,an increase of 7.2 points from *** from 1599 hospitals in the Hospital Quality Monitoring System and Bigdata Observatory Platform for Stroke of China(BOSC)showed that a total of 3,418,432 stroke cases[mean age±standard error(SE)was(65.700±0.006)years,and 59.1%were male]were admitted dur

关键词： Stroke Epidemiological characteristics Treatment Prognosis China

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Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for STING-Mediated Cancer Immunotherapy

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CCS Chemistry 2024年第1期6卷 177-195页

作者： Lang zhao Shao-Hua zhuo Tian-yang Wang Jun-Jun Wu Jing-Yun Su wen-Hao Li Bo-Dou zhang Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain Disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CDNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CDNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CDNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CDN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CDNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CDN NPs promote cellular uptake of CDNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CDN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CDN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

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Flexner's legacy and the future of medical education:Embracing challenge and opportunity

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World Journal of Clinical Cases 2024年第33期12卷 6650-6654页

作者： Quzhen zeren Yan zeng Jun-wen zhang Jian yang Department of Gastroenterology Changdu People's Hospital of XizangChangdu 854000Tibet Autonomous RegionChina Department of Psychology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

This editorial comments on the article by *** focus on the development course,present challenges,and future perspectives of medical *** medical education is gradually undergoing significant and profound changes *** emergence of new ideas,methodologies,and techniques has created opportunities for medical education developments and brought new concerns and challenges,ultimately promoting virtuous progress in medical education *** sustainable development of medical education needs joint efforts and support from governments,medical colleges,hospitals,researchers,administrators,and educators.

关键词： Medical education Medical education reform Abraham Flexner's report Educational administration Challenge and opportunity

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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-Min Wang Min-Yue Xie Yi-Qing Sun Xiao-Huan zhao Yu-Hong Chen Jie-Qiong Chen Si-yang Han Min-wen zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

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A Review on Engineering Design for Enhancing Interfacial Contact in Solid-State Lithium–Sulfur Batteries

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Nano-Micro Letters 2024年第4期16卷 219-252页

作者： Bingxin Qi Xinyue Hong Ying Jiang Jing Shi Mingrui zhang wen Yan Chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116JiangsuPeople’s Republic of China

The utilization of solid-state electrolytes(SSEs)presents a promising solution to the issues of safety concern and shuttle effect in Li–S batteries,which has garnered significant interest ***,the high interfacial impedances existing between the SSEs and the electrodes(both lithium anodes and sulfur cathodes)hinder the charge transfer and intensify the uneven deposition of lithium,which ultimately result in insufficient capacity utilization and poor cycling ***,the reduction of interfacial resistance between SSEs and electrodes is of paramount importance in the pursuit of efficacious solid-state *** this review,we focus on the experimental strategies employed to enhance the interfacial contact between SSEs and electrodes,and summarize recent progresses of their applications in solidstate Li–S ***,the challenges and perspectives of rational interfacial design in practical solid-state Li–S batteries are outlined as *** expect that this review will provide new insights into the further technique development and practical applications of solid-state lithium batteries.

关键词： Solid-state lithium–sulfur batteries Solid-state electrolytes Electrode/electrolyte interface Interfacial engineering Enhancing interfacial contact

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Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer

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Military Medical Research 2024年第4期11卷 616-619页

作者： zhi-wen Luo Ya-Ying Sun Wei Xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-ze Dong Hui Chen Ren-wen Wan Shi-Yi Chen Jie Mei wen-Jun Mao Department of Sports Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalShanghai 200080China Department of Critical Care Medicine the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Department of Oncology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Guangdong Pharmaceutical University Guangzhou 510006China Institute of Acupuncture Research Institutes of Integrative MedicineFudan UniversityShanghai 200433China Department of Cardiothoracic Surgery the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina

Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are *** regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关键词： Physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME)

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Research on the variation of dielectric properties of oil-paper insulation for power equipment over a wide temperature range

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HIGH VOLTAGE 2024年第3期9卷 648-658页

作者： zhang, Mingze Yu, Muhe zhou, wen Liang, Yilin Lei, Shengjie Shi, Yunbo Qu, Limin Harbin Univ Sci & Technol Key Lab Engn Dielect & Its Applicat Minist Educ Harbin Peoples R China Harbin Univ Sci & Technol Sch Measurement & Commun Engn Harbin Peoples R China State Grid Heilongjiang Elect Power Co Ltd Elect Power Res Inst Harbin Peoples R China

