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Advances in targeted therapy for esophageal cancer

Signal Transduction and Targeted Therapy 2020年第1期5卷 585-595页

作者： Yan-Ming Yang Pan Hong wen wen xu Qing-Yu He Bin Li MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringJinan UniversityGuangzhouChina MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina

Esophageal cancer(EC)is one of the most lethal cancers in the world,and its morbidity and mortality rates rank among the top ten in ***,surgical resection,radiotherapy and chemotherapy are the primary clinical treatments for esophageal ***,outcomes are still unsatisfactory due to the limited efficacy and severe adverse effects of conventional *** a new type of approach,targeted therapies have been confirmed to play an important role in the treatment of esophageal cancer;these include cetuximab and bevacizumab,which target epidermal growth factor receptor(EGFR)and vascular endothelial growth factor(VEGF),*** addition,other drugs targeting surface antigens and signaling pathways or acting on immune checkpoints have been continuously *** example,trastuzumab,a monoclonal antibody targeting human epidermal growth factor receptor 2(HER-2),has been approved by the Food and Drug Administration(FDA)as a first-line treatment of HER-2-positive ***,the PD-L1 inhibitor pembrolizumab has been approved as a highly efficient drug for patients with PD-L1-positive or advanced esophageal squamous cell carcinoma(ESCC).These novel drugs can be used alone or in combination with other treatment strategies to further improve the treatment efficacy and prognosis of cancer ***,adverse events,optimal dosages and effective combinations still need further *** this review,we expound an outline of the latest advances in targeted therapies of esophageal cancer and the mechanisms of relevant drugs,discuss their efficacy and safety,and provide a clinical rationale for precision medicine in esophageal cancer.

关键词： esophageal drugs targeted

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Experimental measurement of acoustically induced surface vibration with different soil conditions

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Advances in Manufacturing 2016年第3期4卷 278-285页

作者： Zi-Yang Song Yan-Li Zhang Chi Wang wen-wen xu Wei Ding Department of Precision Mechanical Engineering ShanghaiUniversity Shanghai 200072 People's Republic of China North Automatic Control Technology Research Institute Taiyuan 030006 People's Republic of China Science and Technology on Near-Surface DetectionLaboratory Wuxi 214035 People's Republic of China Shanghai Public Utility School Shanghai 200030 People's Republic of China

Experimental measurement is performed to investigate the acoustically induced surface vibration with different soil conditions. Using the method of scanning detection and analyzing the three-dimensional （3D） char- acteristic diagram of surface vibration, the influence of soil properties, such as porosity and humidity, upon the signal of acoustically induced surface vibration is measured. The experimental results show that the surface vibration redu- ces with the decrease of soil porosity and reduces a little with the increase of soil humidity; and with a big plastic landmine buried, the surface vibration enhances signifi- cantly. It indicates that the signal of acoustically induced surface vibration mainly depends on soil porosity and mechanical effect of buried objects.

关键词： Acoustic-to-seismic (A/S) coupling Soil porosity Humidity - Landmine detection

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Targeting PI3K/Akt signal transduction for cancer therapy

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Signal Transduction and Targeted Therapy 2022年第1期7卷 95-111页

作者： Yan He Miao Miao Sun Guo Geng Zhang Jing Yang Kui Sheng Chen wen wen xu Bin Li MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhouChina Department of Pathology The First Affiliated Hospital of Zhengzhou UniversityHenan Key Laboratory of Tumor PathologyZhengzhouChina MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina

The phosphatidylinositol 3-kinase(PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers,contributing to the occurrenee and progression of *** the upstream and downstream nodes of this pathway could allow full elucidation of its *** on accumulating evidenee,strategies targeting major components of the pathway might provide new in sights for can cer drug *** have explored the use of some in hibitors targeti ng this pathway to block survival ***,because oncogenic PI3K pathway activation occurs through various mechanisms,the clinical efficacies of these inhibitors are ***,pathway activation is accompanied by the development of therapeutic resista ***,strategies involvi ng pathway in hibitors and other can cer treatments in combinati on might solve the therapeutic *** this review,we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes,review the current statuses of different PI3K/Akt in hibitors,and in troduce combi nation therapies con sisti ng of signaling in hibitors and conven tional cancer *** information presented herein suggests that cascading inhibitors of the PI3K/Akt signaling pathway,either alone or in combi nation with other therapies,are the most effective treatment strategy for can cer.

