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Emerging weak antilocalization effect in Ta_(0.7)Nb_(0.3)Sb_(2)semimetal single crystals

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Frontiers of physics 2023年第1期18卷 123-132页

作者： Meng Xu Lei Guo Lei Chen Ying Zhang Shuang-Shuang li weiyao Zhao Xiaolin Wang Shuai Dong Ren-Kui Zheng College of Science Hohai UniversityNanjing 210098China School of Physics Southeast UniversityNanjing 211189China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China School of Materials Science and Engineering Jiangxi Engineering Laboratory for Advanced Functional Thin FilmsNanchang UniversityNanchang 330031China Department of Materials Science&Engineering Monash UniversityClayton 3800 VICAustralia Institute for Superconducting and Electronic Materials &ARC Centre of Excellence in Future Low-Energy Electronics TechnologiesInnovation CampusUniversity of WollongongNorth Wollongong NSW 2500Australia

Weak antilocalization(WAL)effect is commonly observed in low-dimensional systems,three-dimensional(3D)topological insulators and ***,we report the growth of high-quality Ta_(0.7)Nb_(0.3)Sb_(2)single crystals via the chemical vapor transport(CVT).Clear sign of the WAL effect is observed below 50 K,probably due to the strong spin–orbital coupling in 3D *** addition,it is worth noting that a relatively large MR of 120%appears under 1 T magnetic field at T=2 *** measurements and two-band model fitting results reveal high carrier mobility(>1000 cm^(2)·V^(–1)·s^(–1)in 2–300 K region),and off-compensation electron/hole ratio of~8:*** to the angular dependence of the WAL effect and the fermiology of the Ta_(0.7)Nb_(0.3)Sb_(2)crystals,interesting magnetic-field-induced changes of the symmetry of the anisotropic magnetoresistance(MR)from two-fold(≤0.6 T)to four-fold(0.8–1.5 T)and finally to two-fold(≥2 T)are *** phenomenon is attributed to the mechanism shift from the low-field WAL dominated MR to WAL and fermiology co-dominated MR and finally to high-field fermiology dominated *** these signs indicate that Ta_(0.7)Nb_(0.3)Sb_(2)may be a topological semimetal candidate,and these magnetotransport properties may attract more theoretical and experimental exploration of the(Ta,Nb)Sb_(2)family.

关键词： topological semimetal magnetoresistance weak antilocalization effect spin-orbital coupling

Transient Performance Improvement in Tracking Control for a Class of Nonlinear Systems with Input Saturation

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Journal of Systems Science & Complexity 2018年第1期31卷 200-214页

作者： LU Tao LAN weiyao li Zhibin Department of Automation Xiamen University Xiamen 361005 China Academy of Opto-Electronics Chinese Academy of Sciences Beijing 100094 China

这份报纸探讨合成非线性的反馈(CNF ) 为有输入浸透的单个产量的非线性的系统与好短暂性能指向追踪改变引用的一时间的 singleinput 的一个类的控制。CNF 控制法律由一条追踪的控制法律和一个表演赔偿者组成。追踪的控制法律被设计驱使... 详细信息

这份报纸探讨合成非线性的反馈(CNF ) 为有输入浸透的单个产量的非线性的系统与好短暂性能指向追踪改变引用的一时间的 singleinput 的一个类的控制。CNF 控制法律由一条追踪的控制法律和一个表演赔偿者组成。追踪的控制法律被设计驱使系统的输出追踪很快改变引用目标的时间，当性能赔偿者被用来减少追踪的控制法律引起的 overshoot 时。靠近环的系统的稳定性被建立。设计过程和靠近环的系统的短暂性能的改进与一个数字例子和控制凡·德尔·波尔振荡器被说明。

关键词：追踪控制性能改进非线性系统浸透输入设计过程法律

针刀疏筋解结术对类风湿关节炎家兔滑膜炎症的影响及作用机制研究

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中国中医药信息杂志 2024年第7期31卷 91-99页

作者：陈平王海东杜小正井维尧刘翠李浩林陶鹏飞甘肃省中医院风湿骨病中心甘肃兰州730050 甘肃中医药大学甘肃兰州730000

目的观察针刀疏筋解结术对类风湿关节炎(RA)模型家兔膝关节滑膜组织NF-κB/Bcl-2通路活性及肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6、Bax、caspase-3表达的影响,探讨其抑制RA滑膜炎症的作用机制。方法24只新西兰白兔随机分... 详细信息

目的观察针刀疏筋解结术对类风湿关节炎(RA)模型家兔膝关节滑膜组织NF-κB/Bcl-2通路活性及肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6、Bax、caspase-3表达的影响,探讨其抑制RA滑膜炎症的作用机制。方法24只新西兰白兔随机分为正常组、模型组、药物组和针刀组,每组6只,除正常组外,其余组采用卵蛋白+弗氏完全佐剂膝关节腔注射复制RA模型,分别予相应干预,连续18 d。测定家兔膝关节痛阈、膝关节周径,超声观察关节腔积液、滑膜厚度及内部血流信号,HE染色观察膝关节滑膜组织形态,TUNEL染色观察滑膜组织成纤维样滑膜细胞(FLS)凋亡情况,免疫组化检测滑膜组织TNF-α、IL-1β、IL-6表达,RT-PCR检测滑膜组织核因子(NF)-κBp65、Bcl-2mRNA表达,Westernblot检测滑膜组织NF-κBp65、p-NF-κBp65、Bcl-2、Bax、caspase-3蛋白表达。结果与正常组比较,模型组家兔膝关节痛阈降低、膝关节周径增加,超声评分和滑膜组织病理评分增加;滑膜组织FLS凋亡率降低,TNF-α、IL-1β、IL-6表达升高,NF-κBp65、Bcl-2 mRNA和蛋白及p-NF-κBp65蛋白表达升高,Bax、caspase-3蛋白表达降低,差异均有统计学意义(P<0.05)。与模型组比较,药物组和针刀组家兔膝关节痛阈增加、膝关节周径减小,超声评分和滑膜组织病理评分减少;滑膜组织FLS凋亡率升高,TNF-α、IL-1β、IL-6表达降低,NF-κBp65、Bcl-2m RNA和蛋白及p-NF-κBp65蛋白表达降低,Bax、caspase-3蛋白表达升高,差异均有统计学意义(P<0.05)。结论针刀疏筋解结术可能通过降低滑膜组织NF-κB/Bcl-2通路活性,促进FLS凋亡,减少TNF-α、IL-1β、IL-6产生,抑制RA滑膜炎症,减轻膝关节肿胀、提升痛阈。

关键词：针刀疏筋解结术类风湿关节炎成纤维样滑膜细胞滑膜炎症兔

Robust Adaptive Formation Control with Autonomous Surface Vehicles

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Robust Adaptive Formation Control with Autonomous Surface Ve...

从NF-κB/Bcl-2信号通路调控成纤维样滑膜细胞凋亡角度探讨中医药抑制类风湿关节炎滑膜炎症机制的研究进展

第二十九届中国控制会议

作者： PENG Zhouhua1,WANG Dan1,YAO Yubin1,LAN weiyao2,li Xiaoqiang1,SUN Gang1 1.Marine Engineering College,Dalian Maritime University,Dalian 116026,P.R.China2.Department of Automation,Xiamen University,Xiamen 361005,P.R.China

In this paper,a robust adaptive formation control law is proposed for multiple autonomous surface vehicles moving in a leader-follower *** presented method uses only measurements of line-of-sight range and angle by local sensors,no other information about leader is required for control *** networks are trained online to compensate for uncertainties due to unknown velocity of the *** on Lyapunov synthesis,the proposed adaptive NN control ensures that both relative distance and angle track the given bounded reference signals to a small neighborhood of *** effectiveness of proposed formation controller with applications to three autonomous surface vehicles is illustrated by numerical simulations.