The main part of oil-immersed power equipment is oil-paper insulation. At lower ambient temperatures, transformer oil will become viscous. As a result, compared to those at room temperature or operating temperature, the frequency domain dielectric properties of oil-paper insulation at low temperatures are drastically different. For evaluating the insulation condition of electrical equipment, it is essential to accurately determine their dielectric properties. This paper described the FDS test, the DC conductivity test, and the transformer oil viscosity test, which was carried out in a laboratory environment for different ageing of oil-immersed pressboard and transformer oil at 233-373 K. The effects of temperature on the dielectric properties at the competing mechanisms of polarisation and conductivity loss were clarified based on variations of the FDS curves. Considering the viscosity change of ageing transformer oil at low temperatures, the Arrhenius and VFT viscosity equations were used to achieve a fitting calculation in the different temperature zones. Based on the molecular/ion transition model in the force field and electric field, the characterisation relationships between the dynamic viscosity, DC conductivity, and test temperature of transformer oil were established. The limitations of conventional transformer oil equivalent dielectric relaxation models over a wide temperature range were finally clarified by combining the test findings of the DC conductivity over a wide temperature range with observed and simulated calculations. This paper provides an essential theoretical reference when using the FDS test to diagnose the insulation performance of oil-immersed power equipment in extremely cold regions.

关键词： QUANTITATIVE-ANALYSIS ACTIVATION-ENERGY TRANSFORMER OIL AGING CONDITION PRESSBOARD VISCOSITY

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Deformation of Rigid Conjugate Self-dual Galois Representations

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1599-1644页

作者： Yi Feng LIU Yi Chao TIAN Liang XIAO Wei zHANG Xin wen zHU Institute for Advanced Study in Mathematics Zhejiang UniversityHangzhou 310058P.R.China Morningside Center of Mathematics AMSSChinese Academy of SciencesBeijing 100190P.R.China New Cornerstone Lab Beijing International Center for Mathematical ResearchPeking Ui Beijing 100871P.R.China Department of Mathematics Massachusetts Institute of TechnologyCambridge MA 02139United States Department of Mathematics Stanford UniversityStanfordCA 94305United States

In this article,we study deformations of conjugate self-dual Galois *** study is ***,we prove an R=T type theorem for a conjugate self-dual Galois representation with coefficients in a finite field,satisfying a certain property called ***,we study the rigidity property for the family of residue Galois representations attached to a symmetric power of an elliptic curve,as well as to a regular algebraic conjugate self-dual cuspidal representation.

关键词： Galois deformation rigid conjugate self-dual Galois representations

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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： wen-Qian Ma Ming-Chang Miao Ping-An Ding Bi-Bo Tan wen-Bo Liu Shuo Guo Li-Mian Er zhi-Dong zhang Qun zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

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电磁场调制下的应变黑磷烯带间光电导

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物理学报 2024年第13期73卷 317-326页

作者：柏文庆杨江涛杨翠红陈云云南京信息工程大学物理与光电工程学院南京210044 南京信息工程大学江苏省大气海洋光电探测重点实验室南京210044 南京信息工程大学江苏省气象光子学与光电探测国际合作联合实验室南京210044

黑磷烯具有各向异性且独特的光电性能被广泛研究.应变、电压等常用来调制能带结构,进而调制其光电特性.本文采用紧束缚近似哈密顿量,考虑施加垂直磁场、电场、面内面外应变条件下的黑磷烯能带结构,进一步利用Kubo公式研究了黑磷烯光电... 详细信息

黑磷烯具有各向异性且独特的光电性能被广泛研究.应变、电压等常用来调制能带结构,进而调制其光电特性.本文采用紧束缚近似哈密顿量,考虑施加垂直磁场、电场、面内面外应变条件下的黑磷烯能带结构,进一步利用Kubo公式研究了黑磷烯光电导率在多个调制因子下的特征,并从能带结构进行了机理分析.垂直磁场使能带劈裂,产生多通道带间跃迁,光电导率表现出多个峰.随着面内拉伸应变增加能隙增加,光电导峰位依赖于能隙.而面外拉伸应变对能隙的调制区别于面内应变,能隙表现出非单调变化.电场通过带隙的变化,调制光电导率峰值位置.综合不同的调制因子,能带和光电导表现出丰富的调制效果,为研究基于黑磷烯光电器件的应用提供理论支持.

关键词：黑磷烯能带调控各向异性光电导

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