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Effectiveness and tolerability of programmed cell death protein-1 inhibitor+chemotherapy compared to chemotherapy for upper gastrointestinal tract cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1613-1625页

作者： Xiao-Min Zhang Ting Yang Ying-Ying Xu bao-Zhong Li Wei Shen wen-Qing Hu Cai-wen Yan Liang Zong Department of Central Laboratory Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastrointestinal Surgery Yizheng People’s HospitalThe Affiliated Hospital of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina Department of General Surgery Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of General Surgery Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastroenterology Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina

BACKGROUND The combination of programmed cell death protein-1(PD-1)inhibitor and che-motherapy is approved as a standard first-or second-line treatment in patients with advanced oesophageal or gastric ***,it is unclear whether this combination is superior to chemotherapy *** To assess the comparative effectiveness and tolerability of combining PD-1 inhibitors with chemotherapy vs chemotherapy alone in patients with advanced gastric cancer,gastroesophageal junction(GEJ)cancer,or oesophageal *** We searched the PubMed and Embase databases for studies that compared the efficacy and tolerance of PD-1 inhibitors in combination with chemotherapy vs chemotherapy alone in patients with advanced oesophageal or gastric *** employed either random or fixed models to analyze the outcomes of each clinical trial,en-compassing data on overall survival(OS),progression-free survival(PFS),objective response rate,and adverse events(AEs).RESULTS Nine phase 3 clinical trials(7016 advanced oesophageal and gastric cancer patients)met the inclusion *** meta-analysis demonstrated that the pooled PD-1 inhibitor+chemotherapy group had a significantly longer OS than the chemotherapy-alone group[hazard ratio(HR)=0.76,95%confidence interval(CI):0.71-0.81];the pooled PFS result was consistent with that of OS(HR=0.67,95%CI:0.61-0.74).The count of patients achieving an objective response in the PD-1 inhibitor+chemotherapy group surpassed that of the chemotherapy-alone group[odds ratio(OR)=1.86,95%CI:1.59-2.18].AE incidence was also higher in the combination-therapy group than in the chemotherapy-alone group,regardless of whether≥grade 3 only(OR=1.30,95%CI:1.07-1.57)or all AE grades(OR=1.88,95%CI:1.39-2.54)were *** performed a subgroup analysis based on the programmed death-ligand 1(PD-L1)combined positive score(CPS)and noted extended OS and PFS durations within the CPS≥1,CPS≥5,and CPS≥10 subgroups of the PD-1 inhibitor+chemotherapy ***

关键词： Programmed cell death protein-1 inhibitor Chemotherapy Oesophageal squamous cell carcinoma Gastric/gastroesophageal junction adenocarcinoma Overall survival Progression-free survival Objective response rate Adverse event

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声表面波式小波器件对奇异性信号的研究

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系统工程与电子技术 2004年第7期26卷 1000-1003页

作者：文常保朱长纯卢文科刘君华西安交通大学电子与信息工程学院真空微电子研究所陕西西安710049

在研究声表面波式Morlet小波器件具有进行小波变换、消除白噪声和奇异性信号识别功能的基础上 ,将该器件用于对奇异性信号的提取和分析。通过某一航空发动机的故障实例说明了这种器件不仅可以对工业环境噪声、传输和中间处理单元造成的... 详细信息

在研究声表面波式Morlet小波器件具有进行小波变换、消除白噪声和奇异性信号识别功能的基础上 ,将该器件用于对奇异性信号的提取和分析。通过某一航空发动机的故障实例说明了这种器件不仅可以对工业环境噪声、传输和中间处理单元造成的干扰信号进行滤波 ,有效地提高分析信号的信噪比 ,而且也实现了对故障信号的连续小波变换 ,最终完成了对奇异性信号的提取和识别。

关键词：声表面波器件 Morlet小波奇异性信号

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声表面波式小波变换器件的三次行程反射信号的研究

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电子学报 2008年第2期36卷 346-349页

作者：卢文科朱长纯刘清洪刘君华方建安文常保东华大学信息科学与技术学院上海201620 西安交通大学电子与信息工程学院陕西西安710049

本文提出了用同相位法减小三次行程反射信号的方法.当信号频率与叉指换能器中心频率相等,并且主信号的相位等于三次行程反射信号的相位时,从可达到减小三次行程反射信号的影响.并且探讨了双接收叉指换能器并联法,要求双接收叉指换能器... 详细信息