关键词： PI3K/Akt treatment alone

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Identification of miR-515-3p and its targets,vimentin and MMP3,as a key regulatory mechanism in esophageal cancer metastasis:functional and clinical significance

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Signal Transduction and Targeted Therapy 2020年第1期5卷 206-218页

作者： Hui-Fang Hu wen wen xu Wei-Xia Zhang Xin Yan Yang-Jia Li Bin Li Qing-Yu He Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes and MOE Key Laboratory of Tumor Molecular Biology Institute of Life and Health EngineeringJinan UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Bioengineering Medicine and MOE Key Laboratory of Tumor Molecular Biology National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina

Metastasis is the main factor of treatment failure in cancer patients,but the underlying mechanism remains to be elucidated and effective new treatment strategies are urgently *** study aims to explore novel key metastasis-related microRNAs(miRNAs)in esophageal squamous cell carcinoma(ESCC).By comparing miRNA profiles of the highly metastatic ESCC cell sublines,we established through serial in vivo selection with the parental cells,we found that the expression level of miR-515-3p was lower in ESCC tumor tissues than adjacent normal tissues,further decreased in metastatic tumors,and moreover,markedly associated with advanced stage,metastasis and patient *** in vitro and in vivo assays suggested that miR-515-3p could increase the expression of the epithelial markers as well as decrease the expression of the mesenchymal markers,and more importantly,suppress invasion and metastasis of ESCC ***,we revealed that miR-515-3p directly regulated vimentin and matrix metalloproteinase-3(MMP3)expression by binding to the coding sequence and 3′untranslated region,*** addition,the data from whole-genome methylation sequencing and methylation-specific PCR indicated that the CpG island within miR-515-3p promoter was markedly hypermethylated in ESCC cell lines and ESCC tumor tissues,which may lead to deregulation of miR-515-3p expression in ***,our preclinical experiment provides solid evidence that systemic delivery of miR-515-3p oligonucleotide obviously suppressed the metastasis of ESCC cells in nude *** together,this study demonstrates that miR-515-3p suppresses tumor metastasis and thus represents a promising prognostic biomarker and therapeutic strategy in ESCC.

关键词： metastasis esophageal markedly

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KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4217-4233页

作者： Cancan Zheng Xiaomei Yu Taoyang xu Zhichao Liu Zhili Jiang Jiaojiao xu Jing Yang Guogeng Zhang Yan He Han Yang Xingyuan Shi Zhigang Li Jinbao Liu wen wen xu Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education Institutesthe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University.Shanghai 200030China Department of Radiation Oncology the Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory Diseaseand School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511495China

Increasing evidences suggest the important role of calcium homeostasis in hallmarks of cancer,but its function and regulatory network in metastasis remain unclear.A comprehensive investigation of key regulators in cancer metastasis is urgently *** sequencing(RNA-seq)of primary esophageal squamous cell carcinoma(ESCC)and matched metastatic tissues and a series of gain/loss-of-function experiments identified potassium channel tetramerization domain containing 4(KCTD4)as a driver of cancer ***4 expression was found upregulated in metastatic *** KCTD4 expression is associated with poor prognosis in patients with ESCC and contributes to cancer metastasis in vitro and in ***,KCTD4 binds to CLIC1 and disrupts its dimerization,thus increasing intracellular Ca^(2+)level to enhance NFATc1-dependent fibronectin ***4-induced fibronectin secretion activates fibroblasts in a paracrine manner,which in turn promotes cancer cell invasion via MMP24 signaling as positive ***,a lead compound K279-0738 significantly suppresses cancer metastasis by targeting the KCTD4-CLIC1 interaction,providing a potential therapeutic *** together,our study not only uncovers KCTD4 as a regulator of calcium homeostasis,but also reveals KCTD4/CLIC1-Ca^(2+)-NFATc1-fibronectin signaling as a novel mechanism of cancer *** findings validate KCTD4 as a potential prognostic biomarker and therapeutic target for ESCC.

