检索结果-南通市图书馆

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng liu Changyu Zhang Zipeng li Wanying Ma Jia liu Xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

Thermoresponsive helical dendronized poly(arylacetylene)s:modulating the dynamic chirality

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xueting Lu Lei Wang liangxuan Ren wen li Afang Zhang International Joint Laboratory of Biomimetic&Smart Polymers School of Materials Science and EngineeringShanghai University

Helical poly(arylacetylene)s have formed an intriguing class of polymers,whose chiralities are dynamic and liable to external *** combining dendronized polymer topology with dendritic oligoethylene glycols (OEGs),we here report on synthesis of a homologous series of thermoresponsive dendronized poly(arylacetylene)s with either poly(phenyl acetylene) or poly(naphthalene acetylene) as the backbones,and investigate tunability of their helical *** polymers carry dendritic OEG pendants with either methoxyl-or ethoxyl-terminals to tune their unprecedent thermoresponsive behaviors,and at the same time,dendritic shielding plays an important role in mediating their thermal phase transition *** of these polymers is originated from the chiral alanine or phenylalanine moieties within the dendritic pendants,which can be tailored through manipulating solvation in different organic solvents or via thermal dehydration and collapse in ***,achiral additives such as linear or dendritic OEGs and benzene derivatives can act similarly as thermal dehydration to induce chirality transitions of these polymers in aqueous phase through interplay competitions between the additives and the polymers against their hydration.

关键词：

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo li Xingwei Lei liuyang Tang Daochen wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

在线全文

学校读者我要写书评

暂无评论

船舶综合电力系统暂态仿真研究

船舶工程 2014年第S1期36卷 110-113页

作者：兰海曲文秀谭磊文书礼孟杰哈尔滨工程大学自动化学院哈尔滨150001

根据船舶综合电力系统的特点,开发描述其暂态过程的仿真软件。以VC++6.0作为编写软件的平台,以船舶相关设备的数学模型为编程的理论依据,以数据库作为数据支持,以可视化曲线的形式输出暂态仿真结果,直观的反映出暂态过程。最后,应用典... 详细信息

根据船舶综合电力系统的特点,开发描述其暂态过程的仿真软件。以VC++6.0作为编写软件的平台,以船舶相关设备的数学模型为编程的理论依据,以数据库作为数据支持,以可视化曲线的形式输出暂态仿真结果,直观的反映出暂态过程。最后,应用典型的系统进行验证,结果表明了相关数学模型建立的正确性,以及暂态仿真软件的可靠性和实用性。

关键词：船舶综合电力系统数学模型可视化编程暂态仿真

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min li Jiazhi Chen Zhuyong Wang Huantao wen Ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

Chinese Herbal 912 Compound Improves Microcirculatory Disturbances Induced by Endotoxin in Rats

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal 912 Compound Improves Microcirculatory Distur...

CT-6B托卡马克装置上电流上升阶段电子温度的光谱测量

全国中青年中西医结合学术（英语）交流会议

作者： Wang Hong Zhang shu-wen Zhao li-yie Wang bao-en Dept. of Infection and Critical Care Medicine , Beijing Friendship Hospital 100050 Beijing, China

The present study investigated the effects of herbal 912 compound on microcirculatory disturbance induced by endotoxin in rat mesentery. The changes of blood speed and leukocytes behavior in postvenule vessel after endotoxin injection were observed by videomicroscopy continuously during the experiments. Herbal 912 compound significantly prevent the decreased of blood speed, leukocytes adherence and leukocytes thrombi formation in mesenteric postvenule vessel The result indicated that herbal 912 compound has protective effects to improve the microcirculatory disturbances induced by endotoxin in rat mesentery.

关键词： Endotoximia Microcirculation Rat mesentery 912 compound

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

物理学报 1989年第4期38卷 637-644页

作者：李赞良王文书李文莱刘翔李孝昌中国科学院物理研究所成都科学技术大学高温高压物理研究所

在CT-6B托卡马克装置上,用一米掠入射真空紫外单色仪测量了氧杂质各阶离子OII-OVI的谱线辐射的时间变化,用HCN远红外激光干涉仪测量了电子密度的时间变化。利用谱线时间史的方法,由谱线起始时间估算了放电初期电流上升阶段电子温度的时... 详细信息

在CT-6B托卡马克装置上,用一米掠入射真空紫外单色仪测量了氧杂质各阶离子OII-OVI的谱线辐射的时间变化,用HCN远红外激光干涉仪测量了电子密度的时间变化。利用谱线时间史的方法,由谱线起始时间估算了放电初期电流上升阶段电子温度的时间变化。用数值计算分别考察了氧杂质进入通量和约束时间对谱线峰值强度和起始时间的影响。估算得到的电子温度在放电开始后0.36,0.56,0.66,0.90和1.4ms,分别为3.6,5.6,7.3,10.8和21eV,它们反映了放电初期等离子体中心区电子温度的变化。

关键词：电子温度光谱测量托卡马克装置

在线全文

学校读者我要写书评

暂无评论

Clean环的推广

辽宁师范大学学报（自然科学版） 2010年第4期33卷 420-422页

作者：温立书徐岩大连东软信息学院基础教学部辽宁大连116023 北京科技大学数力系北京100083

将clean环的定义推广到任意环(不必有1),证明了以下结论:(强)clean环的理想是(强)clean环;若I是R的一个理想,且I蘆(R),则R是clean环当且仅当R/I是clean环,且其幂等元可提升;R是clean环当且仅当R/J(R)是clean环,且其幂等元可提升;左Arti... 详细信息

将clean环的定义推广到任意环(不必有1),证明了以下结论:(强)clean环的理想是(强)clean环;若I是R的一个理想,且I蘆(R),则R是clean环当且仅当R/I是clean环,且其幂等元可提升;R是clean环当且仅当R/J(R)是clean环,且其幂等元可提升;左Artin环是clean环;直积ΠRi是(强)clean的当且仅当每个Ri是(强)clean的;若R是clean环,G是阶为2的群,满足一定条件,群环RG也是clean环.还证明了有些上三角矩阵环是clean环,推广了已有的一些结果.

关键词： clean环强clean环拟正则元

Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian li wen Yi XiangHui Xue Jie Zeng HaiLun Ye JianYuan Wang JinSong Chen Na li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides