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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin Gan Kun ling Mingfang He Jianshu li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

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Earth and Planetary Physics 2025年第1期9卷 148-158页

作者： ChenChen Zhan RongSheng Wang QuanMing lu San lu XinMin li Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Anhui Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China

The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly *** this article,we present an electron current layer detected at the edge of the magnetotail plasma *** ions were demagnetized inside the electron current layer,but the electrons were still frozen in with the magnetic field ***,this decoupling of ions and electrons gave rise to a strong Hall electric field,which could be the reason for the formation of the embedded thin current *** magnetized electrons,the absence of the nongyrotropic electron distribution,and negligible energy dissipation in the layer indicate that magnetic reconnection had not been triggered within the embedded thin current *** highly asymmetric plasma on the two sides of the current layer and low magnetic shear across it could suppress magnetic *** observations indicate that the embedded electric current layer,probably generated by the Hall electric field,even down to electron scale,is not a sufficient condition for magnetic reconnection.

关键词： magnetotail plasma sheet magnetic reconnection

农用地自然质量分等与耕地地力评级结果的对比衔接

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中国土地科学 2011年第2期25卷 4-10页

作者：李文璐赵庚星山东农业大学资源与环境学院山东泰安271018

研究目的:探寻农用地自然质量分等和耕地地力评级结果间的差异与联系.实现其成果的衔接研究方法:模糊综合指数评判法、聚类分析法、层次分析法、GIS叠加分析法、转移矩阵分析、拟合分析。研究结果:(1)农用地自然质量分等和耕地地力评价... 详细信息

研究目的:探寻农用地自然质量分等和耕地地力评级结果间的差异与联系.实现其成果的衔接研究方法:模糊综合指数评判法、聚类分析法、层次分析法、GIS叠加分析法、转移矩阵分析、拟合分析。研究结果:(1)农用地自然质量分等和耕地地力评价结果之间"等"、"级"变化差异程度不同,同一评价单元农用地自然质量等较多高于耕地地力评价级;(2)平原区"等"与"级"结果的差异程度远大于丘陵区;(3)建立了不同指标区农用地自然质量指数与耕地地力评价指数之间的衔接模型,丘陵区衔接模型的线性相关程度明显高于平原区。研究结论:利用衔接模型,可以在农用地自然质量分等和耕地地力评级结果间进行转换,实现了两者在同一指标区的相互衔接检验和不同指标区之间的统一可比性。

关键词：土地资源农用地分等耕地地力评价对比衔接

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： lifang Zhao Mingkai Zhang Qimeng li Xuemin Wang Jie lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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长初级直线感应电机分段供电切换暂态过程

电机与控制学报 2015年第9期19卷 1-7页

作者：马名中马伟明范慧丽黄垂兵李文禄海军工程大学舰船综合电力技术国防科技重点实验室湖北武汉430033 海军工程大学外训系湖北武汉430033

针对采用常规分段供电方式的长初级直线感应电机由于次级的运动,其覆盖每段定子的长度不断变化,导致通电定子段电机参数不断变化,无法对负载实现精确控制的缺点,设计了带中间母排结构的分段供电网络,可以保证电机在整个运行过程中模型... 详细信息

针对采用常规分段供电方式的长初级直线感应电机由于次级的运动,其覆盖每段定子的长度不断变化,导致通电定子段电机参数不断变化,无法对负载实现精确控制的缺点,设计了带中间母排结构的分段供电网络,可以保证电机在整个运行过程中模型和参数固定不变,能够利用现有各种控制算法实现高性能控制。对于采用反并联晶闸管作为分段供电切换开关,从晶闸管开通和关断的"数学——物理"模型出发,分析了分段供电切换过程中开关暂态过程及其对电机性能的影响。利用某采用分段供电的长初级双边直线感应电动机原理样机进行实验,实验结果与理论分析相吻合,验证了理论分析的正确性。

关键词：长初级直线感应电机分段供电网络反并联晶闸管切换开关物理-数学模型

海外并购与国内并购的价值比较——基于PSM-DID的研究

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技术经济与管理研究 2021年第3期 56-61页

作者：范高乐李文璐天津天狮学院经济管理学院天津301700 河北工业大学经济管理学院天津300401

文章基于2009—2018年中国沪深A股非金融上市公司数据,探究海外并购对我国企业价值的影响,发现:第一,海外并购能够提高企业全要素生产率,并且随着时间推移其影响逐步减小,但海外并购并不会比国内并购带来全要素生产率的额外提高;第二,... 详细信息

文章基于2009—2018年中国沪深A股非金融上市公司数据,探究海外并购对我国企业价值的影响,发现:第一,海外并购能够提高企业全要素生产率,并且随着时间推移其影响逐步减小,但海外并购并不会比国内并购带来全要素生产率的额外提高;第二,海外并购能够对企业创新与企业出口产生显著的积极影响,但与国内并购相比其仅对企业出口存在差异影响,对企业创新水平的提升并不存在差别;第三,海外并购相比国内并购来说,会造成企业短期内的财务风险明显上升;第四,国有企业海外并购以及对非亚洲地区进行海外并购对企业出口扩张的积极影响更大,非国有企业海外并购以及对非亚洲地区的海外并购会导致企业面临更高的财务风险,企业流动比率与速冻比率明显降低。

关键词：海外并购国内并购企业价值双重差分倾向得分匹配

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin lu Jiale liu Lei Bai Xiang li Zhengquan Yu Haiying li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PliN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PliN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PliN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

新冠肺炎疫情下旅游评论主题内容特征——以150篇文章为样本

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技术与创新管理 2020年第5期41卷 495-501页

作者：李文路西南民族大学西南民族研究院四川成都610041 四川省旅游学校四川成都610042

为了解旅游各界对疫情冲击旅游业的评价及应对策略,对旅游企业实施自救、政府制定相关政策、旅游业转型升级,促进旅游业快速复苏及长期健康发展提供重要参考;运用内容分析法,从高频词、网络语义和主题内容3个层面对150篇旅游评论文章的... 详细信息

为了解旅游各界对疫情冲击旅游业的评价及应对策略,对旅游企业实施自救、政府制定相关政策、旅游业转型升级,促进旅游业快速复苏及长期健康发展提供重要参考;运用内容分析法,从高频词、网络语义和主题内容3个层面对150篇旅游评论文章的主题内容特征进行研究。研究发现,现有成果主要关注两大层面内容:一是疫情对旅游业的影响评价,包括影响性质、影响范围、影响程度、影响领域和影响时间尺度等;二是疫情期间及结束后旅游业的复苏与发展建议,包括应对态度、行业信心、面临问题、短期措施和长期策略等。结论认为,现有成果在一定程度上为旅游业复苏和健康发展提供了重要参考价值,但仍需要在研究方法、研究方向、研究内容等方面继续深入研究和探讨。

关键词：影响复苏发展旅游业新冠肺炎疫情

Multi-Stage-Based Siamese Neural Network for Seal Image Recognition

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 405-423页

作者： Jianfeng lu Xiangye Huang Caijin li Renlin Xin Shanqing Zhang Mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and *** seal inspection is commonly audited manually to ensure document ***,manual assessment of seal images is tedious and laborintensive due to human errors,inconsistent placement,and completeness of the *** image recognition systems are inadequate enough to identify seal types accurately,necessitating a neural network-based method for seal image ***,neural network-based classification algorithms,such as Residual Networks(ResNet)andVisualGeometryGroup with 16 layers(VGG16)yield suboptimal recognition rates on stamp ***,the fixed training data categories make handling new categories to be a challenging *** paper proposes amulti-stage seal recognition algorithmbased on Siamese network to overcome these ***,the seal image is pre-processed by applying an image rotation correction module based on Histogram of Oriented Gradients(HOG).Secondly,the similarity between input seal image pairs is measured by utilizing a similarity comparison module based on the Siamese ***,we compare the results with the pre-stored standard seal template images in the database to obtain the seal *** evaluate the performance of the proposed method,we further create a new seal image dataset that contains two subsets with 210,000 valid labeled pairs in *** proposed work has a practical significance in industries where automatic seal authentication is essential as in legal,financial,and governmental sectors,where automatic seal recognition can enhance document security and streamline validation ***,the experimental results show that the proposed multi-stage method for seal image recognition outperforms state-of-the-art methods on the two established datasets.

关键词： Seal recognition seal authentication document tampering siamese network spatial transformer network similarity comparison network