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细胞外囊泡的检测及其在非酒精性脂肪性肝病诊断中的价值

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中华肝脏病杂志 2020年第1期28卷 92-96页

作者：蒋维芸荀运浩浙江中医药大学杭州310053 杭州市西溪医院杭州310023

细胞外囊泡是双层脂质膜小囊泡,可以由大多数类型的细胞释放,并在大多数体液中可检测到,细胞外囊泡可将其生物活性成分转移到受体细胞或激活靶细胞中的信号转导,发挥细胞间通讯的关键功能,从而参与多种疾病包括肝脏疾病的发生和发展。... 详细信息

细胞外囊泡是双层脂质膜小囊泡,可以由大多数类型的细胞释放,并在大多数体液中可检测到,细胞外囊泡可将其生物活性成分转移到受体细胞或激活靶细胞中的信号转导,发挥细胞间通讯的关键功能,从而参与多种疾病包括肝脏疾病的发生和发展。近年来非酒精性脂肪性肝病患病率上升,除有创的肝活组织检查外,目前还没有可靠的肝脏炎症诊断或纤维化分期方法,寻求相应的无创循环标志物的研究持续活跃,细胞外囊泡是其中较受关注者之一。为此综述了目前关于细胞外囊泡的物理特征、生物成分和分离方法的知识,并介绍了利用循环细胞来源囊泡作为非酒精性脂肪性肝病诊断新标志物的概念。

关键词：脂肪肝,非酒精性外泌体生物学标记细胞外囊泡

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后浇带渗漏问题在设计与施工阶段的预控

中国建筑防水 2010年第6期 5-9页

作者：蒋维郓上海凯悦建设咨询监理有限公司上海200063

分析了混凝土后浇带的作用,提出了从设计、施工两大环节控制后浇带质量的具体措施,以确保混凝土结构工程质量。

关键词：混凝土后浇带设计与施工措施渗漏修复

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大型水池裂缝修复工艺

中国建筑防水 2008年第11期 38-40页

作者：蒋维郓上海凯悦建设咨询监理有限公司上海200063

某大型水池是远东最大的科研用水池工程,在施工过程中即发现了大量裂缝。分析了该大型混凝土水池裂缝的产生原因,重点阐述了裂缝修补方案的制订、优化过程以及裂缝的修补工艺。

关键词：混凝土水池裂缝修复

改良Bilhaut-Cloquet术治疗WasselⅠ型和Ⅱ型复拇畸形的临床效果分析

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中国美容医学 2022年第12期31卷 13-16页

作者：姜魏云马蕾南京医科大学附属儿童医院烧伤整形科江苏南京210008

目的:探讨改良Bilhaut-Cloquet术治疗WasselⅠ型和Ⅱ型复拇畸形的临床效果。方法:选取90例WasselⅠ型和Ⅱ型复拇畸形患儿为研究对象,其中对照组43例(传统Bilhaut-Cloquet术),实验组47例(改良Bilhaut-Cloquet术)。术后随访6个月~2年,比... 详细信息

目的:探讨改良Bilhaut-Cloquet术治疗WasselⅠ型和Ⅱ型复拇畸形的临床效果。方法:选取90例WasselⅠ型和Ⅱ型复拇畸形患儿为研究对象,其中对照组43例(传统Bilhaut-Cloquet术),实验组47例(改良Bilhaut-Cloquet术)。术后随访6个月~2年,比较两组术后指关节功能、疗效、拇指外观及满意度。结果:术后,实验组指关节运动范围、关节稳定性优于对照组,成角畸形评分优于对照组,差异有统计学意义(P0.05)。术后,实验组拇指窄小发生率高于对照组,对照组拇指宽大及指甲畸形发生率高于实验组,差异有统计学意义(P<0.05)。实验组温哥华瘢痕量表(Vancouverscarscale,VSS)评分优于对照组,且实验组患儿/家属总满意度高于对照组(93.62%vs76.74%),差异有统计学意义(P<0.05)。结论:改良Bilhaut-Cloquet术治疗WasselⅠ型和Ⅱ型复拇畸形效果好,关节稳定度、活动度等改善程度皆优于传统术式,术后患儿/家属满意度较高,值得推广应用。

关键词：改良Bilhaut-Cloquet术复拇畸形 WasselⅠ型 WasselⅡ型疗效美观度

3D耳模在自体肋软骨移植耳廓再造术中的应用效果探讨

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中国美容医学 2022年第11期31卷 70-74页

作者：姜魏云马蕾南京医科大学附属儿童医院烧伤整形科江苏南京210008

目的:探讨3D耳模在自体肋软骨移植耳廓再造术中的应用效果。方法:选取2018年12月-2020年12月笔者医院整形外科收治的68例耳廓再造患儿为观察对象,根据耳模制作方法不同分为3D耳模组和标准耳模组,各34例。两组均进行术前检查并给予针对... 详细信息

目的:探讨3D耳模在自体肋软骨移植耳廓再造术中的应用效果。方法:选取2018年12月-2020年12月笔者医院整形外科收治的68例耳廓再造患儿为观察对象,根据耳模制作方法不同分为3D耳模组和标准耳模组,各34例。两组均进行术前检查并给予针对性护理,在此基础上3D耳模组行3D打印技术辅助耳廓再造术,标准耳模组行二维标准耳模术辅助耳廓再造术。比较两组再造耳廓整体形态、心理状态、术后并发症发生情况、美学效果满意度及模型应用效果。结果:术后6个月,3D耳模组再造耳廓的三维轮廓、对称性、颅耳角和亚解剖结构还原度评分均高于标准耳模组,差异有统计学意义(P0.05)。两组患儿各种心理状态评分均较术前显著降低,且3D耳模组和标准耳模组比较差异有统计学意义(P0.05)。3D耳模组对再造耳廓的三维轮廓、对称性、颅耳角和功能美学效果满意度评分均高于标准耳模组,差异有统计学意义(P0.05)。耳廓再造医生对3D耳模组模型各方面应用效果评分均高于标准耳模组,差异有统计学意义(P<0.05)。结论:在自体肋软骨移植耳廓再造术中应用3D耳模可有效辅助精细解剖结构的重建提升再造耳廓整体形态,改善患儿心理状态,减少术后并发症发生,提高美学效果满意度,且有助于医生更好地实施耳廓再造术,值得推广应用。

关键词：小耳畸形 3D耳模自体肋软骨移植耳廓再造美学效果护理体会

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu Fan Shuyong jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior