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Space truss construction modeling based on on-orbit assembly motion feature

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Chinese Journal of Aeronautics 2024年第3期37卷 365-379页

作者： Changjie ZHAO weizhong GUO Meng CHEN Jiaxing HU Youcheng HAN Rongfu lin State Key Lab of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Institute of Aerospace System Engineering Shanghai Shanghai 201109China

More space truss construction has been planned to develop and utilize space *** trusses are designed in the way of large-scale,complex,modular,and on-orbit *** meet the upcoming challenge of large-scale space infrastructure construction,it is necessary to study space truss automation design and robotic *** paper proposes an ordinal finite screw adjacency matrix model(OFSAMM),focusing on the relationship between assembly motions,to express and compute a space truss *** this model,a space truss is abstracted as a set of ordered assembly motions,each of which is recorded as a finite screw as the basic element of the truss and its *** operation of truss transformation is also derived under this ***,the truss configuration,the assembly sequence,the truss sub-assembly,the truss components,and the on-orbit assembly task can be expressed and calculated in a unified model,which is calculated and stores the truss topology and assembly with the minimum storage *** the end of this paper,we introduce how to synthesize and optimize space truss design through two *** study will help to improve design ***,it provides a theoretical basis for the automatic construction of space truss structures,especially in the next stage.

关键词： Adjacency matrix Finite screw On-orbit construction modeling Space applications Space trusses Topology design

An Investigation of Bubble Motion in the Fluidic Oscillator

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Journal of Ocean University of China 2023年第2期22卷 459-468页

作者： BIE Haiyan XUE Licheng LI Yulong LI Yunxia lin Zixin AN weizhong College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China

Enhanced gas-liquid mass transfer is significant for the desulfurization and denitration of ship exhaust *** a fluid device,the special structure of the fluidic oscillator generates self-excited oscillations that can effectively enhance the mass transfer process of *** there are few studies on the internal gas-liquid *** transportation of individual bubbles in the fluidic oscillator was investigated by a high-speed camera and digital image *** results show that the bubble experienced a significant deceleration process in the chamber region of the fluidic *** addition,the maximum bubble offset increased with the diameter of the initial *** trajectory of the bubble showed zigzag movement due to the deflecting oscillation of the fluidic *** the same time,the deformation of the bubble was intensified by the deflecting *** deformation ratio of the bubble increased with the increase of Reynolds *** studying the transport process of a single bubble in the fluid oscillator,it is considered that the fluid oscillator has the potential to be a new bubble generator.

关键词： fluidic oscillator bubble deceleration deformation ratio

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Near carbon‑zero cycle from VOCs capture to carbon fixation

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Carbon Neutrality 2022年第1期1卷 249-256页

作者： Zefang Yin Chaojie Cui Xiang Yu Wanghua Zhao Dexi lin Yu Zhang Kang Li weizhong Qian Department of Chemical Engineering Tsinghua UniversityBeijing 100084China Sinochem Quanzhou Petrochemical Co.Ltd. Quanzhou 362103Fujian ProvinceChina Sinopec Engineering Group Luoyang R&D Center of Technologies Luoyang 471003Henan ProvinceChina

A new technical route of organic matter capture and carbon fixation is proposed in response of the increasingly strict emission standards of volatile organic compounds(VOCs)in petrochemical industry and the Chinese national strategic development goals of carbon peak and carbon neutralization.A closed loop from raw materials to adsorbents for gas treatment can be achieved by two key technical characteristics:(1)construct a new mesoporous adsorbent with complete desorption and regeneration function by carbon nanotubes(CNTs);(2)convert gaseous organic matter which cannot be recycled in liquid/gas state to *** realizes the resource integration of"turning waste into treasure"and maximizes the carbon emission reduction effect of waste gas treatment process without consuming extra precious fossil fuel,compared with the traditional technologies of VOCs treatments,including combustion or catalytic ***’s more,the increase in supply of various green electricity is expected to change the current situation of large investment and heavy cost burden of environmental protection technology,and make a great contribution to the national carbon peak and carbon neutrality policy.

关键词： Carbon nanotubes Volatile organic compounds Waste gas treatment Carbon emissions Closed loop

Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis

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Precision Clinical Medicine 2022年第2期5卷 87-99页

作者： Minglei Yang Chenghao lin Yanni Wang Kang Chen Yutong Han Haiyue Zhang weizhong Li Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control of Ministry of Education Sun Yat-Sen UniversityGuangzhou 510080China