关键词： Formation Control Robust Adaptive Control Neural Networks Autonomous Surface Vehicles

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中医研究 2024年第1期37卷 87-91页

作者：陈平杜小正王海东井维尧刘翠李浩林陶鹏飞王金磊甘肃省中医院风湿骨病中心甘肃兰州730050 甘肃中医药大学甘肃兰州730000

类风湿关节炎(rheumatoid arthritis,RA)是一种以关节滑膜炎症为主要特征的自身免疫性疾病,成纤维样滑膜细胞(fibroblast-like synoviocytes,FLS)的抗凋亡是导致该病病情发展的主要因素。如何促进FLS凋亡并抑制炎症反应是目前RA治疗和... 详细信息

类风湿关节炎(rheumatoid arthritis,RA)是一种以关节滑膜炎症为主要特征的自身免疫性疾病,成纤维样滑膜细胞(fibroblast-like synoviocytes,FLS)的抗凋亡是导致该病病情发展的主要因素。如何促进FLS凋亡并抑制炎症反应是目前RA治疗和研究的重点。核因子κB(nuclear factor kappa-B,NF-κB)/B淋巴细胞瘤-2(B-cell lymphoma-2,Bcl-2)信号通路在RA发病过程中发挥了关键作用,其与FLS炎症倾向、抗凋亡等密切相关。研究并探讨NF-κB/Bcl-2信号通路调控FLS凋亡的机制及作用,介绍中医药靶向该通路促进FLS凋亡进而抑制RA滑膜炎症的研究现状,旨在为中医药治疗RA的研究提供一定基础。

关键词：类风湿关节炎滑膜炎症 NF-κB/Bcl-2信号通路成纤维样滑膜细胞凋亡机制

A 3-Parameter Thermal Model for the Skin of Stratospheric Airships and Its Computing Analysis

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A 3-Parameter Thermal Model for the Skin of Stratospheric Ai...

基于“肠-关节”轴探讨电针对类风湿关节炎模型家兔肠道菌群及血清炎症因子的影响

第36届中国控制会议

作者： Nie Hongpeng liN Xianwu li Zhibin LAN weiyao School of Aerospace Engineering Xiamen University Academy of Opto-Electronics Chinese Academy of Science

ISBN: (纸本)9781538629185

The temperature distribution on the skin of the stratospheric airship plays an important role in its thermal behavior. In order to analyze the temperature distribution on the skin of the stratospheric airship, a 3-parameter thermal model is ***, a 3-parameter thermal model for the skin is established under the condition that the attitude of the stratospheric airship changes slowly. Then, based on the net heat method, the calculation method of the 3-parameter thermal model is introduced. At last, the temperature distribution on the skin of the airship is obtained by numerical simulation of the 3-parameter thermal model,and the effectiveness of the 3-parameter thermal model is verified by analyzing the simulation results, which lays the foundation for further simplifying the thermal model of the airship skin.

关键词： Stratospheric Airship 3-Parameter Thermal Model Net Heat Method Temperature Distribution

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中国中医药信息杂志 2024年第4期31卷 124-131页

作者：刘翠杜小正井维尧苏成红刘莉梅袁博张星华张枫帆陈平李向军王海东甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000 甘肃省中医院甘肃兰州730050

目的观察电针对类风湿关节炎(RA)模型家兔肠道菌群及血清炎性因子的影响,探讨其治疗RA的作用机制。方法采用卵蛋白诱导联合完全弗氏佐剂建立RA家兔模型,将造模成功家兔随机分为模型组、益生菌组和电针组,每组6只,另取6只家兔作为正常组... 详细信息

目的观察电针对类风湿关节炎(RA)模型家兔肠道菌群及血清炎性因子的影响,探讨其治疗RA的作用机制。方法采用卵蛋白诱导联合完全弗氏佐剂建立RA家兔模型,将造模成功家兔随机分为模型组、益生菌组和电针组,每组6只,另取6只家兔作为正常组。电针组电针双侧“足三里”“犊鼻”,30 min/次,益生菌组予益生菌胶囊溶液(14.5 mg/kg)灌胃,均1次/d,连续2周。测量家兔膝关节周径、痛阈,HE染色观察结肠组织和滑膜组织病理形态,16S rDNA测序分析肠道菌群结构变化,EliSA检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6含量。结果与正常组比较,模型组家兔膝关节周径显著增加、痛阈显著降低(P<0.01);结肠黏膜损伤严重,杯状细胞缺失,大量炎性细胞浸润;关节囊滑膜表面粗糙,滑膜细胞增生、增厚,炎性细胞浸润明显;肠道菌群物种数目及均匀度减少,变形菌门、厚壁菌门、拟杆菌门相对丰度减少(P<0.05,P<0.01),脱硫杆菌门相对丰度增加(P<0.01),弯曲杆菌属、劳森氏菌属及假单胞菌属相对丰度增加(P<0.01),赫山单胞菌属、草螺菌属相对丰度降低(P<0.01);血清TNF-α、IL-1β、IL-6含量显著升高(P<0.01)。与模型组比较,益生菌组和电针组家兔膝关节周径显著减小、痛阈显著升高(P<0.01,P<0.05);肠黏膜损伤程度减轻,杯状细胞排列基本整齐,炎性细胞浸润减轻;滑膜细胞增生、增厚减轻,少量炎性细胞浸润;肠道菌群物种数目及均匀度增加,变形菌门、厚壁菌门、拟杆菌门相对丰度增加(P<0.05,P<0.01),脱硫杆菌门相对丰度减少(P<0.01),弯曲杆菌属、劳森氏菌属及假单胞菌属相对丰度减少(P<0.01),赫山单胞菌属、草螺菌属相对丰度增加(P<0.05,P<0.01);血清TNF-α、IL-1β、IL-6含量显著降低(P<0.01)。结论电针可显著改善RA家兔症状,降低关节滑膜炎症反应,其机制可能与调控肠道菌群结构有关。

关键词：类风湿关节炎电针肠-关节轴肠道菌群炎性反应兔

CpG DNA enhances the im-mune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs

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Chinese Science Bulletin 2001年第16期46卷 1376-1379页

作者： li Guangjin li Yingjie YAN weiyao XU Quanxin WU Yongqing XIE Yong YOU Yongjin ZHENG Zhaoxin State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200433China Institute of Veterinary Science Shanghai Academy of Agricultural SciencesShanghai 201106China Department of Biology Hong Kong University of Science and TechnologyHong KongChina

CpG DNA is DNA sequence that has immune stimulatory effects. Several lines of investigation over the past few years indicate that CpG DNA plays an important role in the induction of immune responses to DNA vaccines. In this study, CpG DNA-containing synthetic oligodeoxynucleotide (CpG-ODN) was cloned into the eukaryotic expression plasmid encoding a fusion protein containing b- galactosidase from E. coli and immunogenic epitopes of foot- and-mouth disease virus (FMDV) type O, and the immune responses induced by the plasmid were assayed. The results showed that guinea pigs immunized with the recombinant plasmid containing CpG-ODN generated a higher level of FMDV-neutralizing antibody and a stronger T cell proliferative response and protection against viral challenge than those receiving the plasmid containing no CpG-ODN. Our study demonstrated that it is an effective route to enhance the efficacy of DNA vaccines by inserting exogenous CpG DNA into the plasmids, and the DNA vaccine developed here is a promising candidate to prevent FMDV infection.

关键词： CpG DNA DNA vaccine foot-and-mouth disease virus immnostimulatory sequence.

阿魏蘑提取物清除羟自由基和体外抗肿瘤活性的研究

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食用菌学报 2008年第1期15卷 51-54页

作者：李维瑶杨焱唐庆九郝瑞霞刘艳芳张劲松赵勇上海市食用菌工程技术研究中心上海市农业遗传育种重点实验室上海市农业科学院食用菌研究所上海市农业科学院天然药用资源研究与开发中心上海201106 上海水产大学食品学院上海200090

采用乙醇、乙酸乙酯和石油醚3种溶剂对阿魏蘑子实体进行提取,用化学发光法和Alamar Blue法分别对不同的粗提物进行了清除羟自由基和体外抑制肿瘤细胞生长作用的研究。结果显示,各粗提物对羟自由基的抑制作用均随着剂量的增加而逐渐增强... 详细信息

采用乙醇、乙酸乙酯和石油醚3种溶剂对阿魏蘑子实体进行提取,用化学发光法和Alamar Blue法分别对不同的粗提物进行了清除羟自由基和体外抑制肿瘤细胞生长作用的研究。结果显示,各粗提物对羟自由基的抑制作用均随着剂量的增加而逐渐增强,其中乙酸乙酯粗提物清除羟自由基的活性最强;3种粗提物对肿瘤细胞L1210都具有很强的抑制作用。利用HPLC初步分析了粗提物中的组分,结果显示,这3种粗提物中含有某种结构相近的组分,乙醇提取物和乙酸乙酯提取物中化合物的种类较多。

关键词：阿魏蘑羟自由基抗氧化剂抗肿瘤