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Dual roles of α1,4-galactosyltransferase 1 in spermatogenesis of Drosophila melanogaster

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INSECT SCIENCE 2025年第1期32卷 127-139页

作者： Xiao, Yanhong Huang, Bo Chen, Sibo Lin, Zhikai Zhu, Zhiying Lu, Yuzhen Yu, Xiao-Qiang wen, liang Hu, Qihao South China Normal Univ Sch Life Sci Guangdong Prov Key Lab Insect Dev Biol & Appl Tech Guangzhou Key Lab Insect Dev Regulat & Applicat Re Guangzhou 510631 Peoples R China Cent China Normal Univ Sch Life Sci Hubei Key Lab Genet Regulat & Integrat Biol Wuhan Peoples R China

Spermatogenesis is critical for insect reproduction and the process is regulated by multiple genes. Glycosyltransferases have been shown to participate in the development of Drosophila melanogaster;however, their role in spermatogenesis is still unclear. In this study, we found that alpha 1,4-galactosyltransferase 1 (alpha 4GT1) was expressed at a significantly higher level in the testis than in the ovary of Drosophila. Importantly, the hatching rate was significantly decreased when alpha 4GT1 RNA interference (RNAi) males were crossed with w1118 females, with only a few mature sperm being present in the seminal vesicle of alpha 4GT1 RNAi flies. Immunofluorescence staining further revealed that the individualization complex (IC) in the testes from alpha 4GT1 RNAi flies was scattered and did not move synchronically, compared with the clustered IC observed in the control flies. Terminal deoxyribonucleotide transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay showed that apoptosis signals in the sperm bundles of alpha 4GT1 RNAi flies were significantly increased. Moreover, the expression of several individualization-related genes, such as Shrub, Obp44a and Hanabi, was significantly decreased, whereas the expression of several apoptosis-related genes, including Dronc and Drice, was significantly increased in the testes of alpha 4GT1 RNAi flies. Together, these results suggest that alpha 4GT1 may play dual roles in Drosophila spermatogenesis by regulating the sperm individualization process and maintaining the survival of sperm bundles.

关键词： apoptosis alpha 4GT1 galactosyltransferase individualization spermatogenesis

Investigations of inelastic cross sections of H_(2)O molecule by He^(2+) and C^(6+) projectiles with energy range around the Bragg peak

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Nuclear Science and Techniques 2025年第2期36卷 141-154页

作者： Guo-Zhuang Li Cheng-Ye Sun Rui Cheng Yan-Shi Zhang liang-wen Chen Sheng Zhang Xin-Xia Li Lei Yang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Interdisciplinary Center for Fundamental and Frontier Sciences Nanjing University of Science and TechnologyJiangyin 214443China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Inelastic collisions are the dominant cause of energy loss in *** the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead to energy *** study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H_(2)O molecules using He^(2+) and C^(6+) projectiles in the energy range of 10 keV/u to 10 MeV/*** total cross sections,single differential cross sections,impact parameter dependence of SI and SC,and fragmentation cross sections were *** illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak *** the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact *** the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(60°~120°)to large angles(60°~120°),and the removal of electrons is associated with small impact *** energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak *** fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated.

关键词： Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections

轻木人工林生长及各器官碳、氮、磷化学计量对氮添加的响应

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植物营养与肥料学报 2025年第1期31卷 188-200页

作者：文程敬吴俊文赵志娟陈刚李志琪段贵河杜官本梁文西南林业大学林学院云南昆明650224 西南林业大学材料与化工学院云南昆明650224 景洪市景洪农场有限责任公司云南西双版纳666303

【目的】研究轻木(Ochroma lagopus)人工林生长及各器官碳(C)、氮(N)、磷(P)化学计量特征对氮添加的响应,为轻木人工林的栽培提供理论依据。【方法】以两年生轻木为材料,在云南省勐腊县勐醒农场轻木人工林地进行田间试验,采用随机区组设... 详细信息

