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An analysis of treatment preferences and sexual quality of life outcomes in female partners of Chinese men with erectile dysfunction

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Asian Journal of Andrology 2016年第5期18卷 773-779页

作者： Hong-Jun Li wen-Jun Bai Yu-Tian Dai wen-ping xu Chia-Ning Wang Han-Zhong Li Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Urology Peking University People's Hospital Beijing 100044 China Department of Andrology Nanjing Drum Tower Hospital Jiangsu 210008 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China

The impact of erectile dysfunction is distressing to both males and their female partners, but less attention has been paid to identify female partners＇ preferred treatment and sexual quality of life outcomes. The present analysis explores female partners＇ treatment preference for erectile dysfunction in Chinese Men. This was a phase 4, randomized, open-label, multicenter, crossover study in Chinese men with erectile dysfunction who were na＇fve to phosphodiesterase type 5 inhibitor treatments. Eligible patients were randomized to sequential 20-mg tadalafil/100-mg sildenafil or lO0-mg sildenafil/20-mg tadalafil for 8 weeks each. Of 418 patients, female partners of 64 patients agreed to enter the study; of 64 patients who entered the study with female partners, 63 were randomized, and 62 completed the study. Baseline demographics and disease characteristics were comparable between treatment groups. Significantly more couples preferred tadalafil compared with sildenafil overall （75.4% vs 24.6%; P〈 0.001）, and irrespective of erectile dysfunction severity at baseline （P 〈 0.005）. Significant improvements in sexual quality of life scores were reported at endpoint （Visit 8） in male patients and female partners in both tadalafil and sildenafil treatment groups （P 〈 0.001）. Significantly higher mean changes from baseline were observed for male patients in the tadalafil group compared with the sildenafil group for the erectile function （P = 0.013） and overall satisfaction （P = 0.019） International Index for Erectile Function domains and the spontaneity domain （P〈 0.001） of the Psychological and Interpersonal Relationship Scale. No major safety concerns were reported during the study. Though both treatments were effective, safe, and tolerable, more couples preferred tadalafil compared with sildenafil.

关键词： erectile dysfunction partners' preference sexual quality of life sildenafil tadalafil

A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction

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Asian Journal of Andrology 2017年第4期19卷 500-504页

作者： wen-Jun Bai Hong-Jun Li Jian-Jun Jin wen-ping xu Sorsaburu Sebastian Xiao-Feng Wang Department of Urology Peking University People's Hospital Beijing 100044 China Department of Urology Peking Union Medical College Hospital Beijing 100730 China Department of Medical Lilly Suzhou Pharmaceutical Co. Ltd. Shanghai 200021 China Eli Lilly and Company Indianapolis Indiana 46285 USA

Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction （ED）. Recent study results indicate that men with ED in China who were naive to phosphodiesterase inhibitor type 5 （PDE5） therapy prefer tadalafil 20-mg （on-demand） versus sildenafil 100-mg （on-demand）. Differences in psychosocial outcomes may help to explain treatment preference in favor of tadalafih This open-label, randomized, crossover study compared psychosocial outcomes and drug attribute choices between tadalafil and sildenafil in Chinese men with ED na＇（ve to PDE5 inhibitor therapy. Eligible patients were randomized to sequential 20-mg tadalafU/lOO-mg sildenafil （n = 190） or 100-mg sildenafil/20-mg tadalafil （n = 193） for 8 weeks each and were asked which treatment they preferred to take for the 8-week extension phase. Psychosocial outcomes were assessed using the Psychological and Interpersonal Relationship Scale （PAIRS）, Drug Attributes Questionnaire （DRAQ）, and Sexual Life Quality Questionnaire （SLQQ）. When taking tadalafil versus sildenafil, men had a higher mean endpoint score on the PAIRS Spontaneity Domain （tadalafil = 2.86 vs sildenafil = 2.72; P 〈 0.001）, and a lower mean endpoint score on the Time Concerns Domain （tadalafil = 2.41 vs sildenafil = 2.55; P 〈 0.001）. A numerical increase in the Sexual Self-Confidence Domain was observed when taking tadalafil versus sildenafil （tadalafil -- 2.76 vs sildenafil = 2.72; P= 0.102）. The most frequently chosen drug attributes explaining treatment preference were able to get an erection long after having drug, and ability to get an erection every time. SLQQ results were comparable between treatment groups. These psychosocial outcomes may explain why more Chinese men preferred tadalafil versus sildenafil for the treatment of ED in this clinical trial.

关键词： drug attributes erectile dysfunction phosphodiesterase type 5 inhibitor psychological assessment of sexual dysfunction

The Dose-response of Intrathecal Ropivacaine Co-administered with Sufentanil for Cesarean Delivery under Combined Spinal-epidural Anesthesia in Patients with Scarred Uterus

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Chinese Medical Journal 2015年第19期128卷 2577-2582页

作者： Fei Xiao wen-ping xu Yin-Fa Zhang Lin Liu Xia Liu Li-Zhong Wang Department of Anesthesia Jiaxing Maternity and Child Care HospitalJiaxingZhejiang 314050China Jiaxing Genetic and Reproductive Medicine Research Institute JiaxingZhejiang 314050China Department of AnesthesiaJiaxing Maternity and Child Care HospitalJiaxingZhejiang 314050China

Background：Spinal anesthesia is considered as a reasonable anesthetic option in lower abdominal and lower limb *** study was to determine the dose-response of intrathecal ropivacaine in patients with scarred uterus undergoing cesarean delivery under combined spinal-epidural ***：Seventy-five patients with scarred uterus undergoing elective cesarean delivery under combined spinal-epidural anesthesia were enrolled in this randomized,double-blinded,dose-ranging *** received 6,8,10,12,or 14 mg intrathecal hyperbaric ropivacaine with 5 μg *** spinal anesthesia was defined as a T4 sensory level achieved with no need for epidural *** 50％ effective dose （ED50） and 95％ effective dose （ED95） were calculated with a logistic regression ***：ED50 and ED95 ofintrathecal hyperbaric ropivacaine for patients with scarred uterus undergoing cesarean delivery under combined spinal-epidural anesthesia （CSEA） were 8.28 mg （95％ confidence interval [CI]：2.28-9.83 mg） and 12.24 mg （95％ CI：10.53-21.88 mg）,***：When a CSEA technique is to use in patients with scarred uterus for an elective cesarean delivery,the ED50 and ED95 of intrathecal hyperbaric ropivacaine along with 5 μg sufentanil were 8.28 mg and 12.24 mg,*** addition,this local anesthetic is unsuitable for emergent cesarean delivery,but it has advantages for ambulatory patients.

关键词： Cesarean Delivery Dose-response Ropivacaine Scarred Uterus Spinal

ED50 and ED95 of Intrathecal Bupivacaine Coadministered with Sufentanil for Cesarean Delivery Under Combined Spinal-epidural in Severely Preeclamptic Patients

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Chinese Medical Journal 2015年第3期128卷 285-290页

作者： Fei Xiao wen-ping xu Xiao-Min Zhang Yin-Fa Zhang Li-Zhong Wang Xin-Zhong Chen Department of Anesthesia Women's Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310006 China Department of Anesthesia Jiaxing Maternity and Child Care Hospital Jiaxlng Zhejiang 314005 China

Background： Spinal anesthesia was considered as a reasonable anesthetic option in severe preeclampsia when cesarean delivery is indicated, and there is no indwelling epidural catheter or contraindication to spinal anesthesia. However, the ideal dose of intrathecal bupivacaine has not been quantified for cesarean delivery for severe preeclamptic patients. This study aimed to determine the ED50 and ED95 of intrathecal bupivacaine for severely preeclamptic patients undergoing elective cesarean delivery. Methods： Two hundred severely preeclamptic patients are undergoing elective cesarean delivery under combined spinal-epidural anesthesia enrolled in this randomized, double-blinded, dose-ranging study. Patients received 4 rag, 6 mg, 8 mg, or 10 mg intrathecal hyperbaric bupivacaine with 2.5 μg sufentanil. Successful spinal anesthesia was defined as a T6 sensory level achieved within 10 minutes after intrathecal drug administration and/or no epidural supplement was required during the cesarean section. The ED50 and ED95 were calculated with a logistic regression model. Results： ED90 and ED95 ofintrathecal bupivacaine for successful spinal anesthesia were 5.67 mg （95% confidence interval [C/]： 5.20-6.10 mg） and 8.82 mg （95% CI： 8.14-9.87 mg） respectively. The incidence of hypotension in Group 8 mg and Group 10 mg was higher than that in Group 4 mg and Group 6 mg （P 〈 0.05）. The sensory block was significantly different among groups 10 minutes after intrathecal injection （P 〈 0.05）. The use of lidocaine in Group 4 mg was higher than that in other groups （P 〈 0.05）. The use of phenylephrine in Group 8 mg and Group 10 mg was higher than that in the other two groups （P 〈 0.05）. The lowest systolic blood pressure before the infant delivery of Group 8 mg and Group 10 mg was lower than the other two groups （P 〈 0.05）. The satisfaction of muscle relaxation in Group 4 mg was lower than other groups （P 〈 0.05）. There was no significant difference in patients＇ satisfaction and the ne

关键词： Bupivacaine Cesarean Section Dose-response Severe Preeclampsia Spinal

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： wen YANG BIN TANG DAN xu wenXIU YANG Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao Xie Ying-Jie Yu Hai-Jun Zhang Ya-ping Deng wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

The prevalence and associated factors of simple hepatic cysts in Shanghai:a population-based cross-sectional study

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Chinese Medical Journal 2021年第10期134卷 1248-1250页

作者： wen-ping xu Xiao-Hang Wang Shao-ping Wu Pei-Mei Shi Zong-Li Yuan Yi-Bin Guo Xin Zeng Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Endoscopy Center Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Health Statistics Naval Medical UniversityShanghai 200433China Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China

To the Editor:Simple hepatic cyst is a common reason for consultation with gastroenterologists and *** most patients have a benign course,some suffer from serious complications,such as intracystic infection,hemorrhage,and even rupture,or symptoms caused by severe oppression of the surrounding tissues and *** the prevalence of,and characteristics of,and factors associated with simple hepatic cysts is helpful for better treatment of symptomatic *** reported prevalence of the disease varies widely,ranging from 2.5%to 18.0%,and most of them were based on hospital surveys.[1,2,3,4]As an asymptomatic disease in most cases,simple hepatic cysts are usually discovered incidentally on abdominal ***,surveys based on hospital populations cannot represent true ***,due to the absence of healthy controls,surveys with hospital populations have been unable to identify associated factors for simple hepatic cysts.[1,2,3,4].

关键词： prevalence hepatic organs

Feasibility of Virtual Touch Tissues Quantification technique in the assessment of liver fibrosis

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Feasibility of Virtual Touch Tissues Quantification techniqu...

主题团体心理辅导融入体育教学的实验研究——一项“改善羞怯”的团辅融入高校体育课程的干预实践

中华医学会第十次全国超声医学学术会议

作者： SHEN wen,DING Hong,WANG wen-ping,LI Cong,xu Chen,xu Zhi-zhang Department of Ultrasound,Zhongshan Hospital of Fudan University,Shanghai 200032,China

Objective:To evaluate the feasibility of Virtual Touch Tissues Quantification(VTQ) technique in the assessment of liver fibrosis and to find the suitable measuring position of ***:Liver stiffness was meas-

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西南师范大学学报（自然科学版） 2015年第2期40卷 145-149页

作者：文旭平文善恬湖州师范学院心理健康教育指导中心浙江湖州313000 湖州师范学院体育学院浙江湖州313000

为研究体育锻炼与大学生羞怯关系的密切程度,将团体心理辅导引入到体育教学过程中,有针对性地加入以"改善羞怯"为主题的教学内容、活动组织和游戏等,研究发现:这种融入相关团体心理辅导的体育教学与"改善女大学生羞怯"呈正相关,可以降... 详细信息

为研究体育锻炼与大学生羞怯关系的密切程度,将团体心理辅导引入到体育教学过程中,有针对性地加入以"改善羞怯"为主题的教学内容、活动组织和游戏等,研究发现:这种融入相关团体心理辅导的体育教学与"改善女大学生羞怯"呈正相关,可以降低女大学生的羞怯感水平,而正常的体育教学从整体上来说,对女大学生改善羞怯没有显著性的影响;在体育教学中融入团体心理辅导不仅能促进学生心理健康,而且能丰富体育教学形式和内容,提高学生的学习兴趣和成绩.

关键词：团体心理辅导大学生羞怯体育教学