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Chinese Journal of Chemistry 2022年第4期40卷 475-479页

作者： wen-Fang yi Tiwalade A.Adelakun Xue Bai Yu Zhang Xiao-Jiang Hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Comprehensive Summary Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isolated from leaves of Tabernaemontana *** structures were established by a combination of HRESIMS,NMR,single crystal X-ray diffraction,and ECD *** unprecedented pen-ta-lactone ring in tabernaesine J(1)was postulated to be derived from acetyl-CoA enolate *** 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.

关键词： Natural products Alkaloids Structure elucidation Tabernaemontana pachysiphon Tabernaesine J

O-GlcNAcylation, a sweet link to the pathology of diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第5期20卷 437-448页

作者： Hao NIE wen yi MOE Laboratory of Biosystems Homeostasis&Protection College of Life SciencesZhejiang UniversityHangzhou 310058China

O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and *** donor sugar for O-Glc NAcylation,uridine-diphosphate N-acetylglucosamine(UDP-Glc NAc),is synthesized from glucose through the hexosamine biosynthetic pathway(HBP).The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase(OGT)and O-Glc NAcase(OGA),which catalyze the addition and removal of O-GlcNAc,respectively.O-GlcNAcylation is involved in a number of important cell processes including transcription,translation,metabolism,signal transduction,and *** of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer,diabetes,neurodegenerative diseases,and cardiovascular diseases.A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic *** aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases,and its potential as a new clinical target.

关键词： O-GlcNAcylation Cancer Diabetes Neurodegenerative disease Cardiovascular disease

Pier scour monitoring system by bed-level image tracking

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International Journal of Sediment Research 2014年第2期29卷 269-277页

作者： wen-yi CHANG Jihn-Sung LAI Teng-yi YU Franco LIN Lung-Cheng LEE Whey-Fone TSAI Chin-Hsiung LOH National Center for High-Performance Computing National Applied Research Laboratories Research fellow Hydrotech Research InstituteNational Taiwan University Department of Civil Engineering National Taiwan University

A scour monitoring system with a micro camera tracking the bed-level images is proposed in this *** image recognition algorithms have been developed to support the bed-level image tracking *** the laboratory experiments of pier scour,this study demonstrates that the proposed system is able to accurately monitor the scour-depth evolution in real *** addition,five commonly-used temporal scour models are employed to simulate scour-depth evolution and their results are compared with monitoring *** general,the results indicate that the proposed scour monitoring system has the potential for further applications in the field.

关键词： Pier scour Scour monitoring Image recognition Bed-level image tracking Scour prediction

Digital Autofocusing Method Based on Contourlet Transform

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Optoelectronics Letters 2007年第5期3卷 381-384页

作者： JIANG Gang-yi yi wen-juan YU Mei YANG Ming Faculty oflnformation Science and Engineering Ningbo University Ningbo 315211 China China Mobile Shenzhen Limited Shenzhen 518048 China National Key Laboratory of Machine Perception Peking University Beijing 100871 China

The autofocusing technique based on contourlet transform is discussed in this paper and an autofocusing method is proposed for images with much information in certain directions. The experimental results show that the proposed method can focus accurately and the sensitivity ratio is higher than that of the other autofocusing methods based on conventional image processing

关键词：图象处理自动对焦数字技术信号传输

Sensing properties and mechanisms of LaF_(3)-Co_(3)O_(4) nanorods for low-concentration methanol detection

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Rare Metals 2024年第5期43卷 2193-2204页

作者： Xiao-Xi He Hong-Feng Chai yi-wen Zhou Ke-Wei Liu Ze-Xin Yu Chao Zhang College of Mechanical Engineering Yangzhou UniversityYangzhou225127China Institutefor Manufacturing Technologies of Ceramic Components and Composites(IMTCCC) University of Stuttgart70569 StuttgartGermany

Methanol is one of the characteristic gases that distinguish between healthy individuals and lung cancer(LC)lesions in exhaled human *** concentration in exhaled breath is generally below one part per million(1×10^(-6)).The second-phase composite is widely regarded as one of the methods to improve the gas-sensing perfor-mance of metal oxide semiconductor(MOS)*** this study,LaF_(3)-Co_(3)O_(4) was synthesized by a simple hydrothermal method to enhance its low-concentration methanol gas-sensing performance.5 at%LaF_(3)-Co_(3)O_(4) nanorods exhibited excellent methanol detection performance,including a wider linear detection concentration range(0.2×10^(-6)~5×10^(-6)),a response value exceeding 4.0 for 1×10^(-6)methanol at 275°C and 75%relative humidity(RH),long-term stability(maximum deviation within 15%over 2 weeks),and excellent *** mechanism of performance enhancement was studied using various techniques,and density functional *** special spinel structure of Co_(3)O_(4),the high ionic migration of F-in LaF_(3),the larger specific surface area of 5 at%LaF_(3)-Co_(3)O_(4) nanorods,and the generated crystal defects all explain the excellentmethanol gas-sensing *** work provides a novel route to prepare MOS composite materials for low-concentration methanol gas detection.

