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liquid Chromatography-Tandem Mass Spectrometry-Based Characterization of Steroid Hormone Profiles in Healthy 6 to 14-Year-Old Male Children

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Chinese Medical Journal 2018年第7期131卷 862-866页

作者： Bing-Yan Cao Chun-Xiu Gong Di Wu Xue-Jun liang wen-jing li Min liu Chang Su Miao Qin Xi Meng Jia-Jia Chen li-Ya Wei Department of Endocrinology Genetics and Metabolism Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China

To the Editor： Male steroid hormones are synthesized in the adrenal cortex and testis, and pediatric reference intervals for normal steroid hormone levels are essential for the diagnosis of adrenal and gonadal disorders. Importantly, steroid hormone profiles vary with age and pubertal development, and to date, only very limited data have been published concerning normal steroid hormone ranges in terms of age and pubertal development. The absence of such data has been primarily due to the lack of a sufficiently sensitive and specific method for determining appropriate reference intervals for steroid concentrations.

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science China Chemistry 2025年

作者： jing-wen Xie Meng-Ting Wang Yan Jin Si li Jian-Hua Qin Shuang-Quan Zang Tomas C.W.Mak College of Chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University College of Chemistry and Chemical Engineering Luoyang Normal University Department of Chemistry The Chinese University of Hong Kong

Circularly polarized luminescence （CPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for CPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a Cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with Cd2+ions to obtain 2D layers structure,L/*** L/D-Cu4-Cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and CPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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Safety and effectiveness of balloon catheter-assiste d ultrasound-guide d percutaneous microwave ablation in difficult-site liver cancer

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 84-91页

作者： Qi-Yu Zhao Teng Guo jing-jing Hu li-Ting Xie Wei-Lu Chai Guo Tian Tian-An Jiang Department of Ultrasound Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Ultrasound Medicine the First Affiliated HospitalZhejiang University School of MedicineLiangzhu BranchHangzhou 310003China Department of Ultrasound Medicine Ningbo No.2 HospitalNingbo 315010China

Background:Balloon catheter isolation is a promising auxiliary method for thermal ablation treatment of liver cancer. We aimed to explore the safety and effectiveness of balloon catheter isolation-assisted ultrasound-guided percutaneous microwave ablation (MWA) in treating liver cancer in difficult anatomical ***:Data of 132 patients with 145 difficult-site liver cancer treated with ultrasound-guided percutaneous MWA were retrospectively analyzed. Participants were classified into the isolation (n=40)and non-isolation (n=92) groups based on whether the patients were treated using a balloon catheter prior to ablation. The major complication rates, local tumor residuals (LTR), and tumor follow-up for local tumor progression (LTP) at 6 and 12 months post-ablation were compared between the two ***:The rates of major postoperative complications did not significantly differ between the isolation and non-isolation groups (2.5%vs. 4.3%, P=0.609). The postoperative LTR rates were significantly different between the isolation and non-isolation groups (4.8%vs. 17.5%, P=0.032). Balloon catheter isolation [odds ratio (OR)=0.225, 95%confidence interval (CI):0.085–0.595, P=0.009] and tumor diameter(OR=2.808, 95%CI:1.186–6.647, P=0.019) were identified as independent factors influencing LTR *** cumulative LTP rates at 6 and 12 months after ablation showed no significant differences between the isolation and non-isolation groups (2.6%vs. 7.9%, P=0.661;4.9%vs. 9.8%, P=0.676, respectively).Cox proportional hazards regression analysis showed that tumor diameter was an independent risk factor for cumulative LTP rate (OR=3.445, 95%CI:1.406–8.437, P=0.017).Conclusions:Balloon catheter isolation-assisted MWA was safe and effective in the treatment of difficultsite liver cancer. Additionally, tumor diameter significantly influenced LTR and LTP rates after ablation.

关键词： liver cancer Microwave ablation Balloon catheter isolation

A novel telomeric(235 kb)alpha-thalassemia deletion leading to alpha-thalassemia-1

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A novel telomeric(235 kb)alpha-thalassemia deletion leading ...

第十四次全国医学遗传学学术会议

作者： Ji-wei Huang Shi-qiang Luo Zhe-tao li Wu-gao li Ti-zhen Yan Ning Tang jing-wen li Ren Cai Key Laboratory of birth defects prevention and control Department of Clinical Laboratory Liuzhou Municipal Maternity and Child Healthcare Hospital

