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New synthetic way to prepare 2-aryl-8-(piperidin-4-yl)-5,7-dimethoxy-4H-chromen-4-one as key intermediate for CDK inhibitor

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Chinese Chemical Letters 2008年第5期19卷 541-543页

作者： Yan Ling Li Hao fang wen fang xu Bing He Wang School of Pharmacy Shandong University Jinan 250012 China Department of Chemistry Georgia State University Atlanta GA 30302-4098 USA

As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our study, chalcone route has been investigated and the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketone route. This new method will be an efficient way to start further research on new anticancer flavonoids.

关键词： Chalcone route Closure Flavopiridol

A component-based aircraft instrument rapid modeling tool

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第11期11卷 911-918页

作者： fang-wen LI xu-kun SHEN State Key Lab of Virtual Reality Technology and Systems School of Computer Science Beihang University Beijing 100191 China

Component-based software reuse and development is considered to be the best way to improve the efficiency and quality of *** meet the demands of aircraft instrument exhibition in an aviation virtual library,we present a modeling and simulation tool for cockpit instruments on component methods,achieving display functionality and providing a visual interaction platform in the aviation virtual *** the rapid model construction and reuse of virtual library resources,we classify entities in the cockpit into several categories by their behavior,and design a template for each category to describe its *** efficiently reduces the modeling cycle,and thus largely helps users to take advantage of the library resource.

关键词： Components Rapid modeling Simulation

Synthesis and biological evaluation of a new series of histone deacetylases inhibitors

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Chinese Chemical Letters 2008年第6期19卷 673-675页

作者： Jie Jiao Qiang Wang Hua Wei Zhu Hao fang wen fang xu School of Pharmaceutical Science Shandong University Jinan 250012 China

Histone deacetylases （HDACs） play an important role in tumorigenesis. Inhibition of HDACs is considered as a potent strategy for cancer therapy. Two lead compounds （ja and jb） were found to have activities against HDACs with IC50 at about 15 μmol/L. Then a new series of hydroximic acid derivatives were designed and synthesized based on them. The HDACs activity assay in vitro found that compounds J04 and ,109 are nearly as potent as the positive control drug Zolinza.

关键词： HDACs Tumorigenesis Cancer therapy Hydroximic acid

Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors

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Chinese Chemical Letters 2006年第10期17卷 1317-1320页

作者： Xian Chao CHENG Xin Yong LIU wen fang xu Institute of Medicinal Chemistry School of Pharmaceutical Science Shandong University Jinan 250012

A series of novel ligustrazine derivatives were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, ^1H NMR and ESI-MS. The preliminary antiplatelet a... 详细信息

关键词： Synthesis ligustrazine derivatives platelet aggregation inhibitors.

Synthesis of 4-Amino-5-furyl-2-yl-4H-1, 2, 4-triazole-3-thiol Derivatives as a Novel Class of Endothelin(ET) Receptor Antagonists

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Chinese Chemical Letters 2003年第8期14卷 790-793页

作者： Xin Yong LIU wen fang xu Jing De WU School of Pharmacy Shandong UniversityJinan 250012

A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1, 2, 4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor c... 详细信息

关键词： Triazole derivatives ET antagonist.

Regioselective synthesis and anti-HIV activity of the novel 2- and 4-substituted pyrazolo[4,5-e] [ 1,2,4]thiadiazines

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Chinese Chemical Letters 2007年第2期18卷 137-140页

作者： Xin Yong Liu Ren Zhang Yan Nian Gen Chen wen fang xu [a]Institute of Medicinal Chemistry School of Pharmacy Shandong University Jinan 250012 China

The new regioisomer 7-methyl-pyrazolo[4,5-e][1,2,4]thiadiazine nucleus (5) was synthesized, and its novel mono-N2- or N4-substituted pyrazolo[4,5-e][1,2,4]thiadiazines (6, 7) were regioselectively prepared by deprotonation of N2 or/and N4 atoms with different molar ratio of NaH and alkyl halides. Anti-HIV-1 screening tests showed some compounds to be potent as HIV-1 non-nucleoside reverse transcriptase inhibitors (HIV-1 NNRTIs).