关键词： Cancermetastasis Calcium homeostasis NFAT signaling Fibroblasts Esophageal cancer

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Evaluation of corneal endothelium after UVA/riboflavin cross-linking in thin keratoconic corneas

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 321-322页

作者： Wei Chen Zhi-Wei Li Xiao-Min Zhao wen -wen xu Guo-Ying Mu Clinical College of Ophthalmology Tianjin Medical University Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University School of Nursing Binzhou Medical College

Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime importance during CXL treatment. In clinical practice, a corneal thickness （CT） of 400um has traditionally been regarded as the minimum treatable thickness, thereby avoiding damage to the corneal endothelium Although CXL has been applied to thinner corneas, using a hypoosmotic solution onto cornea and inducing edema . CXL safety still needs further evaluation because of lower relative concentration of collagen in the hydrated stroma . This study aims to evaluate the changes of corneal endothelial density （ECD） in cases where the CT is 〈400 um before iatrogenic corneal swelling and CXL treatment.

关键词： UVA Evaluation of corneal endothelium after UVA/riboflavin cross-linking in thin keratoconic corneas

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Genome-wide identification of key regulatory lncRNAs in esophageal cancer metastasis

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Signal Transduction and Targeted Therapy 2021年第3期6卷 621-623页

作者： wen wen xu Can-Can Zheng Qian Zuo Jun-Qi Li Pan Hong Yan-Ru Qin Xin-Yuan Guan Qing-Yu He Hua-Xin Liao Bin Li MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic MedicineInstitute of BiomedicineCollege of Life Science and TechnologyJinan UniversityGuangzhouChina MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment Department of Clinical OncologyFirst Affiliated HospitalZhengzhou UniversityZhengzhouChina Department of Clinical Oncology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina

Dear Editor,Metastasis leads to a poor prognosis of patients with esophageal squamous cell carcinoma(ESCC).1-3 but the study on cancer metastasis has been hampered by a lack of reliable cell and animal *** identification and functional validation of metastasis-associated long non-coding RNAs(lncRNAs)and microRNAs(miRNAs),as well as-their interactions in ESCC are urgently needed.

关键词： metastasis esophageal cancer

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硬质聚氯乙烯自然老化的变色行为与分子结构变化

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高分子学报 2017年第8期27卷 1374-1381页

作者：徐文文熊英郭少云高分子材料工程国家重点实验室四川大学高分子研究所成都610065

以硬质聚氯乙烯(PVC)为研究对象,通过色差实验、FTIR、UV等方法探究了PVC在湿热、辐射低的琼海和暖温、干旱且辐射高的若羌地区自然老化的变色行为与分子结构变化.结果表明,太阳辐射是影响PVC自然老化过程中变色行为和分子结构变化的主... 详细信息

以硬质聚氯乙烯(PVC)为研究对象,通过色差实验、FTIR、UV等方法探究了PVC在湿热、辐射低的琼海和暖温、干旱且辐射高的若羌地区自然老化的变色行为与分子结构变化.结果表明,太阳辐射是影响PVC自然老化过程中变色行为和分子结构变化的主要环境因素,PVC在干旱、辐射高的若羌地区比在湿热、辐射低的琼海地区更易变黄和变红,而在两地变暗的程度相近;这是因为随着自然老化时间的延长,PVC逐渐发生脱除氯化氢反应和氧化反应,在干旱且辐射高的若羌,更易发生脱除氯化氢反应,而在湿热且辐射低的琼海,脱除氯化氢反应和氧化反应的速度相近,在若羌老化的PVC样品生成了更多的共轭长度(n)≥8的C=C长共轭序列所致.

