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Rare Metals 2021年第6期40卷 1604-1613页

作者： Lan-Juan Zhou Xi-Xi zhang wen-yuan zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China United Microelectronics Center Chongqing 401332China

In this paper,ZnZnFe_(2)O_(4) nanorods were prepared using Zn/Fe metal organic framework(MOF)as precursors,and ZnZnFe_(2)O_(4)/reduced graphene oxide(rGO)was prepared by hydrothermal *** morphology and composition of the ZnZnFe_(2)O_(4)/rGO nanocomposite were characterized,and the results showed that the MOF-derived ZnZnFe_(2)O_(4) nanorods are uniformly modified on the surface of *** ZnZnFe_(2)O_(4)/rGO nanocomposite exhibits better SO_(2) gas sensing performance than the single ZnZnFe_(2)O_(4) nanorods at room *** sensing characteristics of single ZnZnFe_(2)O_(4) film sensor,single rGO film sensor and ZnZnFe_(2)O_(4)/rGO composite film sensor at SO_(2)gas concentration(1×10^(-6)-100×10^(-6))were *** response of ZnZnFe_(2)O_(4)/rGO composite sensor can reach 18.32%at room *** with single ZnZnFe_(2)O_(4) and rGO film sensors,the ZnZnFe_(2)O_(4)/rGO composite sensor has better transient response,good sensitivity and *** this work,the improvement of the sensor performance is not only due to the p-n heterostructure between ZnZnFe_(2)O_(4) nanorods and rGO nanosheets,but also to the excellent electrical properties of *** provides a new idea for the detection of SO_(2) at room temperature.

关键词： Ternary metal oxide ZnFe_(2)O_(4)nanorods Reduced graphene oxide SO_(2)gas sensor

Radial Distribution Characteristics of Microstructure and Mechanical Properties of Ti–6Al–4V Butt Joint by Rotary Friction Welding

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1291-1298页

作者： Hai-Yan Chen Li Fu wen-yuan zhang Fen-Jun Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical University Shaanxi Key Laboratory of Friction Welding Technologies

Ti-6Al-4V rods were butt-welded by rotary friction welding in this study. Additionally, the radial differences in microstructure and mechanical property of joints were investigated by hierarchy slicing method. The results displayed that the width of weld zone and heat-affected zone of joints became wider along radial direction. Meanwhile, the tensile strength of joints decreased gradually along the radial direction. According to the theoretical analysis, the temperature gradient and inhomogeneous forging pressure leaded to the radial differences. Through K-type thermocouples, the actual temperatures at different locations were measured, and the results were consistent with the theoretical analysis. Theoretically, the radial differences of rotary friction welding joint are an inherent phenomenon; thus, the size of weldment should be limited strictly below the corresponding critical size. In order to prevent radial differences from enlarging, the welding surface profile of weldment can be processed into oval shape, and a larger forging pressure can be used within the scope of the joint deformation allowed according to causes for radial differences.

关键词： Titanium alloys Friction welding Microstructure Mechanical property

Chronic stress causes protein kinase C epsilon-aldehyde dehydrogenase 2 signaling pathway perturbation in the rat hippocampus and prefrontal cortex,but not in the myocardium

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Neural Regeneration Research 2018年第7期13卷 1225-1230页

作者： wen-yuan zhang Ke-Yi Wang Yun-Jing Li Ying-Ran Li Rong-Zhi Lu Department of Pharmacy Zhongshan Hospital of Sun Yat-sen University Department of Magnetic Resonance Imaging Zhongshan Hospital of Sun Yat-sen University

Chronic stress is strongly associated with the occurrence and development of depression and cardiovascular *** can induce altered mitochondrial function and activation of apoptosis in the cardio-cerebral ***,it is unknown whether the protein kinase C ε（PKCε）-aldehyde dehydrogenase 2（ALDH2） pathway is altered under chronic stress,and this study sought to address this question.A rat model of depression was established using a chronic unpredictable mild stress（CUMS） *** experiencing CUMS for 4 weeks,the sucrose preference test and the forced swim test verified depressive-like *** linked immunosorbent assays showed that ALDH2 activity was decreased in the rat hippocampus and prefrontal cortex,but was not altered in the *** blot assays demonstrated reduced levels of ALDH2 and PKCε,but increased levels of 4-hydroxy-2-nonenal（4 HNE） ***-3 expression did not obviously alter,but active forms of caspase-3 were increased in the hippocampus and prefrontal *** the myocardium,expression of ALDH2,PKCε and 4 HNE adducts did not remarkably alter;while caspase-3 expression was reduced and the active forms of caspase-3 were ***＇s correlation test demonstrated that expression of 4 HNE adducts was positively correlated with levels of the active forms of caspase-3 in the hippocampus and prefrontal cortex,but not in the *** conclusion,chronic stress can damage the PKCε-ALDH2 signaling pathway in the hippocampus and prefrontal cortex,but not in the ***,4 HNE is associated with active forms of caspase-3 in the hippocampus and prefrontal cortex.

