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Machine learning identifies the risk of complications after laparoscopic radical gastrectomy for gastric cancer

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World Journal of Gastroenterology 2024年第1期30卷 79-90页

作者： Qing-Qi Hong su Yan Yong-Liang Zhao Lin Fan Li Yang wen-Bin Zhang Hao Liu He-Xin Lin Jian Zhang Zhi-Jian Ye Xian Shen Li-Sheng Cai Guo-Wei Zhang Jia-Ming Zhu Gang Ji Jin-Ping Chen Wei Wang Zheng-Rong Li Jing-Tao Zhu Guo-Xin Li Jun You Department of Gastrointestinal Oncology surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen 361001Fujian ProvinceChina Department of Gastrointestinal surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina Department of General surgery and Center of Minimal Invasive Gastrointestinal surgery The First Hospital Affiliated to Army Medical UniversityChongqing 400038China Department of General surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of General surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrmuqi 830054Xinjiang Uygur Autonomous RegionChina Department of General surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Gastrointestinal surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Gastrointestinal surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004Fujian ProvinceChina Department of surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of General surgery Unit 4 Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastrointestinal surgery The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361021Fujian ProvinceChina Department of Gastrointestinal Nutrition and Hernia surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Gastrointestinal surgery Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362002Fujian Provin

BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned issue.AIM To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery,guide perioperative treatment strategies for gastric cancer patients,and prevent serious complications.METHODS In total,998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model,and 398 patients were included in the validation group.The clinicopathological data and 30-d postoperative complications of gastric cancer patients were collected.Three machine learning methods,lasso regression,random forest,and artificial neural networks,were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy,and their prediction efficacy and accuracy were evaluated.REsuLTS The constructed complication model,particularly the random forest model,could better predict serious complications in gastric cancer patients undergoing laparoscopic radical gastrectomy.It exhibited stable performance in external validation and is worthy of further promotion in more centers.CONCLUSION Using the risk factors identified in multicenter datasets,highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were established.We hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models.

关键词： Gastric cancer Laparoscopic radical gastrectomy Postoperative complications Laparoscopic total gastrectomy

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数字资本无序扩张的风险与规制

改革 2024年第1期 82-93页

作者：靳文辉苏雪琴重庆大学法学院

防止数字资本无序扩张对于推动数字经济健康和可持续发展具有重要意义。数字资本大规模、非理性的扩张会引发数字平台垄断、数字资本分布失衡、数字财富差距扩大等风险。数字资本的扩张通常依凭规模逻辑、空间逻辑和权力逻辑展开,因此,... 详细信息

防止数字资本无序扩张对于推动数字经济健康和可持续发展具有重要意义。数字资本大规模、非理性的扩张会引发数字平台垄断、数字资本分布失衡、数字财富差距扩大等风险。数字资本的扩张通常依凭规模逻辑、空间逻辑和权力逻辑展开,因此,防范基于不正当手段的规模扩张、避免空间分布失衡和制约数字权力滥用,是防范数字资本无序扩张进而克服其引发风险的规范原理。以规范和引导数字资本健康发展为目标,通过激励性规制工具和约束性规制工具的协调运用,同时构建回应型规制模式,是实践中防止数字资本无序扩张风险的可行策略。

关键词：数字资本资本逻辑无序扩张风险规制

基于随机历史集的有反馈MSIF目标识别方法

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火力与指挥控制 2024年第4期49卷 130-135页

作者：李山权文苏力德空军工程大学空管领航学院西安710051

为提高复杂战场环境下的目标识别准确度,提出了一种分布式MSIF模型,并通过加入反馈信息流,对时域内的序贯信息进行处理。以经典D-S证据理论为基础,针对其不能处理高冲突证据的弊端,采用费雪耶兹洗牌方法,置乱泛传感器矩阵中的信息排序,... 详细信息

为提高复杂战场环境下的目标识别准确度,提出了一种分布式MSIF模型,并通过加入反馈信息流,对时域内的序贯信息进行处理。以经典D-S证据理论为基础,针对其不能处理高冲突证据的弊端,采用费雪耶兹洗牌方法,置乱泛传感器矩阵中的信息排序,生成随机历史集,并随着运算次数增加,算法反复迭代。通过改进算法,修正了由于高冲突证据过早出现所带来的识别结果偏差。数值算例表明,该方法既能提高信息利用率,同时可克服信息先入性陷阱的影响,准确度较高,且计算量较小,能有效减轻系统负担,适合MSIF目标识别中的大数据量处理。

关键词：目标识别证据融合 MSIF 随机历史集

Quantum geometric tensor and the topological characterization of the extended su-Schrieffer-Heeger model

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Chinese Physics B 2024年第3期33卷 260-265页

