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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin ren wen-xuan LIANG wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

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Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1344-1362页

作者： Zi-Ling Hu Yu-Xuan Wang Zi-Yue Lin wen-Shuo ren Bo Liu Hui Zhao Qiong Qin Five Year Program of Ophthalmology and Optometry 2019 Beijing Tong Ren HospitalCapital Medical UniversityBeijing 100054China Four Year Program of Traditional Chinese Pharmacy 2020 School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of TCM Collateral Disease Theory Research Beijing 100069China Five Year Program of Ophthalmology and Optometry 2021 School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Biochemistry&Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual *** evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological *** factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative *** functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been *** the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD *** the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关键词： Nrf2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress

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The role of FMO3 in metabolic diseases

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Traditional Medicine Research 2024年第9期9卷 42-50页

作者： Hui-wen ren He-Yuan Lu Hai-Bo Zhang Rui-Jing Zhang Che Bian Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China College of Basic Medical Sciences Dalian Medical UniversityDalian 116044China Department of Nephrology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Endocrinology and Metabolism The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032China

Flavin containing monooxygenase 3(FMO3)is a member of the flavin monooxygenase family,which can oxidize the precursor Trimethylamine(TMA)provided from food to produce Trimethylamine N-oxide(TMAO).The autosomal recessive inherited disease caused by partial functional loss of Fmo3 gene,which leads to excessive excretion of TMA in body fluids and emits fishy odor,is called Fish Odor Syndrome or *** disease has been documented for 3,000 years ago and was first reported in the case report in ***3 mainly exists in the liver and can participate in the TMA-TMAO metabolic balance in intestinal microorganisms,liver,and kidneys,closely related to insulin resistance,diabetes,cholesterol metabolism,and cardiovascular *** to its wide range of catalytic substrates and low susceptibility to metabolite accumulation,its role in drug metabolism,new drug development,and discovery of new drug targets are increasingly *** review will summarize the research progress on the metabolic process and localization of FMO3,congenital genetic defects,metabolic diseases,and its related possible mechanisms.

关键词： metabolic diseases FMO3 TMA TMAO

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Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury

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Chinese Journal of Traumatology 2024年第2期27卷 97-106页

作者： Peng Qi Meng-Jie Huang Wei Wu Xue-wen ren Yong-Zhi Zhai Chen Qiu Hai-Yan Zhu Department of Emergency First Medical Center of Chinese PLA General HospitalBeijing100853China Department of Nephrology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Anesthesiology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Orthopedics Fourth Medical Center of Chinese PLA General HospitalBeijing100853China

Purpose:Acute kidney injury(AKI)is one of the most common functional injuries observed in trauma ***,certain trauma medications may exacerbate renal ***,the early detection of trauma-related AKI holds paramount importance in improving trauma ***:Qualified datasets were selected from public databases,and common differentially expressed genes related to trauma-induced AKI and hub genes were identified through enrichment analysis and the establishment of protein-protein interaction(PPI)***,the specificity of these hub genes was investigated using the sepsis dataset and conducted a comprehensive literature review to assess their *** raw data from both datasets were downloaded using R software(version 4.2.1)and processed with the"affy"package19 for correction and ***:Our analysis revealed 585 upregulated and 629 downregulated differentially expressed genes in the AKI dataset,along with 586 upregulated and 948 downregulated differentially expressed genes in the trauma ***,the establishment of the PPI network and subsequent topological analysis highlighted key hub genes,including CD44,CD163,TIMP metallopeptidase inhibitor 1,cytochrome b-245 beta chain,versican,membrane spanning 4-domains A4A,mitogen-activated protein kinase 14,and early growth response ***,their receiver operating characteristic curves displayed areas exceeding 75%,indicating good diagnostic ***,our findings postulated a unique molecular mechanism underlying trauma-related ***:This study presents an alternative strategy for the early diagnosis and treatment of trauma-related AKI,based on the identification of potential biomarkers and therapeutic ***,this study provides theoretical references for elucidating the mechanisms of trauma-related AKI.

