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Synthesis of Macrocycles Containing Amino Acid Ester and Aryl-heterocyclic Units

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Chinese Chemical Letters 1997年第12期8卷 0-0,0-0页

作者： Yan Tao CHEN wen ting hua Qi Yi XING(Department of Chemistry Peking University Beijing 100871) Department of Chemistry Peking University Beijing 100871 China

Four kinds of new macrocycles containing amino acids and nyl-heterocyclic units were synthesized by the condensation of di-esters containing Ts-amino acids units with di-halogenated compounds at room temperature. The ... 详细信息

关键词： FAB Synthesis of Macrocycles Containing Amino Acid Ester and Aryl-heterocyclic Units

Chiral Separation of N-Benzoyl Phenylalanine Methyl Ester by Nonaqueous Capillary Electrophoresis

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Chinese Chemical Letters 1999年第4期10卷 303-306页

作者： Yi LI Lun Jia XIE Hu Wei LIU wen ting hua(Department of Chemistry, Peking University, Beijing 100871) Department of Chemistry Peking University Beijing 100871 China

A successful chiral separation of N-benzoyl phenylalanine methyl ester has been achieved by nonaqueous capillary electrophoresis (NACE) using P-CD as chiral selector in formamide (FA). Some experimental parameters inf... 详细信息

关键词： nonaqueous capillary electrophoresis chiral separation N-benzoyl phenylalanine methyl ester

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li hua Zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Pting their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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从校园暴力看加强学生思想道德教育的严峻性

河北师范大学学报（教育科学版） 2005年第5期7卷 74-76页

作者：温廷华路殿国方圆电子音像出版社河北石家庄050071

校园暴力案频发的原因是多方面的,但其中最主要的当属思想道德教育方面的原因。只有牢固树立正确的教育观,把培养合格的下一代做为最基本、最重要的目标,才能营造一个比较良好的社会教育氛围。无论学校、家庭还是社会都应当把培养合格... 详细信息

校园暴力案频发的原因是多方面的,但其中最主要的当属思想道德教育方面的原因。只有牢固树立正确的教育观,把培养合格的下一代做为最基本、最重要的目标,才能营造一个比较良好的社会教育氛围。无论学校、家庭还是社会都应当把培养合格的公民、健全的人格、科学的头脑作为对下一代人的教育目标。

关键词：校园暴力思想道德教育家庭教育学校教育和社会教育

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变害为利、变废为宝、综合利用狼毒资源

山西农业科学 2007年第11期35卷 91-92页

作者：杜文婷冀华山西农业大学山西太谷030801

通过对瑞香狼毒的形态特性、物质组成、毒性危害和应用价值的综述,提出利用其自身价值,通过研究开发并进行生产加工,从而使其变害为利,变废为宝,经过对狼毒资源的综合利用即可以产生经济价值,也为彻底治理狼毒危害提供理论参考。

关键词：瑞香狼毒危害应用价值综合利用

Fingerprinting Analysis of Four Variants of Chrysanthemi Morifoli Flos by RP-HPLC

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Chinese Herbal Medicines 2010年第2期2卷 153-156页

作者： SHEN Zhi1,ZHANG wen-ting2,hua Yun-fei1,ZHAO Wei-liang2 1.College of Pharmacy,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China 2.Zhejiang Institute for Food and Drug Control,Hangzhou 310004,China College of Pharmacy Zhejiang University of Traditional Chinese MedicineHangzhou 310053China Zhejiang Institute for Food and Drug Control Hangzhou 310004China

Objective To establish a RP-HPLC fingerprinting analysis method for quality evaluation and control of the four variants of Chrysanthemi Morifoli *** RP-HPLC was used to establish the fingerprinting *** Despite of the similarity in terms of holistic HPLC chromatograms,the four variants of Chrysanthemi Morifoli Flos exhibit characteristic fingerprints and can be readily recognized by similarity *** A simple and reliable HPLC fingerprinting method has been developed and validated to authenticate the four variants of Chrysanthemi Morifoli Flos,providing a scientific basis for quality control of Chrysanthemi Morifoli Flos.

关键词： Chrysanthemi Morifoli Flos fingerprint quality control RP-HPLC

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu wen-Jia Chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Stretchable Electrochemical Sensors: From Electrode Fabrication to Cell Mechanotransduction Monitoring

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Chinese Journal of Chemistry 2023年第4期41卷 443-457页

作者： wen-ting Fan Wei-hua huang Yan-Ling Liu College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Electrochemical sensing faces huge challenges in characterizing the transient release of biochemical molecules from deformed cells,due to the severely mechanical mismatch between rigid electrodes and soft *** recent years,the emergence of stretchable electrochemical sensors has made a breakthrough by complying with the deformation of living cells and simultaneous monitoring of mechanically evoked biochemical *** review first summarizes two fundamental strategies for the fabrication of stretchable electrodes from the points of structure and ***,recent progresses in construction of functionalized interface to improve the performance of stretchable electrochemical sensors are ***,the application of stretchable electrochemical sensors in real-time monitoring of biomolecules released by mechanically sensitive cells is ***,some perspectives and challenges of stretchable electrochemical sensors regarding cell detection are discussed.

关键词： Stretchable electrode Electrochemical sensing Fabrication Functionalization Cell mechanotransduction

SYSTEM FOR AUTOMATIC GENERALIZATION OF TOPOGRAPHIC MAPS

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Chinese Geographical Science 2006年第2期16卷 165-170页

作者： YAN Hao-wen LI Zhi-lin AI ting-hua School of Mathematics Physics and Software Engineering Lanzhou Jiaotong University Lanzhou 730070 19. R. China GIS Division Department of Geography University of Zurich Zurich Switzerland Department of Land Surveying ancl Geo-lnformatics the Hong Kong Polytechnic University Hong Kong P. R. China School of Resource and Environment Science Wuhan University Wuhan 430079 P. R. China

With the construction of spatial data infi＇astructure, automated topographic map generalization becomes an indispensable component in the community of cartography and geographic information science. This paper describes a topographic map generalization system recently developed by the authors. The system has the following characteristics： 1） taking advantage of three levels of automation, i.e. fully automated generalization, batch generalization, and interactive generalization, to undertake two types of processes, i.e. intelligent inference process and repetitive operation process in generalization; 2） making use of two kinds of sources for generalizing rule library, i.e. written specifications and cartographers＇ experiences, to define a six-element structure to describe the rules; 3） employing a hierarchical structure for map databases, logically and physically; 4） employing a grid indexing technique and undo/redo operation to improve database retrieval and object generalization efficiency. Two examples of topographic map generalization are given to demonstrate the system. It reveals that the system works well. In fact, this system has been used for a number of projects and it has been found that a great improvement in efficiency compared with traditional map general- ization process can be achieved.

关键词： map generalization system map database rule library topographic map