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Bridge Ontology: A Multi-Ontologies-Based Approach for Semantic Annotation

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Wuhan University Journal of Natural Sciences 2004年第5期9卷 617-622页

作者： WANGPeng XUBao-wen LUjian-jiang liyan-hui JIANGJian-hua DepartmentofComputerSeienceandEngineering SoutheastUniversity.Nanjing210096JiangsuChina JiangsuInstituteofSoftwareQuality.Nanjing210096.Jiangsu China SchoolofCommunicationsEngineering People＇sI.iherationArmyUniversityofScienceandTechnology.Nanjing210007.Jiangsu.China

Representing the relationships between ontologies is the key problem of semantic annotations based on multi-ontologies. Traditional approaches only had the ability of denoting the simple concept subsumption relations between ontologies. Through analyzing and classifying the relationships between ontologies, the idea of bridge ontology was proposed, which had the powerful capability of expressing the complex relationships between concepts and relationships between relations in multi-ontologies. Meanwhile, a new approach employing bridge ontology was proposed to deal with the multi-ontologies-based semantic annotation problem. The bridge ontology is a peculiar ontology, which can be created and maintained conveniently, and is effective in the multi-ontologies-based semantic annotation. The approach using bridge ontology has the advantages of low-cost, scalable, robust in the web circumstance, and avoiding the unnecessary ontology extending and integration. Key words semantic web - bridge ontology - multi-ontologies - semantic annotation CLC number TP 391 Foundation item: Supported by the National Natural Science Foundation of China (60373066, 60303024). National Grand Fundamental Research 973 Program of China (2002CB312000), National Re-search Foundation for the Doctoral Program of Higher Education of China (20020286004)Biography: WANG Peng (1977-), male, Ph.D candidate, research direction: semantic web, ontology, and knowledge representation on the Web.

关键词： semantic web bridge ontology multi-ontologies semantic annotation

Query Through Heterogeneous Ontologies Using Association Matrix

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Wuhan University Journal of Natural Sciences 2004年第5期9卷 575-579页

作者： KANGDa-zhou XUBao-wen LUJian-jiang WANGPeng liyan-hui DepartmentotComputerScienceandEngineering SouthcastUniversity.Nanjing210096.JiangsuChina JianasuInstituteofSoftwarcQualily Nanjing210096Jiangsu-China SchoolofCommunicationsEngineering ThePeople＇sI.ibcra-fion：＼rmyUniversityofScienceandTechnologyNanjing210007.Jiangsu.China

This paper introduces the definition and calculation of the association matrix between ontologies. It uses the association matrix to describe the relations between concepts in different ontologies and uses concept vectors to represent queries; then computes the vectors with the association matrix in order to rewrite queries. This paper proposes a simple method of querying through heterogeneous Ontology using association matrix. This method is based on the correctness of approximate information filtering theory; and it is simple to be implemented and expected to run quite fast. Key words semantic Web - information retrieval - ontology - query - association matrix CLC number TP 391 Foundation item: Supported by the National Natural Science Foundation of China (60373066, 60303024), National Grand Fundamental Research 973 Program of China (2002CB312000) and National Research Foundation for the Doctoral Program of Higher Education of China (20020286004)Biography: KANG Da-zhou (1980-), male, Master candidate, research direction: Semantic Web, knowledge representation on the Web.

关键词： semantic Web information retrieval ontology query association matrix

Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma

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Cancer Biology & Medicine 2022年第3期19卷 273-277页

作者： Wei Liu Yongping Cui wen Liu Zhihua Liu liyan Xu Enmin Li College of Science Heilongjiang Institute of TechnologyHarbin 150050China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology the Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan AreaShantou University Medical CollegeShantou 515041China Department of Pathology Key Laboratory of Cellular Physiology(Shanxi Medical University)Ministry of EducationTaiyuan 030001China Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical SciencesXiamen UniversityXiamen 361005China State Key Lab of Molecular Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Proteins are key players in various cellular *** the ultimate executors of cellular processes,they play essential roles in linking genotypes to *** in protein expression and post-translational modifications(PTMs)are closely associated with the initiation and development of cancer,and they carry biological information inaccessible to genomics and *** complements genomic and transcriptomic data,thus enabling comprehensive analysis of cancer pathogenesis and accelerating biomedical research2.

