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通过心脏生物标记物预测心血管病风险:治疗的有效性是否取决于其风险阈值?

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中华高血压杂志 2015年第12期23卷 1108-1108页

作者：刘莉叶鹏 welsh p Hart C papacosta O preiss D McConnachie A Murray H Ramsay S Upton M Watt G Whincup p Wannamethee G Sattar N

研究人员纳入英国区域心脏研究（the British regional heart study,BRHS）中60~79岁男性和MIDSpAN家庭研究（the MIDSpAN family study,MFS）中30~59岁男性与女性,检查心脏标志物氨基末端脑钠尿肽前体（N-terminal pro-brain natriuret... 详细信息

关键词：心血管病氨基末端 natriuretic 肌钙蛋白脑钠尿肽肾上腺髓质素生物标记物生物标志物分类指数风险因子

常规脂蛋白检测和载脂蛋白在心血管病预测中的比较

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中华高血压杂志 2019年第7期27卷 699-699页

作者： welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark pB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund pS Gill J MR pell Jp Sattar N welsh p 刘青(译) 叶鹏(摘、审校) 不详

总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀... 详细信息

总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。

关键词：心血管病风险预测载脂蛋白高密度脂蛋白胆固醇检测他汀类药物总胆固醇风险评估

高敏心肌肌钙蛋白血中浓度与首发心血管事件预后间关系

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心血管病学进展 2018年第1期 134-134页

作者： Willeit p welsh p Evans JDW 袁志敏

高敏心肌肌钙蛋白为心肌损伤的标志物之一,若其血液中水平升高,将明显增加继发心血管事件风险。然而迄今关于心肌肌钙蛋白血中水平与首发心血管事件以及预后间关系尚不清楚,现就此进行相关文献荟萃汇总分析。作者特检查了2016年以前的... 详细信息

高敏心肌肌钙蛋白为心肌损伤的标志物之一,若其血液中水平升高,将明显增加继发心血管事件风险。然而迄今关于心肌肌钙蛋白血中水平与首发心血管事件以及预后间关系尚不清楚,现就此进行相关文献荟萃汇总分析。作者特检查了2016年以前的著名的pubmed、Science、EMBASE等相关数据库文献。结果共检查出涉及28项相关长期前瞻性研究,共计有154 052例基线无心血管病史的个体。

关键词：心肌肌钙蛋白心血管病

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探究白细胞与血压的关系:孟德尔随机研究

中华高血压杂志 2020年第4期28卷 373-373页

作者：周卫(译) 叶鹏(摘/审校) Siedlinski M Jozefczuk E Xu X Teumer A Evangelou E Schnabel RB welsh p Maffia p Erdmann J Tomaszewski M Caulfield MJ Sattar N Holmes MV Guzik TJ 不详

高血压是导致心血管病和死亡的危险因素。肾脏、血管系统和交感神经系统可调节高血压,最近的实验表明免疫细胞可能在高血压中起作用。研究人员借助英国生物资料库,研究主要白细胞类型与血压之间的关系,并采用孟德尔随机化(Mendelian ran... 详细信息

高血压是导致心血管病和死亡的危险因素。肾脏、血管系统和交感神经系统可调节高血压,最近的实验表明免疫细胞可能在高血压中起作用。研究人员借助英国生物资料库,研究主要白细胞类型与血压之间的关系,并采用孟德尔随机化(Mendelian randomization,MR)方法研究750000个来自英国生物资料库和血压与全基因组关联研究联盟的案例,检测哪些白细胞群体可能与血压有因果关系。

关键词：随机研究交感神经系统血管系统全基因组关联研究心血管病免疫细胞孟德尔白细胞

富集在平滑肌中的长链非编码RNA调控细胞增殖

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中华高血压杂志 2016年第4期24卷 399-399页

作者： Ballantyne MD pinel K Dakin R Vesey AT Diver L Mackenzie R Garcia R welsh p Sattar N Hamilton G Joshi N Dweck MR Miano JM McBride MW Newby DE McDonald RA Baker AH 刘莉叶鹏

血管平滑肌细胞（vascularsmoothmusclecells，VSMC）从收缩到合成状态的表型转换涉及到不同的血管病变，包括动脉粥样硬化，斑块稳定和新生内膜增生。而长链非编码RNA（10ngnoncodingRNA，lncRNA）在上述过程中的作用尚未知。

关键词：血管平滑肌细胞非编码RNA 细胞增殖长链调控富集动脉粥样硬化新生内膜增生

Homotypic Vacuole Fusion Requires VTI11 and Is Regulated by phosphoinositides

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Molecular plant 2014年第6期7卷 1026-1040页

作者： Sang Won Han Maria Fernanda Rodriguez-welsh Marcela Rojas-pierce Department of plant and Microbial Biology North Carolina State University Raleigh NC 27695 USA

Most plant cells contain a large central vacuole that is essential to maintain cellular turgor. We report a new mutant allele of VTI11 that implicates the SNARE protein VTI11 in homotypic fusion of protein storage and lytic vacuoles. Fusion of the multiple vacuoles present in vtill mutants could be induced by treatment with Wortmannin and LY294002, which are inhibitors of phosphatidylinositol 3-Kinase （pI3K）. We provide evidence that phosphatidylinositol 3-phosphate （ptdlns（3）p） regulates vacuole fusion in vtill mutants, and that fusion of these vacuoles requires intact microtubules and actin filaments. Finally, we show that Wortmannin also induced the fusion of guard cell vacuoles in fava beans, where vacuoles are naturally fragmented after ABA-induced stomata closure. These results suggest a ubiquitous role of phosphoinositides in vacuole fusion, both during the development of the large central vacuole and during the dynamic vacuole remodeling that occurs as part of stomata movements.

关键词： vacuole SNARE phosphoinositides membrane fusion Wortmannin.

Combined treatment of non-small cell lung cancer using radiotherapy and immunotherapy: challenges and updates

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Cancer Communications 2021年第11期41卷 1086-1099页

作者： Shijie Shang Jie Liu Vivek Verma Meng Wu James welsh Jinming Yu Dawei Chen Department of Radiation Oncology Shandong Cancer Hospital Affiliated to Shandong UniversityJinanShandong 250117P.R.China Department of Radiation Oncology Laboratory of Radio-ImmunologyCancer Research CenterShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117P.R.China Department of Radiation Oncology The University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTexas 77030the United States of America

The efficacy of immunotherapy for advanced non-small cell lung cancer(NSCLC)remains unsatisfactory,as the majority of patients either do not experience an objective response or acquire secondary *** a result,several methods to enhance the systemic efficacy of immunotherapy have been investigated,including a large area of active research by combining immunotherapy with radiation therapy(RT).Given the rapidly burgeoning concept of combining immunotherapy and RT for increasing therapeutic benefit,we review the progress in this field thus far and explore further avenues for enhancing this *** review commences with a discussion of the only two existing randomized trials(and a pooled analysis)showing that the addition of RT to immunotherapy improves the abscopal response rate,progression-free survival,and overall survival in metastatic NSCLC *** then discussed factors and biomarkers that may be associated with a proportionally greater benefit to additional RT,such as low programmed cell death protein ligand 1(pD-L1)status,tumor mutational burden(TMB),and patient’s immune ***,the implementation of RT to overcome immunotherapy resistance is discussed,including a mechanistic discussion and methods with which these mechanisms could be ***,the emerging role of low-dose RT is discussed,which may help to overcome inhibitory signals in the tumor stroma that limit T-cell *** together,given the current state of this rapidly expanding realm,these futuristic strategies may be reflected upon to further enhance the efficacy of immunotherapy for a wider group of patients.

关键词： immune checkpoint inhibitors immunotherapy immunotherapy combined with radiotherapy low-dose radiotherapy non-small cell lung cancer radiotherapy