关键词： Trauma Acutekidney injury Bioinformatic analysis Differentially expressed genes Biomarker

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Black holes as the source of dark energy:A stringent test with high-redshift JWST AGNs

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 181-188页

作者： Lei Lei Lei Zu Guan-wen Yuan Zhao-Qiang Shen Yi-Ying Wang Yuan-Zhu Wang Zhen-Bo Su wen-Ke ren Shao-Peng Tang Hao Zhou Chi Zhang Zhi-Ping Jin Lei Feng Yi-Zhong Fan Da-Ming Wei Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

Studies have proposed that there is evidence for cosmological coupling of black holes(BHs)with an index of k≈3;hence,BHs serve as the astrophysical source of dark ***,the data sample is limited for the redshifts of≤*** recent years,the James Webb Space Telescope(JWST)has detected many high-redshift active galactic nuclei(AGNs)and *** the JWST NIRSpec-/NIRCam-resolved AGNs,three are determined to be in early-type host galaxies with a redshift of z~***,their M_(*)and MBH are in tension with the predicted cosmological coupling of black holes with k=3 at a confidence level of~2σ,which challenges the hypothesis that BHs serve as the origin of dark *** work on high-redshift AGNs using the JWST will further assess such a hypothesis by identifying more early-type host galaxies in the higher mass range.

关键词： dark energy supermassive black hole active galactic nuclei James Webb Space Telescope

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Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： Xiao-Wei Tang wen-Sen ren Shu Huang Kang Zou Huan Xu Xiao-Min Shi Wei Zhang Lei Shi Mu-Han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

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新时代社会主义意识形态建设的创新发展及其经验析论

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南通大学学报（社会科学版） 2024年第1期40卷 1-10,159页

作者：孙绍勇任雯陕西(高校)哲学社会科学重点研究基地“马克思主义创新发展研究中心” 西北工业大学马克思主义学院

意识形态作为观念上层建筑,对经济社会发展具有巨大的反作用。高度重视意识形态建设,牢牢掌握意识形态工作的领导权,是中国共产党的优良传统。新时代以来,面对纷繁复杂的意识形态领域的风险和挑战,中国共产党审时度势、深谋远虑,不断推... 详细信息

意识形态作为观念上层建筑,对经济社会发展具有巨大的反作用。高度重视意识形态建设,牢牢掌握意识形态工作的领导权,是中国共产党的优良传统。新时代以来,面对纷繁复杂的意识形态领域的风险和挑战,中国共产党审时度势、深谋远虑,不断推进社会主义意识形态建设的创新发展。洞察时代大势科学研判社会主义意识形态建设的坐标定位、聚焦本质规律辩证认识社会主义意识形态建设的原则导向、把握历史主动系统优化社会主义意识形态建设的战略举措,深入总结党的十八大以来中国共产党推进社会主义意识形态建设创新发展,以及所积累创造的经验,对于党在新征程上不断提升社会主义意识形态的引领力和凝聚力,进而统一全党全国各族人民的意志和思想,推进全面建设社会主义现代化强国,具有深刻的理论价值和现实意义。

关键词：新时代社会主义意识形态创新发展宝贵经验

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1949年以来抗战题材影片中译员形象的塑造与变迁

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西安外国语大学学报 2024年第1期32卷 78-83页

作者：任文向俊北京外国语大学高级翻译学院中国科学院大学外语系

中华人民共和国成立以来拍摄的涉及多语场景的抗战题材影片数量不少,但鲜有研究关注其中的译员银幕形象,仅个别论文考察此类影片中的“汉奸”译员。本文在认知文体学视阈下结合卡尔波珀的人物塑造认知模型和库克的语篇理论,考察1949—2... 详细信息

中华人民共和国成立以来拍摄的涉及多语场景的抗战题材影片数量不少,但鲜有研究关注其中的译员银幕形象,仅个别论文考察此类影片中的“汉奸”译员。本文在认知文体学视阈下结合卡尔波珀的人物塑造认知模型和库克的语篇理论,考察1949—2023年拍摄的21部抗战题材影片中译员形象的塑造与变迁。研究发现,虽然多数译员银幕形象是对“翻译即叛徒”这一原型的契合,但近年也出现了偏离原型的差异性译员形象。译员银幕形象的变迁折射了翻译作为一个职业的发展,以及人们对翻译活动,尤其是冲突情境下口译活动复杂性认知的变化;同时,译员银幕形象的变迁又进一步促进了观众认知的更新,反映出译员银幕形象和观众对翻译及译员的认知之间的互动关系。

关键词：认知文体学译员银幕形象塑造与变迁原型契合原型偏离

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事件融合与空间注意力和时间记忆力的视频去雨网络

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软件学报 2024年第5期35卷 2220-2234页

作者：孙上荃任文琦操晓春中国科学院信息工程研究所北京100085 中国科学院大学网络空间安全学院北京100049 中山大学网络空间安全学院广东深圳518107

近年来数码视频拍摄设备不断升级,其感光元件宽容度、快门速率的提升虽然极大程度地丰富了可拍摄景物的多样性,雨痕这类由于雨滴高速穿过景深范围的退化元素也更容易被记录到,作为前景的稠密雨痕阻挡了背景景物的有效信息,从而影响图像... 详细信息

近年来数码视频拍摄设备不断升级,其感光元件宽容度、快门速率的提升虽然极大程度地丰富了可拍摄景物的多样性,雨痕这类由于雨滴高速穿过景深范围的退化元素也更容易被记录到,作为前景的稠密雨痕阻挡了背景景物的有效信息,从而影响图像的有效采集.由此视频图像去雨成为一个亟待解决的问题,以往的视频去雨方法集中在利用常规图像自身的信息,但是由于常规相机的感光元件物理极限、快门机制约束等原因,许多光学信息在采集时丢失,影响后续的视频去雨效果.由此,利用事件数据与常规视频信息的互补性,借助事件信息的高动态范围、时间分辨率高等优势,提出基于事件数据融合与空间注意力和时间记忆力的视频去雨网络,利用三维对齐将稀疏事件流转化为与图像大小匹配的表达形式,叠加输入至集合了空间注意力机制的事件-图像融合处理模块,有效提取图像的空间信息,并在连续帧处理时使用跨帧记忆力模块将先前帧特征利用,最后经过三维卷积与两个损失函数的约束.在开源视频去雨数据集上验证所提方法的有效性,同时达到了实时视频处理的标准.

关键词：视频去雨事件数据多模态融合空间注意力时间记忆力

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中国土壤中全氟和多氟烷基物质的分布、迁移及管控研究进展

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环境科学 2024年第1期45卷 376-385页

作者：刘浩然邢静怡任文杰伦敦大学学院市政环境与岩土工程系伦敦WC1E 6BT 西安市生态环境局长安分局西安710199 中国科学院南京土壤研究所土壤环境与污染修复重点实验室南京210008

全氟和多氟烷基物质(PFAS)是近年来备受关注的一类持久性有机污染物,具有种类多、难降解、远距离迁移和易生物蓄积等特点.其在水体和生物体内的分布及其富集性和潜在毒性已在世界范围内受到广泛关注,但在土壤中的分布和迁移规律仍处于... 详细信息

全氟和多氟烷基物质(PFAS)是近年来备受关注的一类持久性有机污染物,具有种类多、难降解、远距离迁移和易生物蓄积等特点.其在水体和生物体内的分布及其富集性和潜在毒性已在世界范围内受到广泛关注,但在土壤中的分布和迁移规律仍处于初步研究阶段.我国土壤PFAS污染调查主要集中在东部经济发达地区,土壤中PFAS的种类和含量与调查区域工业类型、大气沉降和人为活动存在直接关联,并且与国外土壤调查规律类似.传统的全氟烷基羧酸(PFCAs)和全氟烷基磺酸(PFSAs)是我国土壤中最主要的PFAS类型.通过综述我国土壤中PFAS的分布特征、迁移途径及影响因素以及国内外关于PFAS污染的管控政策,指出目前针对土壤中PFAS分布及管控研究的不足,以期为我国土壤PFAS污染调查研究及管控提供参考.

关键词：全氟和多氟烷基物质(PFAS) 土壤污染分布迁移管控政策

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