关键词：硬质PVC 自然老化太阳辐射变色行为 C=C长共轭序列

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超高效液相色谱法分析丝瓜酚类物质组分及其含量

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园艺学报 2016年第7期43卷 1391-1401页

作者：温文旭朱海生温庆放陈敏氡林碧英薛珠政福建省农业科学院作物研究所福州350013 福建省农业科学院蔬菜研究中心福州350013 福建省蔬菜工程技术研究中心福州350013 福建农林大学园艺学院福州350002

建立超高效液相色谱快速测定丝瓜中酚类物质组分及其含量的方法,为丝瓜酶促褐变的后续研究提供技术支持。液相色谱柱为ACQUITY UPLC BEH C18(2.1 mm×100 mm,1.7μm),流动相为甲醇(A)/0.3%乙酸水溶液(B),柱温32℃,进样量2μL,流速为0.25... 详细信息

建立超高效液相色谱快速测定丝瓜中酚类物质组分及其含量的方法,为丝瓜酶促褐变的后续研究提供技术支持。液相色谱柱为ACQUITY UPLC BEH C18(2.1 mm×100 mm,1.7μm),流动相为甲醇(A)/0.3%乙酸水溶液(B),柱温32℃,进样量2μL,流速为0.25 m L·min^(-1)。采用梯度洗脱,洗脱程序0~0.5 min,95%B;0.5~17.5 min,95%~67.5%B;17.5~18 min,67.5%~95%B。检测波长选取283 nm。14种酚类化合物标准品在18 min内完全分离,样品中检测出13种酚酸。线性范围在0.05~4mg·L-1,检出限(S/N=3)为0.004~0.049 mg·L^(-1),决定系数均大于0.999,精密度、重复性、稳定性相对标准偏差均小于5%。平均回收率在95.70%~106.89%,相对标准偏差在0.32%~4.71%。龙胆酸为丝瓜样品中主要酚酸,其次是绿原酸、多巴胺、L–酪氨酸,再次是焦性没食子酸、原儿茶酸、香草酸、儿茶酚、表儿茶酸、对羟基苯甲酸、丁香酸、4–甲基儿茶酚、对香豆酸。

关键词：丝瓜酚类物质超高效液相

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常温常压下醇类溶剂对毛竹的渗透性研究

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林产工业 2018年第1期45卷 30-34页

作者：温旭雯张融靳肖贝覃道春国际竹藤中心竹藤科学与技术重点实验室 International Centre for Bamboo and Rattan Science and Technology Key Laboratory of Bamboo and Rattan

为了探究有机溶剂的物理性质对竹材常压渗透性的影响,选用5种醇类溶剂——甲醇、乙醇、正丙醇、异丙醇和丁醇对毛竹(Phyllostachys edulis)竹条进行常温常压渗透,以单位体积竹材中渗透液体的体积(体积渗透量)和物质的量(摩尔渗透量)作... 详细信息

为了探究有机溶剂的物理性质对竹材常压渗透性的影响,选用5种醇类溶剂——甲醇、乙醇、正丙醇、异丙醇和丁醇对毛竹(Phyllostachys edulis)竹条进行常温常压渗透,以单位体积竹材中渗透液体的体积(体积渗透量)和物质的量(摩尔渗透量)作为评价指标,研究结果表明:醇类对竹材的常压渗透48 h内可完成200 h渗透量的90%以上;醇类分子链长度增加时,溶剂渗入竹材的分子数量减少;液体的渗透量随着醇类极性的增强而增加;液体黏度的倒数与溶剂在竹材中的体积渗透量成正比;醇类在竹材中的流动符合黏性流或线性层流。

关键词：毛竹醇类溶剂渗透性常压

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