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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu wei-Jie Guan Yi-lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing sun Jincun Zhao wen-liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China guangzhou National Laboratory GuangzhouP.R.China school of life sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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Distribution and germination of viable diatom resting stage cells in sediments of the East china Sea

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Acta Oceanologica Sinica 2010年第5期29卷 121-128页

作者： ZHANG Yuyu LU Songhui ZHANG Chuansong GAO Yahui Key Laboratory of Ministry of Education for Coast and Wetland Ecosystems School of Life Sciences Xiamen University Xiamen 361005 China Research Center for Harmful Algae and Aquatic Environment Jinan University Guangzhou 510632 China College of life Science South China Normal University Guangzhou 510631 China College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266100 China

The abundance and temporal patterns of viable diatom resting stage cells in sediments of the East china Sea in 2006 have been *** abundance of viable resting stages was enumerated with the most probable number（MPN） ***,25 diatom species（including varieties） belonging to 16 genera were *** resting stage cells were common,on the order of 103 to 106 cells/g dry *** abundant taxa included Skeletonema marina,***,Chaetoceros curvisetus and Thalassiosira spp.,with Skeletonema accounting for 83.3% of the *** effects of temperature（10,15,20,25 ℃）,salinity（20,25,30,35 psu） and light intensity（0,300,4 000,8 000 lux） on the germination of resting stages in sediment samples were also *** results showed that light intensity had a significant positive effect on the germination of diatom resting stage cells（p 〈0.01） and that diatoms could not germinate in *** and salinity had no noticeable effects on the *** present study suggests that there are abundant diatom resting cells in sediments of the East china Sea,which could serve as a ＂seed bank＂ in the phytoplankton population succession and contribute to the initiation of algal blooms.

关键词： diatom germination MPN resting stages seed bank sediment

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Blind signal separation of underdetermined mixtures based on clustering algorithms on planes

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Progress in Natural Science:Materials International 2007年第6期17卷 670-674页

作者： Xie Shengli, Tan Beihai and Fu Yuli(school of Electronics & Information Engineering, south china university of Technology, guangzhou 510640, china) [a]school of Electronics & Information Engineering South China University of Technology Guangzhou China

Based on clustering method on planes, blind signal separation (BSS) of underdetermined mixtures with three observed signals is discussed. The condition of sufficient sparsity of the source signals is not necessary when clustering method on planes is used. In other words, it needs not that only one source signal plays the main role among others at one time. The proposed method uses normal line clustering of planes first. Then, the mixing matrix can be identified via deciding the intersection lines of the planes. This method is an effective implement of the new theory presented by Georgiev. Simulations illustrate accuracy and restoring capability of the method to estimate the mixing matrix.

关键词： underdetermined mixture sparse representation mixing matrix blind signal separation.

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Synthesis,characterization,structures and magnetic property of chiral oxalate-bridged dicopper(Ⅱ) complexes

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Science china Chemistry 2010年第6期53卷 1255-1260页

作者： WU ling1,WANG Jun2,ZHU CaiFei1,liN YiJi1,CHEN LeiQi1,FAN Jun2 & ZHANG Hui1 1State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen university,Xiamen 361005,china 2school of Chemistry and Environment,south china normal university,guangzhou 510006,china 1. State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China2. School of Chemistry and Environment South China Normal University Guangzhou 510006 China

The oxalato-bridged dicopper(II) complexes [Cu2(μ-ox)(LRR)2(H2O)2(ClO4)2] (1),[Cu2(μ-ox)(LRR)2(CH3COCH3)2(ClO4)2](1a),[Cu2(μ-ox)(LSS)2(H2O)2(ClO4)2] (2) and [Cu2(μ-ox)(LRR)(LSS)2(CH3COCH3)2(ClO4)2] (3) [LRR = (8R,10R)-(-)-[4,5]-pineno2,2′-bipyridine,LSS = (8S,10S)-(+)-[4,5]-pineno-2,2′-bipyridine;ox2= oxalate] were first prepared.A possible mechanism for the formation of the chial dicopper(II) complexes was *** on elemental analysis,conductance measurement,UV-Vis spectra,CD spectra and X-ray single-crystal diffraction,the oxalato-bridged structures of 1 and 2 were deduced to adopt two Cu(II) ions and the bridged oxalate lying in the nearly same *** crystal structures of 1a and 3 reveal that the coordination geometry around each Cu(II) ion is an elongated and distorted octahedron and two axial solvent molecules and two perchlorate ions are anti to each other respectively in both binuclear *** solution CD spectra of 1 and 2 in the visible d-d range show very weak Cotton effects with peaks at 588 and 779 nm,which are approximately of mirror image,suggesting the optical activities may be derived from the vicinal effects of the chiragenic centers at the pinene group of LRR and LSS,*** 1 has been characterized by variable-temperature magnetic susceptibility and the data was least-square fitted to the Blenaey-Bowers *** exchange integral J was found to be -338.41(4) cm-1,indicating a strong antiferromagnetic interaction between two copper(II) ions.

关键词： dicopper(II) complex chiral bipyridine μ-oxalate bridge crystal structure CD spectroscopy magnetic property

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The Perturbation Bound of the Extended Vertical linear Complementarity Problem

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Journal of the Operations Research Society of china 2024年第3期12卷 601-625页

作者： Shi-liang Wu wen li He-Hui Wang school of Mathematics Yunnan Normal UniversityKunming650500YunnanChina school of mathematical sciences South China Normal UniversityGuangzhou510631GuangdongChina school of Mathematics and Statistics Yunnan UniversityKunming650091YunnanChina

In this paper,we discuss the perturbation analysis of the extended vertical linear complementarity problem(EVLCP).Under the assumption of the row W-property,we derive several absolute and relative perturbation bounds ... 详细信息

关键词： The extended vertical linear complementarity problem The row W-property The perturbation bound

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Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

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World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： Jian-Ping wen Shuan-Ji Ou Jia-Bao liu wei Zhang Yu-Dun Qu Jia-Xuan li Chang-liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second school of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were china,Shanghai Jiao Tong university of china,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： Diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

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Artificial synaptic simulating pain-perceptual nociceptor and brain-inspired computing based on Au/Bi_(3.2)La_(0.8)Ti_(3)O_(12)/ITO memristor

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Journal of Materiomics 2024年第6期10卷 1308-1316页

作者： Hao Chen Zhihao Shen wen-Tao Guo Yan-Ping Jiang wenhua li Dan Zhang Zhenhua Tang Qi-Jun sun Xin-Gui Tang school of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou510006China

Recently, memristors have garnered widespread attention as neuromorphic devices that can simulate synaptic behavior, holding promise for future commercial applications in neuromorphic computing. In this paper, we present a memristor with an Au/Bi_(3.2)La_(0.8)Ti_(3)O_(12) (BLTO)/ITO structure, demonstrating a switching ratio of nearly 103 over a duration of 104 s. It successfully simulates a range of synaptic behaviors, including long-term potentiation and depression, paired-pulse facilitation, spike-timing-dependent plasticity, spike-rate-dependent plasticity etc. Interestingly, we also employ it to simulate pain threshold, sensitization, and desensitization behaviors of pain-perceptual nociceptor (PPN). Lastly, by introducing memristor differential pairs (1T1R-1T1R), we train a neural network, effectively simplifying the learning process, reducing training time, and achieving a handwriting digit recognition accuracy of up to 97.19 %. Overall, the proposed device holds immense potential in the field of neuromorphic computing, offering possibilities for the next generation of high-performance neuromorphic computing chips.

关键词： Artificial synapse Memristor Resistive switching Pain-perceptual nociceptor Neuromorphic computing

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OBSERVATION ON DEFECTS IN POLYCRYSTALliNE SIliCON THIN FILMS

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 295-299页

作者： Y.F. Hu1), H. Shen2), L. Wang3), Z.C. liang3), Z.Y. liu1) and L.S. wen1) 1) College of Mechanical Engineering, south china university of Technology, Guan gzhou 510640, china 2) The school of Physics and Engineering, Zhongshan university, guangzhou 510275 , china 3) guangzhou Institute of Energy Conversion, The Chinese Academy of sciences, G uangzhou 510640, china College of Mechanical Engineering South China University of Technology Guangzhou 510640China The school of Physics and Engineering Zhongshan University Guangzhou 510275China guangzhou Institute of Energy Conversion The Chinese Academy of Sciences Guangzhou 510640China

Polycrystalline silicon thin films were prepared by RTCVD (rapid thermal chemica l vapor deposition) method on several substrates such as SSP (silicon sheet from powder) ribbon, poly-Si wafer and mono-Si wafer. Intra-granular defects such as stacking faults, twins and microstructure defects were investigated on thin fil ms by scan electron microscopy (SEM) technique.

关键词： poly-Si thin film intra-granular defects surface cross-section

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Biomolecular condensates and disease pathogenesis

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Science china(life sciences) 2024年第9期67卷 1792-1832页

作者： Ke Ruan Ge Bai Yanshan Fang Dan li Tingting li Xingguo liu Boxun Lu Qing Lu Zhou Songyang Shuguo sun Zheng Wang Xin Zhang wen Zhou Hong Zhang The First Affiliated Hospital&school of life sciences Ministry of Education Key Laboratory for Membrane-less Organelles&Cellular DynamicsHefei National Research Center for Interdisciplinary Sciences at the MicroscaleCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Nanhu Brain-computer Interface Institute Hangzhou 311100China Department of Neurology of Second Affiliated Hospital and school of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou 310058China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China university of Chinese Academy of sciences Beijing 100049China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China CAS Key Laboratory of Regenerative Biology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Joint school of life sciences Guangzhou Medical UniversityGuangzhou 510000China Neurology Department at Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceSchool of Life SciencesFudan UniversityShanghai 200433 China Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of EducationBio-X InstitutesShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Biocontrol MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging ResearchSchool of Life SciencesSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510275China Department of Human Anatomy Hist

Biomolecular condensates or membraneless organelles(MLOs)formed by liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific *** of LLPS or aberrant phase transition that disturbs the formation or material states of MLOs is closely correlated with neurodegeneration,tumorigenesis,and many other pathological ***,we summarize the recent progress in development of methods to monitor phase separation and we discuss the biogenesis and function of MLOs formed through phase *** then present emerging proof-of-concept examples regarding the disruption of phase separation homeostasis in a diverse array of clinical conditions including neurodegenerative disorders,hearing loss,cancers,and immunological ***,we describe the emerging discovery of chemical modulators of phase separation.

关键词： liquid-liquid phase separation biomolecular condensate membraneless organelle

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Object use in insects

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Insect Science 2024年第4期31卷 1001-1014页

作者： Chao wen Cai Wang Xiaoli Guo Hongyu li Haijun Xiao Junbao wen Shikui Dong school of Grassland Science Beijing Forestry UniversityBeijingChina College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhouChina Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijingChina

Insects are the most diverse group of organisms in the animal kingdom,and some species exhibit complex social *** research on insect object use is still in its early stages,insects have already been shown to display rich object-use *** review focuses on patterns and behavioral flexibility in insect object-use behavior,and the role of cultural evolution in the development of object-use *** use in insects is not widespread but has been documented in a diverse set of *** insects can use objects flexibly and display various object-use *** mammals and birds,insects use objects in diverse activities,including foraging,predator defense,courtship,and ***,pre-existing manipulative behaviors,and anatomical structure affect innovations in object *** addition,learning and imitation are the main mechanisms underlying the spread of object-use behaviors within *** that insects are one of the major animal groups engaging in object use,studies of insect object use could provide general insights into object use in the animal kingdom.

关键词： cognition evolution insects learning object use

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