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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： lu Guan Mengting Qiu Na li Zhengxiang Zhou Ru Ye liyan Zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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我国《野生动物保护法》的完善路径

山西省政法管理干部学院学报 2021年第4期34卷 8-11页

作者：王小军李文潞王露上海海洋大学海洋文化与法律学院上海201306

2019年底爆发的新型冠状病毒引发的肺炎(以下简称“新冠肺炎”)疫情使保护野生动物成为我国重大的时代课题。野生动物面临的生存危机和“新冠肺炎”疫情的爆发折射出我国《野生动物保护法》存在诸多问题:立法理念不科学、保护范围狭窄... 详细信息

2019年底爆发的新型冠状病毒引发的肺炎(以下简称“新冠肺炎”)疫情使保护野生动物成为我国重大的时代课题。野生动物面临的生存危机和“新冠肺炎”疫情的爆发折射出我国《野生动物保护法》存在诸多问题:立法理念不科学、保护范围狭窄、相关主管部门权限交叉严重、野生动物保护名录更新迟缓、禁食野生动物条例不健全等。完善《野生动物保护法》,应树立科学的立法理念,扩大野生动物的保护范围,明确各主管部门的职责划分,完善相关名录制度,建立健全禁食野生动物条例。

关键词：野生动物保护法主管部门野生动物名录

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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生物慢滤对污染物的去除效果研究

化学与生物工程 2012年第1期29卷 76-78页

作者：李丽王琳李文露豆洁昆明理工大学建筑工程学院云南昆明650224 昆明市给水工程设计院云南昆明650224

生物慢滤作为预处理可以充分发挥微生物的生物降解作用,初步去除原水中的有机污染物及氮、磷等无机污染物。研究了生物慢滤作为预处理措施处理微污染原水的效果。结果表明,生物慢滤对于去除水中浊度、CODMn、NH4+-N、TN、TP有很好的处... 详细信息

生物慢滤作为预处理可以充分发挥微生物的生物降解作用,初步去除原水中的有机污染物及氮、磷等无机污染物。研究了生物慢滤作为预处理措施处理微污染原水的效果。结果表明,生物慢滤对于去除水中浊度、CODMn、NH4+-N、TN、TP有很好的处理效果,平均去除率分别达到92.3%、34.5%、90.2%、45.2%、30.6%。

关键词：生物慢滤预处理微污染原水去除

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发展中国家对华反倾销的深层次分析

商业研究 2005年第7期 59-62页

作者：王英辉许惠渊李文陆中国农业大学经济管理学院北京100083 石家庄铁道学院经济管理分院河北石家庄050043

经济全球化使得国际贸易竞争态势更加激烈,中国加入WTO后发展中国家对华反倾销趋势有增无减,这种严峻形势要求我国企业必须对发展中国家反倾销的形势、特点有清醒的认识,结合发展中国家的国际贸易地位,产业结构,及反倾销法律环境制定有... 详细信息

经济全球化使得国际贸易竞争态势更加激烈,中国加入WTO后发展中国家对华反倾销趋势有增无减,这种严峻形势要求我国企业必须对发展中国家反倾销的形势、特点有清醒的认识,结合发展中国家的国际贸易地位,产业结构,及反倾销法律环境制定有针对性的应对策略,这样才能提高我国产品在发展中国家的市场占有率,拓展发展中国家市场。

关键词：发展中国家反倾销策略

Operation Risk Analysis of Electric Vehicle With Ultra-fast Charging Integrated to Distribution Network Considering the Bearing Capacity of Power System

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Dianwang Jishu/Power System Technology 2025年第1期49卷 187-197页

作者： Xu, Yanchun li, Sijia Zhang, Tao Mi, lu Hubei Provincial Key Laboratory for Operation and Control of Cascaded Hydropower Station China Three Gorges University Hubei Province Yichang 443002 China Department of Electrical and Computer Engineering Texas A & M University TX 77840 United States

At present, the access of distributed generation and electric vehicles with ultra-fast charging to the distribution network will increase the operational risk of the system. Aiming at the problem that the existing risk assessment indicators fail to consider the system capacity effectively, this paper proposed a comprehensive index of risk assessment of distribution networks considering the power system's capacity. The distributed generation output model and the electric vehicle load model with ultra-fast charging were first constructed. Then, the index based on the distribution entropy theory was used to measure the risk caused by the over-limit of state variables such as voltage and power and the uncertainty of their distribution. The index based on the Theil entropy theory was introduced to measure the risk caused by the equilibrium degree of the incremental distribution of state variables after the load impacted the system. The weight analysis method combining the order relationship method and the objective weighting method was used to evaluate the system risk comprehensively. Finally, the rationality of the comprehensive index was calculated and analyzed by testing the IEEE 33-node system. The results show that the comprehensive index proposed can effectively evaluate the potential risk when the system does not exceed the limit and consider that the ultra-fast charging of electric vehicles will change the time series distribution characteristics of comprehensive risk. The research in this paper can provide theoretical guidance for the safe operation of electric vehicles. with ultra-fast charging connected to the distribution network. © 2025 Power System Technology Press. All rights reserved.

关键词： Risk analysis

Unraveling the origins of PGY-sRNA-6,BZL-sRNA-20,and XKC-sRNA-h3

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Science China life Sciences 2025年

作者： Shanfa lu State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical College Engineering Research Center of Chinese Medicine Resource Ministry of Education

Dear Editor,The regulatory role of herbal sRNAs in humans and animals is an interesting research ***,current evidence is insufficient to conclude that herbal sRNAs are novel precision medicines.I previously showed that HJT-sRNA-m1-HJT-sRNA-m8,identified as herbal sRNAs previously (Du et al.,2019),may be derived from humans and/or animals(lu,2023).To minimize errors during herbal sRNA analysis,I provided a list of matters needing special attention and proposed problem-solving solutions for researchers working on sRNA cross-kingdom regulation (lu,2023).

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Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： liN Yongjie ZHANG Cancan WU Yuting ZHANG Yi lu Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/（Δp）1/3was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29% to 17.18% over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer

The Rational Choice of Five Basic Competition Strategies

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The Rational Choice of Five Basic Competition Strategies