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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal.nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Cl.nic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral.nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transpl.nts for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central.necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabl.ng the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transpl.nts in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal.neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transpl.nts and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral.nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbal.nce between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decl.ne in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Genetic mechanisms and control on hydrocarbon accumulation in transtensional structures: A case study of Gaoqing area, northern Dongying Sag, China

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Energy Geoscience 2023年第3期4卷 203-209页

作者： Juan He weizhong Zhang Exploration&Production Research Institute SINOPECBeijing102206China Geophysical Research Institute of Shengli Oilfield Company SINOPECDongyingShandong257022China

Broom-shaped structures are widely seen in transtensional basins, including those discovered in many sags of the Bohai Bay Basin. Broom-shaped transtensional structural zones are generally petroliferous and thus important targets for hydrocarbon exploration. This study analyzed the evolution and genetic mechanisms of the broom-shaped transtensional structures in the Gaoqing area of the Dongying Sag using the 3D seismic flattening technique and a physical simulation experiment. Furthermore, the control effects of the broom-shaped transtensional structures on hydrocarbon accumulation and distribution were discussed. The research results are as follows. The Gaoqing area is of a broom-shaped transtensional structure in pl.nar view, composed of several arc-shaped secondary faults intersecting with high-level main fault in the same direction. On the seismic section, it appears as a typical semi-flower-like structure. In the early stage (that is, during the deposition of the Kongdian Formation to the lower submember of the 4th member of the Shahejie Formation, Es4(l)), single-fault pattern consisting of single or multiple faults in alignment was developed under extensional stress. While with the change of structural stress (that is, during the deposition of the Es4(U) to the Es2(l)), more secondary faults were formed, and came in a pattern of broom-shaped structure together with the major fault. In the late stage (that is, during the deposition of the Es1 to the Guantao Formation), the en echel.n fault pattern was formed, as the major fault broke into multiple secondary faults. The divergent end of the broom-shaped transtensional structure has many secondary faults developed, the fault pl.nes are gentle, and small-scale fan deltas are the predominant type of deposits. The hydrocarbon tends to laterally migrate far away and accumulate mianly in structural and lithologic-structural traps. On the other hand, in the convergent end, the fault pl.nes are relatively steep, result

关键词： Broonn-shaped tanstensional stucture Physical sirulation Genetic mechanism Contol on hydrocarbon accunulation Gaoqing area Dongying sag

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Some Properties of a Class of Addition Cayley Signed Graph

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Wuhan University Journal of natural Sciences 2022年第4期27卷 296-302页

作者： YUAn Yuqing WAnG weizhong Department of Mathematics Lanzhou Jiaotong UniversityLanzhou 730070GansuChina

let G=Cay^(+)(Z_(p1)×Z_(p1)^(α1)_(p2)^(α2)…_(pk)^(αk),Φ)be a simple graph having vertex set V(G)=Z_(p1)×Z_(p1)^(α1)_(p2)^(α2)…_(pk)^(αk)and edge set E(G)={{x,y}:x+y∈Φ},where all p_(1),p_(2),…,p_(k)are distinct prime factors andΦis the set of all units of the ring Z_(p1)^(α1)_(p2)^(α2)…_(pk)^(αk).letΣ=(G,σ)be a signed graph whose underlying graph is G and signature function isσ:E(G)→{+1,-1}defined asσ({x,y})={+1,ifx∈φ(p_(1))or y∈φ(p_(1)^(α1)p_(2)^(α2)…p_(k)^(αk));-1,*** this paper,we characterize the bal.nce ofΣand some graphs derived from it such asη(Σ),l(Σ)and C_(E)(Σ).Moreover,we investigate the clusterability and sign-compativility ofΣ.

关键词： signed graphs derived graph bal.nce clusterability sign-compatibility

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Anti-amyloid antibodies in Alzheimer’s disease: what did cl.nical trials teach us?

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neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.navarro-lópez neuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative expl.nations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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In situ study of the mechanical properties of airborne haze particles

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Science China(Technological Sciences) 2015年第12期58卷 2046-2051页

作者： DInG MingShuai HAn weizhong lI Ju MA Evan SHAn ZhiWei Center for Advancing Materials Performance from the nanoscale (CAMP-nano) and Hysitron Applied Research Center in China (HARCC) State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong University Department of nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of Technology Department of Materials Science and Engineering Johns Hopkins University

Particulate pollution has raised serious concerns regarding its potential impacts on human health in developing countries. However, much less attention has been paid to the threat of haze particles to machinery and industry. By employing a state-of-the-art in situ scanning electron microscope compression testing technique, we demonstrate that iron-rich and fly ash haze particles, which account for nearly 70% of the total micron-sized spherical haze particles, are strong enough to generate abrasive damage to most engineering alloys, and therefore can generate significant scratch damage to moving contacting surfaces in high precision machineries. Our finding calls for preventive measures to protect against haze related threat.

关键词： haze particle hardness abrasive damage precision industry

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3D forward model.ng and response characteristics of low-resistivity overburden of the CFS-PMl absorbing boundary for ground-well transient electromagnetic method

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International Journal of Mining Science and Technology 2023年第12期33卷 1541-1550页

作者： lijuan Zhao Mingzhong Gao nengzhong lei Hongfei Duan weizhong Qiu Zhaoying Chen State Key laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China School of Civil Engineering and Architecture Wuyi UniversityWuyi 354300China Jinneng Holding Group Taiyuan 030000China China University of Mining and Technology Xuzhou 221116China Shanxi Coal Geology 115 Exploration Institute Co. Ltd.Shanxi Geological Group Co.Ltd.Datong 037003China State Key laboratory of Coal and Coalbed Methane Co-mining Jincheng 048012China

This study used the stable and convergent Dufort-Frankel method to differentially discretize the diffusion equation of the ground-well transient electromagnetic secondary *** absorption boundary condition of complex frequency-shifted perfectly matched layer(CFS-PMl)was used for truncation so that the low-frequency electromagnetic wave can be better absorbed at the model boundary.A typical three-dimensional(3D)homogeneous half-space model was established and a low-resistivity cube model was analyzed under the half-space *** response patterns and drivers of the low-resistivity cube model were discussed under the influence of a low-resistivity *** absorption boundary conditions of CFS-PMl significantly affected the low-frequency electromagnetic *** a low-resistivity cube around the borehole,its response curve exhibited a single-peak,and the extreme point of the curve corresponded to the center of the low-resistivity *** the low-resistivity cube was directly below the borehole,the response curve showed three extreme values(two high and one low),with the low corresponding to the center of the low-resistivity *** total field response of the low-resistivity overburden was stronger than that of the uniform half-space model due to the low-resistivity shielding effect of electromagnetic *** the receiving-transmitting distance gradually increased,the effect of the low-resistivity overburden was gradually weakened,and the response of the low-resistivity cube was *** was affected by the ratio of the overburden resistivity to the resistivity of the low-resistivity body.

关键词： Ground-well transient electromagnetic method CFS-PMl boundary condition 3D forward model.ng low-resistivity overburden

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Characterization of microstructural features of Tamusu mudstone

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1923-1932页

作者： Hongdan Yu Chen lu weizhong Chen Diansen Yang Honghui li State Key laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China China national.nuclear Corporation Key Laboratory on Geological Disposal of High-level Radioactive WasteChina Institute for Radiation ProtectionTaiyuan030006China

Tamusu mudstone formation, located in the Alxa area in western Inner Mongolia, is considered a potential host formation for high-level radioactive waste(HlW) underground disposal in China. In this study, complementary analyses with X-ray diffraction(XRD), field emission scanning electron microscopy(FE-SEM), mercury intrusion porosimetry(MIP), and n_(2) physisorption isotherm were conducted on the Tamusu mudstone to characterize its physical characteristics and microstructural features, such as mineral compositions and pore structure. Several minerals, including carbonates, feldspar, clays and analcime, were identified in Tamusu mudstone by XRD. Images from FE-SEM show that pores in the Tamusu mudstone were dominantly on nanometer scale and generally located within their mineral matrix or at the interface with non-porous minerals. The combination of the MIP and n_2 physisorption curves indicated that the Tamusu mudstone has diverse pore sizes, a porosity varying from 2.34% to 2.84%, and a total pore volume in the range of 0.0065—0.0222 cm^(3)/g with the average pore diameter ranging from 9.6 nm to 19.23 nm. The specific surface area measured by MIP(2.572—5.861 m^(2)/g) was generally higher than that by n_(2) physisorption(1.29—3.04 m^(2)/g), due to the pore network effect, pore shape(e.g. ink-bottle shape), or technique limits. The results related to pore information can be applied as an input in the future to model single-or multi-phase fluid flow and the transport of radionuclides in porous geomedium by migration and diffusion.

关键词： Tamusu mudstone Pore structure Field emission scanning electron microscopy(FE-SEM) n_2 physisorption Mercury intrusion porosimetry(MIP)

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Carbon dioxide reforming of methane over mesoporous nickel aluminate/γ-alumina composites

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Journal of Energy Chemistry 2017年第1期26卷 93-100页

作者： li Zhang Xueguang Wang Xingfu Shang Mingwu Tan weizhong Ding Xionggang lu State Key laboratory of Advanced Special Steel Shanghai UniversityShanghai 200072China Shanghai Key laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200072China

A series of xniAl2O4/γ-Al2O3composites with various ni contents have been prepared via one-step partial hydrolysis of metal.nitrate salts in the absence of surfactants and used for carbon dioxide reforming of methane. The characterization results demonstrated that the niAl2O4/γ-Al2O3materials possessed mesoporous structures of uniform pore sizes; and the ni2+ions were completely reacted with alumina to niAl2O4spinel in the matrices using n2sorption, XRD, TEM, and XPS. The niAl2O4/γ-Al2O3materials exhibited excell.nt catalytic properties and superior l.ng-term stability for carbon dioxide reforming of methane. The effects of ni content on the intrinsic activities and the amounts of coke disposition of the xniAl2O4/γ-Al2O3catalysts were discussed in detail for the carbon dioxide reforming of methane. The results revealed that the ni particle sizes did not affect the intrinsic activity of metallic ni, but smaller ni particles could reduce the rate of coke deposition. © 2016 Science Press

关键词： Alumina Carbon dioxide Characterization Coke Mesoporous materials Methane nickel Pore size Synthesis gas manufacture

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文件比较各显神通

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市场与电脑（PC任我行） 2004年第5期 44-45页

作者： l.n

对于简单的文本文件，可以通过直接阅读来比较两者之间的差别，但如果是内容复杂或者需要按照字节进行比较的文件，我们就不得不借助一些专业的软件或者是某些软件中附带的功能进行比较。

关键词：文件比较工具 Beyond Compare 文件管理器资源管理器文本文件

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