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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao jing-wen li Hui Ye Xue-Zhi Zhang Jian-Xiang liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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On the Adjacent Vertex-distinguishing Equitable Edge Coloring of Graphs

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Acta Mathematicae Applicatae Sinica 2013年第3期29卷 615-622页

作者： jing-wen li Cong WANG Zhi-wen WANG School of Electronic and Information Engineering Lanzhou Jiaotong University School of Mathematics and Computer Sciences Ningxia University

Let G（V, E） be a graph. A k-adjacent vertex-distinguishing equatable edge coloring of G, k-AVEEC for short, is a proper edge coloring f if （1） C（u）≠C（v） for uv ∈ E（G）, where C（u） = {f（uv）｜uv ∈ E}, and （2） for any i, j = 1, 2,… k, we have ｜｜Ei｜｜Ej｜｜ ≤ 1, where Ei = {e｜e ∈ E（G） and f（e） = i}. χáve （G） = min{k｜ there exists a k-AVEEC of G} is called the adjacent vertex-distinguishing equitable edge chromatic number of G. In this paper, we obtain the χ áve （G） of some special graphs and present a conjecture.

关键词： graph adjacent vertex-distinguishing edge coloring adjacent vertex-distinguishing equitable edge coloring

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Global Attractivity of Positive Periodic Solutions for a Survival Model of Red Blood Cells

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Acta Mathematicae Applicatae Sinica 2007年第3期23卷 523-528页

作者： Xin-min Wu jing-wen li Department of Mathematics Shaoyang University Shaoyang 422000 China

In this paper, we deal with a model for the survival of red blood cells with periodic coefficients x＇（g）=-μ（t）x（t）＋P（t）e^-γ（t）x（t-τ（t））,t≥0.（＊）A new sufficient condition for global attractivity of positive periodic solutions of Eq. （＊） is obtained. Our criterion improves corresponding result obtained by li and Wang in 2005.

关键词： A survival model of red blood cells positive periodic solution global attractirvity positiveequilibrium

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Rainbow and Monochromatic Vertex-connection of Random Graphs

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Acta Mathematicae Applicatae Sinica 2022年第4期38卷 966-972页

作者： wen-jing li Hui JIANG Jia-bei HE School of Mathematics and Statistics North China University ofWater Resources and Electric PowerZhengzhou 450046China School of Mathematics Hefei University of TechnologyHefei 230000China

A vertex-colored path P is rainbow if its internal vertices have distinct colors;whereas P is monochromatic if its internal vertices are colored the *** a vertex-colored connected graph G,the rainbow vertex-connection number rvc(G)is the minimum number of colors used such that there is a rainbow path joining any two vertices of G;whereas the monochromatic vertex-connection number mvc(G)is the maximum number of colors used such that any two vertices of G are connected by a monochromatic *** two opposite concepts are the vertex-versions of rainbow connection number rc(G)and monochromatic connection number mc(G)*** study on rc(G)and mc(G)of random graphs drew much attention,and there are few results on the rainbow and monochromatic vertex-connection *** this paper,we consider these two vertex-connection numbers of random graphs and establish sharp threshold functions for them,respectively.

关键词： graph coloring rainbow vertex-connection number monochromatic vertex-connection number random graphs threshold function

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Dual-objective pattern optimization method for land suitability zoning in mountain counties

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Journal of Mountain Science 2023年第1期20卷 209-226页

作者： WANG Lei WU lian ZHANG Wei jing wen-li School of Architecture Chang’an UniversityXi’an710061China

