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Evolution model and failure mechanisms of rainfall-induced cracked red clay slopes:insights from Xinshao County,China

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Journal of Mountain Science 2024年第3期21卷 867-881页

作者： JIAO weizhi ZHANG Ming LI Peng XIE Junjin PANG Haisong LIU Fuxing YANG Long Faculty of Engineering China University of GeosciencesWuhan 430074China

Red clay landslides are widely distributed worldwide,resulting in severe loss of life and *** rainfall-induced red clay slopes have received extensive attention,the role of cracks in the evolutionary process of red clay slopes and their connection to failure mechanisms is still poorly understood.A comprehensive approach integrating field investigation,laboratory tests,and numerical simulations was conducted to study the 1.8 red clay landslides in Xinshao County,*** results show that red clay is prone to forming cracks at high moisture content due to its low swelling and high shrinkage *** failure mode of red clay slopes can be summarized in three stages:crack generation,slope excavation,and slope ***,the retrospective analysis and numerical simulations of the typical landslide in Guanchong indicated that intense rainfall primarily impacts the shallow layer of soil within approximately 0.5 m on the intact ***,cracks change the pattern of rainfall infiltration in the *** infiltrates rapidly through the preferential channels induced by the cracks rather than uniformly and slowly from the slope *** results in a significant increase in both the depth of infiltration and the saturated zone area of the cracked slope,reaching 3.8 m and 36.2 m^(2),***,the factor of safety of the slope decreases by 1..4%compared to the intact slope,ultimately triggering *** study can provide valuable insights into understanding the failure mechanisms of red clay slopes in China and other regions with similar geological settings.

关键词： Red clay slopes Cracks Preferential flow Failure mechanism

Development of a cell-permeable adenine-derived probe for capture of nucleotide-binding proteins in living cells

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Chinese Chemical Letters 2024年第3期35卷 243-246页

作者： Lihong Liu Rui Chen Gang Xue Chenzhou Hao weizhi Weng Zhengying Pan State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Adenine is an essential building block of genetic material and a range of *** probes containing an adenine moiety have been used in kinase profiling studies in cell *** we report that adenine-derived small-molecule probes with an activated ester reactive group can covalently modify a conserved lysine residue of protein kinases and capture a number of nucleotide-binding proteins within living cells.

关键词： Adenine-derived probe Cell-permeable Lysine residue Protein kinases Nucleotide-binding proteins

Investigation of Eccentric PM on High-frequency Vibration in FSCW PM Machine Considering Force Modulation Effect

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Chinese Journal of Electrical Engineering 2024年第2期10卷 59-69页

作者： Jinghua Ji weizhi Jiang Wenxiang Zhao Tong Liu School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China

This study investigates the negative influence of an eccentric permanent-magnet(PM)design on high-frequency electromagnetic vibration in fractional-slot concentrated-winding(FSCW)PM ***,an analytical expression for the sideband current harmonics was derived using the double Fourier series expansion ***,the characteristics of the flux-density harmonics are studied from the perspective of the space-time distribution and initial phase *** influence of the eccentric PM design on high-frequency electromagnetic and concentrated forces was studied based on the electromagnetic force modulation ***,an eccentric PM design is not conducive to reducing the 2pth-order high-frequency electromagnetic ***,two FSCW PM machines with conventional and eccentric PM designs are manufactured and tested to verify the theoretical *** results show that the eccentric PM design worsens high-frequency vibrations.

关键词： Eccentric permanent magnet machine sideband current harmonics electromagnetic force modulation effect fractional-slot concentrated-winding high-frequency vibration

The AaBBX21.AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： weizhi He Hang Liu Zhangkuanyu Wu Qing Miao Xinyi Hu Xin Yan Hangyu Wen Yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li Frontiers Science Center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underlying regulatory mechanism remains *** this study,we demonstrate that ELONGATED HYPOCOTYL5(HY5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHY5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21.as a potential interactor with ***21.showed a trichome-specific expression ***,the AaBBX21.AaHY5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1.AaMYB1.8,and AaORA,encoding positive regulators of artemisinin ***,AaHY5 and AaBBX21.physically interacted with the *** E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1.COP1..In the dark,AaCOP1.decreased the accumulation of AaHY5 and AaBBX21.and repressed the activation of genes downstream of the AaHY5–AaBBX21.complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

A lightweight and efficient raw data collection scheme for IoT systems

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Journal of Information and Intelligence 2024年第3期2卷 209-223页

作者： Yixuan Huang Yining Liu Jingcheng Song weizhi Meng School of Computer and Information Security Guilin University of Electronic TechnologyGuilin 541004China School of Data Science and Artificial Intelligence Wenzhou University of TechnologyWenzhou 325027China School of Computer Science&Engineering LinYi UniversityLinyi 276000China Department of Aplied Mathematics and Computer Science Technical University of DenmarkKongens Lyngby 2800Denmark

With the prevalence of Internet of Things(loT)devices,data collection has the potential to improve people's lives and create a significant ***,it also exposes sensitive information,which leads to privacy *** approach called N-source anonymity has been used for privacy preservation in raw data collection,but most of the existing schemes do not have a balanced efficiency and *** this work,a lightweight and efficient raw data collection scheme is *** proposed scheme can not only collect data from the original users but also protect their ***,the proposed scheme can resist user poisoning attacks,and the use of the reward method can motivate users to actively provide *** and simulation indicate that the proposed scheme is safe against poison ***,the proposed scheme has better performance in terms of computation and communication overhead compared to existing *** efficiency and appropriate incentive mechanisms indicate that the scheme is practical for IoT systems.

关键词： Data privacy Raw data collection loT systems Unlinkability

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数字法学真的来了吗?

现代法学 2024年第1期46卷 78-91页

作者：宋维志上海交通大学凯原法学院上海200030 南昌大学法学院南昌330031

对数字技术发展所带来法律问题的研究推动数字法学作为学术命题被提出。虽然数字法学发展迅速,已成为学界热门研究领域,但关于数字法学立论基础等理论问题的研究仍较为薄弱。一方面,数字法学缺乏明确的问题领域,所研究的问题本质上是技... 详细信息

对数字技术发展所带来法律问题的研究推动数字法学作为学术命题被提出。虽然数字法学发展迅速,已成为学界热门研究领域,但关于数字法学立论基础等理论问题的研究仍较为薄弱。一方面,数字法学缺乏明确的问题领域,所研究的问题本质上是技术问题,可以通过对现有法学理论体系的完善获得解释;另一方面,数字法学缺少充分的理论建构,既没有突破传统权力理论框架,也没有提出技术超越理论。因此,数字法学在问题领域和理论建构两方面均无法被证成。与其说数字法学是一种法学研究新范式,不如承认数字法学本质上是对技术应用场景的模糊概括。数字社会只是观察社会的众多视角之一,数字社会的到来并不必然意味着法学研究转向了数字法学。在法学理论上,数字法学并不是一个真实的学术命题。

关键词：数字法学数字社会数字技术法学理论新法学

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei Guo weizhi Xu Xin Xue Guoqiang Su Long Sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1.04 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(1.7)Lu-labeled LNC1.04 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(1.7)Lu-LNC1.04 induced a transient upregulation of PD-L1.expression in tumor *** combination of^(1.7)Lu-LNC1.04 and anti-PD-L1.immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 1.0%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1.macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(1.7)Lu-LNC1.04 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(1.7)Lu-LNC1.04 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

Long-term in vivo chimeric cells tracking in non-human primate

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Protein & Cell 2024年第3期15卷 207-222页

作者： Junmo Wu Yu Kang Xiang Luo Shaoxing Dai Yuxi Shi Zhuoyao Li Zengli Tang Zhenzhen Chen Ran Zhu Pengpeng Yang Zifan Li Hong Wang Xinglong Chen Ziyi Zhao weizhi ji Yuyu Niu State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650500China

Non-human primates(NHPs)are increasingly used in preclinical trials to test the safety and efficacy of biotech-nology ***,given the ethical issues and costs associated with this model,it would be highly advantageous to use NHP cellular models in clinical ***,developing and maintaining the naive state of primate pluripotent stem cells(PSCs)remains difficult as does in vivo detection of PSCs,thus limiting biotech-nology application in the cynomolgus ***,we report a chemically defined,xeno-free culture system for culturing and deriving monkey PSCs in *** cells display global gene expression and genome-wide hypometh-ylation patterns distinct from monkey-primed *** also found expression of signaling pathways components that may increase the potential for chimera *** for biomedical applications,we were also able to integrate bioluminescent reporter genes into monkey PsCs and track them in chimeric embryos in vivo and in *** engineered cells retained embryonic and extra-embryonic developmental ***,we generated a chimeric monkey carrying bioluminescent cells,which were able to track chimeric cells for more than 2 years in living *** study could have broad utility in primate stem cell engineering and in utilizing chimeric monkey models forclinical studies.

关键词： pluripotent stem cells bioluminescence imaging non-human primates

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教育机器:一种人类教育的新范式

教育研究 2024年第4期45卷 62-72页

作者：谭维智曲阜师范大学中国教育大数据研究院山东曲阜273165 曲阜师范大学教育学院山东曲阜273165

新一代人工智能因为涌现智能而具备了接受教育的条件,智能机器成为新的教育对象,人与机器的关系转变为一种教育关系。像教育人一样教育机器,并不等于像教育机器一样教育人。“机师”与“人师”存在根本性差异,不能让机器以人教人的方式... 详细信息

新一代人工智能因为涌现智能而具备了接受教育的条件,智能机器成为新的教育对象,人与机器的关系转变为一种教育关系。像教育人一样教育机器,并不等于像教育机器一样教育人。“机师”与“人师”存在根本性差异,不能让机器以人教人的方式教育人。智能机器的崛起使教育面临一次由“人人之间”向“人机之间”的范式转型。构建教育机器的新型教育范式需要重新定义学习、教育、教师,更新教育理念,进行教育理论层面的准备,并为新范式的实现提供一个可行的实践模式。相对于以“学”为中心和以“教”为中心的教育范式,教育机器的新型教育范式是“教学合一”的教育范式。经由教育机器来形成一种将“教”和“学”融为一体的结构及其学习发生机制是教育范式转型的关键。

关键词：教育范式教育机器智能机器机器学生