Many large deletions involving the alpha-globin gene cluster on the short arm of the human chromosome 16(16p13.3)result in *** we identified a novel telomeric(35 kb)alpha-thalassemia deletion leading to *** propositus was 37-year-old female with marked microcytosis and hypochromia(Hb:127g/L,MCV:66.4 fL,MCH:21.4 pg,MCHC:323 fL,HbA2:2.5%)at normal ferritin *** search for the common alpha-thalassemia deletions(--SEA,-a3.7,-a4.2)and mutations(aCSa,aQSa,aWSa)was carried out by multiplex PCR and reverse dot blot and no common mutations were *** results prompted us to hypothesize that rare alpha-globin gene mutation gave rise to her thalassemia *** thus performed an MLPA analysis(SALSA MLPA kit P140-B2 HBA,MRC Holland),which identified,for the propositus and two brothers,a large deletion of the a-globin gene cluster.A CGH-array analysis was then carried out to gap the deletion which appeared to be approximately 235kb in length,spanning from the telomeric region in 5’to the AXIN1gene in 3’.The exact a-globin genotype of our proband(—/aa)is in total accordance with thalassemia *** research has shown haploinsufficiency of 800 kb region from the telomere of chromosome 16p leads to the dysmorphic features and mental retardation(ATR-16 syndrome).As the deletion described in the present case report is shorter(sup>235kb),it seems logical not to observe major dysmorphic features for our proband and her *** studies observed that her elder brother(--/aa)and his spouse(—/aa)were alpha(0)-thalassemia *** reproduction needs to be further following up for prenatal diagnosis is need to prevent producing Hb Bart’s hydrops foetus.

关键词： Large deletions Thalassemia Array-CGH

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描述铁电介质慢极化过程的等效电路

无机材料学报 2002年第3期17卷 521-525页

作者：陈敏李智强沈文彬李景德中山大学物理系广州510275

给出快效应和慢效应的等效电路,并对ＴＧＳ单晶的脉冲极化反转实验结果进行了定量计算和定性分析．计算结果与实验结果符合得很好．该等效电路方法也可用于分析铁电发射的基本物理过程．

关键词：铁电介质等效电路慢极化效应极化反转铁电发射硫酸三甘氨酸脉冲反转电流发生器

Preparation and performance of highly-conductive dual-doped li_(7)La_(3)Zr_(2)O_(12)solid electrolytes for thermal batteries

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Green Energy & Environment 2025年第2期10卷 399-409页

作者： Wei li Shu Zhang Xinya Bu jing Luo Yi Zhang Mengyu Yan Ting Quan Yanli Zhu State Key Laboratory of Explosion Science and Safety Protection Beijing Institute of TechnologyBeijing100081China Xi'an North Qinghua Electromechanical Co. Ltd.Xi'an710025China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China

Garnet li_(7)La_(3)Zr_(2)O_(12)(LLZO)electrolytes have been recognized as a promising candidate to replace liquid/molten-state electrolytes in battery applications due to their exceptional performance,particularly Ga-doped LLZO(LLZGO),which exhibits high ionic ***,the limited size of the liþtransport bottleneck restricts its high-current discharging *** present study focuses on the synthesis of Ga^(3+)þand Ba^(2+)þco-doped LLZO(LLZGBO)and investigates the influence of doping contents on the morphology,crystal structure,liþtransport bottleneck size,and ionic *** particular,Ga_(0.32)Ba_(0.15)exhibits the highest ionic conductivity(6.11E-2 S cm^(-1) at 550 C)in comparison with other compositions,which can be attributed to its higher-energy morphology,larger bottleneck and unique liþtransport *** addition to Ba^(2+),Sr^(2+)þand Ca^(2+)have been co-doped with Ga3þinto LLZO,respectively,to study the effect of doping ion radius on crystal structures and the properties of *** characterization results demonstrate that the easier liþtransport and higher ionic conductivity can be obtained when the electrolyte is doped with larger-radius *** a result,the assembled thermal battery with Ga_(0.32)Ba_(0.15)-LLZO electrolyte exhibits a remarkable voltage platform of 1.81 V and a high specific capacity of 455.65 mA h g^(-1) at an elevated temperature of 525℃.The discharge specific capacity of the thermal cell at 500 mA amounts to 63%of that at 100 mA,showcasing exceptional high-current discharging *** assembled as prototypes with fourteen single cells connected in series,the thermal batteries deliver an activation time of 38 ms and a discharge time of 32 s with the current density of 100 mA cm^(-2).These findings suggest that Ga,Ba co-doped LLZO solid-state electrolytes with high ionic conductivities holds great potential for high-capacity,quick-initiating and high-current discharging thermal batteries.

关键词： Element doping Thermal battery Solid electrolyte LLZO Ionic conductivity

瞬态工况下压水堆稳压器波动管热分层现象数值模拟

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原子能科学技术 2015年第1期49卷 58-63页

作者：郭超温丽晶刘宇生张盼马帅环境保护部核与辐射安全中心北京100082

利用计算流体动力学软件ANSYS/CFX,对秦山核电二期扩建工程2×650 MW压水堆核电站四号机组核岛厂房的稳压器波动管进行了三维全尺寸非稳态计算。建立了波动管整体和不同截面的热分层瞬态,对管内热分层流动与换热进行了研究。研究结果表... 详细信息

利用计算流体动力学软件ANSYS/CFX,对秦山核电二期扩建工程2×650 MW压水堆核电站四号机组核岛厂房的稳压器波动管进行了三维全尺寸非稳态计算。建立了波动管整体和不同截面的热分层瞬态,对管内热分层流动与换热进行了研究。研究结果表明:同一截面内高温层流体和低温层流体的升温方式不同;不同截面位置的管内流动温度分布特性差别较大,但均呈现分层流体温差先增大后减小的趋势。计算结果可为后续波动管热应力分析及寿命评价提供一定基础。

关键词：瞬态工况稳压器波动管热分层数值模拟

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions