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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei zhou Wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

肝细胞肝癌预后与病理特征、PCNA和DNA指数的关系

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复旦学报（医学版） 2002年第2期29卷 87-90页

作者：曾文姣许杰周信达张月娥张农复旦大学医学院病理学教研室复旦大学肝癌研究所上海200032

目的　研究肝细胞肝癌 (HCC)患者预后与肿瘤的病理形态特征、PCNA指数及DNA指数的关系。方法　分析 5 1例中等分化HCC患者的临床、随访资料及病理形态特征 ;应用免疫组织化学方法检测其PCNA阳性指数 ;应用图像分析仪进行DNA指数测量。... 详细信息

目的　研究肝细胞肝癌 (HCC)患者预后与肿瘤的病理形态特征、PCNA指数及DNA指数的关系。方法　分析 5 1例中等分化HCC患者的临床、随访资料及病理形态特征 ;应用免疫组织化学方法检测其PCNA阳性指数 ;应用图像分析仪进行DNA指数测量。结果　癌灶单个 ,直径≤ 5cm ,无癌栓、无肿瘤旁子灶及癌性坏死患者预相对较好 ;DNA整数倍体预后好于非整倍体 ,非整倍体中DI1.5者 ;PCNA指数越高 ,患者预后越差 ;DI与PCNA指数有一定的相关 ,且两者与病理形态特征间也有关联。结论　进行病理形态学和PCNA。

关键词：增殖细胞核抗原 DNA指数肝细胞肝癌预后 pCNA 病理特征

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本质与价值:数字时代广告本体的再认识

武汉大学学报（哲学社会科学版） 2025年第1期78卷 125-132页

作者：姚曦任文姣武汉大学新闻与传播学院湖北武汉430072 武汉大学媒体发展研究中心

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值... 详细信息

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值需深耕数字广告实践,用创意提升广告的社会吸引力,建构多主体参与的沟通网络。彰显广告价值还需要在理论层面,以本体观为支点,立足于本土广告实践,重新组织数字广告研究范畴,使用大数据技术与混合研究法探究新问题,为广告学知识体系的建构提供框架与方向。

关键词：广告广告本质广告价值广告本体

维普期刊数据库博看期刊

生育支持与欠发达地区育龄女性的生育意愿——基于贵州省88个区县的生育意愿调查

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河南社会科学 2025年第1期33卷 91-101页

作者：周文贵州省社会科学院博士后工作站贵州贵阳550002 贵州财经大学经济学院贵州贵阳550025

生育支持已经成为强化青年生育意愿和生育行为的重要举措,然而受限于研究数据,以往的研究很少对欠发达地区各类生育支持及其效果进行研究。为了研究欠发达地区各类生育支持对育龄女性生育意愿的作用,基于贵州省88个区县的生育意愿调查数... 详细信息

生育支持已经成为强化青年生育意愿和生育行为的重要举措,然而受限于研究数据,以往的研究很少对欠发达地区各类生育支持及其效果进行研究。为了研究欠发达地区各类生育支持对育龄女性生育意愿的作用,基于贵州省88个区县的生育意愿调查数据,从政府政策支持、社会托育支持和家庭代际支持三个维度研究了生育支持对欠发达地区育龄女性生育意愿的影响。研究发现:(1)当前贵州育龄女性的生育意愿已经下降到了较低水平,未来生育水平有进一步下降的风险。(2)家庭代际支持、社会托育支持和政府政策支持对育龄女性的总体生育意愿都具有显著的促进作用,但只有政府政策支持和家庭代际支持对三孩生育意愿具有显著的影响,社会托育支持对三孩生育意愿的影响不显著。(3)异质性分析则发现各类生育支持对35岁以上的育龄女性影响较大,是对35岁以下年轻群体影响的两倍左右。各类支持对不同学历育龄女性的影响也出现了分化,总体上呈现出低学历女性受到家庭支持与政府政策支持影响较大,而高学历女性受到托育服务影响较大的特征。(4)各类生育支持方式对育龄女性生育意愿的协同效应十分显著,当各类生育支持都较强时,对育龄女性生育意愿的影响较大。基于上述结论,一方面,生育支持体系与生育支持政策既要坚持普惠性,又要兼顾不同群体差异化需求;另一方面,需要进一步完善生育支持体系,充分发挥各类生育支持的协同效应,让育龄女性在生育决策时有更多生育支持方式的选择。

关键词：生育支持体系生育意愿欠发达地区被访者驱动抽样调查

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao wen Ming zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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花生疮痂病菌毒素提取工艺及生物活性研究

沈阳农业大学学报 2018年第3期49卷 272-278页

作者：刘璐焦文莉周如军李元杰许梦雪傅俊范沈阳农业大学植保学院沈阳110161

为明确花生疮痂病菌毒素种类、提取方法及生物活性,对花生疮痂病菌毒素进行颜色反应、紫外-可见光谱分析和薄层色谱分析,以提取液中的毒素含量为指标考察毒素的较优提取工艺,并采用离体叶片测定毒素生物活性。结果表明:花生疮痂病菌毒... 详细信息

为明确花生疮痂病菌毒素种类、提取方法及生物活性,对花生疮痂病菌毒素进行颜色反应、紫外-可见光谱分析和薄层色谱分析,以提取液中的毒素含量为指标考察毒素的较优提取工艺,并采用离体叶片测定毒素生物活性。结果表明:花生疮痂病菌毒素提取液呈红色,遇碱变绿,遇酸恢复为红色;用紫外分光光度计进行全波长扫描,发现在460nm、525nm、565nm处出现最大吸收峰;薄层色谱分析中出现5条清晰条带,Rf值分别为0.68,0.50,0.35,0.22和0.08。初步明确花生疮痂病菌所产毒素为痂囊腔菌素(Elsinochrome)。花生疮痂病菌毒素以超声振荡法提取效果最佳,提取液中毒素含量为3.11mg·g^(-1),较优提取工艺为:提取试剂为丙酮,菌丝粉碎细度为60目,液料比为100∶1,超声温度为40~55℃,超声时间为60min,超声功率为70~100W,超声提取2次。毒素的生物活性测定结果表明,该毒素具有较强的致病性,能够产生与病原菌侵染相似症状,病斑扩展与毒素接种浓度呈正相关,表明毒素痂囊腔菌素是花生疮痂病菌的重要致病因子。

关键词：花生疮痂病菌毒素鉴定提取工艺生物活性

Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 279-281页

作者： Yan zhou Guanghui wen Jialing zhou Tao Yang the Department of Systems Science Southeast University the State Key Laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the State Key Laboratory of Synthetical Automation for Process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

关键词：

Anode material NbO for Li-ion battery and its electrochemical properties

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Rare Metals 2018年第2期37卷 118-122页

作者： Jian Li wen-wen Liu Hong-Ming zhou Zhong-Zhong Liu Bao-Rong Chen wen-jiao Sun School of Materials Science and Engineering Central South UniversityChangsha 410083China Hunan Zhengyuan Institute for Energy Storage Materials and Devices Changsha 410083China

The NbO electrode materials were successfully synthesized by high-temperature solid-phase method using Nb powders and Nb2O5 powders as raw materials. The crystalline structure, morphology, and electrochemical properties of the obtained materials were characterized by X-ray diffi＇action （XRD）, scanning electron microscopy （SEM）, dynamic light scattering instrument （DLSA）, half- cell charge-discharge tests, and cyclic voltammetry （CV）. The reaction mechanism of lithium with NbO was inves- tigated by ex-situ XRD studies. The results show that material average Li storage voltage is nearly located at 1.6 V, and the lithium intercalation into NbO remains a single-phase process. For the first discharge, a capacity of 355 mAh·g^-1 is obtained at a current rate of 0.1C, and 293 mAh·g^-1is maintained after 50 cycles, whereas a capacity of 416 mAh·g^-1 is obtained at a current rate of 0.1C alter ball milling. And 380 mAh·g^-1 reversible capacity remains for the ball milling sample.

关键词： Niobium oxide Anode Electrochemicalproperties Lithium-ion batteries

An Artificial Neural Network Model Combined with Dietary Retinol Intake from Different Sources to Predict the Risk of Nonalcoholic Fatty Liver Disease

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Biomedical and Environmental Sciences 2023年第12期36卷 1123-1135页

作者： LIU Can zhou Shi Hui SU Hong YANG wen Qin LU jiao School of Public Health Shanxi Medical UniversityTaiyuan 030001ShanxiChina School of Management Shanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Medical Administration Affiliated Qingdao Central Hospital of Qingdao UniversityQingdao 266000ShandongChina Primary Medical Department Affiliated Qingdao Central Hospital of Qingdao UniversityQingdao 266000ShandongChina Digestive Endoscopy Minimally Invasive Surgery Center Shanxi Provincial Cancer HospitalChinese Academy of Medical Sciences Cancer Hospital Shanxi HospitalAffiliated Cancer Hospital of Shanxi Medical UniversityTaiyuan 030013ShanxiChina School of Public Policy and Administration Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina

Objective This study aimed to develop an artificial neural network(ANN) model combined with dietary retinol intake from different sources to predict the risk of non-alcoholic fatty liver disease(NAFLD) in American *** Data from the 2007 to 2014 National Health and Nutrition Examination Survey(NHANES)2007–2014 were analyzed. Eligible subjects(n = 6,613) were randomly divided into a training set(n1 =4,609) and a validation set(n2 = 2,004) at a ratio of 7:3. The training set was used to identify predictors of NAFLD risk using logistic regression analysis. An ANN was established to predict the NAFLD risk using a training set. Receiver operating characteristic(ROC) curve analysis was performed to evaluate the accuracy of the model using the training and validation *** Our study found that the odds ratios(ORs) and 95% confidence intervals(CIs) of NAFLD for the highest quartile of plant-derived dietary retinol intake(i.e., provitamin A carotenoids, such as β-carotene)(OR = 0.75, 95% CI: 0.57 to 0.99) were inversely associated with NAFLD risk, compared to the lowest quartile of intake, after adjusting for potential confounders. The areas under the ROC curves were 0.874 and 0.883 for the training and validation sets, respectively. NAFLD occurs when its incidence probability is greater than *** The ANN model combined with plant-derived dietary retinol intake showed a significant effect on NAFLD. This could be applied to predict NAFLD risk in the American adult population when government departments formulate future health plans.

关键词： NAFLD Plant-derived dietary retinol intake ANN Prediction model NHANES