作者：曾相龙赖文喜魏祎雯马余全 School of Science Beijing Information Science and Technology UniversityBeijing 100192China

We investigate the quantum metric and topological Euler number in a cyclically modulated su-Schrieffer-Heeger(SSH)model with long-range hopping terms.By computing the quantum geometry tensor,we derive exact expressions for the quantum metric and Berry curvature of the energy band electrons,and we obtain the phase diagram of the model marked by the first Chern number.Furthermore,we also obtain the topological Euler number of the energy band based on the Gauss-Bonnet theorem on the topological characterization of the closed Bloch states manifold in the first Brillouin zone.However,some regions where the Berry curvature is identically zero in the first Brillouin zone result in the degeneracy of the quantum metric,which leads to ill-defined non-integer topological Euler numbers.Nevertheless,the non-integer"Euler number"provides valuable insights and an upper bound for the absolute values of the Chern numbers.

关键词： quantum geometric tensor topological Euler number Chern number Berry curvature quantum metric su-Schrieffer-Heeger(SSH)model

Staged-probability strategy of processing shotgun proteomic data to discover more functionally important proteins

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Protein & Cell 2012年第2期3卷 140-147页

作者： Hong Xu Guijun Ma Qingqiao Tan Qiang Zhou wen su Rongxiu Li State Key Laboratory of Microbial Metabolism(Shanghai Jiao Tong University)and School of Life Sciences&Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China Department of Bioinformatics and Biostatistics College of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Software Engineering Institute East China Normal UniversityShanghai 200062China

Biologically important proteins related to membrane receptors,signal transduction,regulation,transcription,and translation are usually low in abundance and identified with low probability in mass spectroscopy(MS)-based analyses.Most valuable proteomics information on them were hitherto discarded due to the application of excessively strict data filtering for accurate identification.In this study,we present a stagedprobability strategy for assessing proteomic data for potential functionally important protein clues.MS-based protein identifications from the second(L2)and third(L3)layers of the cascade affinity fractionation using the Trans-Proteomic Pipeline software were classified into three probability stages as 1.00–0.95,0.95–0.50,and 0.50–0.20 according to their distinctive identification correctness rates(i.e.100%–95%,95%–50%,and 50%–20%,respectively).We found large data volumes and more functionally important proteins located at the previously unacceptable lower probability stages of 0.95–0.50 and 0.50–0.20 with acceptable correctness rate.More importantly,low probability proteins in L2 were verified to exist in L3.Together with some MS spectrogram examples,comparisons of protein identifications of L2 and L3 demonstrated that the stagedprobability strategy could more adequately present both quantity and quality of proteomic information,especially for researches involving biomarker discovery and novel therapeutic target screening.

关键词： lower minimum probability threshold probability grade TPP low-abundant protein

Comparison of the osteogenic capability of rat bone mesenchymal stem cells on collagen,collagen/hydroxyapatite,hydroxyapatite and biphasic calcium phosphate

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Regenerative Biomaterials 2018年第2期5卷 93-103页

作者： Xiaoyu sun wen su Xiaomin Ma Huaiying Zhang Zhe sun Xudong Li National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064P.R.China

Collagen(COL),collagen/hydroxyapatite(COL/HA),HA and biphasic calcium phosphate were prepared as representative bone grafting materials with composition analogous to bone,and their structural characteristics were analyzed.The rat bone mesenchymal stem cells(BMSCs)were further seeded onto four groups of materials,and BMSCs grown in basic medium and standard osteogenic medium were set as controls of a reference model to show the basic and osteogenic behavior of cells without the intervention of materials.Cellular behaviors were characterized,including proliferation,spreading morphology and expression of osteogenesis factors.The rat BMSCs proliferated properly with time on four groups of materials as well on two groups of controls,and typical cuboidal,polygonal and extremely-elongated morphologies of cells were observed.According to the real-time polymerase chain reaction data,a higher osteogenic gene expression level was dependent upon the growing morphology but not the proliferation rate of cells,and the osteogenic differentiation capacity of cells onto four groups of materials varied in specific genes.In general,BMSCs exhibited the highest osteogenic capacity onto COL/HA,but the poorest onto HA.The growing behaviors of cells on materials were further discussed in comparison with the cases of OC and BC of the reference model.The present attempt to comparatively analyze cell experimental data with a reference model is expected to be useful for revealing the difference in the osteogenic capability of MSCs onto materials or even the bioactivity of materials.