关键词： esophageal linking carry

Molecular characterization and expression analysis of Patched 1 gene in the half-smooth tongue sole(Cynoglossus semilaevis)

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Acta Oceanologica Sinica 2016年第6期35卷 19-28页

作者： DONG Zhongdian QI Qian ZHANG Ning SHAO Changwei ZHANG liyan wen Haishen CHEN Songlin Fisheries College Ocean University of China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Function Laboratory for Marine Fisheries Science and Food Production Processes National Laboratory for Marine Science and Technology

The signaling molecule hedgehog（Hh） is essential for cellular signaling required for body pattern formation in embryonic and individual development in vertebrate and *** 1（Ptc1）,a receptor of Hh,mediates the activity of Hh by binging the Hh *** this study,the Ptc1 of half-smooth tongue sole Cynoglossus semilaevis（CsPtc1） was cloned and *** full-length of CsPtc1 cDNA is 5 212 nucleotides（nt）,and encodes a protein with 1 543 amino acid ***1 shared many features with Ptc1 of other telesot ***-time quantitative PCR revealed CsPtc1 mRNA expressed in brain,liver,heart,gill,intestines,spleen,gonad and kidney,with expression level in testis significantly higher than in *** testis,hybridization signals were mainly detected in primary spermatocytes,secondary spermatocytes,and sertoli cells,while weak signals were found in ***,the degree of methylation is higher in female than in male and *** indicate that CsPtc1 may be involved in Desert Hedgehog（DHH） maintenance of the male and pseudo-male germ line and spermatogenesis.

关键词： half-smooth tongue sole male and female Patched 1 RACE qRT-PCR methylation

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杭州疗养因子对老年人血压、血脂的影响

中国疗养医学 2010年第7期19卷 581-581页

作者：温丽艳邓燕妮南京军区杭州疗养院海勤疗养区 310002

目的探讨杭州疗养因子对老年人血压、血脂的影响。方法随机选择来院疗养的老年人146名,采用规律饮食、自然疗养因子、药物、运动疗法、景观疗养等综合治疗措施,比较疗养前和疗养15d后血压、血脂变化情况。结果治疗15d后与治疗前比较,血... 详细信息

目的探讨杭州疗养因子对老年人血压、血脂的影响。方法随机选择来院疗养的老年人146名,采用规律饮食、自然疗养因子、药物、运动疗法、景观疗养等综合治疗措施,比较疗养前和疗养15d后血压、血脂变化情况。结果治疗15d后与治疗前比较,血压、血脂有所降低。结论杭州疗养因子对老年人血压、血脂有降低作用。

关键词：疗养因子血压血脂

Lactate anions participate in T cell cytokine production and function

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Science China(Life Sciences) 2021年第11期64卷 1895-1905页

作者： Jing wen Shipeng Cheng Yaguang Zhang Ran Wang Jiefang Xu Zhiyang Ling liyan Ma Xinghao Ai Bing Sun School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China School of Life Science University of Science and Technology of ChinaHefei 230026China Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in Tcells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate(Na L) increased the production of cytokines(such as IFNγ/IL-2/TNFα) more than the addition of sodium chloride(NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, Na L treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the Na L treatment group compared to the Na Cl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function.

关键词： lactate glycolysis TCR activation immunometabolism

The effects of the primary health care providers’prescription behavior interventions to improve the rational use of antibiotics:a systematic review

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Global Health Research and Policy 2020年第1期5卷 92-103页

作者： Lu Yao Jia Yin Ruiting Huo Ding Yang liyan Shen Shuqin wen Qiang Sun Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Lab of Health Economics and Policy Research(Shandong University) Jinan 250012China Cangzhou Central Hospital Cangzhou 061001HebeiChina

Background:Irrational antibiotics use in clinical prescription,especially in primary health care(PHC)is accelerating the spread of antibiotics resistance(ABR)around the *** may be greatly useful to improve the rational use of antibiotics by effectively intervening providers’prescription behaviors in *** study aimed to systematically review the interventions targeted to providers’prescription behaviors in PHC and its’effects on improving the rational use of ***:The literatures were searched in Ovid Medline,Web of Science,PubMed,Cochrane Library,and two Chinese databases with a time limit from January 1st,1998 to December 1st,*** articles included in our review were randomized control trial,controlled before-and-after studies and interrupted time series,and the main outcomes measured in these articles were providers’prescription *** Cochrane Collaboration criteria were used to assess the risk of bias of the studies by two *** analysis was performed to analyze the effect size of ***:A total of 4422 studies were identified in this study and 17 of them were included in the *** 17 included studies,13 studies were conducted in the Europe or in the United States,and the rest were conducted in low-income and-middle-income countries(LMICs).According to the Cochrane Collaboration criteria,12 studies had high risk of bias and 5 studies had medium risk of *** was moderate-strength evidence that interventions targeted to improve the providers’prescription behaviors in PHC decreased the antibiotics prescribing and improved the rational use of ***:Interventions targeted PHC providers’prescription behaviours could be an effective way to decrease the use of antibiotics in PHC and to promote the rational use of ***,we cannot compare the effects between different interventions because of heterogeneity of interventions and outcome measures.

关键词： prescription rational income

Comparison of three remotely sensed drought indices for assessing the impact of drought on winter wheat yield

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International Journal of Digital Earth 2020年第4期13卷 504-526页

作者： Jianxi Huang wen Zhuo Ying Li Ran Huang Fernando Sedano Wei Su Jinwei Dong liyan Tian Yanbo Huang Dehai Zhu Xiaodong Zhang College of Land Science and Technology China Agricultural UniversityBeijingPeople’s Republic of China Key Laboratory of Remote Sensing for Agri-Hazards Ministry of AgricultureBeijingPeople’s Republic of China CMA·Henan Key Laboratory of Agrometeorological Support and Applied Technique ZhengzhouPeople’s Republic of China Henan Institute of Meteorological Sciences ZhengzhouPeople’s Republic of China Department of Geographical Sciences University of MarylandCollege ParkMDUSA Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingPeople’s Republic of China Department of Geography College of GeosciencesTexas A&M UniversityCollege StationTXUSA United States Department of Agriculture Agricultural Research ServiceCrop Production Systems Research UnitStonevilleMSUSA

Agricultural drought threatens food *** remote-sensing drought indices have been developed,but their different principles,assumptions and physical quantities make it necessary to compare their suitability for drought monitoring over large ***,we analyzed the performance of three typical remote sensing-based drought indices for monitoring agricultural drought in two major agricultural production regions in Shaanxi and Henan provinces,northern China(predominantly rain-fed and irrigated agriculture,respectively):vegetation health index(VHI),temperature vegetation dryness index(TVDI)and drought severity index(DSI).We compared the agreement between these indices and the standardized precipitation index(SPI),soil moisture,winter wheat yield and National Meteorological Drought Monitoring(NMDM)*** average,DSI outperformed the other indices,with stronger correlations with SPI and soil *** also corresponded better with soil moisture and NMDM *** jointing and grain-filling stages of winter wheat are more sensitive to water stress,indicating that winter wheat required more water during these ***,the correlations between the drought indices and SPI,soil moisture,and winter wheat yield were generally stronger in Shaanxi province than in Henan province,suggesting that remote-sensing drought indices provide more accurate predictions of the impacts of drought in predominantly rain-fed agricultural areas.

关键词： Agricultural drought remote sensing drought index winter wheat yield

Systematic analysis and functional verification of citrus glutathione S-transferases reveals that CsGSTF1 and CsGSTU18contribute negatively to citrus bacterial canker

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Horticultural Plant Journal 2024年第6期10卷 1309-1320页

作者： Jia Fu liyan Su Jie Fan Qiyuan Yu Xin Huang Chenxi Zhang Baohang Xian wen Yang Shuai Wang Shanchun Chen Yongrui He Qiang Li Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesChongqing 400712China School of Biological and Environmental Engineering Xi'an UniversityXi'anShaanxi 710065China National Citrus Engineering Research Center Chongqing 400712China National Citrus Improvement Center Chongqing 400712China

Citrus bacterial canker(CBC) is resulted from Xanthomonas citri subsp. citri(Xcc) infection and poses a significant threat to citrus *** S-transferases(GSTs) are critical in maintaining redox homeostasis in plants, especially in relation to abiotic and biotic stress responses. However, the function of GSTs in resisting CBC remains unclear. Here, citrus glutathione S-transferases were investigated applying a genome-wide approach. In total, 69 CsGSTs belonging to seven classes were identified, and the phylogeny, chromosomal distribution, gene structures and conserved motifs were analyzed. Several CsGSTs responded to Xcc infection, as observed in the upregulation of CsGSTF1 and CsGSTU18 in the CBC-sensitive ‘Wanjincheng' variety but not in the resistant ‘Kumquat' variety. CsGSTF1 and CsGSTU18 were localized at the cytoplasm. Transient overexpression of CsGSTF1 and CsGSTU18 mediated reactive oxygen species(ROS) scavenging, whereas the virus-induced gene silencing(VIGS) of CsGSTF1 and CsGSTU18 caused strong CBC resistance and ROS burst. The present study investigated the characterization of citrus GST gene family, and discovered that CsGSTF1 and CsGSTU18 negatively contributed to CBC through modulating ROS homeostasis. These findings emphasize the significance of GSTs in infection resistance in plants.

关键词： Citrus Glutathione S-transferases(GSTs) Citrus bacterial canker(CBC) Xanthomonas citri subsp.citri(Xcc) ROS homeostasis