关键词： nerve regeneration stress depression protein kinase C ε aldehyde dehydrogenase 2 4-hydroxy-2-nonenal apoptosis hippocampus prefrontal cortex myocardium neural regeneration

Analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric sepsis by integrating bioinformatics and machine learning

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World Journal of Pediatrics 2023年第11期19卷 1094-1103页

作者： wen‑yuan zhang Zhong‑Hua Chen Xiao‑Xia An Hui Li Hua‑Lin zhang Shui‑Jing Wu Yu‑Qian Guo Kai zhang Cong‑Li Zeng Xiang‑Ming Fang Department of Anesthesiology and Intensive Care School of MedicineThe First Affiliated HospitalZhejiang UniversityQingChun Road 79Hangzhou 310003China Department of Anesthesiology Shaoxing People’s Hospital(Shaoxing HospitalZhejiang University School of Medicine)Shaoxing 312000China Department of Anesthesiology Vagelos College of Physicians and SurgeonsColumbia UniversityNew YorkNYUSA

Background Pediatric sepsis is a complicated condition characterized by life-threatening organ failure resulting from a dysregulated host response to infection in *** is associated with high rates of morbidity and mortality,and rapid detection and administration of antimicrobials have been *** objective of this study was to evaluate the diagnostic biomarkers of pediatric sepsis and the function of immune cell infiltration in the development of this *** Three gene expression datasets were available from the Gene Expression Omnibus ***,the differentially expressed genes(DEGs)were found with the use of the R program,and then gene set enrichment analysis was carried ***,the DEGs were combined with the major module genes chosen using the weighted gene co-expression *** hub genes were identified by the use of three machine-learning algorithms:random forest,support vector machine-recursive feature elimination,and least absolute shrinkage and selection *** receiver operating characteristic curve and nomogram model were used to verify the discrimination and efficacy of the hub *** addition,the inflammatory and immune status of pediatric sepsis was assessed using cell-type identification by estimating relative subsets of RNA transcripts(CIBERSORT).The relationship between the diagnostic markers and infiltrating immune cells was further *** Overall,after overlapping key module genes and DEGs,we detected 402 overlapping *** pediatric sepsis diagnostic indicators,CYSTM1(AUC=0.988),MMP8(AUC=0.973),and CD177(AUC=0.986)were investigated and demonstrated statistically significant differences(P<0.05)and diagnostic efficacy in the validation *** indicated by the immune cell infiltration analysis,multiple immune cells may be involved in the development of pediatric ***,all diagnostic characteristics may correlate with immune cells to varying *** The candida

关键词： Paediatric sepsis Bioinformatics Machine-Learning Biomarkers Immune cell infiltration

Inadvertent perioperative hypothermia and surgical site infections after liver resection

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 579-585页

作者： Yi-De Zhou wen-yuan zhang Guo-Hao Xie Hui Ye Li-Hua Chu Yu-Qian Guo Yi Lou Xiang-Ming Fang Department of Anesthesiology and Intensive Care Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background:In the overall surgical population,inadvertent perioperative hypothermia has been associated with an increased incidence of surgical site infection(SSI).However,recent clinical trials did not validate this *** study aimed to investigate the potential correlation between inadvertent perioperative hypothermia and SSIs following liver ***:This retrospective cohort study included all consecutive patients who underwent liver resection between January 2019 and December 2021 at the First Affiliated Hospital,Zhejiang University School of *** temperature managements were implemented for all patients included in the *** propensity score matching(PSM)was performed to reduce the baseline imbalances between the normothermia and hypothermia *** and after PSM,univariate analyses were performed to evaluate the correlation between hypothermia and *** regression analysis was performed to determine whether hypothermia was an independent risk factor for postoperative transfusion and major *** analyses were performed for diabetes mellitus,age>65 years,and major liver ***:Among 4000 patients,2206 had hypothermia(55.2%),of which 150 developed SSI(6.8%).PSM yielded 1434 individuals in each *** PSM,the hypothermia and normothermia groups demonstrated similar incidence rates of SSI(7.0%vs.6.3%,P=0.453),postoperative transfusion(13.7%vs.13.3%,P=0.743),and major complications(10.1%vs.9.0%,P=0.309).Univariate regression analysis revealed no significant effects of hypothermia on the incidence of SSI in the group with the highest hypothermia exposure[odds ratio(OR)=1.25,95%confidence interval(CI):0.84-1.87,P=0.266],the group with moderate exposure(OR=1.00,95%CI:0.65-1.53,P=0.999),or the group with the lowest exposure(OR=1.11,95%CI:0.73-1.65,P=0.628).The subgroup analysis revealed similar *** liver function,patients in the hypothermia group demonstrated l

关键词： Surgical site infection Perioperative hypothermia Liver resection Postoperative complications Intraoperative care

Navigation techniques assisted kyphoplasty for the treatment of osteoporotic spinal compression fracture

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Chinese Medical Journal 2009年第8期122卷 987-989页

作者： SUN Chang-tai ZHAO Li-lian zhang Qi-wei wen Liang-yuan zhang Hua-chou Department of Orthopeadics Beijing Hospital Beijing 100730 China

Percutaneous kyphon balloon kyphoplasty has achieved encouraging results in the treatment ofosteoporotic compression fractures, both for correcting spinal deformities and relieving pain. Although kyphoplasty is a small invasion, the surgery itself has some defects such as more X-ray fluoroscopy time during the operation and accumulation of radiation dose causing harm to patients and operators, and the puncture is hard to achieve in a highly precise location.

关键词： computer-assisted surgery vertebral column kyphoplasty compression fracture

Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice

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World Journal of Gastroenterology 2012年第47期18卷 7079-7086页

作者： Qing-E Tian Huan-De Li Miao Yan Hua-Lin Cai Qin-You Tan wen-yuan zhang School of Pharmaceutical Sciences Central South University Xiangtan Central Hospital Clinical Pharmacy and Pharmacology Research Institute the Second Xiangya HospitalCentral South University

AIM:To investigate the adjunct anticancer effect of Astragalus polysaccharides in H22 tumor-bearing ***:To establish a solid tumor model,5.0 × 10 6 /mL H22 hepatoma cells were inoculated subcutaneously into the right armpit region of Kunming mice(6-12 wk old,18-22 g).When the tumors reached a size of 100 mm 3,the animals were treated as indicated,and the mice were randomly assigned to seven groups(n = 10 each).After ten days of treatment,blood samples were collected from mouse eyes,and serum was harvested by *** were sacrificed,and the whole body,tumor,spleen and thymus were weighed *** rate of tumor inhibition and organ indexes were *** expression levels of serum cytokines,P-glycoprotein(P-GP) and multidrug resistance(MDR) 1 mRNA in tumor tissues were detected using enzyme-linked immunosorbent assay,Western blotting,and quantitative myeloid-derived suppressor cells reverse transcription-polymerase chain reaction,***:The tumor inhibition rates in the treatment groups of Adriamycin(ADM) + Astragalus polysaccharides(APS)(50 mg/kg),ADM + APS(100 mg/kg),and ADM + APS(200 mg/kg) were significantly higher than in the ADM group(72.88% vs 60.36%,P = 0.013;73.40% vs 60.36%,P = 0.010;77.57% vs 60.36%,P = 0.001).The spleen indexes of the above groups were also significantly higher than in the ADM group(0.65 ± 0.22 vs 0.39 ± 0.17,P = 0.023;0.62 ± 0.34 vs 0.39 ± 0.17,P = 0.022;0.67 ± 0.20 vs 0.39 ± 0.17,P = 0.012),and the thymus indexes of the ADM + APS(100 mg/kg) and ADM + APS(200 mg/kg) groups were significantly higher than in the ADM group(0.20 ± 0.06 vs 0.13 ± 0.04,P = 0.029;0.47 ± 0.12 vs 0.13 ± 0.04,P = 0.000).APS was found to exert a synergistic antitumor effect with ADM and to alleviate the decrease in the sizes of the spleen and thymus induced by *** expression of interleukin-1α(IL-1α),IL-2,IL-6,and tumor necrosis factor-α(TNF-α) was significantly higher in the ADM + APS(50 mg/kg),ADM + APS(100 mg/kg)

关键词： Astragalus polysaccharides Tumor inhibition rate Cytokines P-glycoprotein Adjunct anticancer

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan Fang wen-Jie Fan Chen-Yu zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

Spacecraft self-and soft-docking control approach with electromagnetic/magnetic flux-pinning synergy

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Spacecraft self-and soft-docking control approach with elect...

Spacecraft self-and soft-docking via coupled actuation of magnetic fields

第三十九届中国控制会议

作者： yuan-wen zhang Le-ping Yang Yan-wei Zhu College of Aerospace Science and Engineering National University of Defense Technology

Spacecraft docking controlled by inter-craft electromagnetic fields actuation not only hasn’t propellant consumption and plume contamination, but also provides high-precision control capability of continuous, reversible, synchronous and noncontacting. In addition, with electromagnetic/magnetic flux-pinning synergy, spacecraft docking has 6-DOF passive stability, stiffness and damping effect. This paper deals with the optimized electromagnetic moment design for magnetic flux-pinning and the handover control approach between the two actuation phases. Finally, several numerical simulations are utilized to verify the theoretical design.

关键词： Spacecraft self-and soft-docking Electromagnetic/magnetic flux-pinning synergy Control approach Stiffness Damping effect

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Spacecraft self-and soft-docking via coupled actuation of ma...