关键词： osteogenic differentiation spreading morphology mineralization of collagen bioceramics

A_(3)PO_(4)(A=Li,Na,K,Rb,Cs)电子结构与光学性质的第一性原理研究

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人工晶体学报 2024年第1期53卷 123-131页

作者：王云杰文杜林苏欣伊犁师范大学物理科学与技术学院伊宁835000 伊犁师范大学新疆凝聚态相变与微结构实验室伊宁835000

基于密度泛函理论对P-O配位多面体与不同阳离子构成的系列化合物A_(3)PO_(4)(A=Li,Na,K,Rb,Cs)的几何结构、电子结构、光学性质进行系统探究。研究表明通过碱金属原子替换可以改变结构框架,从而调节系列化合物的带隙及光学性能,为设计... 详细信息

基于密度泛函理论对P-O配位多面体与不同阳离子构成的系列化合物A_(3)PO_(4)(A=Li,Na,K,Rb,Cs)的几何结构、电子结构、光学性质进行系统探究。研究表明通过碱金属原子替换可以改变结构框架,从而调节系列化合物的带隙及光学性能,为设计综合性能优异的材料提供了一条有效途径。能带结构计算表明,五种化合物均为直接带隙化合物且都具有宽的带隙,A_(3)PO_(4)(A=Li,Na,K,Rb,Cs)的带隙依序为5.853、5.153、4.083、3.559、3.405 eV。布居分析发现阳离子A(A=Li,Na,K,Rb)与氧键合形成O—A键,其键长依序逐渐增大并呈现离子键,这也是A_(3)PO_(4)(A=Li,Na,K,Rb)带隙依序减小的主要原因。另一方面,Cs_(3)PO_(4)没有形成离子性质的O—Cs键,导致带隙减小。五种化合物的导带都是由碱金属原子的s和p轨道,以及P-3p轨道组成,价带顶的主要贡献者是O-2p轨道,O原子的2p轨道还在费米能级附近表现出较强的局域性,P-3p轨道与O的2p轨道成键,P—O表现为强的共价键。五种化合物对低能区电磁波响应较弱,主要响应集中在5~15 eV的高能区。

关键词：磷酸盐晶体第一性原理密度泛函理论电子结构光学性能

城市轨道交通信号智能运维系统关键技术及应用研究

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智慧轨道交通 2024年第2期61卷 36-40页

作者：苏雯中车青岛四方车辆研究所有限公司山东青岛266031

本文深入分析了运维系统在现代城市轨道交通中的重要性以及设备维护过程中存在的问题。研究了智能化城市轨道交通信号运维系统架构、智能运维过程中所需使用的先进技术以及在运维系统中应用的可行性,强调了大数据技术应用的必要性。提... 详细信息

本文深入分析了运维系统在现代城市轨道交通中的重要性以及设备维护过程中存在的问题。研究了智能化城市轨道交通信号运维系统架构、智能运维过程中所需使用的先进技术以及在运维系统中应用的可行性,强调了大数据技术应用的必要性。提出了一种基于大数据和人工智能技术的城市轨道交通信号系统智能化运维架构,该架构运用微服务技术进行搭建,融合了大数据分析、机器学习等先进技术,进一步提高城市轨道交通信号运维系统的自动化和智能化程度。

关键词：城市轨道交通信号系统智能运维系统架构大数据分析机器学习

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基于四“新”维度的新质生产力发展路径研究

兰州大学学报（社会科学版） 2024年第2期52卷 15-24页

作者：齐文浩赵晨苏治吉林农业大学经济管理学院/吉林省乡村振兴战略研究中心吉林长春130118 中央财经大学统计与数学学院/经济数据研究中心北京102206

新质生产力的发展是推动我国经济转型,实现高质量发展的关键。基于四“新”维度,新质生产力相较于传统生产力是依靠技术突破创新而产生的生产力跃迁,是以新劳动者、新劳动对象、新劳动工具和新基础设施为核心的生产力。新质生产力依靠... 详细信息

新质生产力的发展是推动我国经济转型,实现高质量发展的关键。基于四“新”维度,新质生产力相较于传统生产力是依靠技术突破创新而产生的生产力跃迁,是以新劳动者、新劳动对象、新劳动工具和新基础设施为核心的生产力。新质生产力依靠科技推动的本质没有发生变化,但其依靠持续的技术突破,摆脱了资源驱动型的传统发展模式,带来的是更清洁、更高效的环境友好型发展模式。随着我国科技创新能力持续增强、新兴产业不断发展壮大、能源转型和新型基础设施建设的不断加快,我国新质生产力发展条件呈现出逐年向好的态势,但也存在新劳动者储备不足、新劳动工具发展受限、新劳动对象应用场景欠缺、新型基础设施协调性较差等问题。新质生产力的发展一是要着重培养新科技人才、数字技术人才和“卡脖子”关键技术人才;二是要以基础研究为依托,推动整体科技创新能力提升,以实现真正的技术突破;三是要尽快建立起数据大市场;四是要以需求为导向推动新型基础设施建设,强调建用并重,强化以用促建。

关键词：新质生产力经济高质量发展科技推动新兴产业未来产业