本文提出了用同相位法减小三次行程反射信号的方法.当信号频率与叉指换能器中心频率相等,并且主信号的相位等于三次行程反射信号的相位时,从可达到减小三次行程反射信号的影响.并且探讨了双接收叉指换能器并联法,要求双接收叉指换能器要完全对称,否则声表面波式小波变换器件频率特性曲线不光滑.

关键词：声表面波小波变换器件三次行程反射信号叉指换能器

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Establishment and evaluation of a prognostic model for patients with unresectable gastric cancer liver metastases

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World Journal of Clinical Cases 2024年第13期12卷 2182-2193页

作者： Zheng-Yao chang wen-Xing Gao Yue Zhang wen Zhao Di Wu Lin Chen Department of General Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Endocrinology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Liver metastases(LM)is the primary factor contributing to unfavorable outcomes in patients diagnosed with gastric cancer(GC).The objective of this study is to analyze significant prognostic risk factors for patients with GCLM and develop a reliable nomogram model that can accurately predict individualized prognosis,thereby enhancing the ability to evaluate patient *** To analyze prognostic risk factors for GCLM and develop a reliable nomogram model to accurately predict individualized prognosis,thereby enhancing patient outcome *** Retrospective analysis was conducted on clinical data pertaining to GCLM(type III),admitted to the Department of General Surgery across multiple centers of the Chinese PLA General Hospital from January 2010 to January *** dataset was divided into a development cohort and validation cohort in a ratio of 2:*** the development cohort,we utilized univariate and multivariate Cox regression analyses to identify independent risk factors associated with overall survival in GCLM ***,we established a prediction model based on these findings and evaluated its performance using receiver operator characteristic curve analysis,calibration curves,and clinical decision curves.A nomogram was created to visually represent the prediction model,which was then externally validated using the validation *** A total of 372 patients were included in this study,comprising 248 individuals in the development cohort and 124 individuals in the validation *** on Cox analysis results,our final prediction model incorporated five independent risk factors including albumin levels,primary tumor size,presence of extrahepatic metastases,surgical treatment status,and chemotherapy *** 1-,3-,and 5-years Area Under the Curve values in the development cohort are 0.753,0.859,and 0.909,respectively;whereas in the validation cohort,they are observed to be 0.772,0.848,and ***,th

关键词： Gastric cancer Liver metastases Nomogram Prognostic model Survival analysis

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Electrochemical Reduction of Benzo[b]thiophene 1,1-Dioxides with HFIP as Hydrogen Donor

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Chinese Journal of Chemistry 2024年第6期42卷 585-591页

作者： Ming-Zhong Guo Mei-Jin Mou Zhuo Chen Shao-Fei Ni Ming Li Li-Rong wen Lin-bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science & TechnologyQingdaoShandong266042 China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantouGuangdong515063 China

A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal-free ***,the tolerance of various functional groups and ... 详细信息

关键词： Electrochemistry Reduction Benzo[b]thiophene 1,1-dioxides Deuterium Hydrogen source

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Construction of a predictive model for acute liver failure after hepatectomy based on neutrophil-to-lymphocyte ratio and albuminbilirubin score

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1087-1096页

作者： Xiao-Pei Li Zeng-Tao bao Li Wang Chun-Yan Zhang wen Yang Department of Family Planning and Assisted Reproductive Technology The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Laboratory Medicine The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Gynecology The First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina

BACKGROUND Acute liver failure(ALF)is a common cause of postoperative death in patients with hepatocellular carcinoma(HCC)and is a serious threat to patient *** neutrophil-to-lymphocyte ratio(NLR)is a common inflammatory indicator that is associated with the prognosis of various diseases,and the albumin-bilirubin score(ALBI)is used to evaluate liver function in liver cancer ***,this study aimed to construct a predictive model for postoperative ALF in HCC tumor integrity resection(R0)based on the NLR and ALBI,providing a basis for clinicians to choose appropriate treatment *** To construct an ALF prediction model after R0 surgery for HCC based on NLR and *** In total,194 patients with HCC who visited The First People’s Hospital of Lianyungang to receive R0 between May 2018 and May 2023 were enrolled and divided into the ALF and non-ALF *** compared differences in the NLR and ALBI between the two *** risk factors of ALF after R0 surgery for HCC were screened in the univariate *** risk factors were analyzed by multifactorial logistic *** then constructed a prediction model of ALF after R0 surgery for HCC.A receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)were used to evaluate the value of the prediction *** Among 194 patients with HCC who met the standard inclusion criteria,46 cases of ALF occurred after R0(23.71%).There were significant differences in the NLR and ALBI between the two groups(P<0.05).The univariate analysis showed that alpha-fetoprotein(AFP)and blood loss volume(BLV)were significantly higher in the ALF group compared with the non-ALF group(P<0.05).The multifactorial analysis showed that NLR,ALBI,AFP,and BLV were independent risk factors for ALF after R0 surgery in *** predictive efficacy of NLR,ALBI,AFP,and BLV in predicting the occurrence of ALT after R0 surgery for HCC was average[area under the curve(AUC)NLR=0.767,AUCALB

关键词： Acute liver failure Hepatocellular carcinoma Hepatectomy Neutrophil-to-lymphocyte ratio Albumin-bilirubin score

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Long non-coding RNA GATA6-AS1 is mediated by N6-methyladenosine methylation and inhibits the proliferation and metastasis of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1019-1028页

作者： Jun-Jie Shen Min-chang Li Shao-Qi Tian wen-Ming Chen Department of Oncology Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Hepatopancreatobiliary Surgery Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Clinical Medical School Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Oncology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

BACKGROUND Through experimental research on the biological function of GATA6-AS1,it was confirmed that GATA6-AS1 can inhibit the proliferation,invasion,and migration of gastric cancer cells,suggesting that GATA6-AS1 plays a role as an anti-oncogene in the occurrence and development of gastric *** experi-ments confirmed that the overexpression of fat mass and obesity-associated protein(FTO)inhibited the expression of GATA6-AS1,thereby promoting the occurrence and development of gastric *** To investigate the effects of GATA6-AS1 on the proliferation,invasion and migration of gastric cancer cells and its mechanism of *** We used bioinformatics methods to analyze the Cancer Genome Atlas(https://***/.The Cancer Genome Atlas)and download expression data for GATA6-AS1 in gastric cancer tissue and normal *** also constructed a GATA6-AS1 lentivirus overexpression vector which was transfected into gastric cancer cells to investigate its effects on proliferation,migration and invasion,and thereby clarify the expression of GATA6-AS1 in gastric cancer and its biological role in the genesis and development of gastric ***,we used a database(http://***/starbase2/)to analysis GATA6-AS1 whether by m6A methylation modify regulation and predict the methyltransferases that may methylate ***,RNA immunoprecipitation experiments confirmed that GATA6-AS1 was able to bind to the m6A methylation modification *** data allowed us to clarify the ability of m6A methylase to influence the action of GATA6-AS1 and its role in the occurrence and development of gastric *** Low expression levels of GATA6-AS1 were detected in gastric *** also determined the effects of GATA6-AS1 overexpression on the biological function of gastric cancer ***6-AS1 had strong binding ability with the m6A demethylase FTO,which was expressed at high levels in gastric cancer and negatively correlat

关键词： Long non-coding RNA GATA6-AS1 N6-methyladenine modification Fat mass and obesity-associated protein Gastric cancer

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Complexity growth in a holographic QCD model

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Chinese Physics C 2024年第3期48卷 142-147页

作者：常文彬侯德富 Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOS) Central China Normal UniversityWuhan 430079China

In this study,we utilize the complexity-action duality to study the evolution of complexity in a holographic QCD model at finite temperature and chemical *** inserting a fundamental string as a probe,we investigated the properties of complexity growth in this Einstein-Maxwell-scalar gravity system,which is affected by the string velocity,chemical potential,and *** results show that the complexity growth is maximized when the probe string is stationary,and it decreases as the velocity of the string *** the string approaches relativistic velocities,the complexity growth always increases monotonically with respect to the chemical ***,we find that the complexity growth can be used to identify phase transitions and crossovers in the model.

