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Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan wang Yun-Qing Zhou li-Juan Luo Cui-Jin wang Nan Shen Hao li Ji-wen wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1

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Object use in insects

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Insect Science 2024年第4期31卷 1001-1014页

作者： Chao wen Cai wang Xiaoli Guo Hongyu li Haijun Xiao Junbao wen Shikui Dong School of Grassland Science Beijing Forestry UniversityBeijingChina College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhouChina Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijingChina

Insects are the most diverse group of organisms in the animal kingdom,and some species exhibit complex social *** research on insect object use is still in its early stages,insects have already been shown to display rich object-use *** review focuses on patterns and behavioral flexibility in insect object-use behavior,and the role of cultural evolution in the development of object-use *** use in insects is not widespread but has been documented in a diverse set of *** insects can use objects flexibly and display various object-use *** mammals and birds,insects use objects in diverse activities,including foraging,predator defense,courtship,and ***,pre-existing manipulative behaviors,and anatomical structure affect innovations in object *** addition,learning and imitation are the main mechanisms underlying the spread of object-use behaviors within *** that insects are one of the major animal groups engaging in object use,studies of insect object use could provide general insights into object use in the animal kingdom.

关键词： cognition evolution insects learning object use

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Carbon fiber confined mixed Ni-based crystal phases with interfacial charge redistribution induced by high bond polarity for electrochemical urea-assisted hydrogen generation

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Carbon Energy 2024年第9期6卷 292-305页

作者： Chun Yin Jiaxin li Shuli wang Huan wen Fulin Yang ligang Feng School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouChina Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanningChina

Interfacial electronic structure modulation of nickel-based electrocata-lysts is significant in boosting energy-conversion-relevant urea oxidation reaction(UOR).Herein,porous carbon nanofibers confined mixed Ni-based crystal phases of Ni_(2)P and NiF_(2) are developed via fluorination and phosphorization of Ni coated carbon nanofiber(Ni_(2)P/NiF_(2)/PCNF),which possess sufficient mesoporous and optimized Gibbs adsorption free energy by mixed phase-induced charge *** novel system further reduces the reaction energy barrier and improves the reaction activity by addressing the challenges of low intrinsic activity,difficulty in active site formation,and insufficient synergism.A considerably high current density of 254.29 mA cm^(-2) is reached at 1.54 V versus reversible hydrogen electrode on a glass carbon electrode,and the cell voltage requires 1.39 V to get 10 mA cm^(-2) in hydrogen generation,with very good stability,about 190 mV less than that of the traditional water *** facile active phase formation and high charge transfer ability induced by asymmetric charge redistribution are found in the interface,where the urea molecules tend to bond with Ni atoms on the surface of heterojunction,and the rate-determining step is changed from CO_(2) desorption to the fourth H-atom *** work reveals a novel catalyst system by interfacial charge redistribution induced by high bond polarity for energy-relevant catalysis reactions.

关键词： carbon fiber nickel fluoride nickel phosphide urea oxidation water electrolysis

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Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma li-Na Sheng Xue-Heng Zhang Shi-Tao wang kai-Long wang Chun-wang Ma Hool-Jin Ong Zhi-Yu Sun Shu-wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement lifetime

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MPI/OpenMP-Based Parallel Solver for Imprint Forming Simulation

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 461-483页

作者： Yang li Jiangping Xu Yun liu wen Zhong Fei wang School of Mechanical Engineering Jiangsu UniversityZhenjiang212016China School of Mechanical Engineering Wuhan Polytechnic UniversityWuhan430023China Shenyang Mint Company limited Shenyang110092China

In this research,we present the pure open multi-processing(OpenMP),pure message passing interface(MPI),and hybrid MPI/OpenMP parallel solvers within the dynamic explicit central difference algorithm for the coining process to address the challenge of capturing fine relief features of approximately 50 *** such precision demands the utilization of at least 7 million tetrahedron elements,surpassing the capabilities of traditional serial programs previously *** mitigate data races when calculating internal forces,intermediate arrays are introduced within the OpenMP *** helps ensure proper synchronization and avoid conflicts during parallel ***,in the MPI implementation,the coins are partitioned into the desired number of *** division allows for efficient distribution of computational tasks across multiple *** simulation examples are conducted to compare the three solvers with serial programs,evaluating correctness,acceleration ratio,and parallel *** results reveal a relative error of approximately 0.3%in forming force among the parallel and serial solvers,while the predicted insufficient material zones align with experimental ***,speedup ratio and parallel efficiency are assessed for the coining process *** pureMPI parallel solver achieves a maximum acceleration of 9.5 on a single computer(utilizing 12 cores)and the hybrid solver exhibits a speedup ratio of 136 in a cluster(using 6 compute nodes and 12 cores per compute node),showing the strong scalability of the hybrid MPI/OpenMP programming *** approach effectively meets the simulation requirements for commemorative coins with intricate relief patterns.

关键词： Hybrid MPI/OpenMP parallel computing MPI OpenMP imprint forming

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Sludge composition and characteristics shaped microbial community and further determined process performance: A study on full-scale thermal hydrolysis-anaerobic digestion processes

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Journal of Environmental Sciences 2024年第3期137卷 96-107页

作者： Wei liu Chenxiang Sun Wei li Tianle li Zhan Chen Jiawei wang Zhengran Ren Xianghua wen School of Environment Tsinghua UniversityBeijing 100084China Jinneng Holding Group DatongShanxi 037000China Research and Development Center Beijing Drainage Group Co.Ltd.Beijing 100124China Beijing Dabeinong Science and Technology Group Co. Ltd.Beijing 100080China

Anaerobic digestion (AD) with thermal hydrolysis (TH) pretreatment is a promising process for excess sludge treatment,while there lacks of the knowledge from full-scale process about the impact of sludge composition and characteristics on microbial community and *** sludge physiochemical indices,microbial community and performance data of four full-scale TH-AD plants were characterized,and their relationships was *** four plants were operated under almost similar total organic loading rate (OLR)but their methanogenesis performance differentiate into two groups,namely superior group(SupG) and the inferior group (Inf G).In both groups,TH effectively solubilized particulate organic compounds,meanwhile raised the ammonia nitrogen (NH_(4)^(+)-N) and volatile fatty acid (VFA) *** with the Sup G,thermal hydrolyzed sludge of Inf G had higher level of VFAs,NH_(4)^(+)-N and total chemical oxygen demand (t COD),which showed higher inhibition effect on microbes,leading to a community with lower diversity,lower abundance of carbohydrate degrading functional guild,higher protein degrading one,and methanogens that adapted to limited substrates,and further declined the methane production ***,it was recommended that OLR alone was not sufficient for controlling the system in design and operation,the concentration of VFAs,NH_(4)^(+)-N and t COD should be equally *** higher concentration,together with the higher abundance of Defluviitoga and Proteiniphilum were recommended as indicators for inferior running *** results proposed that microbial communities played a role of bridge between environmental factors and performance,provided implications for engineering ecology and operational regulation for full-scale sludge TH-AD process.

关键词： Thermal hydrolysis Anaerobic digestion Microbial community Full-scale

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Effect of TiO_(2) addition on microstructures and properties of Mgo-Cao refractory aggregates

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Journal of Iron and Steel Research International 2024年第6期31卷 1547-1554页

作者： Shuai Zhang Jing-ran wang Yuan-gao li Feng-you li wen Yan Hui-ying Shi The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Joint International Research Laboratory of Refractories and Metallurgy Wuhan 430081HubeiChina Shanxi Luweibao Taigang Refractory Co. Ltd.Taiyuan 030003ShanxiChina

MgO-CaO(40 wt.%CaO)refractory aggregates were prepared using the calcined dolomite and light-burned magnesia fine powder as raw materials and TiO_(2) as *** effect of TiO_(2) on their phase composition,microstructures and properties was investigated by X-ray diffraction and scanning electron *** properties such as bulk density,apparent porosity,relative aggregate tube strength and hydration resistance were also *** results showed that the CaTiO_(3) generated by the reaction between CaO and TiO_(2) was distributed around the CaO grain boundaries and intermittently distributed with MgO,which formed an isolation layer around CaO and greatly improved the hydration ***,the introduction of TiO_(2) promoted sintering and increased the grain size,further improving the strengths and hydration resistance of the *** addition,the most significant enhancement in the hydration resistance and strengths of the samples was achieved when 1.0-2.0 wt.%TiO_(2) was *** this case,the relative strength of aggregate increased from 33.3% to 37.3%-43.1%,and the mass gain after the hydration test decreased from 3.13% to 1.26%-1.45%.

关键词： MgO-CaO refractory aggregate TiO_(2)addition Phase composition Microstructure Hydration resistance

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Flexible and Stretchable Electrodes for In Vivo Electrophysiological and Electrochemical Monitoring

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Chinese Journal of Chemistry 2024年第13期42卷 1523-1545页

作者： kai-kai Sheng Yi-Fei Lu wen-Ting Fan Yan-ling liu College of Chemistry and Molecular Sciences Wuhan University WuhanHubei 430072China Core Facilty of Wuhan University WuhanHubei 430072China

In vivo monitoring of bioelectrical and biochemical signals with implanted electrodes has received great interest over the past ***,this faces huge challenges because of the severe mechanical mismatch between conventional rigid electrodes and soft biological *** recent years,the emergence of flexible and stretchable electrodes offers seamless and conformable biological-electronic interfaces and has demonstrated significant advantages for in vivo electrochemical and electrophysiological *** review first summarizes the strategies for electrode fabrication from the point of substrate and conductive ***,recent progress in electrode functionalization for improved performance is ***,the advances of flexible and stretchable electrodes in exploring bioelectrical and biochemical signals are ***,we present some challenges and perspectives ranging from electrode fabrication to application.

关键词： Flexible electrodes Conductive materials Stretchable structures Electrode functionalization In vivo monitoring Biochemical signals Bioelectrical signals

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Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： Jia-lin wang li-Ming Zhang kai Zhang Jian wang Jian-Ping Zhou wen-Feng Peng Fa-liang Yin Chao Zhong Xia Yan Pi-Yang liu Hua-Qing Zhang Yong-Fei Yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization ***,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in *** the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is ***,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different *** address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization *** consists of two *** the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization *** the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical *** two stages are combined using sequential transfer *** the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir *** verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based *** res

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

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Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions

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Zoological Research 2024年第1期45卷 95-107页

作者： Hai-Yang wang Lan-Xiang liu Xue-Yi Chen Yang-Dong Zhang wen-Xia li wen-wen li lian wang Xiao-Long Mo Hong Wei Ping Ji Peng Xie NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China College of Stomatology and Affiliated Stomatological Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China Department of Neurology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China Department of Pathology Faculty of Basic MedicineChongqing Medical UniversityChongqing 400016China Department of Neurology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Yu-Yue Pathology Scientific Research Center Chongqing 401329China

The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many ***,the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain *** study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any *** conducted succinylome analysis of hippocampal proteins in germ-free(GF)and specific pathogen-free(SPF)mice and metagenomic analysis of feces from SPF *** results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of *** bioinformatics analyses revealed 584 succinylation sites on 455 proteins,including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF *** constructed a panoramic map of gut microbiota-regulated succinylation,acetylation,and phosphorylation,and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular *** correlation analysis indicated that 13 taxa,predominantly belonging to the Bacteroidetes phylum,were correlated with the biological functions of post-translational *** correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular *** study highlights the hippocampal physiological changes induced by the absence of gut microbiota,and proteomic quantification of succinylation,phosphorylation,and acetylation,contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes.

关键词： Gut microbiota Hippocampal protein Post-translational modifications Succinylation Acetylation Phosphorylation

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