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Effect of liver transplantation with primary hyperoxaluria type 1:Five case reports and review of literature

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World Journal of Clinical Cases 2023年第5期11卷 1068-1076页

作者： Xin-Yue Wang Zhi-Gui Zeng Zhi-Jun Zhu Lin Wei Wei Qu Ying Liu Yu-Le Tan Jun Wang Hai-Ming Zhang wen shi Li-Ying Sun Department of Critical Liver Diseases Liver Research CenterBeijing Friendship HospitalCapital Medical UniversityBeijing 101100China Liver Transplantation Center Beijing Friendship HospitalCapital Medical UniversityBeijing 101100China Clinical Center for Pediatric Liver Transplantation Capital Medical UniversityBeijing 101100China National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 101100China Beijing Clinical Research Institute Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Primary hyperoxaluria type 1(PH1)is a rare autosomal recessive disease stemming from a deficiency in liver-specific alanine-glyoxylate aminotransferase,resulting in increased endogenous oxalate deposition and end-stage renal disease.Organ transplantation is the only effective treatment.However,its approach and timing remain controversial.CASE SUMMARY We retrospectively analyzed 5 patients diagnosed with PH1 from the Liver Transplant Center of the Beijing Friendship Hospital from March 2017 to December 2020.Our cohort included 4 males and 1 female.The median age at onset was 4.0 years(range:1.0-5.0),age at diagnosis was 12.2 years(range:6.7-23.5),age at liver transplantation(LT)was 12.2 years(range:7.0-25.1),and the follow-up time was 26.3 mo(range:12.8-40.1).All patients had delayed diagnosis,and 3patients had progressed to end-stage renal disease by the time they were diagnosed.Two patients received preemptive LT;their estimated glomerular filtration rate was maintained at>120 mL/min/1.73 m2,indicating a better prognosis.Three patients received sequential liver and kidney transplantation.After transplantation,serum and urinary oxalate decreased,and liver function recovered.At the last follow-up,the estimated glomerular filtration rates of the latter 3 patients were 179,52 and 21 mL/min/1.73 m2.CONCLUSION Different transplantation strategies should be adopted for patients based on their renal function stage.Preemptive-LT offers a good therapeutic approach for PH1.

关键词： Primary hyperoxaluria type 1 Liver transplantation Combined liver and kidney transplantation Sequential liver and kidney transplantation Renal calculi End-stage renal disease Case reports

Effect of dew point on hot-dip galvanizing behavior of a high-manganese TWIP steel for automotive application

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Journal of Iron and Steel Research(International) 2020年第10期27卷 1200-1211页

作者： Ting-dong Ren wen shi Ren-dong Liu Li Lin Hong-gang Yang Lin Li Babar Shahzad School of Materials Science and Engineering Shanghai UniversityShanghai 200072China Ansteel Group Co. Anshan 114021LiaoningChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The effect of dew points(-50,-l0 and+10℃)on the galvanizing properties of a high-manganese twinning-inducedplasticity(TWIP)steel was studied.Scanning electron microscopy(SEM),glow discharge optical emission spectrometry(GDOES)and X-ray photoelectron spectroscopy(XPS)were used for microscopic observation and qualitative analysis of the interfacial layer between the steel surface and the zinc layer after hot-dip galvanizing.SEM analysis results show thatthree diffcrent morphologies of metallic oxides are formed on the interfacial layer under the different dew points.GDOES results show that Al is present in the molten zinc,reacting with Fe on the steel surface to form Fe2Al5,which can increasethe galvanizing properties.XPS results show that the valence states of Mn in the interfacial alloy layer are Mn'*and Mn*+,and the valence stales of Fe are Fe^0,Fe^2+and Fe^3+.The experimental results show that the hot-dip galvanizing performanceis the best at-10℃ and the formation of Mn and Fe intermetallic oxides has a bad effect on hot-dip galvanizing behaviorof the high-manganese TWIP steel.The types of the formed surface oxides(MnO,Mn3O4,Mn2O3,FeO3,and Fe2MnO4)onthe surface of the steel sheet are confirmed.It can obtain the best hot-dip galvanizing performance of the high-manganese TWIP steel by controlling the dew point from-10 to-5℃.