关键词： Pyrazolo[4,5-e]thiadiazine Regioselectivity Synthesis HIV-1 NNRTIs

Corporate Credit Ratings Based on Hierarchical Heterogeneous Graph Neural Networks

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Machine Intelligence Research 2024年第2期21卷 257-271页

作者： Bo-Jing Feng Xi Cheng Hao-Nan xu wen-fang xue Center for Research on Intelligent Perception and Computing National Laboratory of Pattern RecognitionInstitute of AutomationChinese Academy of SciencesBeijing 100190China

order to help investors understand the credit status of target corporations and reduce investment risks,the corporate credit rating model has become an important evaluation tool in the financial *** models are based on statistical learning,machine learning and deep learning especially graph neural networks(GNNs).However,we found that only few models take the hierarchy,heterogeneity or unlabeled data into account in the actual corporate credit rating ***,we propose a novel framework named hierarchical heterogeneous graph neural networks(HHGNN),which can fully model the hierarchy of corporate features and the heterogeneity of relationships between *** addition,we design an adversarial learning block to make full use of the rich unlabeled samples in the financial *** experiments conducted on the public-listed corporate rating dataset prove that HHGNN achieves SOTA compared to the baseline methods.

关键词： Corporate credit rating hierarchical relation heterogeneous graph neural networks adversarial learning

Superior compound coatings prepared by low-temperature vanadium-nitrocarburizing duplex treatment

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Rare Metals 2024年第4期43卷 1828-1835页

作者： Gen Jin fang-fang xu xun-xun Hu Yue xu School of Chemistry Beihang UniversityBeijing100191China Guobiao(Beijing)Testing and Certification Co. LtdBeijing100088China School of Materials Science and Engineering Beihang UniversityBeijing100191China

Superior compound coatings were prepared on CK45 steel surface by vanadium-nitrocarburizing duplex treatment in low-temperature salt *** this study,the microhardness,the phase constitution and the compositional distribution in the coatings prepared under different conditions were systematically *** results indicated that the reactions among activated vanadium,carbon and nitrogen atoms occurred on the steel surface,leading to the formation of compound coatings composed of outermost and compound *** mechanism for the formation of compound layer as well as the growth kinetics of the layer was also *** the duplex treatment,the wear and corrosion resistances of steel surface were significantly *** was found that the growth kinetics of compound layer obeyed the parabolic law,with the activation energy of 122.82 kJ·moL^(-1).

关键词： Vanadium-nitrocarburizing duplex treatment Compound coatings Microstructure Formation mechanism Growth kinetics

Sulfonated poly(aryl ether ketone sulfone)modified by polyoxometalates LaW_(10) clusters for proton exchange membranes with high proton conduction performance

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Tungsten 2024年第2期6卷 454-464页

作者： Meng-Long Liu xu Han wen-wen He Feng-Yu Jiang fang Ji Wang-Wang Shen Tao Zhou Jing-Mei xu Ya-Qian Lan School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China School of Chemistry South China Normal UniversityGuangzhou 510006China

Polyoxometalates(POMs)are classified as solid superacids which can exhibit notable proton conductivity,making them a promising functional inorganic filler for enhancing the proton conductivity of proton exchange membranes(PEMs).In this study,a series of hybrid membranes were obtained by molecular-level hybridization of Weakley-type POM Na_(7)H_(2)LaW_(10)O_(36)(LaW_(10))clusters into sulfonated poly(aryl ether ketone sulfone)(SPAEKS).All hybrid membranes exhibited greater proton conductivity than the pristine membrane in the 30–80℃temperature *** the doping amount of LaW 10 reached 7 wt.%,the proton conductivity of M-LaW 10^(-7)achieved 64 mS·cm^(−1)at 80℃.Lanthanide ions'high coordination number property and variable coordination environment can aid to attract more water molecules from the *** 10 and these bound water can construct denser hydrogen bonds with–SO_(3)H of *** intensive hydrogen bonds will facilitate the constitution of more continuous proton transport channels,and improve the proton conductivity of the hybrid *** work off ers a fresh approach to using POMs containing rare-earth components in PEMs.

关键词： Polyoxometalates Rare-earth elements Sulfonated poly(arylene ether ketone sulfone) Proton exchange membranes