As the basic administrative unit of China,counties have grown rapidly in recent years in the context of rapid urbanization,especially for counties located in mountainous *** drastic changes in land in mountainous areas can easily cause irreversible damage to the sensitive ecological *** the dual-objective suitability zoning of ecological and construction balance,regional sustainable land use patterns can be *** this study,Hantai District in Southern Shaanxi province,China,was chosen as the research area aiming at creating a balance between ecological supply and the development of construction in spatial planning.A dual-objective process evaluation system for ecological protection and construction development was proposed with 15 resistance factors selected from three attributes:natural ecology,economic society,and *** minimum resistance surface discrimination methods for ecological land and construction development land were proposed based on vertical space superposition and horizontal minimum cumulative resistance ***,the land in Hantai District was divided into four development grades from the optimal angle of dual goals,i.e.,the construction core zone being 134.56 km^(2),the suitable construction zone 115.77 km2,the ecological buffer zone 153.74 km^(2),and the ecological control zone 151.93 km^(2),using the method combining resistance difference and threshold *** addition,the development direction of each town under jurisdiction was *** study compensates for the deficiency of traditional methods that evaluate land only from a single vertical or horizontal process.

关键词： Dual-objective pattern Land suitability zoning Minimum cumulative resistance model Mountain county Hantai District

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Synthesis of Sulfur/Selenium-containing Polyester with Recyclability and Controllable Hydrophilicity and Glass Transition Temperature

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Chinese Journal of Polymer Science 2023年第12期41卷 1836-1845,I0004,I0005页

作者： wen-jing li Xiang-Qiang Pan Jian Zhu Zheng-Biao Zhang Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

We present a ring-opening polymerization of bridged cyclic lactone utilizing alcohol as the initiator and organic base as the *** γ-butyrolactone monomers(PhSGBL and PhSeGBL)were synthesized efficiently from commercially available 3-cyclohexene-1-carboxylic *** to the ring strain of the bridged structure,ring-opening polymerization of this type of γ-butyrolactone derivative was successfully carried out under mild conditions,e.g.,using ethylene glycol as the initiator and a commercial catalyst[1,5,7-triazabicyclo[4.4.0 dec-5-ene(TBD)]]as the catalyst at 30℃.The obtained polymer could be degraded to its monomer for recycling in the presence of ZnCl_(2) as a *** and PhSeGBL could also be copolymerized with ε-caprolactone to tune the glass transition ***,the hydrophilicity of the obtained sulfur-containing polymers could be adjusted by selectively oxidizing the thioether side group to sulfone/sulfoxide,which offered a way to tune the hydrophilicity of *** the other hand,the obtained selenium-containing compound could be degraded in the presence of m-CPBA(3-chloroperbenzoic acid),which offered potential application in sustained drug release.

关键词： Ring-opening polymerization Polyester Closed-loop recycling Selective oxidation

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Temperature-pH Sensitive IPN Hydrogels Composed of Silk Sericin and Poly(N-isopropylacrylamide)

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Chinese Chemical Letters 2006年第3期17卷 403-406页

作者： wen WU wen jing li li Qun WANG Ke Hua TU Wei lin SUN Deparment of Polymer Science and Engineering Zhejiang University Hangzhou 310027 Ningbo Institute of Technology Zhejiang University Ningbo 315100

Interpenetrating polymer network （IPN） composed of silk sericin （SS） and poly（N-isopropylacrylamide）（PNIPAAm） was prepared. The morphology of the IPNs, in which the SS phase was stained with ammonium cuprate, was examined with TEM and a relative homogeneous distribution of the two polymers was exhibited. The swelling behavior of the IPN hydrogels showed both temperature and pH dependences.

关键词： Silk sericin poly(N-isopropylacrylamide) interpenetrating polymer network.

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Scalable and High-Quality Monolayer Graphene Transfer onto Polymer Membranes Assisted by Camphor

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Chinese Journal of Polymer Science 2024年第12期42卷 1986-2001,I0011页

作者： Jun-Kan Yue jing liang Qiao-Yu Tan Man Chen jing-wen li Qing Guo Run-Lai li Qiang Fu College of Polymer Science&Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