【目的】研究轻木(Ochroma lagopus)人工林生长及各器官碳(C)、氮(N)、磷(P)化学计量特征对氮添加的响应,为轻木人工林的栽培提供理论依据。【方法】以两年生轻木为材料,在云南省勐腊县勐醒农场轻木人工林地进行田间试验,采用随机区组设计,设置不施氮对照(CK)和施尿素、缓释肥300 g/株(N1、H1)、450g/株(N2、H2)、600 g/株(N3、H3) 7个处理,施肥时间为2023年6月,2023年10月取样,测定轻木树高、胸径,分析叶、枝、根中的C、N、P含量,并计算各器官化学计量特征值。【结果】与CK相比,低施氮量(N1、H1)处理的轻木胸径增加不显著,N1处理的树高增加也不显著,中、高施氮量处理(N2、N3、H2、H3)的胸径、树高均显著高于CK,但这4个处理间差异不显著。施氮对轻木枝和根中C含量无显著影响,但N3和H3降低了叶片中C含量;施氮显著提高枝、叶和根中N含量,且增幅随施氮量的增加而显著提高。施氮显著降低了叶片中P含量,降幅随施氮量的增加而显著升高,但H1处理的叶片P含量显著低于N1,而H2与N2,以及H3与N3处理之间无显著差异;N3、H3处理降低了树枝中P含量;施氮增加了根中P含量,且增幅随施氮量的增加而提高,N3处理的根中P含量显著高于N1处理,而3个硫包衣缓释肥处理间的根中P含量无显著差异。CK处理叶片N:P16,轻木生长由受N元素限制转变为受P元素限制,且H2、H3处理的叶片N:P显著高于N2、N3处理,即施用硫包衣缓释肥带来的磷限制大于尿素。相关性分析表明,轻木生长与各器官的养分含量及化学计量特征显著相关,且轻木生长受各器官的氮含量影响显著。表型可塑性与主成分分析结果显示,氮添加下轻木生长、各器官C、N、P含量及化学计量比特征的表型可塑性指数为0.05~0.52,主成分1和主成分2的累计方差贡献率为63.2%;轻木在氮添加处理下,主要通过调节各器官的N、P含量来适应外界变化,进而促进轻木的生长。【结论】氮添加对轻木人工林生长及各器官C、N、P化学计量特征有显著的影响,施用中、高量氮肥对提高轻木生长的效果优于低量氮肥,而且缓解了氮元素对轻木生长的限制,但影响了C、N、P在各器官中的分布,还引起了磷元素的限制,施用硫包衣缓释肥引起的磷元素限制更加严重。因此,在轻木人工林生产管理中,应注意氮肥的施用量,在施用硫包衣缓释肥时,尤其要注意补充磷肥。

关键词：轻木人工林氮添加化学计量特征相关性表型可塑性主要成分

Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets

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World Journal of Gastroenterology 2025年第9期31卷 9-29页

作者： Wang, Li Lian, Yan-Jie Dong, Jin-Sheng Liu, Ming-Kun Liu, Hong-liang Cao, Zheng-Min Wang, Qing-Nan Lyu, wen-liang Bai, Yu-Ning Department of Gastroenterology Guang’anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Division of Cardiovascular Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing 100010 China Department of Infectious Diseases Guang’anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Department of Dermatology Guang’anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China

Chronic atrophic gastritis (CAG) is an important stage of precancerous lesions of gastric cancer. Effective treatment and regulation of CAG are essential to prevent its progression to malignancy. Traditional Chinese medicine (TCM) has shown multi-targeted efficacy in CAG treatment, with advantages in enhancing gastric mucosal barrier defense, improving microcirculation, modulating inflammatory and immune responses, and promoting lesion healing, etc. Clinical studies and meta-analyses indicate that TCM provides significant benefits, with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation, anti-oxidation, and regulation of cellular proliferation and apoptosis, etc. Finally, it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards, and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function. © 2025 Baishideng Publishing Group Inc. All rights reserved.

关键词： Chronic atrophic Gastric mucosal barrier Traditional Chinese medicine

“双碳”目标驱动能源高质量发展的质态和策略研究

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齐齐哈尔大学学报(哲学社会科学版) 2025年第1期 32-35页

作者：叶文亮许婕东北林业大学马克思主义学院黑龙江哈尔滨150040

碳达峰、碳中和目标的提出为我国能源发展和转型指明了方向。实现“双碳”目标应先在能源供给中加快能源结构优化转型,即保障能源生产的优存量和拓增量,实现集中式能源向分布式能源稳步发展,推动区域能源结构转型升级。利用智能化手段... 详细信息

碳达峰、碳中和目标的提出为我国能源发展和转型指明了方向。实现“双碳”目标应先在能源供给中加快能源结构优化转型,即保障能源生产的优存量和拓增量,实现集中式能源向分布式能源稳步发展,推动区域能源结构转型升级。利用智能化手段和市场杠杆保持能源供需动态平衡,即提升“源网荷储”一体化能源消纳能力,加快能源互联网建设,推进全国统一能源大市场建设。同时,要始终坚持清洁低碳导向、自主可控原则、科技创新驱动、开放共赢共识,发挥理念引领力,最终实现能源绿色低碳转型。

关键词： “双碳”目标能源结构转型智能化绿色低碳

考虑防渗墙塑性损伤的深厚覆盖层上沥青混凝土心墙坝应力渗流分析

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水电能源科学 2025年第2期43卷 142-146,87页