关键词： High-manganese twinning-induced plasticity steel-Hot-dip galvanizing Dew point-Glow discharge optical emission spectrometry X-ray photoelectron spectroscopy Surface oxide

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壳聚糖改性脂质体的制备与稳定性研究

肇庆学院学报 2024年第2期45卷 29-37页

作者：石文陈海洁肇庆学院食品与制药工程学院广东肇庆526061

实验通过乙醇注入法制备壳聚糖包覆脂质体.以粒径作为指标,通过单因素正交实验优化,确定关键工艺为:大豆卵磷脂浓度为10 mg/mL,壳聚糖浓度为150 mg/mL,剪切速度为7000 r/min、剪切时间为2 min,超声时间为10 min,该工艺制备的脂质体粒径... 详细信息

实验通过乙醇注入法制备壳聚糖包覆脂质体.以粒径作为指标,通过单因素正交实验优化,确定关键工艺为:大豆卵磷脂浓度为10 mg/mL,壳聚糖浓度为150 mg/mL,剪切速度为7000 r/min、剪切时间为2 min,超声时间为10 min,该工艺制备的脂质体粒径为711.38 nm.再考察酪蛋白酸钠、辛烯基酸琥珀酸酐、吐温20和吐温804种稳定剂(1%大豆卵磷脂质量比)对脂质体的影响表明,吐温80效果最佳.研究获得一种稳定性强,粒径较小的包覆脂质体.

关键词：壳聚糖脂质体改性稳定性粒径

核用TiNbVMo-(Zr,Cr)系难熔高熵合金的组织和性能

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兰州理工大学学报 2024年第2期50卷 1-8页

作者：李季菁胡世文刘德学兰州理工大学材料科学与工程学院甘肃兰州730050 兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室甘肃兰州730050

开发了三种新型单相BCC结构的韧性Ti_(40)Nb_(25)V_(15)Mo_(5)Zr_(15)、Ti_(40)Nb_(30)V_(20)Mo_(5)Zr_(5)和Ti_(40)Nb_(30)V_(20)Mo_(5)Cr_(5)难溶高熵合金(RHEAs).合金在室温下均表现良好的强韧性,其中Ti_(40)Nb_(25)V_(15)Mo_(5)Zr_(15)的最大抗拉强度为1037 MPa,随着Zr元素含量的降低,Ti_(40)Nb_(30)V_(20)Mo_(5)Zr_(5)的断裂延伸率从8.94%提高至13.96%.Ti_(40)Nb_(30)V_(20)Mo_(5)Cr_(5)在450℃下进行100、300、700 h的静态铅铋饱和氧腐蚀试验后仅形成单层腐蚀扩散层,腐蚀层的厚度没有随时间的增加出现明显变化.

关键词：核用难熔高熵合金力学性能液态铅铋腐蚀

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高质量发展数字经济助力实现东北全面振兴

长春金融高等专科学校学报 2024年第1期 81-85页

作者：苏诗雯吉林大学马克思主义学院吉林长春130015

新时代新征程,东北地区正走向全面振兴的新阶段。构建东北全面振兴的新格局,找寻一条高质量发展、可持续推进的复兴之路成为当前东北振兴工作的重中之重。作为新中国成立以来国家工业和农业的重要战略保障基地,东北地区的发展直接关系... 详细信息

新时代新征程,东北地区正走向全面振兴的新阶段。构建东北全面振兴的新格局,找寻一条高质量发展、可持续推进的复兴之路成为当前东北振兴工作的重中之重。作为新中国成立以来国家工业和农业的重要战略保障基地,东北地区的发展直接关系到国家安全和民生稳定。因此,有必要从数字经济高质量发展的理论视角深入剖析推进东北全面振兴所产生的新目标和新任务。同时,应该从理论层面深刻领悟发展数字经济对东北全面振兴的重要意义,并积极探索发展数字经济的实践举措,助力实现东北全面振兴。

关键词：数字经济东北振兴高质量发展

抗战时期陕甘宁边区乡村法制教育的特征及启示

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山西省政法管理干部学院学报 2024年第1期37卷 89-92页

作者：邓仕文成都文理学院文法学院四川成都610000

抗战时期,陕甘宁边区广大乡村在实施法制教育过程中呈现出主体、方式、目的以及内容方面的多维特征。基层党组作为法制教育的主体,发挥动员群众受教的功能,将多种法制教育实施方式贯通于一体,既多维覆盖边区法制的内容,又重点宣讲乡村... 详细信息

抗战时期,陕甘宁边区广大乡村在实施法制教育过程中呈现出主体、方式、目的以及内容方面的多维特征。基层党组作为法制教育的主体,发挥动员群众受教的功能,将多种法制教育实施方式贯通于一体,既多维覆盖边区法制的内容,又重点宣讲乡村群众抗战紧迫需要了解的法律法规,构建了坚实的抗战基层秩序,成功实现新民主主义法律法规“从纸面到民众”。当前,我国已经进入全面依法治国的新阶段,乡村法制教育作为法治乡村建设和实施乡村振兴战略的题中应有之义,对化解乡村社会中各种矛盾以及处理错综复杂的利益关系具有重大现实意义。陕甘宁边区乡村法制教育的实践精华与历史经验,有利于中国共产党在新时代进一步深化对乡村基层法制教育活动的认识,为当下乡村法制教育实践提供有益经验。