The quest for scalable integration of monolayer graphene into functional composites confronts the bottleneck of high-fidelity transfer onto substrates,crucial for unlocking graphene’s full potential in advanced *** this,our research introduces the camphor-assisted transfer(CAT)method,a novel approach that surmounts common issues of residue and structural deformation endemic to existing *** in the sublimation dynamics of camphor,the CAT method achieves a clean,contiguous transfer of centimeter-scale monolayer graphene onto an array of polymer films,including ultra-thin polyethylene *** resultant ultrathin graphene-polyethylene(gPE)films,characterized by their exceptional transparency and conductivity,reveal the CAT method’s unique ability to preserve the pristine quality of graphene,underscoring its practicality for preparing flexible transparent electrodes by monolayer ***-depth mechanism investigation into the camphor sublimation during CAT has led to a pivotal realization:the porosity of the target polymer substrate is a determinant in achieving high-quality graphene *** that camphor sublimates initially from the polymer side is crucial to prevent the formation of wrinkles or delamination of *** extensive examination of CAT on a spectrum of commonly used polymer films,including PE,PP,PTFE,PI and PET,we have confirmed this important *** discovery offers crucial guidance for fabricating monolayer graphene-polymer composite films using methods akin to CAT,underscoring the significance of substrate selection in the transfer process.

关键词： Polyethylene Monolayer graphene Camphor Graphene/polymer composites van der Waals interaction

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Genetic diversity and temporal changes of an endemic cyprinid fish species, Ancherythroculter nigrocauda,from the upper reaches of Yangtze River

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Zoological Research 2019年第5期40卷 427-438页

作者： Dong-Dong Zhai wen-jing li Huan-Zhang liu wen-Xuan Cao Xin Gao Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei 430072 China University of Chinese Academy of Sciences Beijing 100049 China

Small populations with low genetic diversity are prone to extinction. Knowledge on the genetic diversity and structure of small populations and their genetic response to anthropogenic effects are of critical importance for conservation management. In this study, samples of Ancherythroculter nigrocauda, an endemic cyprinid fish from the upper reaches of Yangtze River, were collected from five sites to analyze their genetic diversity and population structure using mitochondrial cytochrome b gene and 14 microsatellite loci. Haplotype diversity, nucleotide diversity, and expected heterozygosity indicated that the A. nigrocauda populations had low genetic diversity, and decreased heavily from 2001 to 2016. Significant genetic differentiation was found among different populations in the cyt b gene and SSR markers based on the genetic differentiation index (F ST), whereas no differentiation was found in 2001. Haplotype genealogy showed that eight out of 15 haplotypes were private to one population. The SSR STRUCTURE analysis showed that there were four genetic clusters in the A. nigrocauda samples, with each population forming a single cluster, except for the Chishui River (CSR) and Mudong River (MDR) populations, which formed a common cluster. Therefore, loss of genetic diversity and increased genetic differentiation were found in the A. nigrocauda populations, which could be attributed to dam construction, overfishing, and water pollution in the upper Yangtze River. It is therefore recommended that the government should ban fishing, control water pollution, increase river connectivity, and establish artificial breeding and stocking.

关键词： Genetic diversity Population structure Temporal change Conservation

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Electronic Noses Using Quantitative Artificial Neural Network

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Chemical Research in Chinese Universities 2001年第4期17卷 380-386页

作者： wen li-jing BIAN li-ping LU Yu ZHANG Mei-zhuo YU li-ping YANG Peng-yuan Department of Chemistry Fudan UniversityShanghai 200433P.R.China

The present paper covers a new type of electronic nose (e-nose) with a four-sensor array, which has been applied to detecting gases quantitatively in the presence of interference. This e-nose has adapted fundamental aspects of relative error (RE) in changing quantitative analysis into the artificial neural network (ANN). Thus, both the quantitative and the qualitative requirements for ANN in implementing e-nose can be satisfied. In addition, the e-nose uses only 4 sensors in the sensor array, and can be designed for different usages simply by changing one or two sensor(s). Various gases were tested by this kind of e-nose, including alcohol vapor, CO, iiquefied-petrol-gas and CO2. Satisfactory quantitative results were obtained and no qualitative mistake in prediction was observed for the samples being mixed with interference gases.

关键词： E-nose ANN Relative error Quantitative analysis

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