作者：林恒星邹浩冯先伟孙继文李文亮上海勘测设计研究院有限公司上海200434 大连理工大学海岸与近海工程国家重点实验室辽宁大连116024 大连理工大学水利工程学院工程抗震研究所辽宁大连116024

深厚覆盖层上建坝常采用混凝土防渗墙作为防渗结构,常规有限元分析对混凝土防渗墙通常采用线弹性本构,导致防渗墙易出现应力超限现象,而实际上,应力超限后混凝土防渗墙会发生塑性损伤,应力会释放并重新分布,因此线弹性模型计算的防渗墙... 详细信息

深厚覆盖层上建坝常采用混凝土防渗墙作为防渗结构,常规有限元分析对混凝土防渗墙通常采用线弹性本构,导致防渗墙易出现应力超限现象,而实际上,应力超限后混凝土防渗墙会发生塑性损伤,应力会释放并重新分布,因此线弹性模型计算的防渗墙应力不符合实际情况。依托某深厚覆盖层上沥青混凝土心墙坝建立三维有限元模型,对混凝土防渗墙分别采用混凝土塑性损伤和线弹性本构,研究对比防渗墙损伤对沥青混凝土心墙坝应力和渗流的影响。结果表明,采用塑性损伤本构后,防渗墙应力出现重分布,拉压应力有所下降,最大拉应力减小了7.00 MPa,最大压应力减小了3.32 MPa;大坝整体的总水头、压力水头和渗漏量变化不大,防渗墙损伤区域的渗透坡降减小,防渗墙的渗漏量因损伤增大了246.21%,大坝整体的渗漏量仅增大了12.33%。

关键词：沥青混凝土心墙坝三维有限元模型防渗墙应力渗流

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胞质DNA感受器在动脉粥样硬化中的研究进展

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中南药学 2025年第1期23卷 1-8页

作者：陈靓雯章越凡三明医学科技职业学院福建三明365000 上海大学医学院上海200444

胞质DNA感受器可通过识别因入侵病原体或内在损伤而出现在细胞质内的DNA,进而激活细胞内部的不同信号通路,以调控天然免疫防御,维持机体稳态。近年研究发现,DNA感受器在动脉粥样硬化发生发展的各个环节中发挥重要作用,现将胞质DNA感受... 详细信息

胞质DNA感受器可通过识别因入侵病原体或内在损伤而出现在细胞质内的DNA,进而激活细胞内部的不同信号通路,以调控天然免疫防御,维持机体稳态。近年研究发现,DNA感受器在动脉粥样硬化发生发展的各个环节中发挥重要作用,现将胞质DNA感受器的激活机制及其在动脉粥样硬化中的作用进行综述,为后续动脉粥样硬化的机制研究和靶向治疗提供新的思路。

关键词：天然免疫损伤相关模式分子 DNA感受器动脉粥样硬化

Hausdorf Dimension of Quadratic Rational Julia Sets

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Acta Mathematica Sinica,English Series 2014年第2期30卷 331-342页

作者： Jia ZHOU liang wen LIAO Department of Mathematics Nanjing University

Suppose a quadratic rational map has a Siegel disk and a parabolic fixed point. If the rotation number of the Siegel disk is an irrational of bounded type, then the Julia set of the map is shallow. This implies that i... 详细信息

关键词： Shallow Julia sets quadratic rational map Hausdorff dimension

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金沙水电站调速器油泵故障分析与处理

水电站机电技术 2025年第2期48卷 73-76,84页

作者：赵冉李文良四川省能投攀枝花水电开发有限公司四川攀枝花617000

针对金沙水电站水轮发电机组调速器在调试及试运行过程中发生多次油泵损坏问题,开展了故障原因查找及分析工作。从故障发生的现象、经过、原因进行了分析,通过对系统设计、设备制造及现场安装调试等多个维度进行深入分析调查,查清了故... 详细信息

针对金沙水电站水轮发电机组调速器在调试及试运行过程中发生多次油泵损坏问题,开展了故障原因查找及分析工作。从故障发生的现象、经过、原因进行了分析,通过对系统设计、设备制造及现场安装调试等多个维度进行深入分析调查,查清了故障原因主要为油泵管路布置不合理,提出了改进措施,对油泵进油管及出油管进行优化改造,同时增加油泵支撑,通过了现场试验和运行的验证,改造后的油泵运行稳定,油压装置系统平稳,机组的安全稳定进一步提升,对新投运电站或类似方式布置的调速器油泵的故障处理具有一定的借鉴意义和参考价值。

关键词：水电站调速器油泵损坏