关键词：抗战时期陕甘宁边区法制教育新时代乡村

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基于语言输出的高职英语写作能力培养研究

当代教研论丛 2024年第4期10卷 26-30页

作者：祁世文大连航运职业技术学院辽宁大连116052

基于语言输出的高职英语写作能力培养研究,文章探讨了该教学方法对学生写作能力的影响、理论基础以及当前高职英语写作能力培养存在的问题。通过激发学生的学习兴趣和动力,提供充分的写作机会和实践,引导学生进行语言输出和反思,以及提... 详细信息

基于语言输出的高职英语写作能力培养研究,文章探讨了该教学方法对学生写作能力的影响、理论基础以及当前高职英语写作能力培养存在的问题。通过激发学生的学习兴趣和动力,提供充分的写作机会和实践,引导学生进行语言输出和反思,以及提供个性化的指导和反馈,可以有效地提高学生的写作能力和综合素质。然而,当前高职英语写作能力培养仍存在一些问题,如教师普遍注重语法和词汇的教学,而忽视了写作技巧的培养;学生对于写作的兴趣和动力不足等。因此,需要积极探索和应用基于语言输出的教学方法,为高职英语写作能力的培养开辟新的道路。

关键词：教学方法学生写作能力高职英语语言输出

基于论证探式教学模式的高中化学教学——用化学沉淀法去除粗盐中的杂质离子

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化学教育（中英文） 2024年第5期45卷 100-108页

作者：程鸿梅郭诗文顾佳丽渤海大学化学与材料工程学院辽宁锦州121013

论证探究式(ADI)是科学探究活动中融入科学论证的一种教学模式。以人教版高中化学必修二教材中的实验活动“用化学沉淀法去除粗盐中的杂质离子”为例,教师从创设情境提出问题、设计方法及收集证据、构建论证、论证、反思讨论、撰写研究... 详细信息

论证探究式(ADI)是科学探究活动中融入科学论证的一种教学模式。以人教版高中化学必修二教材中的实验活动“用化学沉淀法去除粗盐中的杂质离子”为例,教师从创设情境提出问题、设计方法及收集证据、构建论证、论证、反思讨论、撰写研究报告、同伴互评、报告修改与提交等8个阶段设计教学方案。ADI教学模式有利于巩固学生对化学知识的掌握,培养学生的核心素养和科学思维,提高学生的科学探究能力。

关键词：论证探究式教学模式高中化学化学教学设计粗盐精制

3D printing of multilayered scaffolds for rotator cuff tendon regeneration

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Bioactive Materials 2020年第3期5卷 636-643页

作者： Xiping Jiang Shaohua Wu Mitchell Kuss Yunfan Kong wen shi Philipp N.Streubel Tieshi Li Bin Duan Mary&Dick Holland Regenerative Medicine Program Division of CardiologyDepartment of Internal MedicineUniversity of Nebraska Medical CenterOmahaNE68198USA Molecular Genetics and Cell Biology Program Department of GeneticsCell Biology and AnatomyUniversity of Nebraska Medical CenterOmahaNE68198USA College of Textiles&Clothing Collaborative Innovation Center of Marine Biomass FibersQingdao UniversityQingdao266071China Department of Orthopedic Surgery and Rehabilitation University of Nebraska Medical CenterOmahaNE68198USA Department of Pediatrics University of Nebraska Medical CenterOmahaNE68198USA Department of Surgery College of MedicineUniversity of Nebraska Medical CenterOmahaNE68198USA Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNE68516USA

Repairing massive rotator cuff tendon defects remains a challenge due to the high retear rate after surgical intervention.3D printing has emerged as a promising technique that enables the fabrication of engineered tissues with heterogeneous structures and mechanical properties,as well as controllable microenvironments for tendon regeneration.In this study,we developed a new strategy for rotator cuff tendon repair by combining a 3D printed scaffold of polylactic-co-glycolic acid(PLGA)with cell-laden collagen-fibrin hydrogels.We designed and fabricated two types of scaffolds:one featuring a separate layer-by-layer structure and another with a tri-layered structure as a whole.Uniaxial tensile tests showed that both types of scaffolds had improved mechanical properties compared to single-layered PLGA scaffolds.The printed scaffold with collagen-fibrin hydrogels effectively supported the growth,proliferation,and tenogenic differentiation of human adipose-derived mesenchymal stem cells.Subcutaneous implantation of the multilayered scaffolds demonstrated their excellent in vivo biocompatibility.This study demonstrates the feasibility of 3D printing multilayered scaffolds for application in rotator cuff tendon regeneration.

关键词： Collagen-fibrin hydrogel Tenogenic differentiation Tendon repair Tissue engineering