关键词： AdS/CFT holographic QCD model complexity growth

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Reliability Analysis of a Switched Reluctance Starter/Generator

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Protection and Control of Modern Power Systems 2024年第1期9卷 112-121页

作者： Hao Chen Fan Yang Lijun Xu Qiwei Lu Xiqiang chang Xing Wang Lijiang Dong Yi wen Jiang Chen Gang Miao Jianmin Hu Guanjun Wang Wei Li Xiaohua bao School of Electrical Engineering China University of Mining and TechnologyXuzhou 221116China Xinjiang Institute of Engineering Urumqi 830000China International Joint Research Center of Central and Eastern European Countries on New Energy Electric Vehicle Technology and Equipment Xuzhou 221008China International Cooperation Joint Laboratory of New Energy Power Generation and Electric Vehicles of Jiangsu Province Colleges and Universities Xuzhou 221008China School of Information and Electrical Engineering China University of Mining and TechnologyXuzhouChina China University of Mining and Technology(Beijing) BeijingChina State Grid Xingjiang Electric Power Co. Ltd.UrumqiXinjiangChina China University of Mining and Technology XuzhouChina State Grid Xinjiang Company Limited Electric Power Research Institute UrumqiXinjiangChina Xinjiang Fukang Pumped Storage Power Company Limited UrumqiXinjiangChina State Grid Urumqi Electric Power Supply Company UrumqiXinjiangChina Wuxi Inspection and Testing Certification Research Institute WuxiJiangsuChina Anhui Wannan Electric Machine Co. Ltd.WannanAnhuiChina Hefei University of Technology in Electrical and Automation Engineering

In this paper,the combined k-out-of-n:G model and reliability block diagram model is used to analyze the reliability of a switched reluctance starter/generator ***,the different operational modes of a switched reluctance motor starter/generator are analyzed,and the fault states of the system are briefly *** the fault criteria of the system in different operational states are put ***,a relia-bility block diagram model is established to calculate the system-level reliability,and the k-out-of-n:G model is adopted to analyze the reliability of each part of the switched reluctance starter/generator *** verify effectiveness,the first-order Markov model is also used to analyze the reliability of each part of the switched reluc-tance starter/generator *** the compu-tational complexity and accuracy of the system,the k-out-of-n:G model is more suitable for system component level reliability ***,a 6/4 switched reluctance motor is used as the simulated and experimental platform *** final results verify the effectiveness of the reliability analysis model.

关键词： system switched generator

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建筑可靠性的非线性粗糙多变量不确定分析

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控制工程 2017年第7期24卷 1481-1485页

作者：熊殿华文常保成都艺术职业学院成都611433 长安大学电子与控制工程学院西安710064

针对建筑结构分析中,存在的各种参量的不确定性影响因素,提出基于非线性粗糙多变量建筑可靠性不确定分析。首先,根据建筑物结构中的参量分析所产生的影响程度,依据粗糙集构建不确定性结构模型,并将这种结构模型的不确定性进行区间粗糙... 详细信息

针对建筑结构分析中,存在的各种参量的不确定性影响因素,提出基于非线性粗糙多变量建筑可靠性不确定分析。首先,根据建筑物结构中的参量分析所产生的影响程度,依据粗糙集构建不确定性结构模型,并将这种结构模型的不确定性进行区间粗糙参量描述。其次,基于建筑物结构的可靠性非概率分析形式,结合可靠性区间分析方法和多粗糙变量功能函数,建立新的可靠指标评价方式,实现建筑可靠性分析性能的提升。最后,通过算例分析显示,该分析算法可更为精确的对不确定变量所带来的结构分析影响进行评价,并可提高分析性能。

关键词：结构分析可靠指标多粗糙集非概率区间分析

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