关键词： Gas sensor LaF_(3) Co_(3)O_(4) Methanol Lung cancer

Research on the System of China's Civil Service

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Research on the System of China's Civil Service

Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles(Ⅱ):From triazolothiadiazines to pyrazolotriazoles

2012年公共管理国际会议

作者： WANG yi-wen SUN Zhao-hui Department of School of Humanities and Social Sciences North China Electric Power University

ISBN: (纸本)9787564710316

The civil service system in China began in the mid-1980s, has experienced nearly three decades of reform and development and has been great progress. With the building of our democracy and the rule of law, the civil service is also expanding the civil service system will continue to improve. In order to ensure the civil service system going toward a reasonable direction, this paper will make analysis of the present situation of China’s civil service system and explore the issue of the civil service system.

关键词： Civil service system Developing Perfect

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Chinese Chemical Letters 2011年第7期22卷 804-806页

作者： Guo Qiang Hu Li Li Hou Yong Yang Lei yi Song Qiang Xie Guo Qiang Wang Nan Nan Duan Tie Yao Chao Xiao yi wen wen Long Huang Institute of Chemistry & Biology Henan University Kaifeng 475001 China China Pharmaceutical University Nanjing 210009 China

To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [ 1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial FQs, and their in vitro antitumor activity against L1210, CHO cell lines were evaluated via their respective IC50 values.

关键词： Fluoroquinolone Triazolothiadiazine Pyrazolotriazole Antitumor evaluation

Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

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Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： yi Liu Zhe-Hao Wang Guan-Hua Xue Lin Chen Li-Hua Yuan yi-wen Li Da-Gang Yu Jian-Heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

Effect of Powder Particle Size on Microstructure and Mechanical Property of Ni-Based P/M Superalloy Product

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Journal of Iron and Steel Research International 2003年第3期10卷 71-74页

作者： ZHANG ying ZHANG yi-wen ZHANG Feng-ge TAO Yu CHEN Xi-chun Central Iron and Steel Research Institute

The solid sintering behavior and mechanical properties of Fe Ni powders prepared by mechanical alloying of elemental powders and hot pressing sintering in vacuum atmospheres were investigated. It was observed that the microstructure of the powder particles evolves in three stages. The alloy powder with average grain size of 20-30 nm was obtained. The sinter densification depends crucially on the particle rearrangement and the large amount of internal strain introduced during milling. The theoretical density of over 95 % was obtained after hot pressing sintering at 800 ℃ for 30 min with pressure of 50 MPa. No significant grain growth was observed during sintering. And also relatively high hardness was obtained.

关键词： mechanical alloying nanostructured material mechanical property hot pressing sintering

IFN-γ increases efficiency of DNA vaccine in protecting ducks against infection

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World Journal of Gastroenterology 2005年第32期11卷 4967-4973页

作者： Jian-Er Long Li-Na Huang Zhi-Qiang Qin wen-yi Wang Di Qu Department of Molecular Virology Shanghai Medical College Fudan University Shanghai 200032 China Shanghai Institute of Medical Genetics Shanghai Children's Hospital Shanghai Jiaotong University Shanghai 200040 China

AIM： To detect the effects of DNA vaccines in combination with duck IFN-γ gene on the protection of ducks against duck hepatitis B virus （DHBV） infection. METHODS： DuIFN-γ cDNA was cloned and expressed in COS-γ cells, and the antiviral activity of DuIFN-γ was detected and neutralized by specific antibodies, Ducks were vaccinated with DHBpreS/S DNA alone or coimmunized with plasmid expressing DuIFN-γ. DuIFN-γ mRNA in peripheral blood mononuclear cells （PBMCs） from immunized ducks was detected by semi-quantitative competitive RT-PCR. Anti-DHBpreS was titrated by enzyme-linked immunosorbent assay （EUSA）. DHBV DNA in sera and liver was detected by Southern blot hybridization, after ducks were challenged with high doses of DHBV. RESULTS： DuIFN-γ expressed by COS-γ was able to protect duck fibroblasts against vesicular stomatitis virus （VSV） infection in a dose-dependent fashion, and anti DuIFN-γ antibodies neutralized the antiviral effects. DuIFN-γ in the supernatant also inhibited the release of DHBV DNA from LMH-D2 cells. When ducks were co-immunized with DNA vaccine expressing DHBpreS/S and DuIFN-γ gene as an adjuvant, the level of DuIFN-γ mRNA in PBMCs was higher than that in ducks vaccinated with DHBpreS/S DNA alone. However, the titer of anti-DHBpreS elicited by DHBpreS/S DNA alone was higher than that co-immunized with DuIFN-γ gene and DHBpreS/S DNA. After being challenged with DHBV at high doses, the load of DHBV in sera dropped faster, and the amount of total DNA and cccDNA in the liver decreased more significantly in the group of ducks co-immunized with DuIFN-γ gene and DHBpreS/S DNA than in other groups.

关键词： Duck IFN-γ DHBV DNA vaccine Immuneadjuvant