Background:Evidence has suggested that cytokine storms may be associated with T cell exhaustion(TEX)in ***,the interaction mechanism between cytokine storms and TEX remains ***:With the aim of dissecting the molecular relationship of cytokine storms and TEX through single-cell RNA sequencing data analysis,we identified 14 cell types from bronchoalveolar lavage fluid of COVID-19 patients and healthy *** observed a novel subset of severely exhausted CD8 T cells(Exh T_CD8)that co-expressed multiple inhibitory receptors,and two macrophage subclasses that were the main source of cytokine storms in ***:Correlation analysis between cytokine storm level and TEX level suggested that cytokine storms likely promoted TEX in severe ***–cell communication analysis indicated that cytokines(***10,CXCL11,CXCL2,CCL2,and CCL3)released by macrophages acted as ligands and significantly interacted with inhibitory receptors(***3,DPP4,CCR1,CCR2,and CCR5)expressed by Exh T_*** interactions formed the cytokine–receptor axes,which were also verified to be significantly correlated with cytokine storms and TEX in lung squamous cell ***:Cytokine storms may promote TEX through cytokine-receptor axes and be associated with poor prognosis in *** cytokine-receptor axes may reverse *** finding provides novel insights into TEX in COVID-19 and new clues for cytokine-targeted immunotherapy development.

关键词： COVID-19 immune exhaustion cytokine storm single-cell sequencing data analysis T cell immune checkpoint

Heat exchange at air-sea interface in the South China Sea during monsoon periods in 1986

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Chinese Science Bulletin 2006年第19期51卷 2413-2420页

作者： WU Disheng FENG weizhong XU Jianping YAN Jinghua ZHAO Xue ZHOU Shuihua ZHANG Jiwei QIAO Guanyu lin Fu LU Boming South China Sea Forecast Center State Oceanic Administration Guangzhou 510300 China Laboratory of Ocean Dynamic Processes and Satellite Oceanography (LOPSO) State Oceanic Administration Hangzhou 310012 China Guangzhou Tropic Ocean Atmosphere Institute Guangzhou 510080 China

In order to explore the interaction be- tween the sea and monsoon in the South China Sea, the heat exchanges at air-sea interface during mon- soon periods in 1986 were calculated using observa- tional data. It shows that when the summer monsoon bursts and prevails over the South China Sea, the air-sea interface heat exchange is strong and the latent heat rises rapidly in the intertropical conver- gence zone and the tropic cyclone system near 20.49°N, 114.14°E. On May 24, 1986, the sensible heat became positive in the typhoon system. The heating exchange indicates that heat is transported from ocean to atmosphere, with major contribution of latent heat. When the summer monsoon prevails over the South China Sea and the weather is fine, even SST (sea surface temperature) is high, but sensible heat appears to be negative. The heat exchange indicates that heat is transported from atmosphere to ocean, with major contribution of short-wave radiation absorbed by sea surface and sensible heat. When summer monsoon is over and the northeast monsoon prevails over the South China Sea, the heat ex- change at air-sea interface is very strong. The heat- ing exchange shows that the ocean heats the at- mosphere, with major contribution of latent heat when cold air arrives at the sea surface and the sensible heat rises to positive rapidly. Therefore it can be concluded that the heat exchange at air-sea interface is different from the SST in South China Sea. Whenthe summer monsoon prevails over the South China Sea, the main trend is the ocean responding to the atmosphere.

关键词：南海夏季季风海空热传导观测资料

FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

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Bone Research 2022年第4期10卷 726-740页

作者： Dong Guo Chuangxin lin Yuheng Lu Hong Guan weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai Department of Joint Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Department of Orthopedics Orthopedic Hospital of Guangdong ProvinceAcademy of OrthopedicsGuangdong ProvinceThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina The Third School of Clinical Medicine Southern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases GuangzhouChina Department of Orthopedic Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-sen UniversityShantouChina State Key Laboratory of Organ Failure Research Department of Cell BiologySouthern Medical University School of Basic Medical SciencesGuangzhouChina

Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and ***,the effect of FABP4 on RA remains ***,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in *** increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA *** studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in *** contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in *** findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in ***309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA ***,FABP4 may represent a potential target for RA therapy.

关键词： angiogenesis inhibited synovitis

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1840-1851页

作者： Longlong Xie Feng Shi Yueshuo Li We Li Xinfang Yu lin Zhao Min Zhou Jianmin Hu Xiangjian Luo Min Tang Jia Fan Jian Zhou Qiang Gao weizhong Wu Xin Zhang Weihua Liao Ann MBode Ya Cao Key Laboratory of Carcinogenesis and Invasion Chinese Ministry of EducationDepartment of RadiologyXiangya HospitalCentral South UniversityChangsha 410078China Cancer Research Institute and School of Basic Medical Science Xiangya School of MedicineCentral South UniversityChangsha 410078China Key Laboratory of Carcinogenesis Chinese Ministry of HealthChangsha 410078China Molecular Imaging Research Center of Central South University Changsha 410008 HunanChina Key Laboratory for Carcinogenesis and Cancer Invasion Chinese Ministry of EducationZhongshan HospitalShanghai Medical SchoolFudan UniversityShanghai 200000China Department of Otolaryngology Head and Neck Surgery Xiangya HospitalCentral South UniversityChangsha 410078China Department of Radiology Xiangya HospitalCentral South UniversityChangsha 410078China The Hormel Institute University of MinnesotaAustinMN 55912USA Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics Hunan Province Changsha 410078China National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer Changsha 410078China

Latent membrane protein 1(LMP1)is a major Epstein–Barr virus(EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell ***,mitochondrial fission has been demonstrated as a crucial mechanism in oncovirus-mediated *** dynamin-related protein 1(Drp1)-mediated mitochondrial fission has an impact on the chemoresistance of ***,the mechanism by which oncogenic stress promotes mitochondrial fission,potentially contributing to tumorigenesis,is not entirely *** role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma(NPC)was determined in our *** show that EBV-LMP1 exhibits a new function in remodeling mitochondrial morphology by activating Drp1.A high level of p-Drp1(Ser616)or a low level of p-Drp1(Ser637)correlates with poor overall survival and disease-free ***,the protein level of p-Drp1(Ser616)is related to the clinical stage(TNM stage)of *** Drp1 impairs mitochondrial function and induces cell death in LMP1-positive NPC *** addition,EBV-LMP1 regulates Drp1 through two oncogenic signaling axes,AMPK and cyclin B1/Cdk1,which promote cell survival and cisplatin resistance in *** findings provide novel insight into the role of EBV-LMP1-driven mitochondrial fission in regulating Drp1 phosphorylation at serine 616 and serine *** of Drp1 could be a promising therapeutic strategy for LMP1-positive NPC.

关键词： Drp1 LMP1 cisplatin

Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses

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Cellular & Molecular Immunology 2008年第2期5卷 113-120页

作者： Gefei Wang Juan Zhang weizhong Li Yun Su Yuanli Gao Heng Zhang Guimei lin Xiaoyang Jiao Kangsheng Li Department of Microbiology and Immunology Shantou University MedicalCollege Shantou 515041 China The Key Immunopathology Laboratory of Guangdong Province Shantou University Medical College Shantou 515041 China

Patients with an influenza virus infection can be complicated by acute encephalopathy and encephalitis. To investigate the immune reactions involved in the neurocomplication, mouse microglia and astrocytes were isolated, infected with human H1N1 and avian H5N1 influenza viruses, and examined for their immune responses. We observed homogeneously distributed viral receptors, sialic acid （SA）-a2,3-Galactose （Gal） and SA-a2,6-Gal, on microglia and astrocytes. Both viruses were replicative and productive in microglia and astrocytes. Virus-induced apoptosis and cytopathy in infected cells were observed at 24 h post-infection （p.i.）. Expression of IL-1β, IL-6 and TNF-a mRNA examined at 6 h and 24 h p.i. was up-regulated, and their expression levels were considerably higher in H5N1 infection. The amounts of secreted proinflammatory IL-1β, IL-6 and TNF-a at 6 h and 24 h p.i. were also induced, with greater induction by H5N1 infection. This study is the first demonstration that both human H1N1 and avian H5N1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis, cytopathy, and proinflammatory cytokine production in them in vitro. Our results suggest that the direct cellular damage and the consequences of immunopathological injury in the CNS contribute to the influenza viral pathogenesis. Cellular ＆ Molecular Immunology.

关键词： microglia astrocyte apoptosis cytokine influenza virus

热泵辅助变压精馏分离碳酸二甲酯/甲醇工艺及系统模拟优化

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化工进展 2022年第11期41卷 5722-5730页

作者：林子昕田伟安维中中国海洋大学化学化工学院山东青岛266100

针对传统变压精馏工艺分离碳酸二甲酯(DMC)/甲醇(MeOH)共沸物存在的高能耗问题,提出了基于热泵辅助的改进变压精馏工艺,并探索了不同热泵方案的可行性和经济性。该研究在ASPEN PLUS模拟平台上进行。首先,设计出传统的热集成变压精馏工艺... 详细信息

针对传统变压精馏工艺分离碳酸二甲酯(DMC)/甲醇(MeOH)共沸物存在的高能耗问题,提出了基于热泵辅助的改进变压精馏工艺,并探索了不同热泵方案的可行性和经济性。该研究在ASPEN PLUS模拟平台上进行。首先,设计出传统的热集成变压精馏工艺(H-PSD),并通过塔总组合曲线分析了传统工艺用能瓶颈和工艺改进方向;然后,提出了4种不同型式的热泵辅助的改进工艺,并通过模拟技术取得不同方案的设计参数;最后,采用组合曲线和经济性分析相结合的方法,比较了不同热泵方案的节能效果和经济性。研究表明,各种热泵方案中,基于中间再沸器的蒸汽再压缩式热泵的节能效果及经济性最好。与传统热集成变压精馏比较,过程能耗降低了24.31%,年均操作费用降低了29.43%,年度总成本可降低12.58%,体现了热泵辅助工艺的良好节能效果和经济性。

关键词：二元混合物碳酸二甲酯蒸馏模拟热泵

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